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PLOS One logoLink to PLOS One
. 2024 Mar 14;19(3):e0300026. doi: 10.1371/journal.pone.0300026

Comparison across age groups of causes, circumstances, and consequences of falls among individuals living in Canada: A cross-sectional analysis of participants aged 45 to 85 years from the Canadian Longitudinal Study on Aging

Vanina P M Dal Bello-Haas 1,*,#, Megan E O’Connell 2,#, Jake Ursenbach 2
Editor: Ryota Sakurai3
PMCID: PMC10939241  PMID: 38483932

Abstract

Falls are a leading cause of injury-related deaths and hospitalizations among Canadians. Falls risk has been reported to be increased in individuals who are older and with certain health conditions. It is unclear whether rurality is a risk factor for falls. This study aimed to investigate: 1) fall profiles by age group e.g., 45 to 54 years, 55 to 64 years, 65 to 74 years, 75 to 85 years; and 2) falls profiles of individuals, by age group, living in rural versus urban areas of Canada. Data (N = 51,338) from the Canadian Longitudinal Study on Aging was used to examine the relationship between falls and age, rurality, chronic conditions, need for medical attention, and fall characteristics (manner, location, injury). Self-reported falls within a twelve-month period occurred in only 4.8% (single fall) and 0.8% (multiple falls) of adults. Falls were not related to rural residence or age, but those with memory impairment, multiple sclerosis, as well as other chronic conditions such as mood disorder, anxiety disorder, and hyperthyroidism not often thought to be associated with falls, were also more likely to fall. Older individuals were more likely to fall indoors or fall while standing or walking. In contrast, middle-aged individuals were more likely to fall outdoors or while exercising. Type of injury was not associated with age, but older individuals were more likely to report hospitalization after a fall. This study shows that falls occur with a similar frequency in individuals regardless of age or urban/rural residence. Age was associated with fall location and activity. A more universally applicable multi-facted approach, rather than one solely based on older age considerations, to screening, primary prevention and management may reduce the personal, social, and economic burden of falls and fall-related injuries.

Introduction

Falls and understanding fall risk are important national health care priorities and public health concerns for Canadians. One third of Canadians fall each year [1], with fall rates increasing with increasing age [2, 3]. Prevention of falls is critical to keeping people independent and active across the lifespan, and particularly in later life. Falls have been found to be associated with an array of risk factors [46], and result in a plethora of serious consequences including loss of independence, disability, decline in health and well-being, decreased quality of life, pain, morbidity, institutionalization, and mortality [2, 3, 7]. Almost half of Canadians ages 20 years and older are living with a chronic condition [8], which can put them at increased risk of falls [9]. Falls are the leading cause of injury-related deaths and hospitalizations among all Canadians. Direct and indirect costs of falls are staggering, and societal and personal burden are significant [7, 10, 11].

Canada’s population continues to age [12]. Canada’s rural population is aging faster than its urban and suburban counterparts, with Canadians aged 65 and over comprising 18% of Canada’s rural population [13]. Social and built environment characteristics shape opportunities for and barriers to health promotion [14, 15], and evidence is compelling that social and built environmental characteristics affect health [16, 17]. Research on the connections between community-level factors and health has shown burden of illness to be greater for vulnerable populations, such as older adults [18] and people living in rural and remote areas [1820].

With the expected accelerating pace of aging in Canada, health declines and challenges, such as falls and their related consequences, carry profound implications and highlight the need to understand when falls present and how they change across the lifespan. Understanding falls and fall risk can inform the timing of programs, services, and public health interventions. The reported high incidence of falls that occur with aging, as well as fall-related mortality and morbidity, underscores the importance of preventive measures and interventions for Canadian adults. No research to date has systematically and comprehensively examined age-group differences in mobility, mobility limitation, and fall profiles in Canadians, nor has any research to date examined differences in mobility, mobility limitations, and fall profiles of adults living in rural versus urban Canada. The objectives of our research were to: 1) comprehensively examine fall profiles by age group e.g., 45 to 54 years, 55 to 64 years, 65 to 74 years, 75 to 85 years; 2) compare falls profiles of adults, by age group, living in rural versus urban areas of Canada; and 3) identify any key issues specific to the rural setting (social, built environment) that affect number of falls.

Materials and methods

This was a cross-sectional study, analyzing population-based data from the Canadian Longitudinal Study on Aging (CLSA). A protocol for the planned analysis was submitted the CLSA Data and Sample Access Committee and the University of Saskatchewan Ethics Committee (Beh #250) for approval prior to accessing the data and analysis. Data were accessed on November 13. 2021 for research purposes. At no time did the authors have access to information that could identify individual participants during or after data collection.

Study design and participants

Details on the CLSA study design and methods have been described elsewhere and are briefly outlined here [21, 22]. The CLSA is a large, national, long-term study that will follow for at least 20 years more than 50,000 men and women ages 45 to 85 years at enrolment. Individuals were not eligible to participate if: they were living in one of Canada’s three territories, on First Nation reserves, or in long-term care facilities; were full-time members of the armed forces; were unable to communicate in English or French; or, had overt cognitive deficits. At CLSA baseline 21,241 participants were randomly selected from the 10 Canadian provinces and completed telephone-based questionnaires (i.e., Tracking cohort). Another 30,097 participants were randomly selected from areas extending 25 to 50 kilometres from each of 11 Data Collection Sites located across Canada and provided data by visiting a Data Collection Site and through an in-home interview (i.e., Comprehensive cohort). The aim of the CLSA was to explore multifaceted aspects of aging, and questionnaire/interview/assessment data included information about socioeconomic status, demographics, participation in daily activities, mental health, and objective and subjective measures of cognitive and physical health. Tracking cohort data were collected between 2011-09-22 and 2014-05-03, and the Comprehensive data between 2011-12-05 to 2015-07-07. The Tracking database has a larger proportion of rural Canadians, and the Comprehensive database includes all questionnaires asked of the Tracking cohort but includes additional measures, including physical measurement variables. For the current project, cross sectional data from the baseline Tracking and Comprehensive cohorts were combined, and analyses were restricted to variables measured equivalently across each cohort.

Measures

Demographic data

Binary sex (Male, M; Female, F). education level, marital status, and yearly income were described for the sample. Age was collected and reported as a continuous variable, but for analyses we grouped participants into the following age groups: 45–54, 55–64, 65–74, 75+ years. Categorization of residence for each participant was based on the forward sorting area from postal codes and categorized as rural, secondary urban core, urban fringe centre, and urban, per Statistics Canada classifications [23]. Rural refers rareas of census metropolitan areas (CMAs) and census agglomerations (CAs), formed by one or more adjacent municipalities centered on a population center (urban core), as well as population living in rural areas outside CMAs and CAs. A CMA total population is at least 100,000 of which 50,000 or more live in the core. A CA core population is at least 10,000. A CMA or CA can have: 1) the core, population centre with the highest population, around which a CMA or a CA is delineated; and 2) the secondary core, a population centre within a CMA that has at least 10,000 persons. Urban fringe includes apopulation centres within a CMA or CA that have fewer than 10,000 persons and are not contiguous with the core or secondary core.

Medical conditions

Participants were asked whether a doctor has told them they have a chronic condition (i.e., a transient ischemic attack, stroke, memory problems, dementia or Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, cancer).

Fall data

In the maintaining contact questionnaire, which was asked approximately 18 months after the baseline interview, participants were asked “how many times have you fallen in the past 12 months?” For the current study, participants were grouped as follows: those who reported no fall history (no falls), those who reported a single fall, (single fall) and those who reported two or more falls (multiple falls). Additional fall-related data were collected only for participants who reported one or more falls (i.e., fallers). Fallers were asked to focus on their most serious injury from a fall and were given the following options to describe the nature of their injury: no serious injury, sprain/strain, bruises, cuts, discomfort, hip fracture, leg fracture, arm/wrist fracture, vertebral fracture, head injury, or other. Fallers were asked whether they sought medical attention from a health professional within 48 hours following a fall (yes/no) and whether they were hospitalized due to this fall (yes/no). Participants were then given a list of options to describe where the fall happened i.e., inside home, outside home but inside a building, or outdoors. Finally, participants were provided with the following list to describe how the fall happened: fell while standing/walking, fell on steps/stairs, fell while exercising, fell from height of 1 metre, fell from furniture, fell while getting in/out of bath, fell while getting in/out of shower, fell on snow or ice, or other.

Statistical analyses

Analyses were completed using the Statistical Package for Social Sciences (IBM SPSS®, version 28). Descriptive statistics included mean, standard deviation (SD) and frequency counts; and group-based differences based on age group, sex, or rural/urban status were compared with ANOVAs or chi-square analyses where appropriate.

