Table 1.
Demographics and clinical characteristics of the patients included in this study
| Characteristics* | Sweden | Spain | Total† |
| IBS-D patients | 20 | 30 | 50 |
| Females (%) | 12 (60.0) | 19 (63.3) | 31 (62.0) |
| Age, mean±SD | 48.9±13.4 | 42.8±13.9 | 45.2±13.9 |
| IBS-SSS (mean±SD) at baseline | 282.4±69.3 | 293.8±71.1 | 289.2±69.9 |
| IBS-SSS (mean±SD) at 2 weeks | 194.1±100.3 | 183.8±89.7 | 187.9±93.2 |
| IBS-SSS (mean±SD) at 4 weeks | 157.3±93.2 | 142.5±99.0 | 148.4±94.1 |
| Responders at 2 weeks (%)‡ | 15 (75.0) | 20 (66.7) | 35 (70.0) |
| Responders at 4 weeks (%)‡ | 17 (85.0) | 25 (83.3) | 42 (84.0) |
| SI hypomorphic genotype (0/1/2)§ | 12/4/4 | 15/11/4 | 27/15/8 |
*Demographic, IBS symptom severity scores (IBS-SSS) and SSRD response during the observation period, at 2 and 4 weeks (standard deviation (SD)).
†Swedish and Spanish patients did not significantly differ for age, sex, IBS-SSS scores or SSRD response rates.
‡A positive SSRD response was defined as a drop of 50 IBS-SSS points, compared with baseline.
§SI hypomorphic genotype (non-carriers/single-carriers/double-carriers).
IBS, irritable bowel syndrome; SI, sucrase-isomaltase; SSRD, sucrose and starch-restricted diet.