Abstract
Background
Despite the global surge in the Corona virus disease (COVID-19) pandemic, people's efforts to combat the pandemic have been insufficient. The world has experienced a number of challenges in terms of COVID-19 vaccine acceptance. Therefore, understanding the community's willingness to receive the vaccine will aid in the creation and implementation of effective COVID-19 immunization. As a result, the aim of this study was to assess the magnitude of COVID-19 vaccine acceptance and associated factors among adults in Addis Ababa, Ethiopia.
Methods
A community-based cross-sectional study with 419 household heads was undertaken in Addis Ababa, Ethiopia. To identify factors associated with the outcome and independent variables, bi-variable and multi-variable logistic regression analyses were used. A 95% confidence interval and a p-value of less than 0.05 were deemed sufficient to declare a significant association.
Results
The level of COVID-19 vaccine acceptance was 46.3 % (95 % CI: 43.87–48.73). Moreover, age groups above 58 years (AOR = 0.38, 95: CI: 0.17, 0.84), chronic disease (AOR: 2.09, 95 % CI: 1.28–3.42), a positive attitude (AOR: 1.64, 95 % CI: 1.29–2.04), being a Muslim (AOR: 0.36, 95 % CI: 0.19–0.71) and social support (AOR: 1.7, 95 % CI: 1.04–2.79) were all significantly related to COVID-19 vaccine acceptance.
Conclusion
The findings of this study revealed a lower rate of COVID-19 vaccination acceptance. Age, chronic disease, attitude, and social support were significant predictors of COVID-19 vaccine acceptance. Therefore, emphasis should be given for community mobilization, especially for the elderly, those with limited social engagement, and those who have a negative attitude toward COVID-19 vaccination.
Keywords: COVID-19 vaccination acceptance, Determinants, Ethiopia
Introduction
The novel corona-virus disease 2019 (COVID-19), continues to cause significant morbidity and death throughout the world and resulted a significant loss of human life [1]. Globally, 6,039,440 fatalities and over 455,565,230 confirmed cases were reported as of March 13, 2022 [2]. The World Health Organization (WHO) announced a global campaign of prevention, early detection, and medical treatment in response to the incident, which was declared a pandemic in early 2020 [3]. Subsequently, multiple COVID-19 vaccines were developed and tested in various clinical trials on a variety of populations [4], [5].
Vaccines are life-saving inventions that have helped to eradicate and control a wide range of infectious diseases throughout the world [6]. Vaccination against COVID-19 can significantly lower hospital stays and serious illnesses; a recent modeling study predicted that in the first year of the vaccine's introduction, COVID-19 vaccinations were responsible for the reduction of approximately 14 million deaths [7]. However, vaccine hesitancy described as a “delay in acceptance or refusal of vaccination despite the availability of vaccination services” posed a serious threat to global health [8]. Refusal to receive the COVID-19 vaccine is a major barrier to global efforts to control the pandemic and mitigate its consequences on the economy and public health [9], [10]. According to the World Health Organization (WHO) report, vaccine resistance and hesitancy were among the top ten health risks during 2021 [11].
Ethiopia made the COVID-19 vaccine available since March 13, 2021, and several vaccines were introduced after a national deployment and vaccination plan was developed in accordance with the WHO prioritization road-map particularly with front-line health workers, clinical supportive staff, the elderly with underlying conditions, and other high-risk groups receiving priority for vaccination [12], [13].
Globally, the overall acceptance of the COVID-19 vaccine was reported to be low, with 85.2 % of participants refusing the vaccination [14]. In Ethiopia, only 31.4 % of the general population was willing to accept the COVID-19 vaccine [15]. Moreover, age, gender, marital status, educational level, occupation, place of residence, religion, monthly income, history of COVID-19 infection, family history of COVID-19 infection, chronic illness, being tested, vaccine rumors, personal beliefs, perception with vaccine safety, and a lack of vaccine distribution have all been identified as determinant factors [16], [17], [18].
As a result of the rapid development, testing, approval, and public distribution of COVID-19 injections, the attitudes and views of population towards the vaccine are probably going to have changed during the pandemic [19], [20]. As a result public COVID-19 vaccine hesitation is a major barrier to the delivery [21], [22]. However, there is just a little proof of vaccine acceptance following the administration of the COVID-19 buster dose [23]. Moreover, recently various COVID-19 vaccination acceptance surveys have revealed a significant level of regional and global variations in the level of acceptance and associated determinants [24], [25]. To establish the most effective vaccination strategy in Ethiopia, it is necessary to comprehend the general public's awareness, behavior, hesitancy, and factors influencing their desire to use the COVID-19 vaccine. Moreover, it is necessary to identify the current context-specific factors related with the Ethiopian populations in general and the population of Addis Ababa in particular. Therefore, the aim of this study was to determine the level of COVID-19 vaccine acceptance and associated determinants in Addis Ketema Sub-city, Addis Ababa, Ethiopia, in 2022.
