Abstract
Background
A decrease in the number and activity of thymic epithelial cells (TECs) is an important factor in thymic degeneration. Mesenchymal stem cells (MSCs) treating thymic ageing is a promising strategy, but the DNA methylation modification mechanism in TECs remains unclear.
Methods
Aged rhesus monkeys were treated with MSCs to establish a thymic senescence model, and hematoxylin-eosin (HE) staining, immunofluorescence staining, and ELISA were performed to observe the structure and function of the thymus. TEC aging model and MSCs co-culture system were established to detect DNA methylation modification and transcriptomic changes, correlation analysis between transcription factor methylation and mRNA expression, and q-PCR, immunofluorescence staining, and Western blot were used to identified key genes.
Results
MSCs improved the structure and function of thymus in elderly macaque monkeys; reduced the expression levels of β-Gal, P16, and P21; and increased the activity of aging TECs. There were 501 genes with increased methylation in the promoter region in the treated group compared with the untreated group, among which 23 genes were involved in the negative regulation of cell growth, proliferation and apoptosis, while 591 genes had decreased methylation, among which 37 genes were associated with promoting cell growth and proliferation and inhibiting apoptosis. Furthermore, 66 genes showed a negative correlation between promoter methylation levels and gene transcription; specifically, PDE5A, DUOX2, LAMP1 and SVIL were downregulated with increased methylation, inhibiting growth and development, while POLR3G, PGF, CHTF18, KRT17, FOXJ1, NGF, DYRK3, LRP8, CDT1, PRELID1, F2R, KNTC1 and TRIM3 were upregulated with decreased methylation, promoting cell growth.
Conclusion
MSCs improve the structure and function of aged thymus, which involves the regulation of DNA methylation profiles and a decrease in the methylation level of the transcription factor NGF to specifically upregulate KRT17 and FOXJ1 to promote the proliferation of TECs.
Keywords: Thymus aging, MSCs, TECs, DNA methylation
1. Background
The thymus is the main lymphoid organ and is composed of thymic cells and thymic stromal cells. Thymic stromal cells include thymic epithelial cells (TECs), fibroblasts, dendritic cells and endothelial cells [1,2]. TECs are composed of cortical TECs (cTECs) and medullary TECs (mTECs). They maintain T-cell development at different stages through positive and negative selection, so TECs are an indispensable component of T lymphocyte maturation in the thymus [3,4]. However, in humans and mice, the thymus begins to degenerate after birth, and the reticular structure of the thymus epithelium is gradually replaced by adipose tissue, accompanied by a decrease in T-cell output [5,6]. Some experiments have shown that TECs have lower proliferation potential and that there is a higher percentage of apoptotic and senescent TECs in elderly animals, indicating that these cells may be a potential target for thymus rejuvenation therapy [[7], [8], [9]]. Therefore, the decrease in the number and activity of TECs may be the key factors related to the unfavorable changes in thymus structure and function in ageing.
The best way to reverse thymus ageing is to stimulate growth of the thymus, but this is a challenging scientific and technical problem involving developmental biology. Mesenchymal stem cells (MSCs) have multidirectional differentiation potential and immune regulation capability, secreting a variety of bioactive factors and playing important roles in inflammation, tissue damage repair and aging degeneration. In a study of a rhesus monkey aging model [[10], [11], [12], [13]], we found that bone marrow MSCs (BMMSCs) derived from infant rhesus monkeys restored the structure and function of aging ovaries by promoting follicular and vascular regeneration, reducing the degree of ovarian fibrosis, and inhibiting apoptosis; improved lung structure and function by reducing fibrosis and inhibiting apoptosis, enhancing the division and proliferation of alveolar type II epithelial cells and improving their antioxidative stress ability; and significantly reversed the expression of age-related proteins in serum. In our previous study, it was also observed that MSCs could improve the structure and function of the thymus in elderly mice [14], but this observation needed to be confirmed with further studies in nonhuman primates, which are more closely related to humans. Moreover, the related cellular and epigenetic molecular regulatory mechanisms have not been clarified, leaving this an unanswered scientific question in the field.
DNA methylation is an epigenetic modification mode that regulates gene transcription without changing gene structure. It can turn gene transcription on or off through demethylation or methylation modification of specific genes and their promoters [15,16]. Previous studies have found that the high stability of DNA methylation is an important mechanism for stabilizing gene transcription, which regulates cell growth, division, proliferation, differentiation and secretory function by regulating gene opening and closing [17]. The methylation level of the functional gene itself is also closely related to the transcriptional expression of the gene, but whether it inhibits or promotes gene transcription is also related to the methylation site.
Therefore, we treated elderly macaques with MSCs and explored whether MSCs promote thymus tissue regeneration by acting on TECs in vivo; cocultured senescent TECs with MSCs to reveal the changes in genomic methylation and transcriptional profiles; and clarified the molecular regulatory mechanism to provide theoretical support for the use of MSCs in the treatment of thymic senescence.
2. Results
2.1. MSCs improving tissue structure and function of the thymus in elderly macaque monkeys
Elderly macaque monkeys aged 22–24 years old were treated with MSCs, which was injected into the femoral vein at a dose of 1 × 107/kg once every other day for a total of 3 times. The gross anatomy, morphology, tissue structure and function of the thymus were observed 5 months after the last treatment. In terms of thymus morphology and tissue structure, the results showed that the thymus tissue of elderly macaque monkeys obviously atrophied and degenerated and was replaced by a large amount of adipose tissue; the boundary of the cortical-medullary junction (CMJ) was blurred, and the number of thymocytes decreased. After MSC treatment, the thymus tissue regenerated, revealing that the volume of the thymus increased, the number of thymic epithelial cells, thymocytes and Hassall bodies increased, and the amount of adipose tissue decreased (Fig. 1A and B). In terms of thymus function, the thymus index and the levels of thymosin α and thymopoietin in peripheral blood were decreased, and the decreasing trend was reversed after MSCs treatment (Fig. 1C and D, Table 1). Finally, we detected the expression level of the aging marker gene P16 and the TEC marker molecule CK14 [18], and the results showed that P16 expression decreased, and the proportion of CK14 cells expressing the TEC marker molecule increased after MSCs treatment, (Fig. 1E and F). Those results implied that MSCs treatment improving the structure and function of aging thymus and promoting the regeneration of thymic lobules.
Fig. 1.
MSCs treatment changed thymus morphology, tissue structure, secretory function, and P16 and CK14 expression in aged macaque monkeys. A Comparison of the appearance and morphology of thymus between the Elderly and the Treated: the above figure shows the appearance of thymus of the aged macaque monkeys, represents the area of adipose tissue in the thymus. The figure on the below shows the appearance of the thymus after MSCs treatment, and represents the thymus tissue area. B HE staining of thymus tissue from the senescent elderly group and treatment group (100×, 
represents thymus cortex, 
represents the thymus medulla; 
represents the Hassel body). C and D Comparison of thymus index and the contents of thymopoietin α and thymosin in the elderly and treatment group. E Expression of P16 in the elderly and treatment group (400×). F The expression of CK14 in thymus tissue was detected by immunohistochemistry (400×, brown indicates antibody-positive reaction) (the measured values represent the mean ± standard deviation (`X ± s) of three replicate experiments. ∗∗P < 0.01, ∗∗∗P < 0.001).
Table 1.
Thymus index.
| Group | Thymus massx(g) | Macaque body weight (kg) | Thymus index (organ weight g per kg body weight) | Convert to percentage |
|---|---|---|---|---|
| Elderly1 | 2 | 5.3 | 0.377358490566038 | 37.7358490566038 |
| Elderly2 | 2.8 | 5 | 0.56 | 56 |
| Elderly3 | 3 | 5.6 | 0.535714285714286 | 53.5714285714286 |
| Treated1 | 5 | 6 | 0.833333333333333 | 83.3333333333333 |
| Treated2 | 5.2 | 5.8 | 0.896551724137931 | 89.6551724137931 |
| Treated3 | 4.9 | 5.3 | 0.924528301886793 | 92.4528301886793 |
2.2. Intervention effect of MSCs on senescent TECs in vitro
To demonstrate that MSCs promote thymus tissue regeneration by promoting the growth and differentiation of TECs, we induced the senescence of TECs with 200 μmol/L H2O2 in vitro and cocultured MSCs with ageing TECs for 48 h in Transwells. Firstly, SA-β-gal (senescence–associated β-galactosidase, senescent cells appear blue due to increased β-galactosidase activity) staining showed that 55.3 ± 5.03% of the TECs in the induced senescence group were stained blue, and the number of blue cells decreased significantly after coculture (31.33 ± 7.03%) (Fig. 2A). Secondly, Dynamic observation by a Nanolive 4D microscope showed that MSCs secreted vesicles into the ageing TECs during coculture, which changed the volume of the TECs from large to small, and the loose nucleus became compact (Supplementary video 1). Then, under transmission electron microscopy, heterochromatin aggregation and patchy distribution were observed in senescent TECs, mitochondria were swollen, and no obvious autophagosomes were found in the cells. After coculture, the chromatin distribution of TECs was uniform, the mitochondria were still swollen, and a small number of autophagosomes could be seen in the cells (Fig. 2B). Next, western bloting and immunocytochemical staining were performed to detect the expression of the P16, P21 and Tunel protein, and the results showed that the expression of the ageing-related genes of P16, P21, and apoptosis increased significantly in the induced senescence group (1.59 ± 0.5, 1.17 ± 0.1, 85.66 ± 3.5%), and the expression of P16, P21 and Tunel was decreased after co-cultured with MSCs (1.14 ± 0.3, 1.10 ± 0.3, 33.06 ± 4.3%) (Fig. 2C and D). These results suggested that MSCs improve morphological structure and inhibit the expression of the aging markers SA-β-gal, P16, and P21, and decrease apoptosis to restore the growth of senescent TECs.
Fig. 2.
Intervention effect of MSCs on aging TECs. A SA-β-gal staining of TECs after MSCs coculture (100 ×, represents increased activity of SA-β-gal). B Ultrastructural changes in TECs after MSC coculture (nucleus (N), mitochondria (M), and autophagosome (ASS); the upper scale is 2 μm). C After coculture with MSCs, the TEC senescence genes P16 and P21 were expressed. D TUNEL staining was used to detect the effect of MSCs on H2O2-induced apoptosis (the measured values represent the mean ± standard deviation (`X ± s) of three replicate experiments. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001).
Supplementary video related to this article can be found at https://doi.org/10.1016/j.reth.2024.03.008
The following is/are the supplementary data related to this article:
Video S1
3
Download video file (2MB, mp4)
2.3. Changes in the genomic methylation profile in senescent TECs after MSCs coculture
To explore the intervention effect of MSCs on the whole-genome methylation modification profile of senescent TECs, we used whole-genome methylation sequencing (WGBS) to analyze the whole-genome methylation modification map of TECs after aging and MSCs coculture (Fig. 3A). The bioinformatics analysis method was used to conduct a series analysis of the WGBS database, resulting in 76.1 billion WGBS paired terminal readings (Table 2). The average alignment rate of clean WGBS reads mapped to the reference genome (BSMAP (version: 2.90) was 90.8%, and the coverage rate of the reference C base was 95%. We found that the average genome-wide methylation level of TECs in the induced senescence group was 64.13%. After coculture, the average methylation level of TECs increased (Fig. 3B). In the site methylation level analysis, 57.58% of the CG sites in the induced senescence group were hypermethylated (methylation levels ranged from 70 to 100%). The proportion of hypermethylated CG sites increased after MSCs coculture, while the proportion of hypomethylated CG sites (methylation level <30%) decreased after MSCs coculture (Fig. 3C). Subsequently, we analyzed the methylation level around the gene body, and the methylation level decreased gradually in the upstream 1 kb region of the gene. A significant decrease in methylation level was observed closer to the gene transcription start site (TSS). The methylation level in the gene body region was higher than that in the adjacent region and was relatively stable, while the methylation level in the transcription termination site (TTS) decreased significantly (Fig. 3D). Furthermore, the methylation changes in the TEC gene regulatory series after MSCs coculture were determined, and the annotations of senescence-related genes were extracted from the Gene Ontology Consortium (http://wiki.geneontology.org/index.php)). It was found that 1092 genes had methylation differences in the promoter region (Table 3). Among them, the methylation level in the promoter region of 501 genes was increased, and 23 genes were mainly involved in negative regulation of growth, proliferation and promotion of apoptosis. The methylation level of 591 genes decreased in the promoter region; 37 of these genes promoted cell growth, proliferation and anti-apoptosis (Fig. 3E and F) (Table 4). These results suggest that MSCs methylate the promoter region of genes related to apoptosis promotion, cell cycle arrest and growth inhibition in senescent TECs and turn off the expression of genes related to growth promotion, cell proliferation and apoptosis inhibition.
Fig. 3.
Changes in the genomic methylation profile of senescent TECs after MSC coculture. A DNA methylation analysis workflow. B The average methylation level of the whole genome of senescent TECs after MSCs coculture. C The methylation level of CG loci in senescent TECs after MSCs coculture (orange lines indicate the percentage of low-methylated CG loci, blue histogram shows the percentage of hypermethylated CG loci). D DNA methylation levels at different locations of the gene (abscissa for different locations of the gene, ordinate for methylation level). E The differentially methylated genes in senescent TECs after MSCs coculture (red is the increase in methylation level, green is the decrease in demethylation level). F Enrichment analysis of ageing-related differentially methylated genes in TECs after MSCs coculture (the abscissa is the number of genes, and the ordinate is the GO name).
Table 2.
Overview of WGBS and RNA-seq.
| Sample | Basic data |
Mapping_summary |
Cytosines covgerage summary |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before filter Clean Data(bp) | After filter Clean Data(bp) | After filter Q20(%) | After filter GC(%) | BS Conversion Rate(%) | Mapped Reads | Mapped Ratio(%) | Cover_C_site | Coverage_C_rate(%) | Cover_CG_site | Coverage_CG_rate(%) | Cover_CHG_site | Coverage_CHG_rate(%) | Cover_CHH_site | Coverage_CHH_rate(%) | |
| induced senescence1 | 129935007000.00 | 128996537171.00 | 96.44 | 21.14 | 99.1726 | 785756297 | 91.08 | 1139204604 | 94.99 | 54112170 | 92.2 | 241600401 | 95.26 | 843492031 | 95.1 |
| induced senescence2 | 123296597700.00 | 122388023155.00 | 96.14 | 21.38 | 99.1842 | 743637765 | 90.84 | 1148446802 | 95.76 | 55009497 | 93.73 | 243620231 | 96.06 | 849817072 | 95.82 |
| induced senescence3 | 121363978800.00 | 120054543421.00 | 96.38 | 21.38 | 99.153 | 723202127 | 90.06 | 1151420689 | 96.01 | 55225916 | 94.1 | 244218586 | 96.29 | 851976185 | 96.06 |
| co-culture1 | 135175752300.00 | 134069766573.00 | 96.46 | 21.34 | 99.1876 | 816867744 | 91.01 | 1150752262 | 95.96 | 55194530 | 94.04 | 244111610 | 96.25 | 851446120 | 96 |
| co-culture2 | 123507014100.00 | 122701110877.00 | 96.41 | 21.18 | 99.1815 | 748481642 | 91.23 | 1154482488 | 96.27 | 55464297 | 94.5 | 244859659 | 96.54 | 854158530 | 96.3 |
| co-culture3 | 128602854900.00 | 127696268168.00 | 96.63 | 20.92 | 99.177 | 782219000 | 91.52 | 1142153850 | 95.24 | 54414238 | 92.71 | 242234242 | 95.51 | 845505368 | 95.33 |
| Mean | 126980200800.00 | 125984374894.17 | 96.41 | 21.2233333333333 | 99.1759833333334 | 766694095.833333 | 90.9566666666667 | 1147743449.16667 | 95.705 | 54903441.3333333 | 93.5466666666667 | 243440788.166667 | 95.985 | 849399217.666667 | 95.7683333333333 |
| Total | 761881204800.00 | 755906249365.00 | 4600164575 | ||||||||||||
| Sample | Basic data |
Mapping summary |
sequenced_Total_Genes | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RawDatas | CleanData | AF_Q20(%) | AF_Q30(%) | Total_Mapped | Total_Mapped(%) | Unique_Mapped | Unique_Mapped(%) | Multiple_Mapped | Multiple_Mapped(%) | |||
| induced senescence1 | 63242212 | 63106352 | 98.17 | 94.45 | 61526591 | 97.77 | 59881074 | 95.16 | 1645517 | 2.61 | 14728 | 72.57 |
| induced senescence2 | 88342632 | 88112024 | 98.23 | 94.32 | 86149774 | 98.06 | 83834209 | 95.42 | 2315565 | 2.64 | 14879 | 73.31 |
| induced senescence3 | 72322932 | 72143332 | 98.04 | 94.19 | 70243386 | 97.68 | 68278367 | 94.95 | 1965019 | 2.73 | 14829 | 73.07 |
| co-culture1 | 68212998 | 68069126 | 98.09 | 94.33 | 66420866 | 97.84 | 64655493 | 95.24 | 1765373 | 2.6 | 14709 | 72.48 |
| co-culture2 | 61494366 | 61382532 | 98.13 | 94.36 | 59913926 | 97.88 | 58267348 | 95.19 | 1646578 | 2.69 | 14661 | 72.24 |
| co-culture3 | 61247622 | 61114060 | 98.06 | 94.24 | 59525003 | 97.66 | 57956113 | 95.09 | 1568890 | 2.57 | 14616 | 72.02 |
| Mean | 69143793.6666667 | 68987904.3333333 | 98.12 | 94.315 | 67296591 | 97.815 | 65478767.3333333 | 95.175 | 1817823.66666667 | 2.64 | 14737 | 72.615 |
| Total | 414862762 | 413927426 | 403779546 | 88422 | ||||||||
Table 3.