Binary logistic regression was used to explore whether demographic factors (age measured as a continuous variable, sex, education level, rural/urban) were predictors of fall status, that is no falls versus a single fall or multiple falls (reference group ‘no falls’). We used sampling weights (version 1.2) [24] that were adjusted for the Canadian population to explore if this impacted the findings. Due to similar findings between weighted and unweighted results, we only reported the unweighted results. Sampling weights inflate the observations in the sample to the level of the population to minimize the sampling bias, allowing observations within the sample to be extrapolated to the population of origin. The large sample size for many of these analyses and large number of comparisons were likely to inflate Type I error [25]. For associations we focussed on the magnitude of effect. The following magnitude descriptors were used for associations between dichotomous variables: phi = 0.00 to <0.01, negligible; 0.10 to < 0.20, small; 0.20 to <0.40, moderate; 0.40 to <0.60, relatively large; 0.60 to <0.80, large; 0.80 to 1.00, very large [26]. For the odds ratio (OR) estimates from the logistic regressions, we used the descriptors of magnitude of OR provided by Chen et al. [27] based on a rate of falls of around 5% of OR ~ 1.5 as small, OR ~ 2.7 as medium, and OR ~ 4.6 as large.

Results

Participant demographics are described in Table 1. Of the 46,762 participants who completed the initial falls related question, “how many times have you fallen in the past 12 months?”, the vast majority reported no falls (94.4%) and a further 4.8% reported a single fall in during the preceding 12 months. Very few participants reported multiple falls (0.8%), with the number of falls ranging from 2 to 30 falls. Table 2 includes information about falls (no fall, single fall, multiple falls) with age group comparisons. Age group was not significantly associated with fall status in the smaller sized rural dwelling sample (N = 6,198) but was associated with fall status for urban dwelling participants, likely a Type I error due to the large N (35,779) for the urban sample. Younger participants in the urban-dwelling group were less likely to be in the multiple faller group and older participants were more likely to be the multiple faller group, but these differences were rather small (phi < 0.1). As there were no substantial differences between the urban and rural dwelling groups, no further results by location are reported.

Table 1. Sample characteristics (N = 51,338).

Demographic Variable M (SD) or Count’(%) Missing
Age 62.98 (10.43)
Sex
• F 26155 (50.9%)
• M 25183 (49.1%)
Education Level 133 (0.3%)
• Less than secondary school graduation 3629 (7.1%)
• Secondary school graduation, no post-secondary education 5721 (11.1%)
• Some post-secondary education 3861 (7.5%)
• Post-secondary degree/diploma 37994 (74.0%)
Residence—Rural/Urban 2503 (4.9%)
• Rural 7131 (13.9%)
• Urban Core, Fringe, Centre, Secondary Core 41704 (81.2%)
Marital Status 14 (0.0%)
• Single/Never Cohabitated 4352 (8.5%)
• Married/Common-law 35252 (68.7%)
• Widowed 5170 (10.1%)
• Divorced 5180 (10.1%)
• Separated 1370 (2.7%)
Total Yearly Income (Canadian Dollars) 3311 (6.5%)
• Less than $20,000 2913 (5.7%)
• $20,000 to $50,000 12209 (23.8%)
• $50,000 to $100,000 17127 (33.4%)
• $100,000 to $150,000 8739 (17.0%)
• $150,000 or more 7039 (13.7%)
Diagnosed with a Neurological Condition
• No 27786 (54.1%)
• Yes 23552 (45.9%)
Multiple Falls 4576 (8.9%)
• No 46406 (90.4%)
• Yes 356 (0.7%)
Number of Falls 4576 (8.9%)
• No falls 44164 (86.0%)
• Single fall 2242 (4.4%)
• Multiple falls 356 (0.7%)
High blood pressure or hypertension 19203 (37.4%) 207 (0.4%)
Diabetes, borderline diabetes or blood sugar is high 8863 (17.3%) 129 (0.3%)
Underactive thyroid gland (hypothyroidism) 6408 (12.5%) 569 (1.1%)
Overactive thyroid gland (hyperthyroidism) 1190 (2.3%) 568 (1.1%)
Asthma 6331 (12.3%) 166 (0.3%)
Osteoarthritis in one or both hands 6840 (13.3%) 386 (0.8%)
Osteoarthritis in the hip 4586 (8.9%) 416 (0.8%)
Osteoarthritis in the knee 7927 (15.4%) 458 (0.9%)
Rheumatoid arthritis 2058 (4.0%) 516 (1.0%)
Other type of arthritis 6292 (12.3%) 503 (1.0%)
Osteoporosis 4698 (9.2%) 341 (0.7%)
Cancer 7902 (15.4%) 109 (0.2%)
Intestinal or stomach ulcers 3912 (7.6%) 171 (0.3%)
Urinary incontinence 4388 (8.5%) 125 (0.2%)
Bowel incontinence 1074 (2.1%) 105 (0.2%)
Bowel disorder 4776 (9.3%) 171 (0.3%)
Kidney disease or kidney failure 1460 (2.8%) 160 (0.3%)
Lung-related disorder 3161 (6.2%) 202 (0.4%)
Heart disease 5694 (11.1%) 228 (0.4%)
Heart attack or myocardial infarction 2778 (5.4%) 179 (0.3%)
Angina 2473 (4.8%) 190 (0.4%)
Peripheral vascular disease or poor circulation in limbs 3165 (6.2%) 230 (0.4%)
Macular degeneration 2155 (4.2%) 257 (0.5%)
Experienced a ministroke or TIA 1713 (3.3%) 306 (0.6%)
Migraine headaches 6773 (13.2%) 136 (0.3%)
Memory problem 968 (1.9%) 113 (0.2%)
Mood disorder 8250 (16.1%) 129 (0.3%)
Anxiety disorder 4157 (8.1%) 146 (0.3%)
Other long-term physical or mental condition 21103 (41.1%) 118 (0.2%)

Table 2. Number of falls by age group and rural/urban residence (N = 44,455).

Dwelling AgeGroup(years) Number of Falls
No Falls Single Fall Multiple Falls Total
Rural 45–54 1725 (95.3%) 74 (4.1%) 11 (0.6%) 1810 (100.0%)
55–64 2010 (94.9%) 95 (4.5%) 14 (0.7%) 2119 (100.0%)
65–74 1484 (94.9%) 74 (4.7%) 5 (0.3%) 1563 (100.0%)
75+ 979 (94.0%) 52 (5.0%) 11 (1.1%) 1042 (100.0%)
Total 6198 (94.9%) 295 (4.5%) 41 (0.6%) 6534 (100.0)
Urban (Urban Core, Fringe, Centre, Secondary Core) 45–54 8755 (94.7%) 429 (4.6%) 59 (0.6%) 9243 (100.0%)
55–64 11267 (94.0%) 609 (5.1%) 114 (1.0%) 11990 (100.0%)
65–74 8590 (94.7%) 420 (4.6%) 62 (0.7%) 9072 (100.0%)
75+ 7167 (94.1%) 386 (5.1%) 63 (0.8%) 7616 (100.0%)
Total 35779 (94.4%) 1844 (4.9%) 298 (0.8%) 37921 (100.0%)

Age group was not associated with whether participants sought medical attention after a fall (p = 0.38). While the chi-square was significant (p = 0.011) for the single fall group, the effect size size (phi = 0.071) was trivial in magnitude (Table 3). In contrast age group was weakly associated with hospitalization after a fall, with participants in the older age groups more likely to report being hospitalized than younger participants. The effect size estimate was small in magnitude for both the single fall (phi = 0.12) and multiple falls groups (phi = 0.14), but only the single fall group had a significant chi-square (p < 0.001). A small magnitude association (single falls phi = 0.11; multiple falls phi = 0.18) between where falls occurred and age group was evident (Table 4), with older participants more likely to fall inside the home than outside the home relative to younger participants.

Table 3. Frequency of falls requiring medical attention by age group and single/multiple falls (N = 2,566).

Number of Falls AgeGroup (years) Fall Required Medical Attention
Yes No Total
Single Fall 45–54 321 (60.9%) 206 (39.1%) 527 (100.0%)
55–64 442 (60.8%) 285 (39.2%) 727 (100.0%)
65–74 324 (63.5%) 186 (36.5%) 510 (100.0%)
75+ 313 (69.7%) 136 (30.3%) 449 (100.0%)
Total 1400 (63.3%) 813 (36.7%) 2213 (100.0%)
Multiple Falls 45–54 36 (50.7%) 35 (49.3%) 71 (100.0%)
55–64 80 (59.7%) 54 (40.3%) 134 (100.0%)
65–74 45 (64.3%) 25 (35.7%) 70 (100.0%)
75+ 48 (61.5%) 30 (38.5%) 78 (100.0%)
Total 209 (59.2%) 144 (40.8%) 353 (100.0%)

Multiple Falls Group: two or more falls reported in preceding year (No or Yes)

Table 4. Frequency of falls in different locations by age group and single/multiple falls (N = 2,592).