Methods
Study area and period
The study was conducted in Addis Ababa, Ethiopia. Addis Ababa is divided into 11 sub-cities, with an estimated total population of more than 5.2 million people. Addis Ketema Sub-city is located in Addis Ababa's northwestern region, bordering the sub-cities of Gullele in the north, Arada in the east, Lideta in the south, and Wolfe-Keranio in the west. The study was conducted among adult household heads in Addis Ketema sub-city from May 1st to June 1st, 2022. This study is reported according to STROCSS 2021 guidelines [26].
Study design
A community-based cross-sectional study was carried out. Cross-sectional study designs are commonly referred to as one-shot design that are most appropriate for studies that use a cross-section of the population to determine the prevalence of a phenomenon, situation, problem, attitude, or issue. It assist in creating a broad “picture” of things as they are at the time the study is conducted.
Eligibility criteria
All household heads over the age of 18 who had resided in the study area for at least six months were included in the study. Besides, respondents who were psychologically or seriously ill at the time of the survey, as well as those who had closed their houses on three occasions, were omitted, and the next household head was questioned, and the typical pattern continued.
Sample size determination and sampling procedure
Sample size was determined using a single population proportion formula by considering the study done in Sodo Town, Southern Ethiopia, on COVID-19 vaccination acceptance of 45.5 % [27] as a proportion, with an assumption of a 95 % confidence interval and a 5 % margin of error.
n=.
Finally, considering a 10 % non-response rate, 419 people were needed for the study.
There were eleven districts in the Addis Ketema sub-city. Random samples were drawn from each district and distributed proportionally based on the number of households in each district using a simple random selection technique. Finally, the study participants for the study were picked via simple random selection, with the house number serving as the sample frame.
Study variables and operational definitions
Dependent variable
Acceptance of COVID-19 vaccination was considered the outcome variable. Respondents we asked whether or not they would accept a COVID-19 vaccination if it become available to the general population (Yes or No).
Independent variable
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•
Socio-demographic factors (age, gender, marital status, level of education, monthly income, religion, and so on).
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•
Health status and exposure-related factors (history of COVID-19 infection, family history of COVID-19 infection, having chronic disease, source of information about COVID-19 vaccine, and so on), and
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•
Knowledge- and attitude-related factors (COVID-19 vaccine-related knowledge, COVID-19 vaccine-related attitude, and so on) were all taken as predictor variables.
Respondents' knowledge of the COVID-19 vaccination was calculated by adding all relevant knowledge-related “yes” (one) and “no” (zero) questions. Respondents who scored greater than or equal to the mean value were considered to have good knowledge, while those who scored less than the mean value of the sum of knowledge assessment questions were considered to have poor knowledge [28].
Respondents' attitudes towards the COVID-19 vaccine: COVID-19 vaccine related attitude was calculated by adding all relevant attitude questions to “agree” (1), and “disagree” (0) questions. Respondents were classified as having a positive attitude if their responses were greater than or equal to the mean value of all questions, and as having a negative attitude if their responses were less than the mean value of all attitude related questions [15].
Intention to accept the COVID-19 vaccine: COVID-19 vaccine acceptance was assessed using “yes” and “no” questions. “Did you have any intention to accept the COVID-19 vaccine if it becomes available in the future?” was the question posed to respondents. Responses that were “yes” were given a score of 1, and responses that were “no” were given a score of 0. Respondents who received a score of 1 were therefore assumed to have the intention to receive the COVID-19 vaccination, whereas respondents who received a score of 0 were presumed to have no intention to do so [28].
Data collection and analysis
The data collection tool was developed after reviewing a number of studies [15], [16], [28]. Variables from earlier systematic review studies were incorporated for the theoretical analysis and identification of factors responsible for COVID-19 vaccine hesitation [29], [30]. The survey questionnaire was divided into five sections. The first section includes socio-demographic variables (7 items), the second section includes health status and exposure-related factors (12 items), the third section includes knowledge (9 items), and the fourth section includes attitude (9 items). Part five was used to assess factors related to friends and family (13 questions) and, finally, acceptance of COVID-19 vaccine-related factors (1 item). The validity of the questionnaire content were evaluated by subject-matter experts, including researchers and medical educators. Cronbach's alpha was used to assess reliability; the result was 0.77, indicating that there was no violation of reliability. The tool were pretested among 21 respondents in nearby Yeka sub-city district five before the date of the actual data collection. We made adjustments in the questionnaire and these data were precluded from the final analysis.
Data was entered into EPI-DATA software and then exported to SPSS version 26 for further analysis. In order to ascertain the relationship between the dependent variable and the independent variables, a binary logistic regression analysis was carried out. Then significant variables were considered candidate variables for multi-variable logistic regression analysis if their p-value was less than 0.25. The presence of an association between explanatory variables and respondents' acceptances of the COVID-19 vaccine was assessed using an adjusted odds ratio and a 95 % confidence interval. A significance level of less than 0.05 was used to declare the presence and strength of association between the dependent and independent variables.