Differential methylation analysis.
| id | meth.diff | meth.q |
|---|---|---|
| ENSG00000004534 | 11.1410214995872 | 0.0429895835444528 |
| ENSG00000004534 | 13.2101994115724 | 0.0147077633344553 |
| ENSG00000004660 | 12.8033744321869 | 0.0449216378457375 |
| ENSG00000005206 | 11.9883161229276 | 0.00486888246659608 |
| ENSG00000005206 | 16.4079172001707 | 0.000413089603869239 |
| ENSG00000006611 | 32.9668348954578 | 0.0274261593096852 |
| ENSG00000007171 | 19.2361927144536 | 0.0284955000718223 |
| ENSG00000007264 | 21.036621036621 | 0.0247241716820028 |
| ENSG00000007264 | 35.1750456280073 | 0.00800363463509878 |
| ENSG00000010244 | 11.3078264865938 | 0.0127295348224089 |
| ENSG00000011105 | 13.3912721893491 | 0.0370655291928072 |
| ENSG00000025796 | 13.0936251519889 | 0.0253294671351397 |
| ENSG00000025796 | 24.7747747747748 | 0.000261255054250883 |
| ENSG00000027075 | 23.8587326822621 | 0.00152721677265883 |
| ENSG00000027075 | 23.8587326822621 | 0.00152721677265883 |
| ENSG00000028277 | 12.8211382113821 | 0.0417754562654187 |
| ENSG00000035499 | 19.3525068415346 | 0.0442726305485908 |
| ENSG00000048991 | 10.4895380349152 | 0.00234708565200044 |
| ENSG00000056487 | 19.3288934426229 | 0.000346324136728837 |
| ENSG00000057935 | 11.1359937892835 | 0.0216673574540229 |
| ENSG00000064300 | 15.9053070905649 | 0.0313626607273396 |
| ENSG00000065325 | 30.0664243639554 | 0.028033745947325 |
| ENSG00000067225 | 14.5976635003821 | 0.000140304077436467 |
| ENSG00000070087 | 12.0041443068912 | 0.000751864169014396 |
| ENSG00000073146 | 28.3368254463589 | 1.79227087841047E-11 |
| ENSG00000073670 | 13.6111807121579 | 0.0281038318353025 |
| ENSG00000073849 | 15.5321329234373 | 0.0344241141481933 |
| ENSG00000073861 | 14.2395496716356 | 0.0290369177541354 |
| ENSG00000074211 | 31.0123456790123 | 0.0268393437770578 |
| ENSG00000074219 | 11.9744703965236 | 0.00251060480696872 |
| ENSG00000078124 | 21.7836257309941 | 0.0447363519040377 |
| ENSG00000078549 | 24.8746457379551 | 3.10311426032942E-07 |
| ENSG00000078549 | 19.6142930856553 | 3.5156097137167E-06 |
| ENSG00000080371 | 14.5424394206038 | 0.00141882564824424 |
| ENSG00000080845 | 12.6346909919374 | 0.029591386415805 |
| ENSG00000083067 | 14.2926613616269 | 0.000291709269699351 |
| ENSG00000083444 | 14.6650035637919 | 0.0276533853657112 |
| ENSG00000083444 | 23.5729847494553 | 0.0147972826294937 |
| ENSG00000083454 | 31.5746753246753 | 0.00664142162914082 |
| ENSG00000088992 | 29.6296296296296 | 6.35666270161635E-07 |
| ENSG00000088992 | 26.0344238002964 | 2.45996608894593E-08 |
| ENSG00000088992 | 15.3504296759858 | 0.00698771447860245 |
| ENSG00000089157 | 13.5674931129477 | 0.0398751044579701 |
| ENSG00000089199 | 10.3386382673208 | 0.0247314804971351 |
| ENSG00000089693 | 20.4041378101166 | 0.0169419692816553 |
| ENSG00000091127 | 10.4413102820746 | 0.0474615788486051 |
| ENSG00000091844 | 12.4604847207587 | 0.00656893745208257 |
| ENSG00000092330 | 13.1012070566388 | 0.000153119337328558 |
| ENSG00000092841 | 13.6121856866538 | 0.00589854211004375 |
| ENSG00000095596 | 13.8338208211461 | 0.000133266843577669 |
| ENSG00000095906 | 18.4410777507012 | 0.00106578761632672 |
| ENSG00000096080 | 13.1624423963134 | 3.60710679412085E-13 |
| ENSG00000099385 | 15.1779124333683 | 0.000505029650335907 |
| ENSG00000099995 | 27.3128175630333 | 3.96812611779901E-05 |
| ENSG00000100014 | 14.238574492658 | 0.00257404896789635 |
| ENSG00000100038 | 36.9134363159429 | 3.7826902450755E-05 |
| ENSG00000100147 | 18.4098639455782 | 0.0182070272285959 |
| ENSG00000100209 | 15.8402203856749 | 0.000754006150568186 |
| ENSG00000100288 | 28.4500466853408 | 0.00675645469505879 |
| ENSG00000100344 | 33.1310942578548 | 0.0349828784568553 |
| ENSG00000100739 | 23.1958939264328 | 0.00642102513264005 |
| ENSG00000101057 | 11.4852240425329 | 0.027582108815626 |
| ENSG00000101152 | 10.0759013282732 | 0.0183802377303916 |
| ENSG00000101152 | 15.6436312692794 | 5.99465610526218E-08 |
| ENSG00000101557 | 14.5645645645646 | 0.00498789412500717 |
| ENSG00000101557 | 20.9821428571429 | 0.00296388715080506 |
| ENSG00000101608 | 21.7574085059191 | 0.0119172703899002 |
| ENSG00000101751 | 15.6150627615063 | 0.00847306283066711 |
| ENSG00000102195 | 28.8316266577136 | 4.86516419633658E-05 |
| ENSG00000102539 | 19.0187693038727 | 0.0241727783256494 |
| ENSG00000103056 | 14.531033834334 | 0.0271381137967538 |
| ENSG00000103089 | 23.6152005888848 | 4.1037077680861E-06 |
| ENSG00000103197 | 13.6897001303781 | 0.0385416787972231 |
| ENSG00000103260 | 34.8668280871671 | 0.00576313236691994 |
| ENSG00000104142 | 15.6246783986827 | 0.0355032569018309 |
| ENSG00000104765 | 15.1990920268609 | 0.0215482067013419 |
| ENSG00000104853 | 10.1353178509232 | 0.0182451782141719 |
| ENSG00000105186 | 16.5007301208018 | 0.00452513955835274 |
| ENSG00000105186 | 16.5007301208018 | 0.00452513955835274 |
| ENSG00000106013 | 18.0428023785807 | 0.000524037914938989 |
| ENSG00000106034 | 10.4788838612368 | 0.0288752690171604 |
| ENSG00000106038 | 13.2367119708892 | 0.0116835243402002 |
| ENSG00000106462 | 18.861272695223 | 0.000787825751585364 |
| ENSG00000106689 | 12.1085577087978 | 0.0439548340409723 |
| ENSG00000107551 | 10.7314782200305 | 0.0353103544330602 |
| ENSG00000107831 | 16.358024691358 | 0.0329967000955916 |
| ENSG00000107957 | 27.9484536082474 | 0.00724694443189657 |
| ENSG00000108100 | 15 | 0.0336594557786585 |
| ENSG00000108518 | 13.0415847497698 | 0.0355546305919269 |
| ENSG00000108599 | 11.4219114219114 | 0.00649490868695054 |
| ENSG00000108641 | 14.9391044088868 | 0.00674109795438447 |
| ENSG00000108848 | 15.4737757171834 | 0.0352960887961454 |
| ENSG00000108950 | 15.8198128545928 | 0.000286189101485006 |
| ENSG00000109158 | 20 | 0.0374828243738455 |
| ENSG00000109390 | 14.8784878487849 | 8.36294203163539E-05 |
| ENSG00000109390 | 10.5591956919649 | 0.000460100120298561 |
| ENSG00000109906 | 23.1024365352724 | 0.0024547054883833 |
| ENSG00000109906 | 20.4666732955487 | 0.00140854131257951 |
| ENSG00000110628 | 12.6218323586745 | 0.000905019819790039 |
| ENSG00000110768 | 22.6938199415264 | 0.0266440194266571 |
| ENSG00000110768 | 22.6938199415264 | 0.0266440194266571 |
| ENSG00000111057 | 19.963963963964 | 0.000494478725805716 |
| ENSG00000111057 | 16.6082144805549 | 0.0189635681399841 |
| ENSG00000111271 | 14.5110267534346 | 0.0359526622537845 |
| ENSG00000112312 | 14.2666860408796 | 0.000252933316932294 |
| ENSG00000112312 | 12.0671851302075 | 0.00314034552387615 |
| ENSG00000112539 | 19.8119889253751 | 0.0293719445323917 |
| ENSG00000112837 | 15.3775922785966 | 0.00225950731419919 |
| ENSG00000114026 | 16.5888093013599 | 0.000262572797788145 |
| ENSG00000114026 | 12.4730430727983 | 0.0483647303353267 |
| ENSG00000114405 | 17.9489421227487 | 0.0239681627595053 |
| ENSG00000114978 | 14.891975308642 | 0.0277631947392702 |
| ENSG00000114982 | 11 | 0.0237828902907722 |
| ENSG00000115053 | 18.3673469387755 | 0.0345977207069055 |
| ENSG00000115053 | 13.5922330097087 | 0.00228971892261384 |
| ENSG00000115183 | 16.325731840605 | 0.00978959984261563 |
| ENSG00000115507 | 14.2919726839325 | 2.65335702645699E-05 |
| ENSG00000115507 | 16.5384896605359 | 7.80832598349621E-08 |
| ENSG00000115596 | 19.7204968944099 | 0.0471322320159808 |
| ENSG00000115596 | 18.5969387755102 | 0.0267926070508599 |
| ENSG00000115648 | 12.9906661552231 | 0.000432032159732779 |
| ENSG00000115648 | 11.4707653079293 | 0.00146399547053104 |
| ENSG00000115657 | 20.1540832049307 | 0.0090588160999464 |
| ENSG00000115839 | 15.513830002019 | 0.0282685367705523 |
| ENSG00000115946 | 11.0898606987897 | 0.0151098790541535 |
| ENSG00000116273 | 11.4664169119615 | 0.0291279908353443 |
| ENSG00000117151 | 12.0481071754796 | 0.038042836527265 |
| ENSG00000117597 | 23.6773179675223 | 0.00375105384414285 |
| ENSG00000119004 | 16.7674418604651 | 0.0493690355960005 |
| ENSG00000119547 | 13.0022197558269 | 0.0110827481784365 |
| ENSG00000119547 | 15.0617079629279 | 0.00388583376741845 |
| ENSG00000119547 | 24.4766505636071 | 0.000287897780947743 |
| ENSG00000119599 | 11.9913818624387 | 0.0438215878070369 |
| ENSG00000119953 | 12.8063228783438 | 0.0214469380195495 |
| ENSG00000120063 | 27.1062271062271 | 0.000537666955164323 |
| ENSG00000120063 | 28.0362443368224 | 1.64865091843957E-09 |
| ENSG00000120063 | 24.7522457258766 | 0.00277354571261337 |
| ENSG00000120088 | 25.1940719830628 | 0.00169770212477983 |
| ENSG00000120215 | 11.0236220472441 | 0.006057045539393 |
| ENSG00000120438 | 17.6411657559199 | 0.0197989462066386 |
| ENSG00000121005 | 17.2958735733099 | 0.031629656826347 |
| ENSG00000121210 | 20.8273208273208 | 0.0159666152087347 |
| ENSG00000121236 | 17.0111238971998 | 2.8674824329256E-05 |
| ENSG00000121236 | 17.4084595959596 | 0.000242040623929651 |
| ENSG00000121314 | 21.285580231467 | 0.0498568351160869 |
| ENSG00000121314 | 21.285580231467 | 0.0498568351160869 |
| ENSG00000122545 | 11.8658149722696 | 0.00751222932209738 |
| ENSG00000122545 | 13.4090447412523 | 3.84729012912294E-05 |
| ENSG00000123999 | 19.0433862433862 | 0.0322288314190479 |
| ENSG00000124151 | 14.213317434417 | 0.0017111929157375 |
| ENSG00000124275 | 11.5322171486555 | 0.0494296903067518 |
| ENSG00000124782 | 15.0072481449055 | 0.0228088492132344 |
| ENSG00000124785 | 26.3636363636364 | 0.0139015406017149 |
| ENSG00000125046 | 21.9508196721311 | 0.000297526618890919 |
| ENSG00000125046 | 22.159175750336 | 0.0041679258226915 |
| ENSG00000125144 | 13.0402817859612 | 0.0436043261973361 |
| ENSG00000126457 | 20.6477197620621 | 0.0436507205418902 |
| ENSG00000126934 | 10.3994360902256 | 0.0170523230344648 |
| ENSG00000127720 | 23.4776987718164 | 0.0497599820915567 |
| ENSG00000128191 | 21.8181818181818 | 0.00320151574321917 |
| ENSG00000128594 | 15.0125466477931 | 0.000116796230129294 |
| ENSG00000128645 | 10.2853015529072 | 0.00121747150949854 |
| ENSG00000128710 | 21.0644855381697 | 0.00651839107215014 |
| ENSG00000129084 | 12.0286218655548 | 0.0172605152181004 |
| ENSG00000129197 | 17.9736352881528 | 0.0417143548284744 |
| ENSG00000130165 | 24.6307417627009 | 0.0160328131442227 |
| ENSG00000130475 | 17.9204086677103 | 0.00166294018540342 |
| ENSG00000130475 | 22.6388888888889 | 0.00604959086225118 |
| ENSG00000130479 | 16.3249012522061 | 0.00953304964209787 |
| ENSG00000130508 | 18.2250917171823 | 7.31610284271188E-06 |
| ENSG00000130508 | 23.4640968662222 | 2.01088037520963E-06 |
| ENSG00000130508 | 20.8543619322278 | 0.00416549842488869 |
| ENSG00000130649 | 12.5517602327479 | 0.0273417480446 |
| ENSG00000131016 | 11.7042662497208 | 0.0444354884016374 |
| ENSG00000131023 | 13.9981479848311 | 0.0187010793104534 |
| ENSG00000131351 | 13.4018264840183 | 0.00443589798182927 |
| ENSG00000131477 | 33.4967320261438 | 0.0201872387865446 |
| ENSG00000131558 | 11.5044247787611 | 0.022104739810866 |
| ENSG00000132122 | 11.7731489585157 | 0.0277613788621418 |
| ENSG00000132294 | 30.5308775731311 | 0.0327524240726326 |
| ENSG00000132514 | 24.4631185807656 | 0.0363644555052197 |
| ENSG00000132622 | 17.1397445984385 | 0.00566727737330212 |
| ENSG00000132681 | 16.8425509738779 | 0.000928544009878355 |
| ENSG00000132681 | 17.2377319230102 | 0.00203151969725212 |
| ENSG00000132744 | 14.7559941407756 | 0.00904438540297216 |
| ENSG00000132938 | 18.2909416035017 | 0.00125957506818755 |
| ENSG00000132938 | 16.4396700556302 | 0.029970950411108 |
| ENSG00000133067 | 11.3456085567639 | 0.00214927976159169 |
| ENSG00000133124 | 28.093567251462 | 0.00327712188231578 |
| ENSG00000133124 | 23.2823397075366 | 0.0020688231716342 |
| ENSG00000133392 | 13.6334340382679 | 0.0376927615809148 |
| ENSG00000133800 | 16.4758674298636 | 0.0269458437538327 |
| ENSG00000134317 | 12.8983424355658 | 0.00952901638078628 |
| ENSG00000134684 | 19.620253164557 | 0.0421639713050269 |
| ENSG00000134684 | 13.9845510138397 | 0.0358154604847033 |
| ENSG00000134759 | 20.113269661772 | 0.0003169386702829 |
| ENSG00000135205 | 14.4243978386299 | 0.0176905740804252 |
| ENSG00000135249 | 11.9803313524666 | 4.44647180285375E-06 |
| ENSG00000135249 | 12.0194253338729 | 2.75460972867861E-05 |
| ENSG00000135272 | 21.6901408450704 | 0.0287800161849221 |
| ENSG00000135537 | 18.4814107312256 | 0.000239996476130441 |
| ENSG00000135537 | 17.0307912883184 | 0.000260476898111422 |
| ENSG00000135540 | 11.2881459231205 | 8.23366427538316E-06 |
| ENSG00000135577 | 21.9239829785407 | 5.33522780546147E-07 |
| ENSG00000135577 | 20.2328042328042 | 3.79900715392759E-05 |
| ENSG00000135604 | 10.7653326403326 | 0.0439825159727086 |
| ENSG00000135917 | 15.7698881460808 | 0.0366545557132403 |
| ENSG00000135956 | 10.7649253731343 | 0.00292974515959743 |
| ENSG00000136247 | 12.3814965295412 | 0.0274261593096852 |
| ENSG00000136535 | 25.7446221731936 | 0.00370113043124773 |
| ENSG00000136535 | 15.1667499681494 | 0.0203612063255517 |
| ENSG00000136643 | 10.9614962348717 | 0.00659446668166033 |
| ENSG00000136807 | 17.1372688477952 | 0.0266994300458006 |
| ENSG00000136816 | 11.254543057831 | 0.0476060494941858 |
| ENSG00000136834 | 16.5581622678397 | 0.0197267201252213 |
| ENSG00000137273 | 11.5365398602283 | 0.0062040157982351 |
| ENSG00000137273 | 11.6312366530771 | 0.00713523122493758 |
| ENSG00000137404 | 11.3023930797029 | 0.0255540271725796 |
| ENSG00000138336 | 21.8070362473348 | 0.000861502987558523 |
| ENSG00000138336 | 12.8354483045559 | 0.0268464451559656 |
| ENSG00000138356 | 13.7419056429232 | 0.0008131641239445 |
| ENSG00000138356 | 20.2985074626866 | 2.62625104704409E-05 |
| ENSG00000138356 | 11.8725944161147 | 0.0229952158724666 |
| ENSG00000138463 | 10.0793650793651 | 0.0195000911259593 |
| ENSG00000138613 | 14.0350877192982 | 0.0479560323476768 |
| ENSG00000138735 | 16.2222222222222 | 0.0350319355454426 |
| ENSG00000139218 | 10.8035714285714 | 0.0127859426977211 |
| ENSG00000139436 | 11.7431596386322 | 0.016830731218501 |
| ENSG00000139531 | 10.9577133507184 | 0.0139832071913536 |
| ENSG00000139684 | 11.1080973047053 | 0.00994668784188908 |
| ENSG00000140022 | 24.9410840534171 | 0.0476852247868617 |
| ENSG00000140022 | 24.9410840534171 | 0.0476852247868617 |
| ENSG00000140105 | 14.2249740905105 | 0.0439334492861912 |
| ENSG00000140262 | 14.8026315789474 | 0.0180323921064519 |
| ENSG00000140274 | 11.3766298330057 | 0.0425112978457713 |
| ENSG00000140279 | 11.3766298330057 | 0.0425112978457713 |
| ENSG00000140374 | 12.4095416778344 | 0.0295742567787071 |
| ENSG00000140374 | 10.4160259004452 | 0.0212023889404258 |
| ENSG00000140379 | 12.9888127393671 | 0.00146289741517831 |
| ENSG00000140379 | 10.8886346300534 | 0.0143709320741482 |
| ENSG00000141002 | 22 | 0.000139314238757079 |
| ENSG00000141293 | 11.9499343227696 | 0.026388087032707 |
| ENSG00000142279 | 17.6991150442478 | 4.44499535952698E-05 |
| ENSG00000142534 | 11.3208047990657 | 0.0143487834433811 |
| ENSG00000142538 | 18.8744588744589 | 0.0217087371662691 |
| ENSG00000142552 | 18.1228934404978 | 0.023175861526316 |
