Extended Data Fig. 8 |. DDR-related pathways in TCGA Y_low vs. Y_high BC.

a, Heatmap of the indicated pathways and metadata from BC TCGA data. b–c, box plot of tumor neoantigen burden (TNB) per megabase (P = 0.700) (b), and associated pathway enrichment levels (c) from Y_high and Y_low tumors described in Fig. 1a. Statistical significance was determined by Wilcoxon test (Y_low n = 118 and Y_high n = 182). Boxplots represent the mean with first and third quartile data. Minimum and maximum datapoints are included.