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. 2024 Mar 27;11(12):2470067. doi: 10.1002/advs.202470067

Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia (Adv. Sci. 12/2024)

Yingying Yu, Yunxing Su, Sisi Yang, Yutong Liu, Zhiting Lin, Nupur K Das, Qian Wu, Jiahui Zhou, Shumin Sun, Xiaopeng Li, Wuyang Yue, Yatrik M Shah, Junxia Min, Fudi Wang
PMCID: PMC10966508

Abstract

Iron‐Refractory Anemia

In article number 2307022, Yatrik M. Shah, Junxia Min, Fudi Wang, and co‐workers show hypoxia and the HIF‐PH inhibitor as anemia novel therapies through Hif2α (phoenix) mediated transcriptional upregulation of Fpn (dragon) in the intestinal villi (mountains). Increased Fpn transports more iron into the circulation (depicted by the dragon's breath), thereby treating anemia (red blood cell). The illustration is inspired by the Year of the dragon 2024 and the traditional Chinese story of “The Auspicious Dragon and Phoenix”, symbolic creatures that represent good fortune.

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