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. 2024 Mar 15;15(3):219. doi: 10.1038/s41419-024-06608-7

Retraction Note: ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas

Chuang Huang 1,#, Changhwan Yoon 2,#, Xiao-Hong Zhou 1, Ying-Chun Zhou 1, Wen-Wen Zhou 1, Hong Liu 1, Xin Yang 1, Jun Lu 2,3, Sei Young Lee 4,, Kun Huang 5,
PMCID: PMC10943203  PMID: 38491046

Retraction to: Cell Death and Disease 10.1038/s41419-020-2448-6, published online 23 April 2020

The Editors-in-Chief have retracted this article after concerns were raised about image irregularities. Further investigation by the publisher found the below concerns to be valid. Additionally, the authors failed to provide raw data and evidence for ethics approval for this study.

The Editors-in-Chief therefore no longer have confidence in the results and conclusions present in this article.

  • Partial image overlap between Figure 2A (sh. NANOG, SCC-15 CD44+ cells) and Figure 4G, Migration (SCC-25 CD44+ cells, sh.ERK1/2)

  • Image overlap between Figure 2E (sh.SCr, SCC-15 CD44+ cells) and Figure 3C (SK-LMS-1, Spheroids) of [1]

  • Image overlap between Figure 2E (sh.SCr, SCC-25 CD44+ cells) and Figure 3C (HT1 080, Spheroids) of [1]

  • Multiple image overlaps between Figure 4H, immunofluorescent images and Figure 1D (SNU-668, Spheroids +) of [2]

Kun Huang agrees to retraction. None of the remaining authors have responded to any correspondence from the publisher about this retraction.

Footnotes

These authors contributed equally: Chuang Huang, Changhwan Yoon.

Contributor Information

Sei Young Lee, Email: syleemd@cau.ac.kr.

Kun Huang, Email: feelingkun@126.com.

References

  • 1.Chang KK, Yoon C, Yi BC, Tap WD, Simon MC, Yoon SS. Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas. Oncogenesis. 2018;7:47. doi: 10.1038/s41389-018-0059-1. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
  • 2.Yoon C, Cho SJ, Aksoy BA, Park DJ, Schultz N, Ryeom SW, et al. Chemotherapy resistance in diffuse-type gastric adenocarcinoma is mediated by RhoA activation in cancer stem-like cells. Clin Cancer Res. 2016;22:971–83. doi: 10.1158/1078-0432.CCR-15-1356. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]

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