Number of Fallls Age Group (years) Fall Location
Inside home Outside Home but Inside a Building Outdoors Total
Single Fall 45–54 92 (17.4%) 101 (19.1%) 337 (63.6%) 530 (100.0%)
55–64 133 (18.1%) 140 (19.1%) 461 (62.8%) 734 (100.0%)
65–74 121 (23.4%) 100 (19.4%) 295 (57.2%) 516 (100.0%)
75+ 133 (29.2%) 85 (18.6%) 238 (52.2%) 456 (100.0%)
Total 479 (21.4%) 426 (19.1%) 1331 (59.5%) 2236 (100.0%)
Multiple Falls 45–54 13 (18.1%) 11 (15.3%) 48 (66.7%) 72 (100.0%)
55–64 41 (30.4%) 16 (11.9%) 78 (57.8%) 135 (100.0%)
65–74 28 (40.0%) 5 (7.1%) 37 (52.9%) 70 (100.0%)
75+ 30 (38.0%) 10 (12.7%) 39 (49.4%) 79 (100.0%)
Total 112 (31.5%) 42 (11.8%) 202 (56.7%) 356 (100.0%)

Multiple Falls Group: two or more falls reported in preceding year (No or Yes)

Age group was associated (moderate effect size) with how falls occurred for both the single fall group (phi = 0.24) and the multiple fall group (phi = 0.30) (Table 5). The most pronounced age group differences were for falls while exercising. Not surprising, older participants were less likely to fall during exercise and younger participants were more likely to fall during exercise. Older participants were more likely to report falling while standing or walking than younger participants in both the single and multiple falls group. Older participants who reported a single fall were more likely to report falling on snow or ice than were younger participants, but the converse was apparent for participants in the multiple falls group, with younger participants more likely to report falling on snow or ice. Older participants who were in the single fall group were more likely to report falling from furniture, however reported falls getting in and out of the shower and bath were infrequent regardless of age group Table 6 includes the type of injury experienced during the most serious fall experienced by participants, and these were not significantly associated with age group.

Table 5. Frequency of falls in different manners by age group and single/multiple falls (N = 2551).

Number of Falls Age Group (years) Fall Manner
Fall while standing or walking Fell on stairs or steps Fell while exercising Fell from height of 1 metre Fell from furniture Fell while getting on or out of bath Fell while getting in and out of the shower Fell on snow or ice Other Total
Single Fall 45–54 198 (37.8%) 103 (19.7%) 117 (22.3%) 39 (7.4%) 6 (1.1%) 2 (0.4%) 3 (0.6%) 52 (9.9%) 4 (0.8%) 524 (100.0%)
55–64 307 (42.5%) 119 (16.5%) 119 (16.5%) 54 (7.5%) 24 (3.3%) 4 (0.6%) 3 (0.4%) 88 (12.2%) 5 (0.7%) 723 (100.0%)
65–74 246 (48.2%) 96 (18.8%) 53 (10.4%) 45 (8.8%) 11 (2.2%) 4 (0.8%) 2 (0.4%) 46 (9.0%) 7 (1.4%) 510 (100.0%)
75+ 241 (53.9%) 89 (19.9%) 25 (5.6%) 14 (3.1%) 26 (5.8%) 7 (1.6%) 6 (1.3%) 35 (7.8%) 4 (0.9%) 447 (100.0%)
Total 992 (45.0%) 407 (18.5%) 314 (14.2%) 152 (6.9%) 67 (3.0%) 17 (0.8%) 14 (0.6%) 221 (10.0%) 20 (0.9%) 2204 (100.0%)
Multiple Falls 45–54 34 (47.2%) 11 (15.3%) 11 (15.3%) 5 (6.9%) 0 (0.0%) 0 (0.0%) 1 (1.4%) 10 (13.9%) 0 (0.0%) 72 (100.0%)
55–64 60 (45.8%) 25 (19.1%) 21 (16.0%) 5 (3.8%) 5 (3.8%) 0 (0.0%) 0 (0.0%) 12 (9.2%) 3 (2.3%) 131 (100.0%)
65–74 27 (39.1%) 16 (23.2%) 8 (11.6%) 4 (5.8%) 5 (7.2%) 0 (0.0%) 2 (2.9%) 7 (10.1%) 0 (0.0%) 69 (100.0%)
75+ 47 (62.7%) 9 (12.0%) 4 (5.3%) 3 (4.0%) 4 (5.3%) 1 (1.3%) 1 (1.3%) 4 (5.3%) 2 (2.7%) 75 (100.0%)
Total 168 (48.4%) 61 (17.6%) 44 (12.7%) 17 (4.9%) 14 (4.0%) 1 (0.3%) 4 (1.2%) 33 (9.5%) 5 (1.4%) 347 (100.0%)

Multiple Falls Group: two or more falls reported in preceding year (No or Yes)

Table 6. Frequency of different types of the most serious injury by age group and single/multiple falls (N = 419).

Number of falls Age Group (years) Most serious injury
No serious injury Sprain or strain Bruises Cuts Discomfort Hip fracture Leg fracture Arm or wrist fracture Vertebral fracture Head injury Other Total
Single fall 45–54 5 (5.7%) 32 (36.4%) 8 (9.1%) 8 (9.1%) 7 (8.0%) 1 (1.1%) 4 (4.5%) 11 (12.5%) 2 (2.3%) 7 (8.0%) 3 (3.4%) 88 (100.0%)
55–64 7 (5.7%) 42 (34.1%) 12 (9.8%) 8 (6.5%) 9 (7.3%) 1 (0.8%) 7 (5.7%) 17 (13.8%) 2 (1.6%) 8 (6.5%) 10 (8.1%) 123 (100.0%)
65–74 7 (8.6%) 31 (38.3%) 8 (9.9%) 4 (4.9%) 5 (6.2%) 2 (2.5%) 6 (7.4%) 7 (8.6%) 1 (1.2%) 2 (2.5%) 8 (9.9%) 81 (100.0%)
75+ 5 (7.2%) 15 (21.7%) 12 (17.4%) 3 (4.3%) 8 (11.6%) 3 (4.3%) 3 (4.3%) 10 (14.5%) 0 (0.0%) 4 (5.8%) 6 (8.7%) 69 (100.0%)
Total 24 (6.6%) 120 (33.2%) 40 (11.1%) 23 (6.4%) 29 (8.0%) 7 (1.9%) 20 (5.5%) 45 (12.5%) 5 (1.4%) 21 (5.8%) 27 (7.5%) 361 (100.0%)
Multiple falls 45–54 0 (0.0%) 8 (53.3%) 2 (13.3%) 1 (6.7%) 1 (6.7%) 1 (6.7%) 0 (0.0%) 0 (0.0%) 2 (13.3%) 15 (100.0%)
55–64 1 (4.0%) 10 (40.0%) 4 (16.0%) 3 (12.0%) 1 (4.0%) 1 (4.0%) 2 (8.0%) 1 (4.0%) 2 (8.0%) 25 (100.0%)
65–74 0 (0.0%) 2 (22.2%) 2 (22.2%) 0 (0.0%) 1 (11.1%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 4 (44.4%) 9 (100.0%)
75+ 0 (0.0%) 5 (55.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 2 (22.2%) 1 (11.1%) 1 (11.1%) 9 (100.0%)
Total 1 (1.7%) 25 (43.1%) 8 (13.8%) 4 (6.9%) 3 (5.2%) 2 (3.4%) 4 (6.9%) 2 (3.4%) 9 (15.5%) 58 (100.0%)

Odds ratios for single and multiple falls for participants with chronic conditions are reported in Table 7. The likelihood of having multiple falls was substantially higher (i.e., large magnitude of effect) for participants who reported being diagnosed with memory problems or with multiple sclerosis. Moderately higher likelihood of having multiple falls was also apparent for participants diagnosed with osteoarthritis in the hands, asthma, bowel disorder, anxiety disorder, angina, rheumatoid arthritis, transient ischemic attack, kidney disease, bowel incontinence, and for the few participants who reported diagnoses of Parkinson’s disease or Alzheimer’s disease. For the following other chronic conditions there was an increased likelihood of reporting a single fall or multiple falls, with the magnitude of effect stronger for the multiple fall vs single fall groups: mood disorders, osteoarthritis of the knee, osteoarthritis of the hip, osteoporosis, urinary incontinence, lung related disorders, stroke, and epilepsy. Other significant associations (i.e., where the OR CI did not include 1) were small or trivial.

Table 7. Prevalence of chronic conditions and odds of single or multiple falls relative to participants who did not fall.