| ENSG00000142675 | 11.9416498993964 | 0.0438155979904791 |
| ENSG00000142700 | 18.23190607602 | 1.52116319460919E-07 |
| ENSG00000142700 | 22.2227505051706 | 3.15609809571843E-06 |
| ENSG00000142700 | 12.4779239802585 | 0.000217406168500081 |
| ENSG00000143367 | 11.9555984555985 | 0.000671624021843253 |
| ENSG00000143398 | 15.7577990665684 | 0.0214919289811714 |
| ENSG00000143398 | 13.6726096441736 | 0.00772983254202307 |
| ENSG00000143398 | 11.6687495014491 | 0.0124536348395854 |
| ENSG00000143412 | 12.5132555673383 | 0.0244041195439192 |
| ENSG00000143858 | 28.140350877193 | 0.0449309937694186 |
| ENSG00000143924 | 13.7603049375055 | 0.0407591408789525 |
| ENSG00000144214 | 34.1558441558442 | 0.0284955000718223 |
| ENSG00000144893 | 16.9635493979878 | 0.0306995524670432 |
| ENSG00000145113 | 13.5961321012204 | 0.024083299094284 |
| ENSG00000145536 | 15.5727366159021 | 0.0089577681604829 |
| ENSG00000145592 | 11.6523025372436 | 0.0271636234060285 |
| ENSG00000145757 | 13.6798764796706 | 0.0111201292225156 |
| ENSG00000145779 | 13.0333463762445 | 0.0105378918259197 |
| ENSG00000145779 | 16.1732764862038 | 0.000880696185937804 |
| ENSG00000145936 | 24.8277559055118 | 0.0191371062416153 |
| ENSG00000145945 | 17.0379193964662 | 0.017110700640367 |
| ENSG00000146352 | 17.4763922571934 | 0.00939974597671166 |
| ENSG00000146409 | 35.5370132648695 | 1.40578884203656E-09 |
| ENSG00000146409 | 55.8620689655172 | 2.89770438201437E-13 |
| ENSG00000146433 | 16.5959453088166 | 0.04996939925385 |
| ENSG00000146576 | 11.163315696649 | 0.0311238715775918 |
| ENSG00000146670 | 18.8444463416716 | 0.0367317352416859 |
| ENSG00000147416 | 21.3716108452951 | 0.0105920429195674 |
| ENSG00000147416 | 17.9113018597997 | 0.0474615788486051 |
| ENSG00000148513 | 25.0413343002175 | 0.00269005183248194 |
| ENSG00000148704 | 11.9206939281289 | 0.0253072631085157 |
| ENSG00000149054 | 15.5116844162118 | 0.016766001714366 |
| ENSG00000149506 | 15.5555555555556 | 0.000333635726247543 |
| ENSG00000149506 | 15.3865286262805 | 4.96739707996025E-06 |
| ENSG00000149527 | 29.7297297297297 | 0.00415449304741765 |
| ENSG00000149527 | 29.7297297297297 | 0.00415449304741765 |
| ENSG00000149639 | 10.9286870262367 | 0.0101548299807206 |
| ENSG00000149639 | 12.1855383969921 | 0.0160852095767229 |
| ENSG00000150281 | 15.1779124333683 | 0.000505029650335907 |
| ENSG00000150394 | 26.9042103828859 | 0.0227936744086682 |
| ENSG00000150394 | 27.0412642669008 | 0.0202594079795574 |
| ENSG00000150712 | 12.5114453891432 | 0.0122139770215577 |
| ENSG00000150712 | 10.867677850978 | 0.0214739383140781 |
| ENSG00000150873 | 19.8901098901099 | 0.0405200413725175 |
| ENSG00000151025 | 20.8704311152765 | 0.0202546161115284 |
| ENSG00000151572 | 22.7093641194796 | 0.000482091129609184 |
| ENSG00000151572 | 19.3722868352021 | 0.000468330770938237 |
| ENSG00000151572 | 23.7637362637363 | 0.000220689154440144 |
| ENSG00000151715 | 13.2231404958678 | 2.07242441821259E-05 |
| ENSG00000151892 | 12.1728903263746 | 0.00735053012870515 |
| ENSG00000151952 | 15.5023286759814 | 0.046398850179932 |
| ENSG00000152056 | 19.958988380041 | 0.0198480823550037 |
| ENSG00000152270 | 12.0286218655548 | 0.0172605152181004 |
| ENSG00000152767 | 43.3974358974359 | 0.00117296285928984 |
| ENSG00000152784 | 13.3333333333333 | 0.0231940237759357 |
| ENSG00000153044 | 14.8214009587135 | 0.0216533179341455 |
| ENSG00000153064 | 33.8714590313737 | 0.0495018361148693 |
| ENSG00000153207 | 10.2739726027397 | 0.0026938679402231 |
| ENSG00000153993 | 18.8775510204082 | 0.0241209264996128 |
| ENSG00000154237 | 23.0392156862745 | 0.0363291714716197 |
| ENSG00000154760 | 15.1098628310425 | 0.0347986539044008 |
| ENSG00000154856 | 12.5283446712018 | 0.00037602103468744 |
| ENSG00000154917 | 13.8822434875066 | 0.0230621445524481 |
| ENSG00000155886 | 19.5566361556064 | 0.0116155325394393 |
| ENSG00000156076 | 11.0310823222313 | 0.0268796003918146 |
| ENSG00000157538 | 15.0242571255306 | 0.00203121890774945 |
| ENSG00000157766 | 15.0971621989181 | 0.00676995036797155 |
| ENSG00000157766 | 12.5436141184755 | 0.00464440476763111 |
| ENSG00000157851 | 16.7903733693207 | 0.0289398471369681 |
| ENSG00000158106 | 12.4241021843762 | 0.0188313265083686 |
| ENSG00000158258 | 19.1297901887926 | 0.00225261451838968 |
| ENSG00000158473 | 11.0937760919869 | 0.0128090642870108 |
| ENSG00000158497 | 11.1524313836453 | 0.0150878523101572 |
| ENSG00000158578 | 56.8181818181818 | 0.0336364256100912 |
| ENSG00000158578 | 56.8181818181818 | 0.0336364256100912 |
| ENSG00000160213 | 24.7969090548841 | 0.0122376863994378 |
| ENSG00000160218 | 19.3254265056808 | 0.0133364009262115 |
| ENSG00000160352 | 24.7552447552448 | 0.0295173147012498 |
| ENSG00000160352 | 23.5333087964667 | 0.00337460458680132 |
| ENSG00000160396 | 14.1804407713499 | 0.0211463722081773 |
| ENSG00000160957 | 15.3463203463204 | 0.0486141677182154 |
| ENSG00000161204 | 25.6061169104647 | 8.31439836576701E-07 |
| ENSG00000161204 | 13.7002182214948 | 0.0473029553225241 |
| ENSG00000161270 | 28.8167770419426 | 0.000660996990069051 |
| ENSG00000161270 | 19.0286206954846 | 0.000119598769573488 |
| ENSG00000161277 | 19.8897168020455 | 8.75707968258849E-08 |
| ENSG00000161277 | 23.7220969376083 | 3.0737873482305E-10 |
| ENSG00000161940 | 15.4950032850375 | 0.0139482207896637 |
| ENSG00000162385 | 12.0503936791575 | 0.000736637004004158 |
| ENSG00000162650 | 12.1210093032595 | 0.030390884371614 |
| ENSG00000162650 | 10.6566159389371 | 0.0107260867722815 |
| ENSG00000162669 | 38.9926183239253 | 0.0271186450532488 |
| ENSG00000162670 | 24.0847486704409 | 0.00013024571749572 |
| ENSG00000162670 | 20.3247232472325 | 0.000579881644268407 |
| ENSG00000162745 | 13.1313131313131 | 0.0136091156485706 |
| ENSG00000162745 | 13.1313131313131 | 0.0136091156485706 |
| ENSG00000162972 | 14.4257014957965 | 0.0186020820238185 |
| ENSG00000163040 | 14.046926910299 | 0.000944854924481721 |
| ENSG00000163126 | 20.1949317738791 | 0.0481825564972396 |
| ENSG00000163159 | 15.7577990665684 | 0.0214919289811714 |
| ENSG00000163159 | 13.6726096441736 | 0.00772983254202307 |
| ENSG00000163444 | 15.3428899552931 | 0.0196806547786023 |
| ENSG00000163531 | 17.5438596491228 | 0.00676389422859917 |
| ENSG00000163719 | 12.999359111301 | 0.000112140354846795 |
| ENSG00000163749 | 65.1083591331269 | 8.36339221793695E-08 |
| ENSG00000163884 | 15.0589955100762 | 0.0428100098509375 |
| ENSG00000163888 | 13.1516566237808 | 0.0186911733603567 |
| ENSG00000164111 | 14.0333333333333 | 0.0282875420942757 |
| ENSG00000164362 | 13.683310187527 | 5.87564337928306E-05 |
| ENSG00000164694 | 21.9051799824407 | 0.0303086708577827 |
| ENSG00000164694 | 18.1836945304438 | 0.00134095427583391 |
| ENSG00000164920 | 13.8862559241706 | 0.00141583621004862 |
| ENSG00000165238 | 24.0134453781513 | 0.00494478632453144 |
| ENSG00000165379 | 13.6731125022176 | 0.0016025149040758 |
| ENSG00000165480 | 13.5407905803196 | 0.0216946706962642 |
| ENSG00000165606 | 19.1199183733706 | 5.5872052215603E-07 |
| ENSG00000165606 | 17.3925998740535 | 4.2808694077257E-05 |
| ENSG00000165934 | 18.75 | 0.00971460786186196 |
| ENSG00000165966 | 10.0216919739696 | 0.0305898143328863 |
| ENSG00000166126 | 35.6637863315004 | 0.00259242502228986 |
| ENSG00000166183 | 24.2622180451128 | 0.0190593482630599 |
| ENSG00000166347 | 13.769569637411 | 0.0403563026530201 |
| ENSG00000166477 | 15.1330878013432 | 0.00123670273324628 |
| ENSG00000166477 | 12.283264834318 | 0.015419621646927 |
| ENSG00000166501 | 19.6266805146847 | 0.00153775224272866 |
| ENSG00000166573 | 17.4718111346018 | 0.00729498953313671 |
| ENSG00000166707 | 20.0104529616725 | 0.00163780758425276 |
| ENSG00000166707 | 20.0104529616725 | 0.00163780758425276 |
| ENSG00000166823 | 26.8245838668374 | 0.0495363996427847 |
| ENSG00000166920 | 16.5035117421258 | 0.00589449445291069 |
| ENSG00000166923 | 14.9973367002703 | 0.00447230701951687 |
| ENSG00000166923 | 33.1261645269149 | 1.25223166306352E-10 |
| ENSG00000166963 | 20.3389830508475 | 0.0300087921518017 |
| ENSG00000167065 | 11.2352309344791 | 0.0139136993223702 |
| ENSG00000167157 | 25.9079443434864 | 0.000277416303600727 |
| ENSG00000167232 | 19.6491228070175 | 0.0476188588590909 |
| ENSG00000167461 | 13.3822689555548 | 0.0371522468391887 |
| ENSG00000167461 | 20.9423888008136 | 6.06355227548763E-05 |
| ENSG00000167525 | 10.1274599061559 | 0.0152810805363086 |
| ENSG00000167721 | 14.9361391296875 | 0.00380753155245858 |
| ENSG00000167861 | 25.9545923632611 | 0.00358556744024635 |
| ENSG00000167941 | 11.7389526051318 | 0.0285708560755144 |
| ENSG00000168003 | 29.6517223220933 | 1.10573298130736E-15 |
| ENSG00000168003 | 19.3742150067451 | 4.26219762277615E-18 |
| ENSG00000168310 | 20.4081632653061 | 0.0279896116071751 |
| ENSG00000168412 | 17.3148504684893 | 0.000716521181689353 |
| ENSG00000168418 | 14.3181818181818 | 0.0182567992005783 |
| ENSG00000169026 | 18.6301369863014 | 0.0342770267372644 |
| ENSG00000169223 | 12.2437275985663 | 0.0435324183677553 |
| ENSG00000169375 | 10.4188521863726 | 0.016114367702584 |
| ENSG00000169393 | 12 | 0.0493167198534707 |
| ENSG00000169427 | 11.247220890187 | 0.0496254884892535 |
| ENSG00000169760 | 17.5231031128405 | 0.0186654039857985 |
| ENSG00000170145 | 10.5361665414266 | 0.0175465943593796 |
| ENSG00000170185 | 29.4871794871795 | 0.000630400715875306 |
| ENSG00000170465 | 12.962743471218 | 0.0469277428773242 |
| ENSG00000170561 | 12.7706888335892 | 0.0391539116619081 |
| ENSG00000171100 | 22.871835443038 | 0.0106092170610959 |
| ENSG00000171126 | 11.1359937892835 | 0.0216673574540229 |
| ENSG00000171311 | 13.8118664281455 | 0.0237183365918712 |
| ENSG00000171311 | 14.3968033579405 | 0.00413581751691176 |
| ENSG00000171320 | 10.3273952816562 | 0.0167954591819699 |
| ENSG00000171502 | 23.609756097561 | 0.0335180537417258 |
| ENSG00000171680 | 13.5460627895008 | 0.00929318330919313 |
| ENSG00000171703 | 14.2619545269168 | 0.00131329403970655 |
| ENSG00000171863 | 11.5938898723481 | 2.56390100406467E-10 |
| ENSG00000172020 | 42.5376344086022 | 0.000695352188831056 |
| ENSG00000172020 | 24.2295293359123 | 0.047280709287646 |
| ENSG00000172264 | 10.5454049631852 | 0.028981547758041 |
| ENSG00000172375 | 22.5297619047619 | 0.00867841999556837 |
| ENSG00000172638 | 14.5147565340717 | 0.0381796105921428 |
| ENSG00000172731 | 11.4101485842445 | 0.00944905513209447 |
| ENSG00000172969 | 11.7578638155014 | 0.044921147652781 |
| ENSG00000173093 | 24.06191369606 | 0.022181003499463 |
| ENSG00000173120 | 14.2551674982181 | 0.0496394849462093 |
| ENSG00000173200 | 10.8415600053979 | 0.0320176211096451 |
| ENSG00000173200 | 15.7881024750326 | 0.00412154700403832 |
| ENSG00000173992 | 22.1199059561129 | 0.00699934725544673 |
| ENSG00000174013 | 13.9814282192456 | 0.0394900528618909 |
| ENSG00000174567 | 27.1601770479184 | 0.000340861700810797 |
| ENSG00000174600 | 15.6376618349176 | 0.00642989573367869 |
| ENSG00000175155 | 22.7486965589155 | 0.0111237785068831 |
| ENSG00000175164 | 24.4719418821125 | 0.00013283575228985 |
| ENSG00000175262 | 35.1402458241412 | 0.000497173920808733 |
| ENSG00000175334 | 11.5209950030916 | 0.00625243526719106 |
| ENSG00000175334 | 18.6723832789092 | 4.6428109674143E-13 |
| ENSG00000175334 | 14.2765027897673 | 0.00241994485726501 |
| ENSG00000175548 | 14.4444444444444 | 0.00890661766993383 |
| ENSG00000176533 | 13.5220678740988 | 0.00373615812375045 |
| ENSG00000176635 | 16.6083998306865 | 0.000355215220754848 |
| ENSG00000176697 | 14.5359848484848 | 4.5109359222386E-08 |
| ENSG00000176884 | 22.6031645486097 | 2.01796375984741E-06 |
| ENSG00000177453 | 14.4259397990741 | 0.035363394156332 |
| ENSG00000178031 | 19.7603325996576 | 0.0258744050846556 |
| ENSG00000178568 | 27.5180140945443 | 1.07565396326703E-07 |
| ENSG00000178568 | 24.3478260869565 | 5.81968691395407E-05 |
| ENSG00000178726 | 13.8271604938272 | 0.00489698578846567 |
| ENSG00000178726 | 12.2430146449565 | 0.0156330860854684 |
| ENSG00000178796 | 15.9005323983898 | 0.0307982983889641 |
| ENSG00000178913 | 13.6939768148448 | 0.0350368105979069 |
| ENSG00000178965 | 14.2696312974951 | 0.00808516641508364 |
| ENSG00000179168 | 17.4945100909756 | 0.0282001376411957 |
| ENSG00000179636 | 20.9585643419901 | 0.0220602019465386 |
| ENSG00000179698 | 10.7581561220446 | 0.041618804863787 |
| ENSG00000179698 | 12.4260355029586 | 0.000242145115872396 |
| ENSG00000179862 | 30.6855636123929 | 0.0340220750692895 |
| ENSG00000179862 | 31.8367346938776 | 0.0473541282756217 |
| ENSG00000180035 | 27.2213855421687 | 0.00125428492354235 |
| ENSG00000180035 | 21.2121212121212 | 2.95009274710322E-05 |
| ENSG00000180035 | 13.9821235937741 | 0.00317629723505787 |
| ENSG00000180061 | 10.306341393051 | 0.016226004542076 |
| ENSG00000180071 | 13.3963417501293 | 0.049540677234967 |
| ENSG00000180535 | 27.2674953959484 | 0.0123714822722483 |
| ENSG00000180535 | 30.4133568696676 | 3.48980020306252E-05 |
| ENSG00000181867 | 11.7798103234996 | 0.018306081939418 |
| ENSG00000182175 | 18.0971659919028 | 5.80609091628168E-05 |
| ENSG00000182175 | 11.1104582843713 | 0.0199735193033375 |
| ENSG00000182636 | 15.5402283677645 | 0.0126531387699157 |
| ENSG00000183145 | 29.3362193362193 | 0.00926579917665838 |
| ENSG00000183145 | 13.9260640631856 | 0.0192253482887195 |
| ENSG00000183496 | 11.2032238578196 | 0.0074459077399667 |
| ENSG00000183496 | 14.5393689412893 | 0.000320527649816425 |
| ENSG00000183605 | 15.0648824006488 | 0.0303008750130128 |
| ENSG00000183734 | 16.6808029403449 | 0.0281162336753472 |
| ENSG00000184005 | 16.106135986733 | 0.00865451355324339 |
| ENSG00000184113 | 15.9938784938785 | 0.0229272665000222 |
| ENSG00000184408 | 15.9975819857942 | 0.000678111680074365 |
| ENSG00000184672 | 14.7358898326381 | 0.0435408963672579 |
| ENSG00000184731 | 13.2576254294631 | 0.0104233490346365 |
| ENSG00000184922 | 25.2331606217617 | 2.42984978950435E-06 |
| ENSG00000185024 | 19.2857142857143 | 0.0135154364114851 |
| ENSG00000185278 | 10.0415503473349 | 7.16094124589841E-06 |
| ENSG00000185278 | 11.3561664874827 | 2.51200912416616E-06 |
| ENSG00000185742 | 19.151173422737 | 0.0008552619353144 |
| ENSG00000185742 | 15.1043660559657 | 0.00314120109200504 |
| ENSG00000185774 | 20.952635804121 | 0.0397044858541228 |
| ENSG00000185813 | 15.2209951485897 | 0.0181017550145296 |
| ENSG00000185825 | 12.8256688232208 | 5.28646186599738E-05 |
| ENSG00000185825 | 10.0686749295466 | 0.0401229285764378 |
| ENSG00000185896 | 10.5979766173941 | 0.024117608616727 |
| ENSG00000185896 | 20.1874052638832 | 0.024131183824719 |
| ENSG00000185896 | 13.7539177418424 | 3.0049488144737E-05 |
| ENSG00000185905 | 12.3398479913138 | 0.000156319984376192 |
| ENSG00000185905 | 14.0702500253062 | 0.00153387336316091 |
| ENSG00000185958 | 16.1471861471861 | 0.0307218007696011 |
| ENSG00000186073 | 14.7708578143361 | 0.0174551525895769 |