Results
Socio-demographic characteristics of the study participants
This study had 408 study participants and a response rate of 97.4 %. Men made up 229 (56.1 %) of the study participants. The respondents' mean (±SD) age was 38.5 ± 14.7 years with a range of 18 to 71 years, and the majority of participants (219, or 53.7 %), were married. The majority of participants (148, 36.3 %) were self-employed, with 175 (42.9 %) holding a diploma or higher. Furthermore, 352 (86.3 %) of the participants live in cities, and the majority of them, 207 (50.7 %), are orthodox Christians (Table 1).
Table 1.
Socio-demographic characteristics of respondents.
| Variables | Category | Frequency | Percent |
|---|---|---|---|
| Age | 18–27 | 91 | 22.3 |
| 28–37 | 156 | 38.3 | |
| 38–47 | 52 | 12.7 | |
| 48–57 | 41 | 10.0 | |
| >58 | 68 | 16.7 | |
| Sex | Male | 229 | 56.1 |
| Female | 179 | 43.9 | |
| Educational status | Illiterate | 33 | 8.1 |
| primary education | 77 | 18.9 | |
| secondary education | 123 | 30.1 | |
| Diploma and above | 175 | 42.9 | |
| Marital status | Never married | 138 | 33.8 |
| Married | 219 | 53.7 | |
| Divorced | 23 | 5.6 | |
| Widowed | 28 | 6.9 | |
| Occupational status | government employee | 108 | 26.5 |
| private employee | 90 | 22.1 | |
| self-employed | 148 | 36.3 | |
| Unemployed | 52 | 12.6 | |
| Others | 10 | 2.5 | |
| Residence | Urban | 352 | 86.3 |
| Rural | 56 | 13.7 | |
| Religion | Orthodox | 207 | 50.7 |
| Muslim | 91 | 22.3 | |
| Protestants | 103 | 25.3 | |
| Others | 7 | 1.7 |
Health status of participants and exposure-related factors
In response to inquiries regarding their exposure and health status, 296 (72.5 %) and 299 (73.3 %) of the participants stated that neither they nor anyone in their family had ever had COVID-19 infection. However, 108 (26.5 %) of them had tested, and the results showed that 57 (14.4 %) of them were positive and the remaining 51 (12.5 %) were free of the illness. Out of them, 190 (46.6 %) were concerned about catching COVID-19 in the future. Out of all the participants, only 91 (22.3 %) reported that they had a chronic illnesses. The prevalence of diabetes, hypertension, COPD, asthma, renal, and cardiac disease was 70 (17.2 %), 68 (16.7 %), 38 (9.3 %), 31 (7.6 %) and 37 (9.2 %), respectively. Besides this, the majority 247 (60.5 %) believed that they had a medium risk of developing this illness. Additionally, 226 people (54.4 %) think there is a treatment for COVID-19. (Table 2).
Table 2.
Health status of the study participants.
| Variables | Category | Frequency | Percent |
|---|---|---|---|
| History of COVID-19 infection | Yes | 112 | 27.5 |
| No | 296 | 72.5 | |
| Family history of COVID-19 infection | Yes | 109 | 26.7 |
| No | 299 | 73.3 | |
| Increased risk of getting COVID-19 in the future | Yes | 190 | 46.6 |
| No | 218 | 53.4 | |
| Tested for COVID-19 | Yes | 108 | 26.5 |
| No | 300 | 73.5 | |
| If tested your result | Positive | 57 | 14.0 |
| Negative | 51 | 12.5 | |
| Do you have any history of chronic disease | Yes | 91 | 22.3 |
| No | 317 | 77.7 | |
| Do you have a history of diabetes mellitus | Yes | 68 | 16.7 |
| No | 340 | 83.3 | |
| Do you have a history of chronic obstructive pulmonary disease | Yes | 42 | 10.3 |
| No | 366 | 89.7 | |
| Do you have a history of hypertension | Yes | 70 | 17.2 |
| No | 338 | 82.8 | |
| Do you have a history of bronchial asthma | Yes | 38 | 9.3 |
| No | 370 | 90.7 | |
| Do you have a history of renal disease | Yes | 31 | 7.6 |
| No | 377 | 92.4 | |
| Do you have a history of cardiac disease | Yes | 38 | 9.3 |
| No | 371 | 90.8 | |
| Perception of the risk of these exposure |
high-risk | 64 | 15.7 |
| medium risk | 247 | 60.5 | |
| low risk | 97 | 23.8 | |
| Do you believe that there is a cure for COVID-19 | Yes | 226 | 55.4 |
| No | 182 | 44.6 |
Knowledge and attitude towards the COVID-19 disease and vaccine
When asked about their awareness of COVID-19 and the vaccine, participants replied that the illness's symptoms include fever, cough, otitis media, chills, headache, loss of smell, and no symptoms at all. The majority of study participants 279 (68.4 %)—reacted to the mode of COVID-19 transmission through inhalation of respiratory droplets from infected patients and 260 (63.7 %) contact with contaminated objects, while 238 (58.3 %) did so through eating or touching wild animals, 181 (44.4 %) did so through consuming unclean food, and 140 (34.3 %) did so through consuming unclean water. The following were mentioned by the respondents as COVID-19 infection prevention strategies: wearing a face mask; taking vitamin C; refraining from touching the face, mouth, or eyes; washing hands with normal soup; using detergent; taking zinc; avoiding meat; and utilizing herbs. In terms of knowledge of the COVID-19 vaccine, 312 (76.5 %) believe they are aware of its development and 312 (76.5 %) believe it is effective. However, 261 (64.0 %) think that using an excessive amount of the COVID-19 vaccine is risky because 219 (53.7 %) think it increases immune disease and 219 (53.7 %) think it increases allergic reactions (Table 3).