Chronic Condition Count (%) Missing Count (%) Odds Ratio [95% CI]
Single Fall Multiple Falls
Other long-term physical or mental condition 21103 (41.1%) 118 (0.2%) 1.170 [1.074–1.274] 1.619 [1.313–1.996]
High blood pressure or hypertension 19203 (37.4%) 207 (0.4%) 1.107 [1.015–1.207] 1.113 [0.899–1.378]
Diabetes, borderline diabetes or blood sugar is high 8863 (17.3%) 129 (0.3%) 1.090 [0.977–1.216] 1.814 [1.435–2.292]
Mood disorder 8250 (16.1%) 129 (0.3%) 1.465 [1.319–1.627] 3.353 [2.702–4.163]
Cancer 7902 (15.4%) 109 (0.2%) 1.076 [0.960–1.206] 1.332 [1.024–1.733]
Osteoarthritis in the knee 7927 (15.4%) 458 (0.9%) 1.476 [1.328–1.641] 2.393 [1.902–3.012]
Osteoarthritis in one or both hands 6840 (13.3%) 386 (0.8%) 1.428 [1.276–1.599] 2.837 [2.254–3.570]
Migraine headaches 6773 (13.2%) 136 (0.3%) 1.284 [1.142–1.443] 2.248 [1.764–2.865]
Under-active thyroid gland 6408 (12.5%) 569 (1.1%) 1.345 [1.196–1.511] 1.673 [1.280–2.187]
Other type of arthritis 6292 (12.3%) 503 (1.0%) 1.323 [1.175–1.491] 1.590 [1.207–2.096]
Asthma 6331 (12.3%) 166 (0.3%) 1.397 [1.243–1.571] 2.471 [1.938–3.151]
Heart disease (including congestive heart failure, or CHF) 5694 (11.1%) 228 (0.4%) 1.056 [0.926–1.205] 1.962 [1.508–2.554]
Bowel disorder 4776 (9.3%) 171 (0.3%) 1.312 [1.147–1.501] 2.239 [1.705–2.941]
Osteoporosis 4698 (9.2%) 341 (0.7%) 1.639 [1.447–1.857] 2.820 [2.182–3.643]
Osteoarthritis in the hip 4586 (8.9%) 416 (0.8%) 1.487 [1.305–1.693] 2.966 [2.301–3.823]
Urinary incontinence 4388 (8.5%) 125 (0.2%) 1.547 [1.358–1.762] 2.461 [1.876–3.227]
Anxiety disorder 4157 (8.1%) 146 (0.3%) 1.424 [1.239–1.637] 3.345 [2.592–4.316]
Intestinal or stomach ulcers 3912 (7.6%) 171 (0.3%) 1.213 [1.044–1.409] 1.992 [1.470–2.699]
Peripheral vascular disease or poor circulation in limbs 3165 (6.2%) 230 (0.4%) 1.304 [1.112–1.528] 1.904 [1.362–2.663]
Emphysema, chronic bronchitis, COPD, or chronic changes in lungs due to smoking 3161 (6.2%) 202 (0.4%) 1.524 [1.309–1.773] 3.137 [2.361–4.170]
Heart attack or myocardial infarction 2778 (5.4%) 179 (0.3%) 0.854 [0.701–1.041] 1.529 [1.043–2.240]
Angina 2473 (4.8%) 190 (0.4%) 0.937 [0.765–1.147] 2.133 [1.501–3.032]
Macular degeneration 2155 (4.2%) 257 (0.5%) 1.225 [1.010–1.486] 1.794 [1.200–2.682]
Rheumatoid arthritis 2058 (4.0%) 516 (1.0%) 1.191 [0.972–1.458] 2.273 [1.559–3.315]
Experienced a ministroke or TIA 1713 (3.3%) 306 (0.6%) 1.244 [1.003–1.542] 2.321 [1.551–3.472]
Kidney disease or kidney failure 1460 (2.8%) 160 (0.3%) 1.171 [0.921–1.488] 2.760 [1.844–4.131]
Over-active thyroid gland (hyperthyroidism) 1190 (2.3%) 568 (1.1%) 0.778 [0.470–1.288] 3.591 [1.927–6.693]
Bowel incontinence 1074 (2.1%) 105 (0.2%) 1.496 [1.165–1.922] 3.003 [1.922–4.689]
Memory problem 968 (1.9%) 113 (0.2%) 1.409 [1.069–1.859] 5.534 [3.822–8.013]
Stroke or CVA 912 (1.8%) 144 (0.3%) 1.567 [1.203–2.040] 2.313 [1.349–3.966]
Epilepsy 488 (1.0%) 98 (0.2%) 1.804 [1.279–2.545] 3.528 [1.920–6.482]
Multiple sclerosis 343 (0.7%) 89 (0.2%) 1.701 [1.118–2.586] 5.969 [3.388–10.514]
Parkinsonism or Parkinson’s Disease 203 (0.4%) 86 (0.2%) 1.113 [0.588–2.107] 3.544 [1.448–8.674]
Dementia or Alzheimer’s disease 111 (0.2%) 89 (0.2%) 1.231 [0.539–2.812] 2.596 [0.638–10.573]

Values in bold indicate the odds ratio is statistically significantly different from 1 at the 95% confidence level.

Discussion

Our study has contributed important information regarding the incidence of falls and fall-related injuries in community-dwelling Canadians ages 45 to 75+ years. We sought to explore rural–urban location as a factor to advance the understanding of falls and fall rates in high-income countries. We hypothesized there may be urban-rural differences, as disparities in health status [11, 28, 29], risk factors associated with poorer health including physical inactivity [3032], and barriers to accessing and utilizing health services and facilities and health information [33], all of which can affect falls, have been reported. While we did not find rural-urban differences in fall rates across any age group in the CLSA baseline data, it is not known whether this finding will continue to be observed as data are examined over time.

Our findings indicate that several health conditions typically not thought of to be associated with falls, such as mood disorder, anxiety disorder, and hyperthyroidism are associated with higher likelihood of multiple falls. Chronic health conditions and diseases may directly, indirectly, and synergistically increase fall risk and fall rates such as through the direct effects of the condition or disease; indirectly with the health condition affecting other physiological systems resulting in decreased physical activity and/or causing muscle weakness, sensory or other impairments and causing poor balance; or a combination of direct and indirect effects. Previous research has suggested chronic diseases and multiple pathologies to be most important predictors of falls and more important than other risk factors such as polypharmacy [34], which was not explored in the current study.

While the results related to where falls occur based on age group and the higher likelihood of falls in individuals with some of the chronic conditions were not surprising, the low incidence of falls overall and lack of difference in fall rate between age groups were unexpected. Similar to Verma and colleagues’ 2016 study of falls and fall-related injuries of adults in the United States of America [35], the number of fallers in the older age groups was lower than previously reported. Several studies have reported that about a third of community-dwelling adults 65 years of age and older report falling in one year. Much of the literature to date has focused on falls in the older adult population, while data on fall incidence among younger, working aged adults is rare [35]. Our findings and the work of Verma et al suggest falls screening and identification of individuals at high risk of falls and fall-related injuries should be comprised of a more multi-faceted pragmatic approach across the adult lifespan; for example, considering falling and falls as a universal vital sign of potential functional or other health issues, regardless of age e.g., versus only people who are 60 or 65 years and older; condition or disease e.g., versus only individuals who have a neurological condition that affects balance or muscle strength; or health care context e.g., expanding beyond settings such as acute or long-term care to public health, ambulatory and mental health care settings.

Routine inquiring about falls and fall-related injuries, for younger aged adults or those without known risk factors or health conditions, is limited, as the vast majority of falls and falls screening evidence to date is focused on older adults. For example, the American Geriatrics Society and British Geriatrics Society published a clinical practice guideline on fall risk screening, assessment, and management, with recommendations to screen all adults aged 65 years and older for fall risk annually [36]; recently published world guidelines on falls prevention and management are focused on older adults [37]; and government initiatives also suggest people aged 65 years and older be asked about their fall risk annually [38, 39], or with a significant change in clinical status [39].

Incorporating questions about falls and fall-related injuries on an annual basis or with significant change in health status, as per the guidelines for older adults, into all clinical and health visits regardless of age of the individual and care context would serve as a basis to direct more robust screening and assessment as needed. Interventions and education to increase awareness implemented early on and earlier may be useful in preventing falls as the individual ages or the health condition progresses. While recognizing that fall prevention in older adults is a priority, targeting increased awareness about falls and fall risk identification and prevention across all age groups, as well as addressing and controlling chronic health conditions and diseases earlier may also be important and beneficial public health strategies.