| ENSG00000186197 | 19.3347193347193 | 0.000387011438726581 |
| ENSG00000186523 | 21.9221835075494 | 0.0405200413725175 |
| ENSG00000186998 | 21.6491228070175 | 0.0107697078177381 |
| ENSG00000187122 | 12.6247181293053 | 0.0425111463293409 |
| ENSG00000187135 | 24.4343891402715 | 0.0102763374326046 |
| ENSG00000187231 | 24.3589743589744 | 0.0244160737034669 |
| ENSG00000187266 | 15.5664069780445 | 0.0240826009703214 |
| ENSG00000187527 | 18.0937892398339 | 0.00270096155507299 |
| ENSG00000187527 | 27.905701754386 | 0.0122003472943511 |
| ENSG00000187821 | 17.301758961799 | 0.0262473787545817 |
| ENSG00000187848 | 49.1819291819292 | 3.72008212902467E-10 |
| ENSG00000188153 | 12.1476617552851 | 0.0439126087216701 |
| ENSG00000188162 | 32.9668348954578 | 0.0274261593096852 |
| ENSG00000188229 | 11.2701937064543 | 0.00466411582880679 |
| ENSG00000188493 | 14.2631246046806 | 0.0052381158340976 |
| ENSG00000188522 | 29.9446964518735 | 0.0024547054883833 |
| ENSG00000188822 | 19.4871794871795 | 0.0431051281570937 |
| ENSG00000188916 | 18.2413204325555 | 4.63633125090392E-06 |
| ENSG00000196074 | 12.1661315424197 | 0.0106092170610959 |
| ENSG00000196074 | 10.6353071608165 | 0.00457266157639662 |
| ENSG00000196090 | 14.2025776415148 | 0.00695143377982781 |
| ENSG00000196090 | 14.810846844273 | 0.0063343819436355 |
| ENSG00000196132 | 15.3465882437845 | 0.0118293720940106 |
| ENSG00000196277 | 19.1864578603335 | 0.00237980339670023 |
| ENSG00000196358 | 36.0210777490555 | 0.000800203526648617 |
| ENSG00000196361 | 34.7555923777962 | 0.00223050817172084 |
| ENSG00000196418 | 37.8125 | 0.0495930018339292 |
| ENSG00000196498 | 23.0205156060669 | 5.350072520849E-05 |
| ENSG00000196570 | 18.4998443821973 | 0.022094705739058 |
| ENSG00000196576 | 20.02442002442 | 0.0143206955470071 |
| ENSG00000197321 | 26.6782608695652 | 0.0141433998222048 |
| ENSG00000197355 | 20.8519179304193 | 0.000840561887852749 |
| ENSG00000197442 | 12.9341199606686 | 0.0468764097793746 |
| ENSG00000197497 | 13.7522892102181 | 0.000266565975725615 |
| ENSG00000197620 | 24.2486554887694 | 0.00550099733479635 |
| ENSG00000197713 | 15.7586006447181 | 0.000195240360198019 |
| ENSG00000197713 | 12.9293159423592 | 0.00174790476518585 |
| ENSG00000197977 | 13.1134277680514 | 0.00393456326723536 |
| ENSG00000197977 | 20.7747752921919 | 2.32967856639697E-05 |
| ENSG00000198055 | 18.4998443821973 | 0.022094705739058 |
| ENSG00000198435 | 12.6049245940254 | 0.0352599400113216 |
| ENSG00000198538 | 11.0856852275616 | 0.034699107985298 |
| ENSG00000198553 | 12.7099236641221 | 0.0324911160618064 |
| ENSG00000198553 | 16.3043478260869 | 0.00529968603181151 |
| ENSG00000198625 | 13.7817587098737 | 6.35144577459527E-05 |
| ENSG00000198691 | 16.1113699906803 | 0.0178381603850453 |
| ENSG00000198691 | 16.1113699906803 | 0.0178381603850453 |
| ENSG00000203734 | 18.4851120338159 | 9.09164293803858E-05 |
| ENSG00000204104 | 15.3368121442125 | 0.0219176387353552 |
| ENSG00000204104 | 15.3368121442125 | 0.0219176387353552 |
| ENSG00000204231 | 16.1843515541265 | 0.0363731258486073 |
| ENSG00000204231 | 15.0719651642069 | 0.0222603667551141 |
| ENSG00000204524 | 16.3571716688827 | 0.0281033417170994 |
| ENSG00000204538 | 17.7033492822966 | 0.0186818574618526 |
| ENSG00000204604 | 11.0856852275616 | 0.034699107985298 |
| ENSG00000204612 | 18.7839937839938 | 0.00250813598583812 |
| ENSG00000204612 | 16.5474182682596 | 0.00148912704912215 |
| ENSG00000204764 | 45.4649588670207 | 3.9838278218345E-12 |
| ENSG00000205022 | 38.382257012394 | 0.000546765217802043 |
| ENSG00000205358 | 13.0402817859612 | 0.0436043261973361 |
| ENSG00000211887 | 10.8259823576584 | 0.0293719445323917 |
| ENSG00000211888 | 10.8259823576584 | 0.0293719445323917 |
| ENSG00000211904 | 25.2304811293575 | 0.0199603966385628 |
| ENSG00000211905 | 25.2304811293575 | 0.0199603966385628 |
| ENSG00000211967 | 29.6948356807512 | 0.047288778192247 |
| ENSG00000213337 | 20.1949317738791 | 0.0481825564972396 |
| ENSG00000213563 | 20.0679658366414 | 4.60696397442978E-06 |
| ENSG00000213585 | 12.0044548440804 | 2.76132243255278E-07 |
| ENSG00000215131 | 13.6776422610731 | 0.0301144898207834 |
| ENSG00000215131 | 17.3587154236969 | 0.0164588521031709 |
| ENSG00000215218 | 62.7596721936345 | 1.23161776512788E-11 |
| ENSG00000215375 | 24.7302410313901 | 0.000291709269699351 |
| ENSG00000215612 | 25.1071179459926 | 0.00154876825761241 |
| ENSG00000220201 | 14.9630274032188 | 0.00661633019678567 |
| ENSG00000221890 | 13.7059142702116 | 0.0467389184859929 |
| ENSG00000221890 | 22.6050420168067 | 0.0345626215065825 |
| ENSG00000222014 | 23.8909634055265 | 0.0395536522028147 |
| ENSG00000224051 | 30.1339896089691 | 0.0291683709558524 |
| ENSG00000224982 | 11.9933191381297 | 0.0336814320680362 |
| ENSG00000225528 | 16.3925127623369 | 0.0436056297319412 |
| ENSG00000225528 | 31.4965408423352 | 0.0162309007913253 |
| ENSG00000226174 | 19.4751640112465 | 0.0458245501469545 |
| ENSG00000226807 | 19.5400013256446 | 0.000741069205726134 |
| ENSG00000230778 | 36.6425783514318 | 1.53623391923156E-06 |
| ENSG00000235007 | 12.1781869246372 | 0.000684486983272381 |
| ENSG00000236597 | 25.2304811293575 | 0.0199603966385628 |
| ENSG00000237521 | 11.8684113978232 | 0.0372737808864645 |
| ENSG00000238205 | 39.5 | 0.0123595376844097 |
| ENSG00000240041 | 25.2304811293575 | 0.0199603966385628 |
| ENSG00000241878 | 14.4855688682885 | 6.15403543233231E-07 |
| ENSG00000242887 | 25.2304811293575 | 0.0199603966385628 |
| ENSG00000243811 | 10.9948112363571 | 0.012370849740844 |
| ENSG00000243811 | 20.4896907216495 | 0.0239166953197774 |
| ENSG00000243910 | 26.4705882352941 | 0.0319767800481153 |
| ENSG00000249715 | 12.6467285903848 | 0.0355790310664249 |
| ENSG00000250312 | 40.0960827790096 | 0.0238001723600601 |
| ENSG00000253873 | 16.2661776264082 | 0.00844151005684433 |
| ENSG00000254167 | 15.7396250735562 | 0.00428564303869565 |
| ENSG00000254656 | 25.5557672764228 | 6.97580628217678E-05 |
| ENSG00000254656 | 23.0608724225745 | 0.000886141005522823 |
| ENSG00000255432 | 18.7762014492351 | 0.0187775057128133 |
| ENSG00000257950 | 31.5746753246753 | 0.00664142162914082 |
| ENSG00000258555 | 14.238574492658 | 0.00257404896789635 |
| ENSG00000258588 | 17.0111238971998 | 2.8674824329256E-05 |
| ENSG00000258588 | 17.4084595959596 | 0.000242040623929651 |
| ENSG00000258947 | 38.1408450704225 | 0.0406766051931808 |
| ENSG00000258947 | 48.0519480519481 | 0.0233247232177374 |
| ENSG00000260903 | 14.7750399639444 | 0.00194658086042017 |
| ENSG00000268089 | 41.6075650118203 | 0.00169713877307405 |
| ENSG00000269179 | 27.7445652173913 | 0.00395963160047802 |
| ENSG00000269556 | 20.2995867768595 | 0.0233828766140779 |
| ENSG00000269556 | 27.2380570052188 | 0.0271154900160762 |
| ENSG00000270185 | 51.3157894736842 | 0.0114374641511294 |
| ENSG00000270647 | 13.6887306242145 | 0.0340582253498451 |
| ENSG00000272297 | 17.3148504684893 | 0.000716521181689353 |
| ENSG00000272674 | 18.5499058380414 | 0.045620588761505 |
| ENSG00000273559 | 13.2909328114808 | 0.00698099756874393 |
| ENSG00000274523 | 10.4329004329004 | 0.0490673225866567 |
| ENSG00000274997 | 11.3590263691684 | 1.80362232316675E-09 |
| ENSG00000275183 | 21.6338207247298 | 0.0263061606240809 |
| ENSG00000277494 | 17.5513524506813 | 0.0489012910315538 |
| ENSG00000278318 | 14.3568939512144 | 0.00278221664468368 |
| ENSG00000278318 | 11.0946344439549 | 0.0235804961090268 |
| ENSG00000278615 | 18.7762014492351 | 0.0187775057128133 |
| ENSG00000279301 | 14.9986327590922 | 0.0358444715341303 |
| ENSG00000283428 | 14.5281551621609 | 0.0269976535385308 |
| ENSG00000284479 | 24.417945690673 | 0.00156850485441185 |
| ENSG00000284976 | 24.8106060606061 | 0.0406005676956223 |
| id | meth.diff | meth.q |
| ENSG00000003400 | -13.0225905823676 | 0.0261886189599571 |
| ENSG00000005073 | -11.4742264489008 | 0.00408833030390649 |
| ENSG00000005073 | -11.3833525260578 | 0.00652630708889119 |
| ENSG00000005189 | -14.1243862520458 | 0.0117387368539422 |
| ENSG00000005249 | -22.4074705782023 | 0.0352264426559156 |
| ENSG00000005249 | -15.4167949096437 | 0.0091222647432768 |
| ENSG00000008128 | -25.3486464315012 | 0.000465458078818736 |
| ENSG00000010030 | -15.5217903415783 | 0.0407326950579055 |
| ENSG00000011465 | -15.7456922162804 | 0.00476646652256708 |
| ENSG00000011677 | -15.3903308896374 | 0.0355759656096261 |
| ENSG00000013375 | -18.7974626999017 | 0.000142007746958989 |
| ENSG00000013563 | -24.0516545601291 | 0.0292778679893094 |
| ENSG00000022976 | -12.6479289940828 | 0.0252722406682501 |
| ENSG00000023191 | -10.4196194039723 | 0.0179302817320542 |
| ENSG00000029534 | -22.2705696202532 | 0.0154280889548072 |
| ENSG00000035928 | -18.6948694869487 | 0.00661633019678567 |
| ENSG00000037280 | -28.6324786324786 | 0.000113858936619995 |
| ENSG00000037897 | -13.2831444200079 | 0.0266330771143665 |
| ENSG00000040531 | -18.9925925925926 | 0.00373615812375045 |
| ENSG00000040531 | -19.751056964842 | 4.01914267959484E-11 |
| ENSG00000040531 | -10.1102852823329 | 0.005665190996256 |
| ENSG00000041988 | -12.7544307716121 | 0.0079544377861888 |
| ENSG00000047849 | -18.2554287817446 | 0.0121742321252513 |
| ENSG00000053501 | -15.0684931506849 | 0.00762921671917297 |
| ENSG00000054938 | -23.3424567997059 | 6.90248566006469E-07 |
| ENSG00000055955 | -30.8197855413352 | 0.0447552421906043 |
| ENSG00000057468 | -11.2298918708992 | 0.00886470049709088 |
| ENSG00000057468 | -11.2298918708992 | 0.00886470049709088 |
| ENSG00000058335 | -28.6184210526316 | 0.021551196675812 |
| ENSG00000061455 | -17.042217042217 | 0.0395150600972023 |
| ENSG00000061455 | -17.8731762065095 | 0.0291279908353443 |
| ENSG00000063245 | -29.8245614035088 | 0.00238767155978859 |
| ENSG00000064309 | -13.5096968555828 | 0.00274623489394904 |
| ENSG00000064489 | -18.0312897671981 | 7.66402129046302E-11 |
| ENSG00000064489 | -11.0689307272696 | 2.42044046543343E-05 |
| ENSG00000064490 | -12.9920364050057 | 4.69893374366678E-05 |
| ENSG00000064490 | -18.0312897671981 | 7.66402129046302E-11 |
| ENSG00000064490 | -11.0689307272696 | 2.42044046543343E-05 |
| ENSG00000065665 | -25.9183673469388 | 0.0279148217974277 |
| ENSG00000067840 | -25.5321766949674 | 0.0318898662698066 |
| ENSG00000068831 | -21.2225274725275 | 0.0176828752271213 |
| ENSG00000069667 | -31.0036671004097 | 1.45503265323416E-10 |
| ENSG00000069667 | -34.0985832454934 | 3.94666393261877E-09 |
| ENSG00000070526 | -12.1204579392733 | 0.00116892883638087 |
| ENSG00000071054 | -15.9047619047619 | 0.0193214939202338 |
| ENSG00000071054 | -14.9546683023135 | 0.0294939797114423 |
| ENSG00000071246 | -20.5575757575758 | 0.00952758607868016 |
| ENSG00000072736 | -11.8219296976711 | 0.039605780802127 |
| ENSG00000074317 | -14.8832515572259 | 0.00327521117174258 |
| ENSG00000074527 | -17.6912487708948 | 0.00153326978684318 |
| ENSG00000074527 | -29.7578828828829 | 2.32852552380807E-07 |
| ENSG00000076662 | -14.6666666666667 | 0.0178617418311501 |
| ENSG00000081087 | -10.7036870503597 | 0.024280154447413 |
| ENSG00000085185 | -12.9503169855334 | 0.0012299560929773 |
| ENSG00000085719 | -24.3063912831355 | 0.00523531558745069 |
| ENSG00000087074 | -16 | 0.0109242806066318 |
| ENSG00000087076 | -32.8944618599791 | 0.0373715106173832 |
| ENSG00000087269 | -13.5926535562679 | 0.0214541103864009 |
| ENSG00000087269 | -11.5588273279091 | 0.0292988774562968 |
| ENSG00000088305 | -11.6281866281866 | 0.0427151981393461 |
| ENSG00000089163 | -11.6727376062414 | 0.0380803051192107 |
| ENSG00000089356 | -15.3979991300565 | 0.0389538034184871 |
| ENSG00000090975 | -18.4948822296214 | 0.0320990923624484 |
| ENSG00000090975 | -16.8482117513483 | 0.00248333432253196 |
| ENSG00000090975 | -26.3362068965517 | 0.0330829773524249 |
| ENSG00000091640 | -17.1887796887797 | 0.0391464914463182 |
| ENSG00000092036 | -13.8428155282088 | 0.00590952601630159 |
| ENSG00000092847 | -17.1730139751857 | 0.00350462007914844 |
| ENSG00000099308 | -32.6042378673958 | 0.000411211410265582 |
| ENSG00000099326 | -19.1756272401434 | 0.0433201581859275 |
| ENSG00000100154 | -29.8284256897751 | 0.00023937218706629 |
| ENSG00000100324 | -22.0239481899082 | 0.0065659318113759 |
| ENSG00000100417 | -22.0987654320988 | 0.000320527649816425 |
| ENSG00000100417 | -16.4880952380952 | 0.00798977532106798 |
| ENSG00000100462 | -14.8990364474235 | 0.0382347891822333 |
| ENSG00000100462 | -16.7780783436508 | 0.00287845042103186 |
| ENSG00000100650 | -11.8654311039484 | 0.0326720487121621 |
| ENSG00000100842 | -29.4416399901502 | 4.41221894215986E-11 |
| ENSG00000100842 | -33.4745340376757 | 1.57828678813707E-09 |
| ENSG00000100842 | -18.0075840643275 | 0.0302217013684655 |
| ENSG00000100983 | -17.9347968631154 | 0.00964959585556572 |
| ENSG00000101126 | -14.0618841150966 | 0.00587985622880035 |
| ENSG00000101146 | -46.3265306122449 | 0.00730784583795025 |
| ENSG00000101188 | -17.1462829736211 | 0.025914734875891 |
| ENSG00000101216 | -10.3382163724572 | 0.0370962647151181 |
| ENSG00000101246 | -13.2554549434345 | 0.0464070147864675 |
| ENSG00000101282 | -12.6426591470327 | 0.000122122341510126 |
| ENSG00000101333 | -15.386492289674 | 0.006884029143443 |
| ENSG00000101445 | -15.8599476439791 | 0.00700729207991631 |
| ENSG00000101463 | -20.5708661417323 | 0.0126535233533451 |
| ENSG00000101489 | -12.8653907837058 | 0.00122182854297472 |
| ENSG00000101850 | -45.7032411537318 | 2.79648097865614E-08 |
| ENSG00000102081 | -10.752688172043 | 0.0317139609470535 |
| ENSG00000102387 | -19.7678018575851 | 5.12150640091635E-07 |
| ENSG00000102409 | -13.0988450577471 | 6.69073628060357E-05 |
| ENSG00000102898 | -22.1505376344086 | 0.0253551987953626 |
| ENSG00000102898 | -13.7839737582006 | 0.00814065825509914 |
| ENSG00000103194 | -13.7551771744133 | 0.0375901937391954 |
| ENSG00000103199 | -16.4232218449086 | 0.00130471132303523 |
| ENSG00000103227 | -19.5967357469363 | 0.0493579705524396 |
| ENSG00000103742 | -11.8318663094783 | 0.0312017387759491 |
| ENSG00000104299 | -11.8751264926128 | 0.01769137676129 |
| ENSG00000104818 | -16.7496106894336 | 0.0252435277943326 |
| ENSG00000104969 | -24.4159883528555 | 0.00479288133087388 |
| ENSG00000104976 | -29.2960597052685 | 0.00253837046745113 |
| ENSG00000105063 | -17.0643350701044 | 0.0190330469630085 |
| ENSG00000105193 | -17.1887159533074 | 0.0363822127069507 |
| ENSG00000105229 | -18.4522905318895 | 0.0444289457526795 |
| ENSG00000105270 | -23.5294117647059 | 0.00688536703967539 |
| ENSG00000105278 | -23.4672631850641 | 0.000755438972190894 |
| ENSG00000105370 | -37.6114081996435 | 0.00458280012729838 |
| ENSG00000105516 | -21.0976523476523 | 0.0222779988761963 |
| ENSG00000105550 | -27.290780141844 | 8.5961537559472E-06 |
| ENSG00000105552 | -16.6190476190476 | 0.0166368308688395 |
| ENSG00000105552 | -12.2747099004197 | 0.0213279395522083 |
| ENSG00000105568 | -14.599785512333 | 0.00298145839645139 |