Table 3.
Knowledge-related factors.
| Category | Response | Frequency | Percent | |
|---|---|---|---|---|
| What are the symptoms of COVID-19 | Fever | Yes | 347 | 85.0 |
| No | 61 | 15.0 | ||
| Chills | Yes | 284 | 69.6 | |
| No | 124 | 30.4 | ||
| Cough | Yes | 350 | 85.8 | |
| No | 58 | 14.2 | ||
| Otitis media | Yes | 318 | 77.9 | |
| No | 90 | 22.1 | ||
| Headache | Yes | 265 | 65.0 | |
| No | 143 | 35.0 | ||
| Loss of smell and taste | Yes | 217 | 53.2 | |
| No | 191 | 46.8 | ||
| No symptom | Yes | 93 | 22.8 | |
| No | 315 | 77.2 | ||
| How is COVID-19 transmitted | Drinking unclean water | Yes | 140 | 34.3 |
| No | 268 | 65.7 | ||
| Eating unclean food | Yes | 181 | 44.4 | |
| No | 227 | 55.6 | ||
| Contact of contaminated object | Yes | 260 | 63.7 | |
| No | 148 | 36.3 | ||
| Inhalation of respiratory droplet to infected Patients |
Yes | 279 | 68.4 | |
| No | 129 | 31.6 | ||
| Eating or touching wild animals | Yes | 238 | 58.3 | |
| No | 170 | 41.7 | ||
| Prevention of COVID-19 infection | Wearing face mask | Yes | 308 | 75.5 |
| No | 100 | 24.5 | ||
| Washing hand with regular soup | Yes | 287 | 70.3 | |
| No | 121 | 29.7 | ||
| Using detergent | Yes | 241 | 59.1 | |
| No | 167 | 40.9 | ||
| Social distancing | Yes | 320 | 78.4 | |
| No | 88 | 21.6 | ||
| Avoid touching face mouth nose eyes | Yes | 295 | 72.3 | |
| No | 113 | 27.7 | ||
| Consume vitamin C | Yes | 308 | 75.5 | |
| No | 100 | 24.5 | ||
| Consume Zink | Yes | 212 | 52.0 | |
| No | 196 | 48.0 | ||
| Avoid eating meat | Yes | 192 | 47.1 | |
| No | 216 | 52.9 | ||
| Consume herbs | Yes | 170 | 41.7 | |
| No | 238 | 58.3 | ||
| Does COVID-19 vaccination increase allergic reaction | Yes |
219 |
53.7 |
|---|---|---|---|
| No | 189 | 46.3 | |
| Does vaccination increase out immune disease | Yes | 223 | 54.7 |
| No | 185 | 45.3 |
Regarding attitudes toward the COVID-19 vaccine, 301 respondents (73.8 %) agreed that it is safe and should be used to encourage family and friends to get immunized, while 110 respondents (27 %) disagreed. The majority of respondents (29.1 %) were unsure whether vaccination was the best way to combat COVID-19 spread.
The intention of study participants to accept the COVID-19 vaccine
If the vaccine becomes available in the future, 46.3 % (95 % CI: 43.87–48.73) of study participants claimed that they would use it (Fig. 1). Health status percentages had an average score of 49.2 %. From the 408 respondents, 203 (49.8 %) had a chronic illness or had been exposed to COVID-19 virus disease, while 165 (40.4 %) had sufficient knowledge of COVID-19 and the vaccine (with a percentage mean score of 37.24 %). However, only 45.3 % of them, with a percentage mean score of 24 %, had a favorable attitude toward the vaccine. In addition, 189 (46.3 %) of the participants said that friends or other social figures influenced them.
Fig. 1.
Intention of respondents to accept covid-19 vaccines.
Predictors of vaccine acceptance
In the binary logistics regression model, variables such as age, educational level, occupational status, religion, health and exposure status of the study participants, knowledge, attitude, and social support had a statistically significant association with COVID-19 vaccine acceptance at a p-value less than 0.25. In multi-variable logistic regression analysis, variables with a p-value less than 0.05 were considered as determinants of COVID-19 vaccine acceptance. As a result age groups above 58 years (AOR = 0.38, 95: CI: 0.17, 0.84), having a chronic disease (AOR: 2.09, 95 % CI: 1.28–3.42), positive attitude (AOR: 1.64, 95 % CI: 1.29–2.04), being a Muslim (AOR: 0.36, 95 % CI: 0.19–0.71) and social support (AOR: 1.7, 95 % CI: 1.04–2.79) were all significantly related to COVID-19 vaccine acceptance (Table 4).