Identifying individuals at high-risk of fall is complex, as evidenced by the ever-increasing number of falls screening and risk tools that have been developed for older adults specifically, people with various health conditions, as well as for specific care continuum contexts e.g., acute care, inpatient care, long-term care and rehabilitation facilities. Many individuals are referred to and engage in a fall prevention program (screening, assessment, intervention) after sustaining a fall-related injury, which may be too late to be consequential in the longer-term. Due to the significant morbidity, mortality, social and economic burden of falls and fall-related injuries in the Canadian population [7, 3943], a primary versus secondary prevention approach to fall risk and falls across the lifespan is warranted.

Limitations

This study was a cross-sectional study of CLSA baseline data and is thus representative of the CLSA participant population (i.e., versus representative of the full Canadian population). Cross-sectional data analysis does not provide a prospective analysis of causal relationships, and our analysis was limited by the type of data items collected. For example our data found younger participants were more likely to report falling on snow or ice, however we cannot delve further and analyze whether these falls occurred during sports activities versus when walking because of how the related question was asked. Our sample was comprised of largely urban-dwelling participants and was generally reflective of participants with higher socioeconomic status and level of education than the wider Canadian population and for whom CLSA study participation may have fewer barriers, introducing possible biases. The CLSA dataset does not include adult participants ages 20 to 44 years, thus our findings were limited to middle- and older- age groups.

Retrospective recording of falls is a low-cost, convenient, time-efficient, and widely used method [44]. However retrospective self-report of falls may not provide as accurate a picture as data collected prospectively or via direct measures; and may have introduced recall bias and led to under-reporting of falls and fall-related injuries. Further while seeking medical attention may be indicative of more serious fall, this may also reflect sociodemographic and personal factors that influence the likelihood of getting medical care after a fall [34].

While a strength of study is the use of a large, population-based dataset that aimed to be representative and utilized in-person interview to collect data, due to the large sample size statistical significance findings should be interpreted with some caution. Some community-dwelling population groups e.g., individuals living in the Canadian territories, and veterans are excluded from the CLSA and representation of ethnicity and race is limited, decreasing the broader applicability of the findings.

Conclusion

Approximately one in twenty adults in the CLSA baseline sample reported experiencing a fall in the preceding year, and about one in one hundred reported falling multiple times. Likelihood of falls was similar regardless of age or urban/rural residence, but age was associated with fall location or situation. Risk factors for single and multiple falls were consistent with previous literature, although some unexpected risk factors for multiple falls were identified (self-reported mood and anxiety disorders, hyperthyroidism). A more multifaceted approach, not based solely on older age, to screening, primary prevention, assessment and management of falls and fall-related risk factors, including chronic disease management across the lifespan is warranted to reduce the personal, social, and economic burden of falls and fall-related injuries.

Acknowledgments

This research was made possible using the data collected by the Canadian Longitudinal Study on Aging (CLSA). This research has been conducted using the CLSA datasets Baseline Tracking Dataset version 3.4, Baseline Comprehensive Dataset version 4.0, under Application Number 171011. The CLSA is led by Drs. Parminder Raina, Christina Wolfson and Susan Kirkland.

We thank Shoshanna Green, Research Coordinator, University of Saskatchewan; and Katelyn Madigan, Research Assistant, McMaster University for their editorial assistance with the manuscript.

Data Availability

Data are available from the Canadian Longitudinal Study on Aging (www.clsa-elcv.ca) for researchers who meet the criteria for access to de-identified CLSA data.

Funding Statement

McMaster Institute of Research on Aging (MIRA) for Canadian Longitudinal Study on Aging (CLSA) data access. Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Decision Letter 0

Ryota Sakurai

5 Dec 2023

PONE-D-23-32442Decade-by-decade comparison of falls in adults living in urban and rural Canada: A cross-sectional analysis from the Canadian Longitudinal Study on AgingPLOS ONE

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Reviewer #1: Yes

Reviewer #2: Yes

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Comment-(i)

Line 1

“Decade-by-decade comparison of falls in adults living in urban and rural Canada: A cross-sectional analysis from the Canadian Longitudinal Study on Aging”

See Comment-(viii). Also, the comparison between urban and rural areas is only one of the several axes of comparison, as well as the results on this axe were negative. My suggested title is then;

“Comparison across age groups of causes, circumstances, and consequences of falls among adults living in Canada: a cross-sectional analysis from the Canadian Longitudinal Study of Aging”

Comment-(ii)

Line18-20

Background:

Please briefly describe the purpose of the study.

Comment-(iii)

Comment deleted.

Comment-(iv)

Line24

“Falls were not related to rural residence or age, but those with memory problems or multiple sclerosis were more likely to fall. Higher likelihood of falls was also observed in people with chronic conditions not often thought to be associated with falls.”

Can these two sentences be combined into one? My suggestion is;

“Falls were not related to rural residence or age, but those with memory impairment, multiple sclerosis, as well as other chronic conditions such as xxx, yyy, zzz, not often thought to be associated with falls were also more likely to fall.”

Comment-(v)

Line 32

“A more universal approach to screening, primary prevention and management may reduce the personal, social, and economic burden of falls and fall-related injuries.”

What is the opposite concept of “universal approach” here? Please see also comment-(xxiv).

Comment-(vi)

Comment deleted.

Comment-(vii)

Comment deleted.

Comment-(viii)

Line 63

“The objectives of our research were to: 1) comprehensively examine fall profiles decade-by-decade e.g., 45 to 54 years, 55 to 64 years, 65 to 74 years, 75 to 85 years;…”

The term "decade-by-decade" is to me more reminiscent of changes by era, such as the 1980s, 1990s, 2000s... rather than by age group. How about expressions like “age-stratified analysis of…” or “comparison across age groups”?

Comment-(ix)

Table 1

I think it would be better to place related diseases closer together rather than in the order of frequency of diseases. For example, it is natural to place “Other type of arthritis” below other types. However, I do not strongly urge the author to do so, as he/she may have own ideas. Please consider it if a reviewer other than me has the same opinion as mine.

Comment-(x)

Line 142

“What is readily apparent and surprising is the low prevalence of falls.”

In the "Results" section, it is better to state only the facts in a straightforward manner. I propose to delete this sentence.

Comment-(xi)

Line 147

“Table 2 includes information about falls (no fall, single fall, multiple falls) with decade-by-decade comparisons.”

Again, perhaps a phrase such as "age group comparisons" would be more appropriate than "decade-by-decade comparisons"?

Comment-(xii)

Line 162

“The effect size estimate was small in magnitude for both the single fall and multiple falls groups, but only the larger single sized fall group had a significant chi-square.”

Please consider replacing this sentence with the following;

“The effect size estimate was small in magnitude for both the single fall and multiple falls groups, but only the single fall group had a significant chi-square.”

Comment-(xiii)

Line 163

“A weak association between where falls occurred and age was evident (Table 4), with older participants were more likely to fall inside the home than outside the home relative to younger participants.”

(xiii-i) “Weak” sounds subjective. “An association between...” would be more appropriate.

(xiii-ii) It seems necessary to state this more objectively by showing some statistical significance. For example, how about combining the two categories of “Inside Home” and “Outside home but inside a building”, making fall location binary data, and applying the Cochran-Armitage trend test?

Comment-(xiv)

Line 174

“Older participants who reported a single fall were more likely to report falling on snow or ice than were younger participants, but the converse was apparent for participants in the multiple falls group, with younger participants more likely to report falling on snow or ice.”

Question;

Do falls on snow or ice include those related to winter sports such as skiing or skating? I think this is an important point in interpreting the results.

Comment-(xv)

Line 168

“Age was moderately associated with how falls occurred for both the single fall group and the multiple fall group (Table 5).”

I suggest removing "moderately", since it seems to lack objectivity.

Comment-(xvi)

Line 177

“Older participants who were in the single fall group were more likely to report falling from furniture, however reported falls getting in and out of the shower and bath were infrequent.”

Instead, I suggest the following sentence;

“Older participants in the single fall group were more likely to report falling from furniture. Falls getting in and out of the shower and bath were infrequent regardless of age group.”

Comment-(xvii)

Line184

“The likelihood of having multiple falls versus a single fall was substantially higher (i.e., large magnitude of effect) for participants who reported being diagnosed with memory problems or with multiple sclerosis.”

The story is too complex to consider multiple falls in comparison to a single fall. I suppose the following sentence suffices;

“The likelihood of having multiple falls was substantially higher (i.e., large magnitude of effect) for participants who reported being diagnosed with memory problems or with multiple sclerosis.”

Comment-(xviii)

Line194

“These OR are reported in Table 7.”

Please provide a reference to Table 7 at the beginning of the paragraph, not at the end.

Comment-(xix)

Line 206

“Our findings indicate that several health conditions typically not thought of to be associated with falls had higher likelihood of multiple falls, such as mood disorder, anxiety disorder, and hyperthyroidism.”