| ENSG00000105609 | -25.4920714825069 | 0.014731951681206 |
| ENSG00000105639 | -10.6699490065061 | 0.00837345213299676 |
| ENSG00000105639 | -11.5959821428571 | 0.00328479040719733 |
| ENSG00000105655 | -30.9553938627017 | 0.0168610619104421 |
| ENSG00000105655 | -27.6315789473684 | 0.000286470074845706 |
| ENSG00000105852 | -14.6870554765292 | 0.0375158059469258 |
| ENSG00000105989 | -19.7711245302141 | 0.00207953564236401 |
| ENSG00000105989 | -14.9031811894882 | 0.0128575818853282 |
| ENSG00000106144 | -12.3389400190416 | 0.0314189626104258 |
| ENSG00000106244 | -14.7058823529412 | 6.15633218377445E-05 |
| ENSG00000106245 | -14.7058823529412 | 6.15633218377445E-05 |
| ENSG00000107282 | -12.6867335562988 | 0.0337841907588973 |
| ENSG00000107362 | -11.3020890206718 | 0.015856947109812 |
| ENSG00000107443 | -20.8430295324233 | 2.10698806649647E-05 |
| ENSG00000107736 | -15.539071680376 | 0.00666888599889314 |
| ENSG00000108381 | -20.3422053231939 | 0.00257135725773325 |
| ENSG00000108839 | -13.7001793301776 | 0.0363397921517671 |
| ENSG00000108984 | -17.3495320151243 | 0.0346550934924646 |
| ENSG00000109458 | -12.616004666702 | 0.0411833707244456 |
| ENSG00000109475 | -29.4538606403013 | 0.0381811229547991 |
| ENSG00000109475 | -18.9792663476874 | 0.0451290699962029 |
| ENSG00000109738 | -35.099846390169 | 0.0327601799288268 |
| ENSG00000110148 | -33.2332933173269 | 0.00346896135886557 |
| ENSG00000110660 | -21.9194342095502 | 0.000235854083096956 |
| ENSG00000110900 | -14.5840229504579 | 0.0299976369432143 |
| ENSG00000110975 | -20.0274364785876 | 0.00272717077717902 |
| ENSG00000111664 | -15.6848179488836 | 0.00257413439830448 |
| ENSG00000112309 | -30.8820662768031 | 2.86639765886729E-06 |
| ENSG00000112541 | -18.4981562185719 | 0.0200177787462048 |
| ENSG00000112576 | -16.3205266840532 | 0.00281098485768811 |
| ENSG00000113356 | -30.4485219164118 | 0.0128237638132768 |
| ENSG00000113356 | -30.4485219164118 | 0.0128237638132768 |
| ENSG00000113360 | -13.2024460073839 | 0.000889075765212803 |
| ENSG00000113360 | -11.4206595619703 | 0.0395953589414958 |
| ENSG00000113396 | -10.7508473103328 | 0.000222229285000517 |
| ENSG00000113719 | -40.4600301659125 | 0.00364018917025852 |
| ENSG00000114391 | -14.7478070175439 | 0.000179247076510977 |
| ENSG00000114391 | -14.5098841172461 | 0.000278596416985043 |
| ENSG00000114473 | -12.5049648435403 | 0.00644783960827106 |
| ENSG00000114487 | -16.8965253036049 | 0.00508044584013533 |
| ENSG00000114487 | -20.4324228659076 | 0.00210512320114037 |
| ENSG00000114742 | -23.7758620689655 | 0.00189481574489691 |
| ENSG00000114742 | -21.9666048237477 | 0.00854398233095821 |
| ENSG00000114784 | -36.394156610108 | 3.79465602442319E-05 |
| ENSG00000115539 | -10.9105125366788 | 0.0163551846730581 |
| ENSG00000115616 | -12.828429432203 | 0.0317264087153831 |
| ENSG00000115761 | -15.6470588235294 | 1.34064823464507E-05 |
| ENSG00000116014 | -18.3325135268077 | 0.0328810899473227 |
| ENSG00000116017 | -24.6754643907337 | 0.00721459066489451 |
| ENSG00000116497 | -15.2564510990761 | 0.0325259241056017 |
| ENSG00000116497 | -11.8800281184097 | 0.0239625938500126 |
| ENSG00000116580 | -15.6574072798887 | 0.0388050857433615 |
| ENSG00000116815 | -15.8136401282222 | 0.000915128561518491 |
| ENSG00000116962 | -15.572105619499 | 0.0330821942950349 |
| ENSG00000117632 | -22.127940529173 | 0.00508881441496338 |
| ENSG00000117751 | -55.1142005958292 | 0.00823190880858581 |
| ENSG00000118985 | -15.2974664454833 | 0.0372468840756965 |
| ENSG00000119541 | -15.2993348115299 | 0.0255955821057175 |
| ENSG00000119559 | -41.9905956112853 | 0.00238126889066042 |
| ENSG00000119630 | -12.5075895567699 | 0.0450264295667423 |
| ENSG00000119630 | -10.7784431137725 | 0.00695950565232784 |
| ENSG00000119878 | -10.8361336915488 | 0.00655953508969455 |
| ENSG00000119878 | -10.9735694413114 | 0.00835818942302695 |
| ENSG00000120784 | -10.4694508425264 | 0.0102714888088208 |
| ENSG00000121274 | -10.2296314811394 | 0.0408612226104307 |
| ENSG00000121316 | -15.976285802279 | 0.0306290082498898 |
| ENSG00000121316 | -16.9739750803858 | 0.00365812101598888 |
| ENSG00000121316 | -13.1297947335683 | 0.0234652036229857 |
| ENSG00000121690 | -24.4730918764068 | 0.000156981828754297 |
| ENSG00000122691 | -14.2683562492956 | 0.000251244013240575 |
| ENSG00000122863 | -17.6983287497356 | 0.00205605071100639 |
| ENSG00000123130 | -37.3015873015873 | 5.00924521270897E-06 |
| ENSG00000123143 | -23.00803673938 | 0.0478792095442045 |
| ENSG00000123159 | -20.3386330786702 | 0.0177393022391982 |
| ENSG00000123178 | -14.8057128610607 | 0.0275489351598191 |
| ENSG00000123360 | -15.4106531766106 | 0.00851060967044734 |
| ENSG00000123407 | -10.9556347791642 | 0.0142153062123272 |
| ENSG00000124222 | -12.3358585858586 | 0.00423793375162113 |
| ENSG00000124614 | -10.6719405397908 | 0.04406634342951 |
| ENSG00000125207 | -23.0804597701149 | 1.12993284829733E-05 |
| ENSG00000125375 | -11.9933456946298 | 0.0395889380296399 |
| ENSG00000125484 | -10.9840042359837 | 0.00307962939304754 |
| ENSG00000125510 | -25 | 0.0405222568610454 |
| ENSG00000125703 | -15.0007463800567 | 0.0266746959628891 |
| ENSG00000125787 | -12.9496402877698 | 0.00114656647454784 |
| ENSG00000125787 | -19.3181818181818 | 0.00173392732935099 |
| ENSG00000125820 | -11.3668021986296 | 0.00382045804138979 |
| ENSG00000126391 | -22.9202037351443 | 0.000154722264355363 |
| ENSG00000126562 | -31.8491609335819 | 2.09007355450092E-05 |
| ENSG00000126870 | -15.622650240037 | 0.0286387794400106 |
| ENSG00000126882 | -11.474980351061 | 0.0431523638296012 |
| ENSG00000127125 | -17.3795119886894 | 0.0283863465926657 |
| ENSG00000127415 | -36.1538461538462 | 0.000655153273081841 |
| ENSG00000127529 | -26.0351966873706 | 0.0223192198423381 |
| ENSG00000127586 | -23.5960889504197 | 0.0106052756412346 |
| ENSG00000127663 | -33.3638743455497 | 0.000100926955366392 |
| ENSG00000127990 | -32.3784722222222 | 0.00950903648521135 |
| ENSG00000128011 | -20.6728860658992 | 0.00861580075079421 |
| ENSG00000128016 | -18.5567010309278 | 0.013230362760599 |
| ENSG00000128016 | -18.6214217731898 | 0.0353039817458317 |
| ENSG00000128298 | -20.8948991391494 | 0.0175681937283948 |
| ENSG00000128422 | -13.7385720060132 | 0.0117581512531377 |
| ENSG00000129472 | -21.1173943261515 | 0.000387158567669044 |
| ENSG00000129484 | -10.2674847144049 | 5.0998273735677E-05 |
| ENSG00000129654 | -10.6407004024644 | 6.26010353840451E-06 |
| ENSG00000129654 | -20.2244563946692 | 6.16199680477102E-11 |
| ENSG00000129654 | -13.5787172011662 | 0.00135771137135729 |
| ENSG00000130045 | -12.9216699638587 | 0.00155013269955672 |
| ENSG00000130045 | -15.3130946203079 | 0.0218319135747878 |
| ENSG00000130159 | -18.7433778342869 | 0.0410766095470683 |
| ENSG00000130182 | -13.5927280789269 | 0.045902210404969 |
| ENSG00000130294 | -18.8954248366013 | 0.00877421386783813 |
| ENSG00000130294 | -28.8836229594523 | 7.24042379336115E-05 |
| ENSG00000130487 | -15.3873507747016 | 0.000529655572901532 |
| ENSG00000130538 | -42.8571428571429 | 0.00933674892573389 |
| ENSG00000130714 | -14.0240632969332 | 0.00963961443844441 |
| ENSG00000130717 | -11.0306725090493 | 0.0150416028353088 |
| ENSG00000130720 | -19.3835242771413 | 0.0472934196741187 |
| ENSG00000131015 | -17.3019350127784 | 0.0489828462430321 |
| ENSG00000131381 | -24.6941896024465 | 0.0275157239159661 |
| ENSG00000131398 | -35.6111111111111 | 0.0356514356017021 |
| ENSG00000131409 | -38.4105960264901 | 0.0015304011826433 |
| ENSG00000131620 | -23.3758708893317 | 7.69815899489769E-05 |
| ENSG00000132199 | -12.1509735929581 | 0.00665502017260467 |
| ENSG00000132773 | -18.0035650623886 | 0.00122867731832998 |
| ENSG00000133111 | -21.1876681150424 | 0.0249387687490626 |
| ENSG00000133243 | -11.1267839362761 | 0.00243882056963042 |
| ENSG00000133321 | -13.4793202549044 | 0.0211467246998243 |
| ENSG00000133321 | -16.0883591014595 | 2.83828725507107E-05 |
| ENSG00000133393 | -10.355408388521 | 0.00435617482647642 |
| ENSG00000133937 | -15.1024651024651 | 0.00679486399082597 |
| ENSG00000133937 | -15.7077476299444 | 0.0373418607525007 |
| ENSG00000133943 | -15.2855105139649 | 0.00238509340205644 |
| ENSG00000133958 | -17.9266379142823 | 5.11406800358734E-06 |
| ENSG00000133958 | -29.7367668097282 | 1.08787851078348E-08 |
| ENSG00000133958 | -23.9583333333333 | 0.0470977877712396 |
| ENSG00000133983 | -25.126213592233 | 0.0333275081725526 |
| ENSG00000134160 | -21.6216216216216 | 0.0311442667394412 |
| ENSG00000134215 | -16.6288096607246 | 0.000979592583486402 |
| ENSG00000134259 | -19.9652777777778 | 0.00459426665426082 |
| ENSG00000134686 | -16.0714285714286 | 0.0353876886095324 |
| ENSG00000135070 | -30.6306306306306 | 0.0287505845364152 |
| ENSG00000135070 | -29.2885375494071 | 0.0148111641287168 |
| ENSG00000135116 | -13.5057471264368 | 0.034558826714043 |
| ENSG00000135116 | -13.0969049373618 | 0.0166690647998171 |
| ENSG00000135452 | -15.9663763909047 | 0.0364290421425044 |
| ENSG00000135625 | -13.1926672653561 | 0.000180728729306327 |
| ENSG00000135747 | -14.5836288835296 | 0.00349485787643516 |
| ENSG00000135747 | -13.4898365882822 | 0.0171288842575121 |
| ENSG00000135776 | -10.0856722215261 | 0.0439649286170108 |
| ENSG00000135821 | -16.3918557262899 | 0.000488928158744758 |
| ENSG00000135821 | -18.4593133896628 | 0.00119169070034406 |
| ENSG00000135824 | -12.9420579420579 | 0.0118868224955648 |
| ENSG00000135968 | -24.1077441077441 | 0.019223536336163 |
| ENSG00000136146 | -30.6409130816506 | 0.0269348481620303 |
| ENSG00000136327 | -32.3391812865497 | 0.00880486435194367 |
| ENSG00000136352 | -13.5327327327327 | 0.0236714264555738 |
| ENSG00000136485 | -11.0469225080122 | 0.0100108377098408 |
| ENSG00000136630 | -15.0338171894158 | 0.0403037861767516 |
| ENSG00000136861 | -12.3891937526382 | 0.00589132460144071 |
| ENSG00000137094 | -22.8049057460822 | 3.40669087085994E-05 |
| ENSG00000137094 | -13.0273229458248 | 0.0325217962410283 |
| ENSG00000137198 | -28.0144806460596 | 0.000313980355193008 |
| ENSG00000138131 | -15.5605381165919 | 0.025521439514233 |
| ENSG00000138134 | -20.9755709397629 | 0.0408173872099301 |
| ENSG00000138600 | -10.1742758959254 | 0.0348499608751473 |
| ENSG00000138834 | -10.4375895004986 | 0.0167826181251203 |
| ENSG00000138835 | -13.2712583869643 | 0.0392329312376509 |
| ENSG00000138944 | -37.8117457763475 | 0.0169445660029793 |
| ENSG00000139192 | -13.983892321271 | 0.00885711294205875 |
| ENSG00000139192 | -11.6258525762183 | 0.00751529202601257 |
| ENSG00000139714 | -11.1285362853629 | 0.00582711461235512 |
| ENSG00000139899 | -15.5924528301887 | 0.00708357967547035 |
| ENSG00000140015 | -13.9915288422751 | 0.0428923094078256 |
| ENSG00000140044 | -19.5838163051278 | 0.000727341401953011 |
| ENSG00000140104 | -13.5344543356413 | 0.0289879131876795 |
| ENSG00000140416 | -23.959373959374 | 4.21840608750738E-05 |
| ENSG00000140416 | -20.4453441295547 | 0.0138015923316579 |
| ENSG00000140451 | -18.4220251293422 | 0.0260071904102253 |
| ENSG00000140474 | -23.1256085686465 | 0.0425453638576046 |
| ENSG00000141337 | -13.456108559147 | 0.000382942170809787 |
| ENSG00000141391 | -13.0301243304339 | 0.00610268151373784 |
| ENSG00000141867 | -25.8426966292135 | 0.00119747111310554 |
| ENSG00000141873 | -19.2689677629437 | 0.0139942362377622 |
| ENSG00000141905 | -35.3565571954084 | 6.5431611235357E-09 |
| ENSG00000141905 | -27.0154620640058 | 0.00212688984984319 |
| ENSG00000142273 | -19.4395149364094 | 0.0341414149043605 |
| ENSG00000142507 | -11.1580362944047 | 0.0418281146152015 |
| ENSG00000142621 | -45.6707317073171 | 0.000863683454995586 |
| ENSG00000142731 | -21.0726198609492 | 0.000484552422247172 |
| ENSG00000142867 | -13.1578947368421 | 0.00619428006528507 |
| ENSG00000142867 | -13.1578947368421 | 0.00619428006528507 |
| ENSG00000143033 | -18.3116883116883 | 0.0284952940005011 |
| ENSG00000143033 | -18.3116883116883 | 0.0284952940005011 |
| ENSG00000143355 | -12.3834498834499 | 0.0346025307894399 |
| ENSG00000143374 | -15.6125484033896 | 0.0155077808974864 |
| ENSG00000143374 | -17.1239876794688 | 0.00428702673106584 |
| ENSG00000143379 | -13.626623811437 | 0.00440828768941389 |
| ENSG00000143479 | -13.636249655207 | 0.0401229285764378 |
| ENSG00000143761 | -18.0174498055293 | 0.00381098926362394 |
| ENSG00000143761 | -22.6227795193312 | 0.0255923303695082 |
| ENSG00000143867 | -15.8305140941493 | 7.6395234090418E-06 |
| ENSG00000143921 | -13.8744216787839 | 0.0186267917434666 |
| ENSG00000144229 | -22.6389063087922 | 0.034404389349106 |
| ENSG00000144909 | -16.7247386759582 | 0.00327712188231578 |
| ENSG00000145029 | -10.7424071991001 | 0.0174515769503486 |
| ENSG00000145214 | -36.1538461538462 | 0.000655153273081841 |
| ENSG00000145730 | -20.8618331053352 | 0.0486535583651227 |
| ENSG00000145734 | -14.2168981776475 | 0.0331361591998198 |
| ENSG00000146197 | -11.3651300952356 | 0.0309216170969307 |
| ENSG00000146250 | -21.2040252916555 | 0.00848045384869553 |
| ENSG00000146250 | -22.0065591325882 | 0.00296624203140471 |
| ENSG00000146374 | -15.4091075682609 | 0.00783375990203119 |
| ENSG00000146374 | -20.1172319599363 | 0.0115010741507591 |
| ENSG00000146374 | -38.2486388384755 | 1.37237832032523E-05 |
| ENSG00000147246 | -20.514950166113 | 0.0239095391739468 |
| ENSG00000147251 | -26.3721552878179 | 0.000932126740918554 |
| ENSG00000147394 | -11.4991684485626 | 0.0297789394824325 |
| ENSG00000147548 | -13.7248594580519 | 0.00616478390735392 |
| ENSG00000147548 | -13.040664654268 | 0.0288179691676682 |
| ENSG00000148655 | -15.4956427015251 | 0.00901490620617616 |
| ENSG00000149328 | -14.6648803730994 | 0.0012525258652476 |
| ENSG00000149328 | -19.1528624152433 | 0.00214493242740375 |
| ENSG00000149451 | -14.8878885783086 | 0.0162992720438351 |
| ENSG00000149582 | -14.3974688825534 | 0.0247275946396006 |
| ENSG00000149582 | -14.0256827368629 | 0.000459350694151369 |
| ENSG00000149654 | -15.4766951290902 | 0.015362223159322 |
| ENSG00000149654 | -20.1642804175461 | 0.000992524624161035 |
| ENSG00000151229 | -13.166266050701 | 0.00173813692311102 |
| ENSG00000151725 | -15.0714229652304 | 0.0395704516303525 |
| ENSG00000152193 | -15.2238805970149 | 0.0308984735161578 |
| ENSG00000152380 | -23.051948051948 | 0.0348877300166107 |
| ENSG00000152700 | -29.6397151235861 | 0.0440101312546697 |
| ENSG00000152977 | -22.3263027295285 | 0.0148703640447006 |
| ENSG00000153201 | -25.95867173846 | 6.03476649807237E-07 |
| ENSG00000153495 | -18.1541313559322 | 0.0412507118962655 |
| ENSG00000153786 | -12.0300751879699 | 0.0146452802851786 |
| ENSG00000153975 | -17.2638259994582 | 0.00550962296253264 |
| ENSG00000154380 | -10.5780632411067 | 0.00338062852938879 |
| ENSG00000154485 | -22.2101692240937 | 0.00385139279194034 |
| ENSG00000154957 | -10.5852304975721 | 0.0272186139291782 |
| ENSG00000154957 | -11.9181175784949 | 0.0231333663975567 |
