Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 13;23(2):620–677. doi: 10.1007/s12311-022-01506-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 12 — Schematic drawing showing migratory steps of GABAergic and glutamatergic neurons composing the cerebellar nuclei. All sagittal sections are oriented with rostral to the right. a Between E10.5 and E11.5 glutamatergic projection neurons (light blue cells) originate from the ATOH1 ⁺ and PAX6 ⁺ progenitors (light blue spheroids) localized in the Rhombic Lip (Rl, Triangular shape). They migrate apposed to the pia mater, forming the subpial stream (SPS, curved line) away from the Rl (gray arrow) expressing the genes indicated in Box 1. Few neurons reach the nuclear transitory zone (Ntz). GABAergic neurons differentiate from ASCL1 ⁺ and PTF1A ⁺ common progenitors (green spheroids) in the ventricular zone (Vz, rectangular shape) from which NEUROG2 ⁺ or PAX2 ⁺ transit amplifier populations originate (green spheroids). Postmitotic NEUROG2 ⁺ or PAX2 ⁺ GABAergic (green cells) neurons leave the Vz expressing IRX3 or Dmbx1. b Between E12.5 and E13.5 glutamatergic projection neurons continue their migration expressing several markers (Box 2) and start to reach the Ntz, where they express other markers (Box 3). GABAergic neurons move towards the Ntz and express SOX14 and DMBX1 while IRX3 is downregulated. Neurogenesis of NEUROG2 ⁺ and PAX2 ⁺ neurons appears to continue until E12.25-E12.5. c By E14.5 all the prospective glutamatergic CN neurons are located in the Ntz surrounded by a GABAergic population, where they further mature and prepare to descend into their final position in the central mass (grey arrows). d By E18.5 all the neurons are in the central mass, occupying different territories: glutamatergic neurons localize dorsally while NEUROG2 ⁺ GABAergic neurons are in ventral and lateral positions. A few PAX2 ⁺ GABAergic neurons are intermingled in the neuronal mass, while the prospective PAX2 ⁺ GABAergic interneurons surround the cerebellar nuclei mass. e By P4, the GABAergic and glutamatergic neurons continue small movements to reach their terminal destination. Color fonts of expressed molecules during development indicate the known destination of the cells. The numbers of cells illustrated do not reflect the actual cell numbers, which are mostly unknown