Instead, I suggest the following sentence;

“Our findings indicate that several health conditions typically not thought of to be associated with falls, such as mood disorder, anxiety disorder, and hyperthyroidism are associated with higher likelihood of multiple falls.”

Comment-(xx)

Line 221

“Our findings and the work of Verma et al suggest falls screening and identification of individuals at high risk of falls and fall-related injuries should be comprised of a more universal and pragmatic approach across the adult lifespan; for example, falls as a vital sign of potential functional or other health issue, regardless of age, condition or disease, or health care context.”

About the last part, I understand that “age” can be disregarded, but wouldn't it be more in line with the context of this study to consider “condition” and “disease”?

Comment-(xxi)

Line 225

“Routine inquiring about falls and fall-related injuries, for younger aged adults or those without known risk factors or health conditions, is not being conducted.”

What country is this about? Do you mean that it is not done anywhere in the world?

Comment-(xxii)

Line 265

“Approximately one in twenty adults in the CLSA baseline sample reported experiencing a fall in the last year, and about one in one hundred reported falling multiple times.”

“Previous year” or “preceding year” rather than “last year” would be more appropriate for an objective description.

Comment-(xxiii)

Line 266

“Likelihood of falls occurring was similar regardless of age or urban/rural residence, but age was associated with fall location and activity.”

The last part sounds a bit strange to me. My suggestion is;

“Likelihood of falls was similar regardless of age or urban/rural residence, but age was associated with fall location or situation.”

Comment-(xxiv)

Line 269

“A more universal approach to screening, primary prevention, assessment and management of falls and fall-related risk factors, including chronic disease management across the lifespan is warranted to reduce the personal, social, and economic burden of falls and fall-related injuries.”

The meaning of “universal” sounds ambiguous.

Is it like “a more multifaceted approach that is not based solely on age” ?

Reviewer #2: Summary:

I would like to express my gratitude to the authors for their manuscript, which provides important insights into falls among middle-aged and older adult populations residing in both urban and rural regions of Canada. Its credibility is strongly supported by the utilization of a substantial dataset drawn from the Canadian Longitudinal Study on Aging (CLSA). The research presents some noteworthy findings that challenge prevailing preconceptions regarding fall-related factors, carrying substantial implications for the development of preventive measures and the allocation of healthcare resources. The study's concluding remarks underscore the imperative of adopting a comprehensive and universally applicable approach to the prevention and management of falls.

General comment:

Given the study exclusively includes 45+ years old adults (middle-aged and older adults), I recommend that authors clearly define or reconsider the use of the term 'adults' to avoid potential confusion throughout the manuscript. For example, information in ln. 42-43 indicate that adults would be defined as 20 years and older “Almost half of Canadians ages 20 years and older are living with a chronic condition”.

Specific comments:

Manuscript's title:

- The current title, 'The 'decade-to-decade'...', may benefit from a more explicit indication that the study pertains to age groups, specifically middle-aged and older adults.

Abstract:

- While the background information is relevant, it would be beneficial to explicitly state the study's key objectives in the abstract. This would provide readers with a clearer understanding of the study's focus, which extends beyond older individuals.

Introduction:

- I recommend addressing my earlier comment on defining the term 'adults' for clarity.

- Overall, the introduction effectively contextualizes the study and provides a clear foundation for the research objectives, helping readers understand the rationale and significance of the study.

Methods:

- In the brief outline, consider including the years when the data were collected or specifying the data collection period within the method section to provide clarity.

- To enhance reader understanding, it would be beneficial to clearly differentiate between 'age groups' and age as a continuous variable.

- In line 96, please expand 'M/F' to 'Male/Female'.

- For lines 99-102, adding a citation for the categorization and providing a brief in-text definition of rural areas would be helpful.

- Please specify the type of logistic regression used (e.g., binary/univariate logistic regression)

- In line 136, consider citing a reference.

- In line 138, I suggest including 'phi' to prepare readers for subsequent mentions.

- Ln. 129-130 “Logistic regression was used to explore whether demographic factors (age measured as a continuous variable), sex, education level, rural/urban) were predictors of fall status, that is no falls, a single fall, or multiple falls (reference group ‘no falls’).”

o Please, ensure consistency between the variables listed here and those reported in the results (e.g. results on sex and education level).

Results:

- Ensure that all tables can stand alone.

- Table 1. I suggest that you specify the time period for income, and add '$...CAD' for international readers.

- For Tables 3-5, clarify in a footnote how the variable 'multiple falls' was treated when falls occurred in different locations.

- Table 7. Please explain the bold font.

Discussion:

- The discussion effectively summarizes key findings, offers valuable insights and recommendations for addressing falls and fall-related injuries across the lifespan, and identifies potential areas for future research. I have couple of suggestions:

o In line 220, you mention 'younger, working-aged adults'. Consider finding a place, such as the limitations section, to clarify that this dataset does not include young adults (ages 20 to 44).

- Regarding reference no. 33, check if referring to a more recent paper, such as Montero-Odasso et al., 2022 (DOI: 10.1093/ageing/afac205), might provide more up-to-date information.

Conclusion:

- The study's conclusion closely matches its objectives. It successfully summarizes findings on falls, age [groups], urban/rural residence, and risk factors while highlighting the need for universal fall prevention across the lifespan.

Minor comments:

- Please address instances where periods are missing, and ensure that citations are positioned after punctuation marks.

- In line 112, there appears to be missing information in the sentence starting with 'Additional fall-related…'.

**********

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Reviewer #1: Yes: Narumi Kojima

Reviewer #2: No

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PLoS One. 2024 Mar 14;19(3):e0300026. doi: 10.1371/journal.pone.0300026.r002

Author response to Decision Letter 0


26 Jan 2024

I have uploaded a response to reviewers document, I do not understand what is required here that would be different. So I am cutting and pasting my letter in this space ....

January 16, 2024

Ryota Sakurai, Ph.D.

Academic Editor

PLOS ONE

Dear Dr. Sakurai,

On behalf of the co-authors, I would like to thank you and the Reviewers for their very thoughtful reviews, comments and feedback to enhance our paper.

All comments received have been cut and paste and our responses to each comment, and found below. Our responses are highlighted in yellow in the revised manuscript document.

Revisions within the manuscript have also been highlighted in yellow and are evident via track changes; and/or manuscript sections where the revisions were made are noted in this letter because page and line numbers have changed from the original submission, because of additions made, and page and line numbers differ between the marked-up and clean copies.

We believe the comments and feedback received and subsequent revisions have greatly improved our paper and we look forward to hearing from you soon.

Please note: We have revised the ACKNOWLEDGEMENTS AND FUNDING SECTIONS. We moved the following section to the FUNDING, similar to other CLSA publications within PLOSONE and in articles published as recently as 2023 [e.g., Khan D, Edgell H, Rotondi M, Tamim H. The association between shift work exposure and cognitive impairment among middle-aged and older adults: Results from the Canadian Longitudinal Study on Aging (CLSA). PLoS One. 2023 Aug 23;18(8):e0289718. doi: 10.1371/journal.pone.0289718]:

Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia.

Sincerely,

Vanina Dal Bello-Haas, PT, PhD

FEEDBACK RECEIVED

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Per the data access and publication agreements we have signed with the Canadian Longitudinal Study on Aging we are not able to deposit the data.

Per the agreements we included the following statement within the Data Availability section, this remains the same, see page XX:

Data are available from the Canadian Longitudinal Study on Aging (www.clsa-elcv.ca) for researchers who meet the criteria for access to de-identified CLSA data.

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McMaster Institute of Research on Aging (MIRA) for Canadian Longitudinal Study on Aging (CLSA) data access.

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This research was made possible using the data collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia. This research has been conducted using the CLSA datasets Baseline Tracking Dataset version 3.4, Baseline Comprehensive Dataset version 4.0, under Application Number 171011. The CLSA is led by Drs. Parminder Raina, Christina Wolfson and Susan Kirkland.

We thank Shoshanna Green, Research Coordinator, University of Saskatchewan; and Katelyn Madigan, Research Assistant, McMaster University for their editorial assistance with the manuscript.

We note that you have provided funding information that is not currently declared in your Funding Statement. However, funding information should not appear in the Acknowledgments section or other areas of your manuscript. We will only publish funding information present in the Funding Statement section of the online submission form.

We have revised the ACKNOWLEDGEMENTS AND FUNDING SECTIONS. We moved the following section to the FUNDING, similar to other CLSA publications within PLOSONE and in articles published as recently as 2023 [e.g., Khan D, Edgell H, Rotondi M, Tamim H. The association between shift work exposure and cognitive impairment among middle-aged and older adults: Results from the Canadian Longitudinal Study on Aging (CLSA). PLoS One. 2023 Aug 23;18(8):e0289718. doi: 10.1371/journal.pone.0289718]:

Funding for the Canadian Longitudinal Study on Aging (CLSA) is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference: LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces, Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta, and British Columbia.