Table 4.
Factors affecting COVID-19 vaccine acceptance.
| Variables |
Category Vaccine acceptance |
COR (95 % CI) | AOR (95 % CI) | |||
|---|---|---|---|---|---|---|
| Yes | No | |||||
| Age | 18–27 | 42 | 49 | 1 | 1 | |
| 28–37 | 53 | 103 | 1.67 (0.98, 2.83) | 1.62 (0.84, 3.11) | ||
| 38–47 | 23 | 29 | 1.08 (0.55, 2.14) | 0.96 (0.39, 2.35) | ||
| 48–57 | 28 | 13 | 0.39 (0.18, 0.87) | 0.43 (0.16, 1.14) | ||
| >58 | 43 | 25 | 0.49 (0.26, 0.95) | 0.38 (0.17, 0.84)* | ||
| Educational status | Illiterate | 21 | 12 | 1 | 1 | |
| Primary education | 32 | 45 | 2.46 (1.06, 5.71) | 1.32 (0.42, 4.10) | ||
| Secondary education | 55 | 68 | 2.16 (0.98, 4.78) | 0.94 (0.34, 2.63) | ||
| Diploma and above | 81 | 94 | 2.03 (0.94, 4.38) | 0.61 (0.23, 1.64) | ||
| Occupational status | Government employee | 49 | 59 | 1 | 1 | |
| Private employee | 46 | 44 | 0.79 (0.45, 1.39) | 0.84 (0.40, 1.77) | ||
| Self employed | 68 | 80 | 0.98 (0.59, 1.61) | 0.81 (0.44, 1.46) | ||
| Unemployed | 26 | 36 | 1.87 (0.93, 3.76) | 2.17 (0.98, 4.83) | ||
| Religion | Orthodox | 93 | 114 | 1 | 1 | |
| Muslim | 53 | 38 | 0.59 (0.36, 0.96) | 0.36 (0.19, 0.71)* | ||
| Protestants | 43 | 67 | 1.27 (0.79, 2.04) | 1.23 (0.65,2.30) | ||
| Health and exposure status | Free from chronic disease | 111 | 94 | 1 | 1 | |
| Had a chronic disease | 78 | 125 | 1.89 (1.28, 2.81) | 2.09 (1.28,3.42)* | ||
| Knowledge | Poor knowledge | 118 | 125 | 1 | 1 | |
| Good knowledge | 71 | 94 | 1.25 (0.84, 1.86) | 1.42 (0.87,2.31) | ||
| Attitude | Negative attitude | 95 | 128 | 1 | 1 | |
| Positive attitude | 94 | 91 | 1.52 (1.01, 2.06) | 1.64 (1.29,2.04)* | ||
| Social supports | Yes | 77 | 112 | 1 | 1 | |
| No | 112 | 107 | 1.52 (1.03, 2.26) | 1.70 (1.04, 2.79)* | ||
=p-value less than 0.05.
Discussion
To bring an end to the COVID-19 pandemic, ongoing attempts are being done. In various nations, including Ethiopia, different COVID-19 vaccinations have been made available. Effective COVID-19 vaccination promotion strategies would be developed and put into action with an understanding of the communities' readiness for the immunization as well as the significant factors influencing their acceptance. As a result, the aim of this study was to determine the level of vaccine acceptance and associated factors in Addis Ketema Sub-city, Addis Ababa, Ethiopia.
According to the findings of this study, the rate of vaccination acceptance was 46.3 %. Overall low level of COVID-19 vaccination acceptance rate has been documented, which could have significant implications for the inefficiency, ineffectiveness, and long-term sustainability of COVID-19 control measures. The results of the current study were consistent with earlier research from Kuwait (53.1 %) [31], and Wolaita Sodo town, Ethiopia, 46.1 % [32].
However, the current finding was lower than study finding of Bangladesh (61.2 %) [33], China (82·6%) [34], and Ethiopia (62.6 %) [16]. The possible reason for the discrepancy is that the study carried out in Ethiopia were conducted a year before this study, during a time when the pandemic was devastating and the vaccine was thought to be groundbreaking and the only treatment available. In the other hand convenience sampling procedures were employed in the Chinese study, which involved selecting participants based on their interest in the COVID-19 vaccination, while online surveys were utilized to gather data from Bangladesh, potentially leading to exaggerated replies. Differences in study periods may also be a major factor in all cases.