| ENSG00000156017 | -13.5395109245756 | 0.0214605900398261 |
| ENSG00000156398 | -13.6112071947423 | 0.0442108996079291 |
| ENSG00000157193 | -10.0792079207921 | 0.00307962939304754 |
| ENSG00000158553 | -16.7250599299281 | 1.01677867799016E-06 |
| ENSG00000158850 | -16.0014655212734 | 0.00265513690925244 |
| ENSG00000159086 | -48.6111111111111 | 0.00341946937420944 |
| ENSG00000159111 | -15.317317888898 | 0.0290015907298838 |
| ENSG00000159217 | -21.919589706017 | 4.65076018775794E-13 |
| ENSG00000159217 | -21.8456181679169 | 6.08350558115787E-14 |
| ENSG00000159217 | -13.1358159469513 | 0.00272604922768381 |
| ENSG00000159217 | -17.1470999301188 | 0.00963809575114907 |
| ENSG00000159217 | -29.0376091029566 | 9.73097876752809E-21 |
| ENSG00000159217 | -28.7603305785124 | 5.92217776925561E-12 |
| ENSG00000159409 | -15.4835847382431 | 0.0188191907781351 |
| ENSG00000159592 | -30.1703163017032 | 4.96306823337162E-05 |
| ENSG00000159592 | -21.9911969517803 | 0.00012860799914889 |
| ENSG00000159873 | -23.3333333333333 | 0.0427919778007068 |
| ENSG00000160284 | -10.0910730522142 | 0.00355482199628395 |
| ENSG00000160789 | -23.2076407839246 | 0.0205853009889123 |
| ENSG00000160951 | -14.4109149277689 | 0.038467462223309 |
| ENSG00000160959 | -23.3835005574136 | 0.00101322585276091 |
| ENSG00000161677 | -23.7462537462537 | 0.0236354015373858 |
| ENSG00000161681 | -31.2189740761169 | 0.0241663529211224 |
| ENSG00000161914 | -42.1052631578947 | 0.00358926842407119 |
| ENSG00000162194 | -26.884236453202 | 1.99755793333376E-06 |
| ENSG00000162374 | -15.7203751065644 | 0.0214515366994642 |
| ENSG00000162510 | -34.2105263157895 | 0.0341490515681589 |
| ENSG00000162526 | -11.6745825034472 | 0.022486348070365 |
| ENSG00000162572 | -14.9247403010388 | 0.0205495188120766 |
| ENSG00000162576 | -23.2708528584817 | 0.0018469989151733 |
| ENSG00000162598 | -13.216585768218 | 0.029516186368158 |
| ENSG00000162738 | -23.0551626591231 | 0.0445079711706162 |
| ENSG00000163216 | -29.9435028248588 | 0.0254715229528836 |
| ENSG00000163354 | -10.1694915254237 | 0.00590858951859975 |
| ENSG00000163354 | -10.5489734343955 | 0.0267551521436017 |
| ENSG00000163357 | -10.1694915254237 | 0.00590858951859975 |
| ENSG00000163508 | -16.0858149906488 | 0.041677504344468 |
| ENSG00000163565 | -11.0395892164983 | 0.00942619045704688 |
| ENSG00000163565 | -16.6825901668196 | 5.06081383180988E-06 |
| ENSG00000163792 | -16.4178297089689 | 0.0456416556009675 |
| ENSG00000163935 | -28.2106782106782 | 0.0451608969415679 |
| ENSG00000164008 | -15.6722709914199 | 0.025593910912043 |
| ENSG00000164049 | -21.8555093555094 | 0.0348123187776853 |
| ENSG00000164253 | -12.1276434472826 | 0.0140062768426212 |
| ENSG00000164576 | -10.2767967431584 | 0.00185764298357138 |
| ENSG00000164808 | -24.6117882785106 | 0.00106320574342346 |
| ENSG00000164808 | -14.6056693797362 | 0.0088680500066369 |
| ENSG00000164853 | -10.6209444844989 | 0.0440954421453351 |
| ENSG00000164898 | -20.2627939142462 | 0.00811583720494599 |
| ENSG00000165030 | -12.2485195433424 | 0.00382368928474016 |
| ENSG00000165169 | -54.8235294117647 | 0.0246917998898834 |
| ENSG00000165181 | -13.645390070922 | 0.0108554690065924 |
| ENSG00000165181 | -15.7554434688752 | 1.17460044209381E-05 |
| ENSG00000165181 | -11.5519875424874 | 0.00246095170022225 |
| ENSG00000165194 | -15.5302183471198 | 0.0210567244935989 |
| ENSG00000165572 | -10.0391913480215 | 0.00368247816992669 |
| ENSG00000165626 | -18.5858585858586 | 0.0197444308039569 |
| ENSG00000165626 | -10.4583151462244 | 0.0343280241839522 |
| ENSG00000165688 | -12.2080440996325 | 1.88001695122534E-05 |
| ENSG00000165714 | -11.8648473034438 | 0.00183779313657834 |
| ENSG00000165716 | -15.6248478652451 | 0.0196132833917005 |
| ENSG00000165731 | -12.1427535180618 | 0.0180091631493048 |
| ENSG00000165775 | -12.0743034055728 | 3.59947718491836E-06 |
| ENSG00000165775 | -15.0654403961797 | 9.86078794046642E-09 |
| ENSG00000165799 | -24.1837299391256 | 0.00857990103345192 |
| ENSG00000165799 | -19.8527720266851 | 0.0447136844752293 |
| ENSG00000165801 | -24.4671912000611 | 0.000480223775456203 |
| ENSG00000165959 | -26.508875739645 | 0.0066475031340021 |
| ENSG00000165973 | -20.0363825363825 | 0.0165481327387899 |
| ENSG00000165985 | -30.5448408871745 | 1.2732236675273E-08 |
| ENSG00000166091 | -19.7257850508625 | 0.027040457578079 |
| ENSG00000166173 | -13.8671875 | 0.00281660749850881 |
| ENSG00000166173 | -14.943388164922 | 0.000592748819450959 |
| ENSG00000166377 | -15.276467878841 | 6.07950471947656E-06 |
| ENSG00000166426 | -22.4036511156187 | 0.0437852700044924 |
| ENSG00000166592 | -15.2411982984886 | 0.0135579700736489 |
| ENSG00000166592 | -25.5485893416928 | 0.0100758731655927 |
| ENSG00000166803 | -20.5533596837945 | 0.00278344805297171 |
| ENSG00000166803 | -18.065229408513 | 0.00528917522230573 |
| ENSG00000166847 | -26.7138142385667 | 0.0319767800481153 |
| ENSG00000166896 | -12.7930294300401 | 0.00190635401196762 |
| ENSG00000167074 | -21.9168717528028 | 0.00476822611347794 |
| ENSG00000167081 | -11.5329115329115 | 0.0192254916025242 |
| ENSG00000167470 | -10.062893081761 | 0.0449721395775338 |
| ENSG00000167476 | -38.25 | 0.0195079520010307 |
| ENSG00000167513 | -18.2418326468431 | 0.00513538343420379 |
| ENSG00000167523 | -16.751269035533 | 5.8315626359607E-08 |
| ENSG00000167523 | -17.4025110168787 | 2.59983673643989E-05 |
| ENSG00000167526 | -11.1692867520976 | 0.00118618030478542 |
| ENSG00000167634 | -16.58892394933 | 0.0196502517532655 |
| ENSG00000167671 | -12.8785228377065 | 0.013573497275049 |
| ENSG00000167851 | -10.7694353573233 | 0.00869527291826573 |
| ENSG00000167851 | -12.1889157822876 | 0.0117343371568843 |
| ENSG00000167881 | -26.2898150453897 | 0.000434071699893402 |
| ENSG00000167996 | -10.9699648123324 | 0.0187914208163955 |
| ENSG00000168038 | -22.1369316957552 | 0.00724974359040535 |
| ENSG00000168038 | -25 | 0.00266342702191425 |
| ENSG00000168175 | -10.1085977789299 | 2.69470160653853E-06 |
| ENSG00000168175 | -13.507607398568 | 9.77047420209518E-06 |
| ENSG00000168269 | -25.6733573511752 | 1.75027828135518E-09 |
| ENSG00000168269 | -10.7177100894752 | 0.0055792105653023 |
| ENSG00000168269 | -18.1694737322562 | 0.00716701190068403 |
| ENSG00000168303 | -10.4314805239289 | 0.000306902994481113 |
| ENSG00000169057 | -19.6876932591218 | 0.026724249858753 |
| ENSG00000169083 | -23.5576923076923 | 0.0187144195458153 |
| ENSG00000169084 | -29.0322580645161 | 0.00483664148292746 |
| ENSG00000169093 | -31.3492063492063 | 0.0365158697709021 |
| ENSG00000169100 | -28.75 | 0.0250757960225838 |
| ENSG00000169230 | -22.6702952333828 | 0.0422632036507693 |
| ENSG00000169242 | -15.2898949137421 | 0.00804460478387819 |
| ENSG00000169439 | -14.8148148148148 | 0.0348352182574728 |
| ENSG00000169609 | -24.4485294117647 | 0.00825846345734721 |
| ENSG00000170421 | -11.9796380090498 | 0.0442678426582623 |
| ENSG00000170906 | -17.3944093042236 | 0.00018791758917765 |
| ENSG00000170961 | -23.5421686746988 | 0.00034629022757534 |
| ENSG00000170961 | -10.357760079819 | 0.000129085578271494 |
| ENSG00000171357 | -26.2054681027341 | 0.00139141019560311 |
| ENSG00000171448 | -10.0970016329942 | 0.0272909112444354 |
| ENSG00000171490 | -10.0909620468701 | 0.0304261330467838 |
| ENSG00000171540 | -16.0863742885839 | 0.0218407491899384 |
| ENSG00000171540 | -16.5043695380774 | 0.0490076716034 |
| ENSG00000171695 | -18.0929778025967 | 8.69053858390073E-05 |
| ENSG00000171695 | -20.9542066027689 | 0.0020914999076222 |
| ENSG00000171777 | -16.0386774797255 | 0.000440982847656926 |
| ENSG00000171811 | -16.2222724362596 | 0.0150934255049598 |
| ENSG00000171811 | -19.6726772550452 | 0.00308927350924729 |
| ENSG00000171824 | -12.1212121212121 | 0.0220298071571259 |
| ENSG00000171827 | -20.2595729013255 | 0.00112689504985543 |
| ENSG00000171827 | -10.5717191529549 | 0.0405200413725175 |
| ENSG00000171885 | -21.1733080328906 | 0.0300082453887271 |
| ENSG00000172009 | -24.4159883528555 | 0.00479288133087388 |
| ENSG00000172175 | -24.6776273372018 | 0.0251899708065854 |
| ENSG00000172175 | -32.8273244781784 | 0.016068778755576 |
| ENSG00000172175 | -13.6658199347632 | 0.0450575089860559 |
| ENSG00000172175 | -18.6102466574458 | 0.012763378554628 |
| ENSG00000172183 | -14.7980689979983 | 0.00039915484149278 |
| ENSG00000172201 | -11.4285714285714 | 0.042727357222922 |
| ENSG00000172247 | -24.1772860943845 | 0.000756263656187047 |
| ENSG00000172247 | -22.1130952380952 | 0.0151972472985044 |
| ENSG00000172543 | -17.4823053589484 | 0.0217420827203701 |
| ENSG00000172977 | -15.757705479452 | 0.0330323736724333 |
| ENSG00000173530 | -16.4157644250816 | 0.0412017199604227 |
| ENSG00000173535 | -23.287380699894 | 0.0342494992145822 |
| ENSG00000173572 | -19.6588967145891 | 3.55848863666085E-06 |
| ENSG00000173572 | -16.3610193887055 | 0.0037142313706764 |
| ENSG00000173838 | -10.265975242556 | 0.0440156989220841 |
| ENSG00000173926 | -37.8290903821071 | 1.03898737983963E-08 |
| ENSG00000174125 | -14.4927536231884 | 0.0224341959055047 |
| ENSG00000174130 | -14.4927536231884 | 0.0224341959055047 |
| ENSG00000174238 | -19.4229028637631 | 0.000501109262746203 |
| ENSG00000174358 | -18.1610431509612 | 0.0369536902924354 |
| ENSG00000174460 | -13.1848284166165 | 0.0180513136022626 |
| ENSG00000174527 | -18.6987248716345 | 0.0295172703754136 |
| ENSG00000174586 | -16.0897801884099 | 0.0232162403378778 |
| ENSG00000174611 | -10.2596396047278 | 0.000836643340794033 |
| ENSG00000174917 | -27.7447219789181 | 7.86270040653903E-05 |
| ENSG00000175175 | -17.5662061024755 | 0.00310539182240812 |
| ENSG00000175175 | -13.876012145749 | 0.0223192198423381 |
| ENSG00000175938 | -19.1143728869465 | 0.000609551618847887 |
| ENSG00000176720 | -15.028624757978 | 0.000491904426861521 |
| ENSG00000176720 | -18.056002574831 | 0.000841690120167665 |
| ENSG00000176973 | -27.5773195876289 | 0.0385986893303241 |
| ENSG00000177042 | -12.1807497077709 | 0.00600774773082857 |
| ENSG00000177106 | -16.1576011157601 | 0.0274773889313824 |
| ENSG00000177106 | -12.1807497077709 | 0.00600774773082857 |
| ENSG00000177674 | -18.691169878978 | 0.0283655568248335 |
| ENSG00000177992 | -10.8843537414966 | 0.0114479177109907 |
| ENSG00000178201 | -13.7678872053872 | 0.0129363494631834 |
| ENSG00000178209 | -12.8916281458654 | 0.0224823455081024 |
| ENSG00000178234 | -18.9923469387755 | 0.0193669089939285 |
| ENSG00000178234 | -22.2923816060398 | 9.30459330102401E-05 |
| ENSG00000178645 | -12.648988053376 | 0.0469137584786117 |
| ENSG00000179094 | -13.4310850439883 | 0.0355759656096261 |
| ENSG00000179331 | -21.9194342095502 | 0.000235854083096956 |
| ENSG00000180287 | -24.0886330665918 | 0.00852227254789977 |
| ENSG00000180818 | -11.8653524270039 | 0.0285551186534443 |
| ENSG00000180834 | -18.060221475675 | 0.0201026712084086 |
| ENSG00000181104 | -13.6891228909896 | 0.0435232730481889 |
| ENSG00000181104 | -18.0640976638058 | 1.14813876834968E-05 |
| ENSG00000181104 | -22.6280986455405 | 0.000111828657367155 |
| ENSG00000181192 | -12.6157900070944 | 0.00754488631590946 |
| ENSG00000181350 | -18.2209259934378 | 0.000396760300992857 |
| ENSG00000181392 | -13.9805515702216 | 0.000969860854511591 |
| ENSG00000182111 | -10.9364529819075 | 0.012680610291506 |
| ENSG00000182149 | -35.0862068965517 | 0.00826722019021418 |
| ENSG00000182256 | -16.1525907792738 | 0.038574221482599 |
| ENSG00000182348 | -18.1128025756191 | 0.0194939041437827 |
| ENSG00000182508 | -13.0498281786942 | 0.032867434303606 |
| ENSG00000182508 | -14.4618262692722 | 0.00166153295956751 |
| ENSG00000182687 | -26.2898150453897 | 0.000434071699893402 |
| ENSG00000183048 | -18.5163996948894 | 0.0208771553597651 |
| ENSG00000183715 | -10.8016877637131 | 0.00612124554796258 |
| ENSG00000183733 | -10.0493848806289 | 0.00256565663957455 |
| ENSG00000183837 | -30.594441063096 | 0.00594580436285597 |
| ENSG00000183837 | -28.5073037127206 | 5.99242522804126E-05 |
| ENSG00000184209 | -19.0350877192982 | 0.00357549061671981 |
| ENSG00000184209 | -14.5669093648004 | 0.0101738819058995 |
| ENSG00000184220 | -10.7100415923945 | 0.0189969303520165 |
| ENSG00000184226 | -20.1388888888889 | 0.00122241909616555 |
| ENSG00000184254 | -14.297763338748 | 0.0098100477552559 |
| ENSG00000184445 | -28.9085545722714 | 1.10468522189305E-19 |
| ENSG00000184470 | -10.5525364848336 | 1.22641272400171E-07 |
| ENSG00000184486 | -11.9779353821907 | 0.0197742056775144 |
| ENSG00000184486 | -14.6947506993582 | 0.0308993694062091 |
| ENSG00000184903 | -17.3484848484848 | 0.0100846794029084 |
| ENSG00000185085 | -12.7741935483871 | 0.00355548903022132 |
| ENSG00000185164 | -28.9317134478425 | 0.00766039313216227 |
| ENSG00000185198 | -20.9677419354839 | 0.00800363463509878 |
| ENSG00000185274 | -36.7777777777778 | 4.13866236096393E-08 |
| ENSG00000185551 | -25 | 4.12989508384209E-05 |
| ENSG00000186094 | -15.7203751065644 | 0.0214515366994642 |
| ENSG00000186994 | -17.9708162334701 | 0.0380436486008334 |
| ENSG00000187049 | -21.4250497288291 | 0.000190407930326322 |
| ENSG00000187094 | -30.3257394084732 | 0.0148136929111902 |
| ENSG00000187773 | -24.3055555555556 | 0.010424771548779 |
| ENSG00000187800 | -18.8722605235133 | 0.00097347513700514 |
| ENSG00000188051 | -13.5283993115318 | 0.0284862998415288 |
| ENSG00000188051 | -16.4764492753623 | 0.00830673370301929 |
| ENSG00000188177 | -24.021164021164 | 0.00403947268078688 |
| ENSG00000188389 | -18.1108669779365 | 0.00597294639909556 |
| ENSG00000188501 | -16.9491525423729 | 0.0264267102325099 |
| ENSG00000188529 | -15.3846153846154 | 0.0488977801585413 |
| ENSG00000188554 | -16.2792058516196 | 2.78883070497941E-05 |
| ENSG00000188706 | -10.5804820799856 | 0.0407427459034703 |
| ENSG00000188706 | -18.876314577561 | 0.000205941242025698 |
| ENSG00000188807 | -14.1644210192597 | 0.00214158534118136 |
| ENSG00000188921 | -16.1585066317341 | 0.0076260149012931 |
| ENSG00000188921 | -17.3934430588423 | 0.00829600867835282 |
| ENSG00000188981 | -10.4969898808761 | 0.0245604522604636 |
| ENSG00000189099 | -10.7433380084151 | 0.0471893075050864 |
| ENSG00000189120 | -26.8765133171913 | 0.0118293720940106 |
| ENSG00000189120 | -16.2003903708523 | 0.0123035857744294 |
| ENSG00000189134 | -21.6028708133971 | 0.0420091386650367 |
| ENSG00000196110 | -13.8728706833698 | 0.0420544804809331 |
| ENSG00000196123 | -11.8119658119658 | 0.0011790794908365 |
| ENSG00000196381 | -10.4694508425264 | 0.0102714888088208 |
| ENSG00000196407 | -16.2735824568326 | 1.63439555606411E-10 |
| ENSG00000196407 | -16.9854280510018 | 3.65742313994721E-10 |
| ENSG00000196440 | -21.7175066312997 | 0.0141480507556097 |
| ENSG00000196460 | -12.2420683467906 | 9.84035291008814E-05 |
| ENSG00000196636 | -15.222285848148 | 0.0128524806273957 |
| ENSG00000196653 | -28.7365177195686 | 0.000498526638073357 |
| ENSG00000196923 | -10.1846285959639 | 0.0125269750370792 |