We have left the other statements within ACKNOWLEDGEMENTS.

See Page XX.

Please remove any funding-related text from the manuscript and let us know how you would like to update your Funding Statement. Currently, your Funding Statement reads as follows:

McMaster Institute of Research on Aging (MIRA) for Canadian Longitudinal Study on Aging (CLSA) data access.

There is no funding-related text in the manuscript.

Please include your amended statements within your cover letter; we will change the online submission form on your behalf.

We have added this information to the cover letter.

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Co-author Megan O'Connell is a Member - Psychology Working Group, Canadian Longitudinal Study on Aging (CLSA) https://www.clsa-elcv.ca/

We note that one or more of the authors are employed by a commercial company: Psychology Working Group, Canadian Longitudinal Study on Aging.

Dr. Megan O’Connell is not employed by the Psychology Working Group, Canadian Longitudinal Study on Aging – her role is a non-paid service role. Dr. O’Connell has no commercial affiliation with the CLSA.

To be as encompassing as possible regarding any perceived Conflict of Interest, because Dr. O’Connell is a member of a Canadian Longitudinal Study on Aging Working Group, even though it is NOT a paid position and there is no commercial affiliation, we included her role and a [potential perceived] Conflict of Interest.

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Data are available from the Canadian Longitudinal Study on Aging (www.clsa-elcv.ca) for researchers who meet the criteria for access to de-identified CLSA data.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

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Reviewer #1: Yes

Reviewer #2: Yes

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: Yes

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: Yes

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Comment-(i)

Line 1

“Decade-by-decade comparison of falls in adults living in urban and rural Canada: A cross-sectional analysis from the Canadian Longitudinal Study on Aging”

See Comment-(viii). Also, the comparison between urban and rural areas is only one of the several axes of comparison, as well as the results on this axe were negative. My suggested title is then;

“Comparison across age groups of causes, circumstances, and consequences of falls among adults living in Canada: a cross-sectional analysis from the Canadian Longitudinal Study of Aging”

We have made this change; and we have also made additional revisions to the title per Reviewer #2’s comments, see below.

Comment-(ii)

Line18-20

Background:

Please briefly describe the purpose of the study.

We have added this information to the Abstract background section.

Comment-(iii)

Comment deleted.

Comment-(iv)

Line24

“Falls were not related to rural residence or age, but those with memory problems or multiple sclerosis were more likely to fall. Higher likelihood of falls was also observed in people with chronic conditions not often thought to be associated with falls.”

Can these two sentences be combined into one? My suggestion is;

“Falls were not related to rural residence or age, but those with memory impairment, multiple sclerosis, as well as other chronic conditions such as xxx, yyy, zzz, not often thought to be associated with falls were also more likely to fall.”

We have made this change.

Comment-(v)

Line 32

“A more universal approach to screening, primary prevention and management may reduce the personal, social, and economic burden of falls and fall-related injuries.”

What is the opposite concept of “universal approach” here? Please see also comment-(xxiv).

We have revised the statement in the Abstract to clarify and better reflect our intended thoughts and perspectives.

Comment-(vi)

Comment deleted.

Comment-(vii)

Comment deleted.

Comment-(viii)

Line 63

“The objectives of our research were to: 1) comprehensively examine fall profiles decade-by-decade e.g., 45 to 54 years, 55 to 64 years, 65 to 74 years, 75 to 85 years;…”

The term "decade-by-decade" is to me more reminiscent of changes by era, such as the 1980s, 1990s, 2000s... rather than by age group. How about expressions like “age-stratified analysis of…” or “comparison across age groups”?

We have changed to “age groups …” [in the Abstract and throughout the manuscript].

Comment-(ix)

Table 1

I think it would be better to place related diseases closer together rather than in the order of frequency of diseases. For example, it is natural to place “Other type of arthritis” below other types. However, I do not strongly urge the author to do so, as he/she may have own ideas. Please consider it if a reviewer other than me has the same opinion as mine.

We have revised Table 1.

Comment-(x)

Line 142

“What is readily apparent and surprising is the low prevalence of falls.”

In the "Results" section, it is better to state only the facts in a straightforward manner. I propose to delete this sentence.

The sentence has been deleted, see Results section.

Comment-(xi)

Line 147

“Table 2 includes information about falls (no fall, single fall, multiple falls) with decade-by-decade comparisons.”

Again, perhaps a phrase such as "age group comparisons" would be more appropriate than "decade-by-decade comparisons"?

We have replaced with “age group”, see Table 2.

Comment-(xii)

Line 162

“The effect size estimate was small in magnitude for both the single fall and multiple falls groups, but only the larger single sized fall group had a significant chi-square.”

Please consider replacing this sentence with the following;

“The effect size estimate was small in magnitude for both the single fall and multiple falls groups, but only the single fall group had a significant chi-square.”

We have made this change, see Results section.

Comment-(xiii)

Line 163

“A weak association between where falls occurred and age was evident (Table 4), with older participants were more likely to fall inside the home than outside the home relative to younger participants.”

(xiii-i) “Weak” sounds subjective. “An association between...” would be more appropriate.

We have made this change, removing the word weak, see Results section.

(xiii-ii) It seems necessary to state this more objectively by showing some statistical significance. For example, how about combining the two categories of “Inside Home” and “Outside home but inside a building”, making fall location binary data, and applying the Cochran-Armitage trend test?

Thank you for this interesting suggestion. We kept the categories separate. Although both are considered “indoors”, one setting is a familiar setting (“Inside Home”) and the other setting is considered an unfamiliar setting (Outside the home but inside a building”). An unfamiliar environment may be an important extrinsic falls risk factor, worthy of exploring. Keeping the variables separate is also in keeping with other research using large data sets e.g., Moreland BL, Kakara R, Haddad YK, Shakya I, Bergen G. A Descriptive Analysis of Location of Older Adult Falls That Resulted in Emergency Department Visits in the United States, 2015. Am J Lifestyle Med. 2020 Aug 7;15(6):590-597. doi: 10.1177/1559827620942187.

Comment-(xiv)

Line 174

“Older participants who reported a single fall were more likely to report falling on snow or ice than were younger participants, but the converse was apparent for participants in the multiple falls group, with younger participants more likely to report falling on snow or ice.”

Question;

Do falls on snow or ice include those related to winter sports such as skiing or skating? I think this is an important point in interpreting the results.

We agree this would be an interesting and important consideration. Unfortunately, the CLSA data does not allow us to delve into this. Below is how the question is asked of participants and entered into the CLSA database.

We have added this as an example to the Limitations section.

FAL_Q05

FAL_HOW_TRM

How did your fall happen? READ LIST, CODE ONLY ONE RESPONSE

Fell while standing or walking .............................. 01

Fell on stairs or steps ........................................... 02

Fell while exercising (except walking) .................. 03

Fell from height of greater than 1 meter or

3 feet (for example, ladder, tree, roof) ............... 04

[ONLY ASK IF FAL_Q04/FAL_WHERE_TRM=1 OR 2]

Fell from furniture (for example, bed, chair) ......... 05

[ONLY ASK IF FAL_Q04/FAL_WHERE_TRM=1 OR 2]

Fell while getting in or out of the bathtub ............. 06

[ONLY ASK IF FAL_Q04/FAL_WHERE_TRM=1 OR 2]

Fell while getting in or out of the shower ............. 07

[ONLY ASK IF FAL_Q04/FAL_WHERE_TRM=3]

Fell on snow or ice ............................................... 08

FAL_HOW_OTSP_TRM Other (please specify: ______________) ........... 97

[DO NOT READ] Don’t know/No answer ............ 98

[DO NOT READ] Refused ................................... 99

Comment-(xv)

Line 168

“Age was moderately associated with how falls occurred for both the single fall group and the multiple fall group (Table 5).”

I suggest removing "moderately", since it seems to lack objectivity.

We have made this change, see Results section.

Comment-(xvi)

Line 177

“Older participants who were in the single fall group were more likely to report falling from furniture, however reported falls getting in and out of the shower and bath were infrequent.”

Instead, I suggest the following sentence;

“Older participants in the single fall group were more likely to report falling from furniture. Falls getting in and out of the shower and bath were infrequent regardless of age group.”

We have made this change, see Results section.

Comment-(xvii)

Line184

“The likelihood of having multiple falls versus a single fall was substantially higher (i.e., large magnitude of effect) for participants who reported being diagnosed with memory problems or with multiple sclerosis.”

The story is too complex to consider multiple falls in comparison to a single fall. I suppose the following sentence suffices;

“The likelihood of having multiple falls was substantially higher (i.e., large magnitude of effect) for participants who reported being diagnosed with memory problems or with multiple sclerosis.”