The current finding, however, was higher than a prior study finding from Addis Ababa, Ethiopia (19.1 %) [35] and from Zambia 46.3 %. It's possible that the variation from Zambia is due to the sample process (hard copy interviewer-based questioners), the timing of data collection, and/or a geographical difference. Due to the data collection method used to calculate the acceptance rate and the different study period where no information about the vaccination was available, in the context of the Addis Ababa study.
Respondents' ages showed a strong correlation with their willingness to accept COVID-19 vaccination. People over the age of 58 had a 38 % less acceptance of COVID-19 vaccine compared to those between the ages of 18 and 27 years. Theories of behavioral change lend support to it [36]. Individuals are classified into five categories in behavioral change models, and as they aged, they become skeptical of innovations or new things. Because the COVID-19 vaccination is a new thing, they might be hesitant to accept it.
The second socio-demographic factor linked to COVID-19 vaccine acceptance was religion. Being a Muslim had a 64 % lower odds of accepting COVID-19 vaccinations. This result was consistent with earlier literature [37], [38]. The need to enlighten the public about the safety and effectiveness of the COVID-19 vaccine underscores the possibility that the lack of adequate information from religious and medical authorities may be the cause.
This study also found a significant and positive association between the health status of individuals and COVID-19 vaccine acceptance. The odds of having chronic disease and exposure to COVID-19 vaccine acceptance were nearly two times higher among those who have chronic diseases such as hypertension, diabetes, asthma, cardiac disease, and renal disease. It was consistent with different studies [16], [39]. A higher chance of case fatality is associated with higher frequency of health-risk behaviors in COVID-19-infected persons. It might make patients more receptive to the COVID-19 vaccination.
The odds of having a positive attitude were nearly two times higher for the acceptance of COVID-19 vaccine. This finding was supported by different research findings [31], [37], indicating that those who believe the vaccine is safe and important are willing to take it without suspicion.
It was discovered that accepting the COVID-19 vaccination and having strong social support were related. There was almost twice as much likelihood that friends and family would encourage someone to get the COVID-19 vaccinations. The social control hypothesis explains the ways in which various aspects of family relationships may impact health-related behaviors [35]. Family interactions affect health behaviors through both indirect and direct control mechanisms, claims the social control theory. By applying rules to oneself, one can exercise indirect social control. People with strong family ties feel more accountable to themselves [40].
Limitations of the study
The findings of this study are limited to the Addis Ketema sub-city. The discovery may not apply to adults in Addis Ababa and Ethiopia. In addition, the study was based on prior experience and exposure which may have been influenced by recollection bias, social desirability bias, and subjective beliefs about the chronic disease.
Conclusion
This study led to the conclusion that only a small percentage of study participants accepted the COVID-19 vaccination. Additionally, acceptance of the COVID-19 vaccine was significantly influenced by age, religion, health status, attitude toward the vaccine, and social support. As a result, emphasis should be given for community mobilization, especially for the elderly, those with limited social engagement, and those who have a negative attitude toward COVID-19 vaccination. A qualitative study into the reasons behind the lower acceptance rate could be beneficial for future studies.
Ethical consideration
Ethical approval was obtained from Yanet College Research and Review Board with an ID Y/13/2022. Then permission letter was secured from Addis Ababa city administration higher officials. The data was collected after obtaining written informed consent from each study participant.
Consent for publication
Not applicable
Funding
The authors received no specific funding for this work.
CRediT authorship contribution statement
Genanew Kassie Getahun: Writing – review & editing, Visualization, Formal analysis. Hailu Sefefe: Validation, Funding acquisition, Formal analysis, Conceptualization. Tewodros Shitemaw: Writing – original draft, Validation, Formal analysis, Conceptualization. Betselot Yirsaw Wubete: Writing – original draft, Supervision, Formal analysis.
Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgment
We would like to acknowledge the study participants and data collectors for this study.
Data availability
Data will be made available on request.
References
- 1.Rodriguez-Morales A.J., Cardona-Ospina J.A., Gutiérrez-Ocampo E., Villamizar-Peña R., Holguin-Rivera Y., Escalera-Antezana J.P., et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020;34 doi: 10.1016/j.tmaid.2020.101623. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Worldometer. Coronavirus (COVID-19) Mortality Rate. Worldometer, February 21st 2022.
- 3.GradYH, LarremoreDB.Model-informedCOVID-19 vaccine prioritization strategies by age and sero status.2021;921(February):916–21.