| ENSG00000197079 | -15.5820105820106 | 0.0385511399220718 |
| ENSG00000197081 | -21.8181818181818 | 0.00318594967466865 |
| ENSG00000197128 | -17.6767676767677 | 0.0134216004209188 |
| ENSG00000197128 | -20.2912102591504 | 0.0247558735443318 |
| ENSG00000197451 | -11.3869559539578 | 0.00256448161697349 |
| ENSG00000197451 | -21.9268510258698 | 1.00569142011319E-07 |
| ENSG00000197557 | -28.8865979381443 | 0.0260989117867014 |
| ENSG00000197766 | -27.8711484593837 | 0.0367699367462675 |
| ENSG00000197785 | -15.5625079271128 | 0.0058251957156053 |
| ENSG00000197935 | -21.5945242456377 | 0.000214694174478014 |
| ENSG00000197991 | -15.5700753252682 | 0.0450051741900873 |
| ENSG00000198125 | -10.6796116504854 | 0.041804252368166 |
| ENSG00000198125 | -10.6796116504854 | 0.041804252368166 |
| ENSG00000198171 | -11.3691260430391 | 0.0492812514169258 |
| ENSG00000198208 | -12.0056651051313 | 0.0134097078395219 |
| ENSG00000198231 | -10.7800751879699 | 0.0425875740986927 |
| ENSG00000198464 | -16.8132902878666 | 0.0230462164545817 |
| ENSG00000198561 | -10.5533596837945 | 0.00500520808218314 |
| ENSG00000198633 | -12.5153938057164 | 0.0405828566192806 |
| ENSG00000198729 | -15.178272046496 | 0.00629617981725982 |
| ENSG00000198797 | -14.8354404976921 | 0.00662519298755446 |
| ENSG00000198885 | -24.6820349761526 | 0.025466515731314 |
| ENSG00000198911 | -10.7121944078466 | 0.00210231479703907 |
| ENSG00000198944 | -15.3587625526401 | 0.0293127616163585 |
| ENSG00000203883 | -12.3390634262004 | 0.0146275199407374 |
| ENSG00000204128 | -24.5085483767689 | 0.0052252260379734 |
| ENSG00000204128 | -33.2793334876186 | 9.50251948882142E-06 |
| ENSG00000204161 | -18.4558131926553 | 0.0110080534024279 |
| ENSG00000204161 | -16.8376205787781 | 0.0451923472289257 |
| ENSG00000204308 | -18.1073374959397 | 0.0218284313380497 |
| ENSG00000204308 | -19.8579431772709 | 0.0166281458453145 |
| ENSG00000204397 | -25.547055684042 | 0.036555069792132 |
| ENSG00000204599 | -22.2016522344979 | 0.00142926075835363 |
| ENSG00000204599 | -15.4369398207426 | 0.0188931632771714 |
| ENSG00000204704 | -14.9842086793777 | 0.0295866997565394 |
| ENSG00000204704 | -14.9842086793777 | 0.0295866997565394 |
| ENSG00000204889 | -13.903743315508 | 4.01874758669504E-05 |
| ENSG00000204909 | -10.4985439596305 | 0.000245160528169384 |
| ENSG00000204920 | -10.3541162486425 | 0.0375594462005039 |
| ENSG00000205221 | -10.2626190688151 | 0.0166542415969332 |
| ENSG00000205364 | -14.3932579717191 | 0.0209663026917388 |
| ENSG00000205364 | -22.7849311575727 | 2.75613743411553E-08 |
| ENSG00000205544 | -25.2622377622378 | 0.0374908539061022 |
| ENSG00000205659 | -20.3245942571785 | 0.00640464663479342 |
| ENSG00000205659 | -17.2039116262224 | 0.00192938109327571 |
| ENSG00000205702 | -31.1950970377937 | 0.00353438535321241 |
| ENSG00000205702 | -30.6146572104019 | 0.00836764608199518 |
| ENSG00000205730 | -16.9912609238452 | 0.00548780640878567 |
| ENSG00000206172 | -17.1837108213224 | 0.00285232058509603 |
| ENSG00000206262 | -12.5686982199984 | 0.0372534055870424 |
| ENSG00000206262 | -13.4922856787358 | 0.0125498653646383 |
| ENSG00000211644 | -10.7890102148644 | 0.00621622387146682 |
| ENSG00000211647 | -22.3450830713965 | 0.0119776508408652 |
| ENSG00000212747 | -17.5645161290323 | 0.034797418404917 |
| ENSG00000213463 | -25.126213592233 | 0.0333275081725526 |
| ENSG00000213999 | -18.0312897671981 | 7.66402129046302E-11 |
| ENSG00000213999 | -11.0689307272696 | 2.42044046543343E-05 |
| ENSG00000214212 | -20.3813785733369 | 0.00225671200629606 |
| ENSG00000214891 | -13.9580680757151 | 0.0388767095822126 |
| ENSG00000215217 | -25.9943714821764 | 3.04217072748092E-05 |
| ENSG00000215472 | -27.8483245149912 | 0.0397619153720593 |
| ENSG00000215817 | -13.5190841590305 | 0.00675659074205503 |
| ENSG00000217236 | -20.5956813104989 | 0.0287502245020191 |
| ENSG00000221988 | -15.437030075188 | 0.000881217599989722 |
| ENSG00000221988 | -12.5576953684546 | 0.0151972472985044 |
| ENSG00000223547 | -41.025641025641 | 0.048531701906358 |
| ENSG00000223547 | -41.025641025641 | 0.048531701906358 |
| ENSG00000223547 | -36.1852433281005 | 0.00120676448013167 |
| ENSG00000224041 | -26.5662172878668 | 0.0141737948892525 |
| ENSG00000224470 | -35.0862068965517 | 0.00826722019021418 |
| ENSG00000232237 | -18.4426964277711 | 0.00706947340347165 |
| ENSG00000232434 | -15.4621775059731 | 6.92750811815583E-05 |
| ENSG00000233041 | -25 | 0.0498242721317406 |
| ENSG00000233436 | -10.5533596837945 | 0.00500520808218314 |
| ENSG00000236398 | -23.7884872824632 | 0.0339178520847889 |
| ENSG00000240505 | -16.1968400674452 | 0.043591041794672 |
| ENSG00000241697 | -20.2541827541828 | 0.0197473266150249 |
| ENSG00000243646 | -15.8593909666871 | 0.0498537960889873 |
| ENSG00000243943 | -13.5289634146341 | 0.00548177529708554 |
| ENSG00000244187 | -12.7288319237544 | 0.000563775169064139 |
| ENSG00000244187 | -20.4971229760471 | 0.00570246594908727 |
| ENSG00000254995 | -12.3358585858586 | 0.00423793375162113 |
| ENSG00000254997 | -17.9655870445344 | 0.0315032058089109 |
| ENSG00000255221 | -25.547055684042 | 0.036555069792132 |
| ENSG00000255690 | -11.6808149405772 | 0.0189770213776895 |
| ENSG00000255690 | -12.3504896041879 | 0.000512147430381347 |
| ENSG00000256463 | -16.3964019723133 | 0.0248820738071412 |
| ENSG00000256463 | -21.898750249406 | 1.95468984574037E-06 |
| ENSG00000256463 | -24.0959541711421 | 0.000163854290307613 |
| ENSG00000257520 | -13.5327327327327 | 0.0236714264555738 |
| ENSG00000258388 | -15.437030075188 | 0.000881217599989722 |
| ENSG00000258388 | -12.5576953684546 | 0.0151972472985044 |
| ENSG00000258644 | -25.126213592233 | 0.0333275081725526 |
| ENSG00000260596 | -32.0075757575758 | 0.000264090097761395 |
| ENSG00000262481 | -25.2622377622378 | 0.0374908539061022 |
| ENSG00000265681 | -27.8483245149912 | 0.0397619153720593 |
| ENSG00000267001 | -19.2689677629437 | 0.0139942362377622 |
| ENSG00000267110 | -21.4364035087719 | 0.000722902618995026 |
| ENSG00000267335 | -24.5206349206349 | 0.00395336958051468 |
| ENSG00000267477 | -42.1052631578947 | 0.00358926842407119 |
| ENSG00000267552 | -18.7379567745855 | 0.00601386696065428 |
| ENSG00000267631 | -24.5206349206349 | 0.00395336958051468 |
| ENSG00000267748 | -11.7440499414748 | 0.0351157095258298 |
| ENSG00000268163 | -17.6767676767677 | 0.0134216004209188 |
| ENSG00000268163 | -20.2912102591504 | 0.0247558735443318 |
| ENSG00000270800 | -10.6719405397908 | 0.04406634342951 |
| ENSG00000272896 | -12.7288319237544 | 0.000563775169064139 |
| ENSG00000272896 | -20.4971229760471 | 0.00570246594908727 |
| ENSG00000273049 | -11.8653524270039 | 0.0285551186534443 |
| ENSG00000273154 | -13.2554549434345 | 0.0464070147864675 |
| ENSG00000273259 | -16.4386737769534 | 0.0364912699901172 |
| ENSG00000273706 | -13.5100521545781 | 1.51867451212391E-07 |
| ENSG00000273749 | -12.1543294020032 | 0.000191335185544997 |
| ENSG00000277462 | -14.5836288835296 | 0.00349485787643516 |
| ENSG00000277462 | -13.4898365882822 | 0.0171288842575121 |
| ENSG00000278685 | -16.6554459502971 | 0.0446906038244175 |
| ENSG00000278685 | -23.0212765957447 | 0.0282787667085562 |
| ENSG00000282881 | -23.4083850931677 | 0.0226508605392879 |
| ENSG00000283189 | -10.7424071991001 | 0.0174515769503486 |
| ENSG00000283526 | -18.0124833163225 | 3.86317235533345E-06 |
| ENSG00000283526 | -19.2275318817793 | 4.43243451267144E-09 |
| ENSG00000283580 | -15.6722709914199 | 0.025593910912043 |
| ENSG00000283586 | -10.150711301 | 0.0134787535587177 |
| ENSG00000283586 | -12.0691131760373 | 0.0371369270217128 |
| ENSG00000284194 | -12.589080993989 | 0.0188369897278606 |
| ENSG00000284713 | -11.5865202574782 | 0.0125498653646383 |
| ENSG00000284713 | -12.4206553439698 | 0.025610830019555 |
| ENSG00000284906 | -15.7713467817686 | 0.045902210404969 |
| ENSG00000285077 | -15.7713467817686 | 0.045902210404969 |
| ENSG00000285471 | -13.0089802670448 | 0.00513538343420379 |
| ENSG00000285471 | -15.86969610546 | 0.000385506270676657 |
| ENSG00000288611 | -10.381169344394 | 0.00449479933783133 |
Table 4.
Biological function of genes with elevated methylation levels.
| GO:0030308/negative regulation of cell growth |
| ENSG00000100739 |
| ENSG00000166923 |
| GO:0008285/negative regulation of cell proliferation |
| ENSG00000088992 |
| ENSG00000103197 |
| ENSG00000135956 |
| ENSG00000140105 |
| ENSG00000165238 |
| ENSG00000178568 |
| ENSG00000182636 |
| ENSG00000183145 |
| ENSG00000198625 |
| GO:0007050//cell cycle arrest |
| ENSG00000123999 |
| ENSG00000162670 |
| GO:0043065/positive regulation of apoptotic process; |
| ENSG00000064300 |
| ENSG00000104765 |
| ENSG00000109906 |
| ENSG00000120063 |
| ENSG00000131023 |
| ENSG00000138613 |
| ENSG00000145779 |
| ENSG00000171680 |
| ENSG00000176884 |
| ENSG00000197442 |
| Biological function of genes with decreased methylation levels |
| GO:0010720/positive regulation of cell development |
| ENSG00000005073 |
| ENSG00000128422 |
| GO:0008284/positive regulation of cell proliferation |
| ENSG00000037280 |
| ENSG00000105550 |
| ENSG00000105989 |
| ENSG00000110148 |
| ENSG00000119630 |
| ENSG00000135452 |
| ENSG00000135625 |
| ENSG00000136630 |
| ENSG00000169057 |
| ENSG00000169083 |
| ENSG00000170961 |
| ENSG00000172201 |
| ENSG00000180818 |
| ENSG00000181104 |
| ENSG00000184486 |
| ENSG00000187094 |
| GO:0043066/negative regulation of apoptotic process |
| ENSG00000071054 |
| ENSG00000101188 |
| ENSG00000106144 |
| ENSG00000108839 |
| ENSG00000134259 |
| ENSG00000143479 |
| ENSG00000143867 |
| ENSG00000169230 |
| ENSG00000172175 |
| ENSG00000173530 |
| ENSG00000188389 |
| ENSG00000197785 |
| ENSG00000198171 |
| GO:0050728//negative regulation of inflammatory response |
| GO:0006979//response to oxidative stress |
| ENSG00000069667 |
| ENSG00000128016 |
| ENSG00000100983 |
| ENSG00000122691 |
| ENSG00000174130 |
| ENSG00000184470 |
2.4. MSCs regulate gene transcription by inducing DNA methylation modification
To study the relationship between the DNA methylation modification pattern and gene transcription during MSCs reversal of TEC senescence, the genes in TECs were divided into four groups according to transcription level (high, medium, low and negative expression). We found that there was a negative correlation between DNA methylation and transcription in the promoter region (upstream 1 kb), a positive correlation between DNA methylation and transcription in the gene body region (Fig. 4A). In addition, the Pearson correlation coefficients (r) between DNA methylation levels and corresponding gene expression levels in the coculture group were calculated. The results also showed that DNA methylation levels in promoter and gene body regions were negatively correlated and positively correlated, respectively, with DNA methylation levels (Fig. 4B).
Fig. 4.
MSCs regulate gene transcription by inducing DNA methylation modification. A In the process of reversing the aging of TECs via MSCs, the methylation level of different positions of the gene is associated with the transcriptional level (the abscissa shows different gene locations divided into upstream 1k, gene body and downstream 1k; the ordinate is the methylation level; the red curve indicates high transcription, the green represents low transcription, the blue curve represents medium transcription, and the purple curve represents no transcription). B Promoter (above) and gene body region (below) DNA methylation levels and corresponding gene transcription scatter plots (the red and blue curves represent gene transcription levels and DNA methylation levels in promoter and genomic regions, respectively). The horizontal axis below each box from left to right represents the level of gene transcription from high to low. C Nine-quadrant diagram of the relationship between DNA methylation and gene RNA-seq data in the promoter region (the abscissa is the RNA-seq log2fc value, the ordinate is the differential methylation level, and the upper left and lower right represent a significant negative correlation between promoter methylation and the transcriptional level). D GO enrichment analysis showed that the level of DNA methylation in the promoter region was negatively correlated with gene expression (ordinate: GO term, abscissa: number of genes; red indicates upregulated genes, and green indicates downregulated genes). E KEGG enrichment analysis of genes with decreased methylation levels. F The expression of RAPA1, SRC and ITGB3, the key proteins of the Rap1 signaling pathway (the measured values represent the mean ± standard deviation (`X ± s) of three replicate experiments. ∗∗P < 0.01, ∗∗∗P < 0.001). G A nine-quadrant map of the relationship between DNA methylation and gene RNA-seq in the gene body region (the abscissa is the RNA-seq log2fc, and the ordinate is the differential methylation level). H In the gene body region, the DNA methylation level was negatively correlated with gene expression and positively correlated with enriched GO terms (BNG indicates that the methylation level was negatively correlated with gene expression; BPG indicates that the methylation level was positively correlated with gene expression).
In the promoter region, after MSC coculture, 66 genes in senescent TECs exhibited a significant negative correlation between promoter methylation and transcription (Fig. 4C and Table 5). Methylation of PDE5A, DUOX2, LAMP1 and SVIL in the promoter region led to the downregulation of transcription. The expression of these genes mainly inhibited cell development, differentiation and the cell cycle. The demethylation of POLR3G, PGF, CHTF18, KRT17, FOXJ1, NGF, DYRK3, LRP8, CDT1, PRELID1, F2R, KNTC1 and TRIM3 in the promoter region led to an increase in transcriptional levels, and their expression mainly promoted the cell cycle, cell growth and development and epithelial cell differentiation (Fig. 4D). KEGG analysis showed that the genes with decreased methylation levels were mainly enriched in the Rap1 signaling pathway (Fig. 4E). Furthermore, the expression of key proteins RAP1, SRC and ITGB3 in the RAP1 signaling pathway was detected by Western blotting. The results showed that the expression of the key proteins RAP1, SRC and ITGB3 increased significantly after MSCs coculture, suggesting that the decreased methylation of PGF and NGF activated the RAP1 signaling pathway (Fig. 4F). The results showed that MSCs induced a decrease in the methylation level in the promoter region of ageing-promoting genes, promoted the demethylation of cell growth gene promoters, inhibited the expression of ageing-promoting genes, promoted an increase in cell growth gene expression, and finally reversed the senescence of TECs. The increased expression level of genes related to the RAP1 signaling pathway played an important role in this process.
Table 5.
Promoter methylation is negatively correlated with gene expression.
