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[Preprint]. 2024 Mar 14:2024.03.11.584527. [Version 1] doi: 10.1101/2024.03.11.584527

In-Space Fabrication of Janus Base Nano-Matrix for Improved Assembly and Bioactivities

Anne Yau, Maxwell Landolina, Mari Anne Snow, Pinar Mesci, Brandon Williams, Jay Hoying, Derek Duflo, Honglu Wu, Jana Stoudemire, Rose Hernandez, Yupeng Chen
PMCID: PMC10979921  PMID: 38559052

Abstract

In-space manufacturing of nanomaterials is a promising concept while having limited successful examples. DNA-inspired Janus base nanomaterials (JBNs), used for therapeutics delivery and tissue regeneration, are fabricated via a controlled self-assembly process in water at ambient temperature, making them highly suitable for in-space manufacturing. For the first time, we designed and accomplished the production of JBNs on orbit during the Axiom-2 (Ax-2) mission demonstrating great promising and benefits of in-space manufacturing of nanomaterials.

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