- 4.Dror AA, Eisenbach N, Taiber S, Morozov NG, Mizrachi M, Zigron A. Vaccine hesitancy : the nextchallenge in the fight against COVID 19. Eur J Epidemiol [Internet]. 2020;35(8):775–9. Availablefrom: doi: 10.1007/s10654-020-00671-y. [DOI] [PMC free article] [PubMed]
- 5.Shrotri M, Swinnen T, Kampmann B, Parker EPK. Correspondence An interactive website trackingCOVID-19. Lancet Glob Heal [Internet]. 2021;9(5):e590–2. Available from:http://dx.doi.org/10.1016/S2214-109X(21)00043-7. [DOI] [PMC free article] [PubMed]
- 6.Valckx S., Crèvecoeur J., Verelst F., Vranckx M., Hendrickx G., Hens N., et al. Individual factors influencing COVID-19 vaccine acceptance in between and during pandemic waves (july–december 2020) Vaccine. 2022 Jan 3;40(1):151–161. doi: 10.1016/j.vaccine.2021.10.073. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Watson O.J., Barnsley G., Toor J., Hogan A.B., Winskill P., Ghani A.C. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis. 2022 Sep 1;22(9):1293–1302. doi: 10.1016/S1473-3099(22)00320-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Geoghegan S., Callaghan K.P.O., Offit P.A. Vaccine Safety: Myths and Misinformation. 2020;11(March):1–7. doi: 10.3389/fmicb.2020.00372. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Paul E., Steptoe A., Fancourt D. Attitudes towards vaccines and intention to vaccinate against COVID-19: implications for public health communications. The Lancet Regional Health-Europe. 2021 Feb;1(1):10001. doi: 10.1016/j.lanepe.2020.100012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Wake A.D. The willingness to receive COVID-19 vaccine and its associated factors:“vaccination refusal could prolong the war of this pandemic”–a systematic review. Risk Managem Healthcare Policy. 2021 Jun;21:2609–2623. doi: 10.2147/RMHP.S311074. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.World Health Organization. Global action plan on physical activity 2018-2030: more active people for a healthier world. World Health Organization; 2019 Jan 21.
- 12.Yilma D, Mohammed R, Getahun S, Wendemagegn A, Seifu F, Pareyn M, et al. vaccine acceptance ability among healthcare workers in Ethiopia: Do we practice what we preach ? 2022;418–25. [DOI] [PMC free article] [PubMed]
- 13.Adane M, Ademas A, Kloos H. Knowledge, attitudes, and perceptions of COVID-19 vaccine and refusal to receive COVID-19 vaccine among healthcare workers in northeastern Ethiopia. BMC Public Health [Internet].2022;1–14,.Available from: doi: 10.1186/s12889-021-12362-8. [DOI] [PMC free article] [PubMed]
- 14.Peretti-Watel P, Seror V, Cortaredona S, Launay O, Raude J, Verger P, Fressard L, Beck F, Legleye S, l'Haridon O, Léger D. A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation. The Lancet infectious diseases. 2020 Jul 1;20(7):769-70. [DOI] [PMC free article] [PubMed]
- 15.Belsti Y., Gela Y.Y., Akalu Y., Dagnew B., Getnet M., Abdu Seid M., et al. Willingness of ethiopian population to receive COVID-19 vaccine. J Multidiscip Healthc. 2021 May;28:1233–1243. doi: 10.2147/JMDH.S312637. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Abebe H., Shitu S., Mose A. Understanding of COVID-19 vaccine knowledge, attitude, acceptance, and determinates of COVID-19 vaccine acceptance among adult population in Ethiopia. Infection and drug resistance. 2021 Jun;1:2015–2025. doi: 10.2147/IDR.S312116. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Nigussie H. The coronavirus intervention in Ethiopia and the challenges for implementation. Frontiers in Communication. 2021 May;21(6) [Google Scholar]
- 18.Getahun G.K., Dinku A., Jara D., Shitemaw T., Negash Z. Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia. PLOS Global Public Health. 2023 Aug 17;3(8):e0000420. doi: 10.1371/journal.pgph.0000420. [DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted]
- 19.Pogue K., Jensen J.L., Stancil C.K., Ferguson D.G., Hughes S.J., Mello E.J., et al. Influences on attitudes regarding potential COVID-19 vaccination in the United States. Vaccines. 2020 Oct 3;8(4):582. doi: 10.3390/vaccines8040582. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 20.Al-Kafarna M., Matar S.G., Almadhoon H.W., Almaghary B.K., Zaazouee M.S., Elrashedy A.A., et al. Public knowledge, attitude, and acceptance toward COVID-19 vaccines in Palestine: a cross-sectional study. BMC Public Health. 2022 Mar 17;22(1):529. doi: 10.1186/s12889-022-12932-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Al-Qerem W.A., Jarab A.S. COVID-19 vaccination acceptance and its associated factors among a middle eastern population. Front Public Health. 2021 Feb;10(9) doi: 10.3389/fpubh.2021.632914. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 22.Mose A., Yeshaneh A. COVID-19 vaccine acceptance and its associated factors among pregnant women attending antenatal care clinic in Southwest Ethiopia: institutional-based cross-sectional study. Int J Gen Med. 2021;14:2385. doi: 10.2147/IJGM.S314346. