Influence of Age, memory ability, cognitive status, and AD Biomarker Status on modeled guessing strategies in the MST. A) Compared to younger adults, older adults exhibit a higher likelihood of guessing new and a lower tendency to guess similar. B) Among older adults, those with no age-related memory deficits show no significant differences in guessing strategies when compared to individuals with age-related memory deficits. C) Individuals with MCI demonstrate a greater bias towards guessing old and are less inclined to guess similar or new relative to cognitively healthy older adults. D) There are no differences in guessing strategies between Aβ− and Aβ+ older adults. E) Older adults with elevated pTau levels display a marked shift from guessing similar towards guessing old compared to pTau negative older adults. For panels A-E, the metric for guessing old (γO) is represented in yellow, for guessing similar (γS) in pink, and for guessing new (γN) in blue.