We have made this change, see Results section.

Comment-(xviii)

Line194

“These OR are reported in Table 7.”

Please provide a reference to Table 7 at the beginning of the paragraph, not at the end.

We have made this change, see Results section.

Comment-(xix)

Line 206

“Our findings indicate that several health conditions typically not thought of to be associated with falls had higher likelihood of multiple falls, such as mood disorder, anxiety disorder, and hyperthyroidism.”

Instead, I suggest the following sentence;

“Our findings indicate that several health conditions typically not thought of to be associated with falls, such as mood disorder, anxiety disorder, and hyperthyroidism are associated with higher likelihood of multiple falls.”

We have made this change, see Discussion section.

Comment-(xx)

Line 221

“Our findings and the work of Verma et al suggest falls screening and identification of individuals at high risk of falls and fall-related injuries should be comprised of a more universal and pragmatic approach across the adult lifespan; for example, falls as a vital sign of potential functional or other health issue, regardless of age, condition or disease, or health care context.”

About the last part, I understand that “age” can be disregarded, but wouldn't it be more in line with the context of this study to consider “condition” and “disease”?

We have revised the statement to clarify and better reflect our intended thoughts and perspectives, see Discussion section.

Comment-(xxi)

Line 225

“Routine inquiring about falls and fall-related injuries, for younger aged adults or those without known risk factors or health conditions, is not being conducted.”

What country is this about? Do you mean that it is not done anywhere in the world?

We were wanting to convey that a lifespan approach to falls screening, falls interventions/programs seems to be limited – literature and web-based searches confirm this. The focus of research and initiatives has been and seems to continue to be on older adults and this seems applicable globally. For example, one can only find documents that state “older adults over 65 years should be considered a high risk for falls” versus documents that state “everyone you see clinically should be asked about falls”.

We have revised the statement to clarify and better reflect our intended thoughts and perspectives, see Discussion section.

Comment-(xxii)

Line 265

“Approximately one in twenty adults in the CLSA baseline sample reported experiencing a fall in the last year, and about one in one hundred reported falling multiple times.”

“Previous year” or “preceding year” rather than “last year” would be more appropriate for an objective description.

We have changed “last year” to “preceding year”, see Conclusion section.

Comment-(xxiii)

Line 266

“Likelihood of falls occurring was similar regardless of age or urban/rural residence, but age was associated with fall location and activity.”

The last part sounds a bit strange to me. My suggestion is;

“Likelihood of falls was similar regardless of age or urban/rural residence, but age was associated with fall location or situation.”

We have made this change, see Conclusion section.

Comment-(xxiv)

Line 269

“A more universal approach to screening, primary prevention, assessment and management of falls and fall-related risk factors, including chronic disease management across the lifespan is warranted to reduce the personal, social, and economic burden of falls and fall-related injuries.”

The meaning of “universal” sounds ambiguous.

Is it like “a more multifaceted approach that is not based solely on age” ?

We have made this change, and made additional revisions to better convey our thoughts and perspectives, see Conclusion section.

Reviewer #2: Summary:

I would like to express my gratitude to the authors for their manuscript, which provides important insights into falls among middle-aged and older adult populations residing in both urban and rural regions of Canada. Its credibility is strongly supported by the utilization of a substantial dataset drawn from the Canadian Longitudinal Study on Aging (CLSA). The research presents some noteworthy findings that challenge prevailing preconceptions regarding fall-related factors, carrying substantial implications for the development of preventive measures and the allocation of healthcare resources. The study's concluding remarks underscore the imperative of adopting a comprehensive and universally applicable approach to the prevention and management of falls.

Thank you.

General comment:

Given the study exclusively includes 45+ years old adults (middle-aged and older adults), I recommend that authors clearly define or reconsider the use of the term 'adults' to avoid potential confusion throughout the manuscript. For example, information in ln. 42-43 indicate that adults would be defined as 20 years and older “Almost half of Canadians ages 20 years and older are living with a chronic condition”.

We have addressed this comment by changing from adults to people, individuals, Canadians etc, as applicable, throughout the manuscript.

Specific comments:

Manuscript's title:

- The current title, 'The 'decade-to-decade'...', may benefit from a more explicit indication that the study pertains to age groups, specifically middle-aged and older adults.

See response to Reviewer 1 comment above as well. We have revised the Title to address both Reviewers’ comments.

Abstract:

- While the background information is relevant, it would be beneficial to explicitly state the study's key objectives in the abstract. This would provide readers with a clearer understanding of the study's focus, which extends beyond older individuals.

We have added this information, see Abstract.

Introduction:

- I recommend addressing my earlier comment on defining the term 'adults' for clarity.

As above - We have addressed this comment by changing from adults to people, individuals, Canadians, etc, as applicable, in the Abstract and throughout the manuscript.

- Overall, the introduction effectively contextualizes the study and provides a clear foundation for the research objectives, helping readers understand the rationale and significance of the study.

Thank you.

Methods:

- In the brief outline, consider including the years when the data were collected or specifying the data collection period within the method section to provide clarity.

We have added this information, see Methods section.

- To enhance reader understanding, it would be beneficial to clearly differentiate between 'age groups' and age as a continuous variable.

- In line 96, please expand 'M/F' to 'Male/Female'.

We have made this change, see Methods section.

- For lines 99-102, adding a citation for the categorization and providing a brief in-text definition of rural areas would be helpful.

We have added this information and added citations, see Methods section.

- Please specify the type of logistic regression used (e.g., binary/univariate logistic regression)

We have added this information, see Methods section.

- In line 136, consider citing a reference.

We have added a reference, see Methods section.

- In line 138, I suggest including 'phi' to prepare readers for subsequent mentions.

We have added this information and citation, see Methods section.

- Ln. 129-130 “Logistic regression was used to explore whether demographic factors (age measured as a continuous variable), sex, education level, rural/urban) were predictors of fall status, that is no falls, a single fall, or multiple falls (reference group ‘no falls’).”

o Please, ensure consistency between the variables listed here and those reported in the results (e.g. results on sex and education level).

We have made revisions and believe we have captured all instances of previous non-alignment, see Methods section.

Results:

- Ensure that all tables can stand alone.

- Table 1. I suggest that you specify the time period for income, and add '$...CAD' for international readers.

Table 1 has been revised, see Results section.

- For Tables 3-5, clarify in a footnote how the variable 'multiple falls' was treated when falls occurred in different locations.

We have added a footnote to Tables 3 to 5.

- Table 7. Please explain the bold font.

We have added an explanation to Table 7.

Discussion:

- The discussion effectively summarizes key findings, offers valuable insights and recommendations for addressing falls and fall-related injuries across the lifespan, and identifies potential areas for future research.

Thank you.

I have couple of suggestions:

o In line 220, you mention 'younger, working-aged adults'. Consider finding a place, such as the limitations section, to clarify that this dataset does not include young adults (ages 20 to 44).

We have made this addition to the Limitations section.

- Regarding reference no. 33, check if referring to a more recent paper, such as Montero-Odasso et al., 2022 (DOI: 10.1093/ageing/afac205), might provide more up-to-date information.

Conclusion:

- The study's conclusion closely matches its objectives. It successfully summarizes findings on falls, age [groups], urban/rural residence, and risk factors while highlighting the need for universal fall prevention across the lifespan.

Thank you.

Minor comments:

- Please address instances where periods are missing, and ensure that citations are positioned after punctuation marks.

We have reviewed the manuscript and made the necessary changes and believe we have captured all applicable instances.

- In line 112, there appears to be missing information in the sentence starting with 'Additional fall-related…'.

This has been corrected, see Fall data sub-section (Methods).

6. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: Yes: Narumi Kojima

Reviewer #2: No

Attachment

Submitted filename: Response to Reviewers.docx

pone.0300026.s001.docx (54.8KB, docx)

Decision Letter 1

Ryota Sakurai

21 Feb 2024

Comparison across age groups of causes, circumstances, and consequences of falls among individuals living in Canada: A cross-sectional analysis of participants aged 45 to 85 years from the Canadian Longitudinal Study on Aging

PONE-D-23-32442R1

Dear Dr. Dal Bello-Haas,

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Reviewer #1: As I wrote in the previous round, the Abstract does not describe the purpose of the study.

Please summarize at the last part of Background in one sentence like "The study aims to investigate ....", what you wrote in lines 62-66.

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Acceptance letter

Ryota Sakurai

5 Mar 2024

PONE-D-23-32442R1

PLOS ONE

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Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    Attachment

    Submitted filename: Response to Reviewers.docx

    pone.0300026.s001.docx (54.8KB, docx)

    Data Availability Statement

    Data are available from the Canadian Longitudinal Study on Aging (www.clsa-elcv.ca) for researchers who meet the criteria for access to de-identified CLSA data.


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