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Piccaluga P.P., Di Guardo A., Lagni A., Lotti V., Diani E., Navari M., et al. COVID-19 vaccine: between myth and truth. Vaccines. 2022 Feb 23;10(3):349. doi: 10.3390/vaccines10030349. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Lazarus J.V., Ratzan S.C., Palayew A., Gostin L.O., Larson H.J., Rabin K., et al. A global survey of potential acceptance of a COVID-19 vaccine. Nat Med. 2021 Feb;27(2):225–228. doi: 10.1038/s41591-020-1124-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 25.Szilagyi P.G., Thomas K., Shah M.D., Vizueta N., Cui Y., Vangala S., et al. National trends in the US public’s likelihood of getting a COVID-19 vaccine—April 1 to december 8, 2020. JAMA. 2021 Jan 26;325(4):396–398. doi: 10.1001/jama.2020.26419. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26.Mathew G., Agha R., Albrecht J., Goel P., Mukherjee I., Pai P., et al. STROCSS 2021: strengthening the reporting of cohort, cross-sectional and case-control studies in surgery. International Journal of Surgery Open. 2021 Dec;1(37) doi: 10.1016/j.ijsu.2021.106165. [DOI] [PubMed] [Google Scholar]
- 27.Mesele M. COVID-19 vaccination acceptance and its associated factors in Sodo town, wolaita zone, southern Ethiopia: cross-sectional study. Infection and Drug Resistance. 2021 Jun;24:2361–2367. doi: 10.2147/IDR.S320771. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Bhartiya S., Kumar N., Singh T., Murugan S., Rajavel S., Wadhwani M. Knowledge, attitude and practice towards COVID-19 vaccination acceptance in West India. Int J Community Med Public Health. 2021 Feb 24;8(3):1170–1176. [Google Scholar]
- 29.Patwary M.M., Alam M.A., Bardhan M., Disha A.S., Haque M.Z., Billah S.M., et al. COVID-19 vaccine acceptance among low-and lower-middle-income countries: a rapid systematic review and meta-analysis. Vaccines. 2022 Mar 11;10(3):427. doi: 10.3390/vaccines10030427. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 30.Roy D.N., Biswas M., Islam E., Azam M.S. Potential factors influencing COVID-19 vaccine acceptance and hesitancy: a systematic review. PLoS One. 2022 Mar 23;17(3):e0265496. doi: 10.1371/journal.pone.0265496. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 31.Alqudeimat Y., Alenezi D., AlHajri B., Alfouzan H., Almokhaizeem Z., Altamimi S., et al. Acceptance of a COVID-19 vaccine and its related determinants among the general adult population in Kuwait. Med Princ Pract. 2021;30(3):262–271. doi: 10.1159/000514636. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Zewude B., Habtegiorgis T. Willingness to take COVID-19 vaccine among people most at risk of exposure in southern Ethiopia. Pragmatic and observational research. 2021 May;27:37–47. doi: 10.2147/POR.S313991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33.Haque M.M., Rahman M.L., Hossian M., Matin K.F., Nabi M.H., Saha S., et al. Acceptance of COVID-19 vaccine and its determinants: evidence from a large sample study in Bangladesh. Heliyon. 2021 Jun 1;7(6):e07376. doi: 10.1016/j.heliyon.2021.e07376. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34.Pan J., Liu Z., Zhang P., Xu Z., Guo X., Liu G., et al. Factors that impact acceptance of COVID-19 vaccination in different community-dwelling populations in China. Vaccines. 2022 Jan;10(1):91. doi: 10.3390/vaccines10010091. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 35.Dereje N, Tesfaye A, Tamene B, Alemshet D, Abe H, Tesfa N, Gedion S, Biruk T, Lakew Y. COVID-19 Vaccine hesitancy in Addis Ababa, Ethiopia: A mixed-methods study (preprint). [DOI] [PMC free article] [PubMed]
- 36.Heimlich J.E., Ardoin N.M. Understanding behavior to understand behavior change: a literature review. Environ Educ Res. 2008 Jun 1;14(3):215–237. [Google Scholar]
- 37.Aziz S, Niazi MA, Ghani U. Effect of knowledge, social and religious factors effecting the intention of Muslims in Pakistan to receive COVID-19 vaccination: mediating role of attitude towards COVID-19 vaccination. Journal of Islamic Marketing. 2022 Jun 2(ahead-of-print).
- 38.Wong L.P., Alias H., Megat Hashim M.M., Lee H.Y., AbuBakar S., Chung I., et al. Acceptability for COVID-19 vaccination: perspectives from muslims. Hum Vaccin Immunother. 2022 Nov 30;18(5):2045855. doi: 10.1080/21645515.2022.2045855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 39.Berihun G., Walle Z., Berhanu L., Teshome D. Acceptance of COVID-19 vaccine and determinant factors among patients with chronic disease visiting Dessie comprehensive specialized hospital. Northeastern Ethiopia Patient preference and adherence. 2021 Aug;17:1795–1805. doi: 10.2147/PPA.S324564. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Sriram U., Morgan E.H., Graham M.L., Folta S.C., Seguin R.A. Support and sabotage: a qualitative study of social influences on health behaviors among rural adults. J Rural Health. 2018 Jan;34(1):88–97. doi: 10.1111/jrh.12232. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Data Availability Statement
Data will be made available on request.

