The authors from «Association between Modifiable Risk Factors and Levels of Blood-Based Biomarkers of Alzheimer’s and Related Dementias in the Look AHEAD Cohort», J Aging Res & Lifestyle 2024;13:1-21, note a correction to change the units of measure in Table 1 from micrograms/deciliter (μg/dl) to picograms/deciliter (pg/dl).
Table 1 (continued).
Baseline Characteristics of Participants by Randomization Group
| Characteristic | Total (n= 779) | DSE (n= 383) | ILI (n= 396) | P-value |
|---|---|---|---|---|
| Baseline | ||||
| Aβ-40, mean ± SD, pg/dl | 66.7 ± 19.5 | 67.0 ± 20.9 | 66.5 ± 18.0 | 0.14 |
| Aβ-42, mean ± SD, pg/dl | 4.9 ± 1.4 | 4.9 ± 1.4 | 4.8 ± 1.4 | 0.12 |
| Aβ-42/40, mean ± SD, pg/dl | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.1 ± 0.0 | 0.60 |
| GFAP, mean ± SD, pg/dl | 93.3 ± 40.5 | 92.5 ± 39.7 | 94.0 ± 41.4 | 0.88 |
| NfL, mean ± SD, pg/dl | 13.8 ± 6.5 | 14.3 ± 7.3 | 13.4 ± 5.5 | 0.68 |
| pTau-181, mean ± SD, pg/dl | 9.2 ± 5.1 | 9.1 ± 5.0 | 9.4 ± 5.2 | 0.20 |
| Years 8-13 | N=770 | N=377 | N=393 | |
| Aβ-40, mean ± SD, pg/dl | 89.3 ± 34.8 | 91.1 ± 36.2 | 87.4 ± 33.2 | 0.77 |
| Aβ-42, mean ± SD, pg/dl | 6.0 ± 2.3 | 6.1 ± 2.3 | 5.9 ± 2.3 | 0.25 |
| Aβ-42/40, mean ± SD, pg/dl | 0.1 ± 0.0 | 0.1 ± 0.3 | 0.1 ± 0.0 | 0.96 |
| GFAP, mean ± SD, pg/dl | 153.1 ± 74.7 | 152.7 ± 71.3 | 153.5 ± 77.9 | 0.62 |
| NfL, mean ± SD, pg/dl | 25.1 ± 18.7 | 24.9 ± 18.1 | 25.4 ± 19.3 | 0.07 |
| pTau-181, mean ± SD, pg/dl | 9.9 ± 5.5 | 9.7 ± 5.3 | 10.2 ± 5.6 | 0.47 |
Abbreviations Aβ, Amyloid beta; APOE ε4, Apolipoprotein E gene, ε4 carrier status; CVD, cardiovascular disease; DSE, diabetes support and education; GFAP, glial fibrillary acidic protein; eGFR, estimated glomerular filtration rate; HbA1c, hemoglobin A1c; Hx, history; ILI, intensive lifestyle intervention; kg/m2, kilogram per square meter; Meds, medications; NfL, neurofilament light chain; oz, ounces; SD, standard deviation, Trt, treatment; pg/dl, picogram per deciliter; wk, week; Yrs, years