| id | meth.diff | meth.q | gene_fc | gene_p |
|---|---|---|---|---|
| ENSG00000169393 | 12 | 0.0493167198534707 | -3.16992500144231 | 0.0182157396451062 |
| ENSG00000140279 | 11.3766298330057 | 0.0425112978457713 | -3 | 0.0192457689020148 |
| ENSG00000183496 | 14.5393689412893 | 0.000320527649816425 | -1.77258950389693 | 0.00215297544876282 |
| ENSG00000166147 | 15.6619833863194 | 0.0468581371125151 | -1.07480383893417 | 5.03157126804725E-30 |
| ENSG00000138735 | 16.2222222222222 | 0.0350319355454426 | -1.03585333801322 | 7.42879931992132E-58 |
| ENSG00000178568 | 27.5180140945443 | 1.07565396326703E-07 | -0.888968687611259 | 0.0032937298473144 |
| ENSG00000221890 | 22.6050420168067 | 0.0345626215065825 | -0.690795412733281 | 0.0176007089136136 |
| ENSG00000143412 | 12.5132555673383 | 0.0244041195439192 | -0.651006139135347 | 3.21495919043423E-06 |
| ENSG00000145536 | 15.5727366159021 | 0.0089577681604829 | -0.64965904943743 | 2.45479952909829E-05 |
| ENSG00000188153 | 12.1476617552851 | 0.0439126087216701 | -0.616462780545589 | 5.88521426071701E-15 |
| ENSG00000167861 | 25.9545923632611 | 0.00358556744024635 | -0.600339911716719 | 1.51057836248098E-06 |
| ENSG00000198691 | 16.1113699906803 | 0.0178381603850453 | -0.587156714134073 | 0.000809594934608358 |
| ENSG00000138336 | 21.8070362473348 | 0.000861502987558523 | -0.587007426706185 | 0.000973023962220727 |
| ENSG00000101751 | 15.6150627615063 | 0.00847306283066711 | -0.556330347365361 | 0.00314889263219378 |
| ENSG00000197321 | 26.6782608695652 | 0.0141433998222048 | -0.501773106156611 | 5.87968999963141E-08 |
| ENSG00000184731 | 13.2576254294631 | 0.0104233490346365 | -0.431430376467744 | 9.26373589126763E-08 |
| ENSG00000164920 | 13.8862559241706 | 0.00141583621004862 | -0.390157290173661 | 4.66508235306963E-06 |
| ENSG00000196498 | 23.0205156060669 | 5.350072520849E-05 | -0.365364917610353 | 0.0024253152303974 |
| ENSG00000110628 | 12.6218323586745 | 0.000905019819790039 | -0.364197318260097 | 0.0233052964014367 |
| ENSG00000111271 | 14.5110267534346 | 0.0359526622537845 | -0.353001616041892 | 0.00560907003355677 |
| ENSG00000149639 | 12.1855383969921 | 0.0160852095767229 | -0.347636760659084 | 0.00218329338042741 |
| ENSG00000170561 | 12.7706888335892 | 0.0391539116619081 | -0.347476890469923 | 0.00333298319309075 |
| ENSG00000224051 | 30.1339896089691 | 0.0291683709558524 | -0.322945709676845 | 0.0220990443969277 |
| ENSG00000175155 | 22.7486965589155 | 0.0111237785068831 | -0.313192706891764 | 0.00257815783289071 |
| ENSG00000185896 | 20.1874052638832 | 0.024131183824719 | -0.270676478852593 | 1.05874659873463E-05 |
| ENSG00000134259 | -19.9652777777778 | 0.00459426665426082 | 1.83064557204383 | 0.00941141544514754 |
| ENSG00000138944 | -37.8117457763475 | 0.0169445660029793 | 1.37586690199816 | 0.00219311995651581 |
| ENSG00000101216 | -10.3382163724572 | 0.0370962647151181 | 1.35675568344045 | 1.7949955026023E-14 |
| ENSG00000119630 | -10.7784431137725 | 0.00695950565232784 | 0.888209174542443 | 0.00320217443092626 |
| ENSG00000129654 | -10.6407004024644 | 6.26010353840451E-06 | 0.795729596937978 | 0.0271087679454225 |
| ENSG00000142273 | -19.4395149364094 | 0.0341414149043605 | 0.74612559345168 | 0.0088904789182297 |
| ENSG00000165799 | -19.8527720266851 | 0.0447136844752293 | 0.678071905112639 | 0.0177003751106127 |
| ENSG00000157193 | -10.0792079207921 | 0.00307962939304754 | 0.666209101707102 | 5.04376339464156E-11 |
| ENSG00000181104 | -13.6891228909896 | 0.0435232730481889 | 0.621100205187945 | 3.5853266552734E-08 |
| ENSG00000143479 | -13.636249655207 | 0.0401229285764378 | 0.606004916283042 | 0.00637638237944121 |
| ENSG00000128422 | -13.7385720060132 | 0.0117581512531377 | 0.539551979134848 | 2.51234780697392E-20 |
| ENSG00000005189 | -14.1243862520458 | 0.0117387368539422 | 0.529489164822724 | 7.66287517170509E-05 |
| ENSG00000163565 | -11.0395892164983 | 0.00942619045704688 | 0.515773668044346 | 0.000690038898638332 |
| ENSG00000037897 | -13.2831444200079 | 0.0266330771143665 | 0.513225279513817 | 0.00221165164613025 |
| ENSG00000188807 | -14.1644210192597 | 0.00214158534118136 | 0.50354766909851 | 2.372630415506E-05 |
| ENSG00000134686 | -16.0714285714286 | 0.0353876886095324 | 0.49406131874452 | 5.10831089048732E-11 |
| ENSG00000123130 | -37.3015873015873 | 5.00924521270897E-06 | 0.489750774803252 | 0.00176615938851862 |
| ENSG00000156398 | -13.6112071947423 | 0.0442108996079291 | 0.487008729785849 | 0.0128476275418884 |
| ENSG00000167470 | -10.062893081761 | 0.0449721395775338 | 0.476336091099384 | 5.09652754620344E-09 |
| ENSG00000173530 | -16.4157644250816 | 0.0412017199604227 | 0.468398314663583 | 0.000143462486375593 |
| ENSG00000167523 | -16.751269035533 | 5.8315626359607E-08 | 0.464668267003444 | 0.0158976675818633 |
| ENSG00000118985 | -15.2974664454833 | 0.0372468840756965 | 0.409987808996061 | 4.97570168541322E-07 |
| ENSG00000184445 | -28.9085545722714 | 1.10468522189305E-19 | 0.397728662866405 | 9.03292391205679E-06 |
| ENSG00000167513 | -18.2418326468431 | 0.00513538343420379 | 0.395126956365581 | 3.04930833769411E-05 |
| ENSG00000113356 | -30.4485219164118 | 0.0128237638132768 | 0.390375445044573 | 0.0389512379357209 |
| ENSG00000273706 | -13.5100521545781 | 1.51867451212391E-07 | 0.389539574228011 | 0.0429548369026055 |
| ENSG00000196923 | -10.1846285959639 | 0.0125269750370792 | 0.375828051950098 | 0.00067391254848192 |
| ENSG00000087269 | -11.5588273279091 | 0.0292988774562968 | 0.359962553043222 | 0.00139454612866975 |
| ENSG00000003400 | -13.0225905823676 | 0.0261886189599571 | 0.357439579522302 | 0.00293504239997059 |
| ENSG00000172175 | -13.6658199347632 | 0.0450575089860559 | 0.341152662152261 | 0.0324220388410544 |
| ENSG00000127586 | -23.5960889504197 | 0.0106052756412346 | 0.339380789036883 | 0.0444323090993345 |
| ENSG00000169230 | -22.6702952333828 | 0.0422632036507693 | 0.314585152068477 | 6.08022403373139E-07 |
| ENSG00000197451 | -11.3869559539578 | 0.00256448161697349 | 0.309912043537486 | 6.84334406811732E-06 |
| ENSG00000131620 | -23.3758708893317 | 7.69815899489769E-05 | 0.303751434937819 | 0.00347391075687533 |
| ENSG00000132773 | -18.0035650623886 | 0.00122867731832998 | 0.287830317680935 | 0.0230792818269578 |
| ENSG00000172009 | -24.4159883528555 | 0.00479288133087388 | 0.287040237001174 | 0.00229691390720688 |
| ENSG00000142731 | -21.0726198609492 | 0.000484552422247172 | 0.282650503348821 | 0.00173861229602644 |
| ENSG00000204599 | -15.4369398207426 | 0.0188931632771714 | 0.27892876502747 | 0.0479497582826186 |
| ENSG00000171824 | -12.1212121212121 | 0.0220298071571259 | 0.276012259832004 | 0.00631234215092042 |
| ENSG00000165688 | -12.2080440996325 | 1.88001695122534E-05 | 0.27115480052629 | 0.000390441450012896 |
| ENSG00000285077 | -15.7713467817686 | 0.045902210404969 | 0.266423004081944 | 0.0468961829118312 |
In the gene body region, there was a significant negative correlation between methylation level and gene transcription in MSCs-cocultured senescent TECs, and these genes (534 risk-related genes) were defined as BNGs (Fig. 4G and Table 6). These genes are mainly involved in biological processes such as cell population proliferation, epithelial cell differentiation and regulation of epithelial cell proliferation (Fig. 4H). However, there was a significant positive correlation between the methylation level of more genes (553 risk-related genes) and gene transcription, and these genes were defined as BPGs (Fig. 4G). Interestingly, BPGs also had biological processes similar to those of BNGs (Fig. 4H). These results suggest that methylation changes in the gene body region may not only inhibit gene transcription but may also promote gene transcription in the process by which MSCs reverse TEC ageing.
Table 6.
genebody methylation is correlated with gene expression.
| id | meth.diff | meth.q | gene_fc | gene_p | |
|---|---|---|---|---|---|
| ENSG00000140379 | 17.1726137641281 | 0.0460288318272713 | 7.75933340719466 | 0.0367406623189661 | BPG |
| ENSG00000198626 | 24.7863247863248 | 0.0428569231124602 | 5.4374053123073 | 0.0297721172788166 | BPG |
| ENSG00000273217 | 12.0838262633091 | 0.0017609206903326 | 5.32192809488736 | 0.0445013525732622 | BPG |
| ENSG00000185339 | 45.2941176470588 | 0.0247584438639287 | 4.3037807481771 | 0.00178271206325163 | BPG |
| ENSG00000047457 | 13.4175878772823 | 0.0283611057261894 | 3.22994977251453 | 1.66788126916758E-24 | BPG |
| ENSG00000288520 | 36.7167919799499 | 0.00179587138482442 | 2.7004397181411 | 0.0288626152504842 | BPG |
| ENSG00000152953 | 35.8585858585859 | 0.0108455530672616 | 2.32192809488736 | 0.0352806015308715 | BPG |
| ENSG00000197641 | 12.020202020202 | 0.0382074798208661 | 1.92619869958988 | 1.92719648884193E-25 | BPG |
| ENSG00000198768 | 10.8635026873542 | 0.0455223482400552 | 1.91753783980803 | 0.0395432526802723 | BPG |
| ENSG00000149557 | 30.7784252203795 | 0.0362978205542385 | 1.73142547723426 | 1.52589890721511E-08 | BPG |
| ENSG00000081985 | 21.5675057208238 | 0.0323846219542733 | 1.72582503656101 | 0.0427904082297945 | BPG |
| ENSG00000162711 | 17.6871052985175 | 0.000259725399986543 | 1.53605290024021 | 2.06547568623394E-07 | BPG |
| ENSG00000259207 | 19.1260923845193 | 0.0176749247514635 | 1.49185309632967 | 5.16678595835762E-10 | BPG |
| ENSG00000139278 | 10.7863631180875 | 0.000163880514573194 | 1.40892736291598 | 1.16755566875088E-14 | BPG |
| ENSG00000154678 | 18.3439422018102 | 0.0436144473018669 | 1.39854937649027 | 0.0282987501155144 | BPG |
| ENSG00000130164 | 21.9712015888779 | 0.0293316809944489 | 1.38476472870143 | 1.68437434910057E-68 | BPG |
| ENSG00000288602 | 10.0578466131741 | 8.69490707846433E-06 | 1.38133628405012 | 1.22193778792156E-06 | BPG |
| ENSG00000101216 | 14.0663390663391 | 0.00599990842666912 | 1.35675568344045 | 1.7949955026023E-14 | BPG |
| ENSG00000163485 | 22.2225941422594 | 0.000337583593079858 | 1.34513548604869 | 0.0424124417976442 | BPG |
| ENSG00000188001 | 19.9379675241744 | 0.0462884117852547 | 1.33763299559323 | 1.51293275212706E-05 | BPG |
| ENSG00000090339 | 21.8632075471698 | 7.55280953546309E-10 | 1.22517486200778 | 1.17341214937116E-27 | BPG |
| ENSG00000196639 | 10.9243697478992 | 0.0226627811165279 | 1.12687176584051 | 2.79229839886979E-11 | BPG |
| ENSG00000002587 | 12.3692427790788 | 0.0030212729838875 | 1.09953567355091 | 0.00241065519046194 | BPG |
| ENSG00000167914 | 24.1176470588235 | 0.00878621065548137 | 1.0790715709912 | 0.00212095639712 | BPG |
| ENSG00000255398 | 10.5249083129584 | 0.00555500233808119 | 1.0759488532333 | 0.0213799392158058 | BPG |
| ENSG00000124496 | 11.8697478991597 | 0.0197051200937206 | 1.05475976867859 | 9.74227997345186E-09 | BPG |
| ENSG00000185022 | 21.4285714285714 | 0.00027811976367497 | 1.03023961317768 | 4.14560461289623E-22 | BPG |
| ENSG00000112096 | 14.5454545454546 | 0.046217877185254 | 1.00829655641631 | 0.0277179645543597 | BPG |
| ENSG00000138316 | 17.4206525733516 | 0.0304301935480177 | 1 | 0.00942259240403998 | BPG |
| ENSG00000118515 | 11.5896851801896 | 0.000186787297261282 | 0.986540356802792 | 1.56070357468565E-40 | BPG |
| ENSG00000125730 | 22.6524064171123 | 0.0001539492364998 | 0.940197017497937 | 1.10578488599274E-13 | BPG |
| ENSG00000164120 | 28.8961038961039 | 0.0361783351821684 | 0.934782340553516 | 0.0395141713878454 | BPG |
| ENSG00000163568 | 11.2735708508918 | 0.0279618332417633 | 0.931046368249858 | 7.94510291344592E-10 | BPG |
| ENSG00000182752 | 27.8974358974359 | 0.0415386692927686 | 0.883355081147731 | 1.45670435422431E-15 | BPG |
| ENSG00000111700 | 10.3794923347575 | 0.0474623507181872 | 0.867939147909315 | 0.0025682878525908 | BPG |
| ENSG00000100379 | 10.7658959537572 | 0.015640943861462 | 0.8600179616186 | 3.78521809513934E-05 | BPG |
| ENSG00000198121 | 11.5673799884326 | 0.000235463010867662 | 0.853133922996195 | 2.54618474694495E-12 | BPG |
| ENSG00000129521 | 25.5984555984556 | 0.0222067965182979 | 0.84358980503217 | 2.59806804251617E-05 | BPG |
| ENSG00000100060 | 21.0711768851304 | 0.0106912163846665 | 0.828631581688019 | 0.0273481690302178 | BPG |
| ENSG00000075131 | 19.4487577639752 | 0.0424731991250545 | 0.816530118457942 | 0.00474497942871165 | BPG |
| ENSG00000114541 | 28.8600288600289 | 0.0474421974610935 | 0.815747086313056 | 1.42922170794235E-22 | BPG |
| ENSG00000174640 | 16.9152167909417 | 0.0387405060017022 | 0.800012946716431 | 0.00209466071836222 | BPG |
| ENSG00000129654 | 16.5985021511659 | 0.0298086831017226 | 0.795729596937978 | 0.0271087679454225 | BPG |
| ENSG00000156299 | 22.9379548628979 | 1.07161511929475E-05 | 0.792603966282472 | 5.65041318074885E-06 | BPG |
| ENSG00000105137 | 10.7254534083802 | 0.04654172520713 | 0.786429083203057 | 0.000279118337134963 | BPG |
| ENSG00000095303 | 16.1793847253354 | 0.0211069184576635 | 0.764794459829562 | 1.5199467943708E-06 | BPG |
| ENSG00000134954 | 23.1418370658877 | 0.0277963868963604 | 0.761605766840066 | 2.56715039043354E-44 | BPG |
| ENSG00000103546 | 16.2875313398153 | 0.00349398264893309 | 0.758806642705791 | 0.0418443211370969 | BPG |
| ENSG00000160256 | 13.6070021316453 | 0.0214647227421257 | 0.753891509689743 | 0.0332320116864089 | BPG |
| ENSG00000164023 | 21.25 | 0.011922179126476 | 0.746225542778568 | 0.000363807452821192 | BPG |
| ENSG00000123358 | 15.8217347220942 | 2.16626464371985E-05 | 0.737561626003184 | 5.9249188956385E-06 | BPG |
| ENSG00000157654 | 15.244622339966 | 0.0376927615809148 | 0.735084635567444 | 0.00032002751951902 | BPG |
| ENSG00000104856 | 25.2747252747253 | 0.000251979891967708 | 0.724771694854199 | 1.12785792226896E-07 | BPG |
| ENSG00000138829 | 38.4102564102564 | 0.0495299856395462 | 0.713477241243836 | 0.0417689085213096 | BPG |
| ENSG00000198517 | 10.0071965456581 | 0.000250857317643525 | 0.710892082556315 | 1.95937520854343E-12 | BPG |
| ENSG00000140525 | 12.7136879856545 | 0.0492349249753731 | 0.703928500914718 | 1.88197511468814E-10 | BPG |
| ENSG00000034152 | 26.2759170653907 | 0.00144846259665856 | 0.693086631049928 | 5.24816371136761E-05 | BPG |
| ENSG00000213397 | 26.1435608726249 | 0.0272650692982965 | 0.689932060322699 | 0.000404367736333311 | BPG |
| ENSG00000184408 | 26.011760636458 | 0.039074500980129 | 0.667424660913128 | 0.0384781428522723 | BPG |
| ENSG00000077238 | 12.7857142857143 | 0.00257455533047546 | 0.662159614919003 | 1.55807095924066E-27 | BPG |
| ENSG00000116396 | 26.0964408725603 | 0.0096893888071383 | 0.657112286476989 | 1.35258473501439E-06 | BPG |
| ENSG00000145220 | 23.3350488934637 | 0.00284511941794192 | 0.652682641836568 | 0.000888214720779499 | BPG |
| ENSG00000135074 | 28.6655462184874 | 0.00818970336907842 | 0.650885862801071 | 1.17888754456392E-37 | BPG |
| ENSG00000008517 | 14.6666666666667 | 0.0123730750888345 | 0.648782870854652 | 0.0124472970165069 | BPG |
| ENSG00000134070 | 16.1204481792717 | 0.0327234089529168 | 0.642404392962848 | 0.00154731554224759 | BPG |
| ENSG00000130066 | 19.1561875661065 | 0.0406547451253858 | 0.639525806945979 | 0.000483308213269925 | BPG |
| ENSG00000115109 | 17.8514588859416 | 4.29516076726877E-06 | 0.631074425575469 | 0.0210371778011025 | BPG |
| ENSG00000006432 | 28.8508118776352 | 0.00145775249728922 | 0.629872816855305 | 2.88466436771349E-27 | BPG |
| ENSG00000126091 | 12.0560248048754 | 0.0298997792651608 | 0.626850897011178 | 0.00839083915114877 | BPG |
| ENSG00000185033 | 12.3076923076923 | 0.0246845329093198 | 0.625898044084284 | 2.59811443497528E-21 | BPG |
| ENSG00000073756 | 11.7949854686961 | 4.76806497395308E-10 | 0.624200327276437 | 4.92058830388309E-17 | BPG |
| ENSG00000127666 | 20.7014835777378 | 0.0361625798985242 | 0.617666665793861 | 2.82406615980706E-06 | BPG |
| ENSG00000171612 | 10.2189781021898 | 0.0299114399803943 | 0.616403847923919 | 3.85613698182859E-06 | BPG |
| ENSG00000188352 | 14.4671841919548 | 0.0234512792736483 | 0.616017225301995 | 1.77958293421601E-09 | BPG |
| ENSG00000154217 | 10.3516533749092 | 0.000322810648896246 | 0.615899482470343 | 0.000662697989781469 | BPG |
| ENSG00000112159 | 14.5891528611334 | 0.015561117088738 | 0.610708775591004 | 0.00592967658047154 | BPG |
| ENSG00000143479 | 19.2099637918248 | 0.0216185651681438 | 0.606004916283042 | 0.00637638237944121 | BPG |
| ENSG00000250021 | 11.3825232938806 | 0.0240344121618717 | 0.593732710348888 | 0.00848014211495732 | BPG |
| ENSG00000128294 | 10.5763517528223 | 0.00140043111047096 | 0.59321592735501 | 0.0345827448979271 | BPG |
| ENSG00000154655 | 18.9600840336134 | 0.0123963264712088 | 0.59183345241 | 1.03930323127386E-06 | BPG |
| ENSG00000165650 | 18.3908045977011 | 0.0015304926249123 | 0.579453598291972 | 0.0453755163033109 | BPG |
| ENSG00000179583 | 23.2768127929418 | 0.0270751116053932 | 0.577751585826059 | 0.000353913888725189 | BPG |
| ENSG00000140945 | 37.7016129032258 | 0.00981463319013045 | 0.574978412148533 | 0.00366332390862918 | BPG |
| ENSG00000128578 | 10.0450605262153 | 0.0130192453752586 | 0.574341384964587 | 0.00284139827758737 | BPG |
| ENSG00000131941 | 19.8850447662209 | 0.00447847862477616 | 0.573258396588686 | 1.74407845148977E-14 | BPG |
| ENSG00000175832 | 11.9083269671505 | 0.0394262915203526 | 0.571278916880122 | 0.000200810502007593 | BPG |
| ENSG00000166444 | 17.8225806451613 | 0.0194673305790636 | 0.56545984417481 | 4.99627819602438E-09 | BPG |
| ENSG00000156113 | 26.7635590216235 | 0.0105659788754113 | 0.562791119722535 | 0.0227562050853387 | BPG |
| ENSG00000142185 | 51.7641129032258 | 8.09380543598331E-08 | 0.561438218660123 | 0.0293332076847108 | BPG |
| ENSG00000145675 | 22.5126646403242 | 0.0137608208710987 | 0.55549389265715 | 0.02168041321141 | BPG |
| ENSG00000133773 | 23.4776987718164 | 0.0497599820915567 | 0.553529152545131 | 0.0232769540006936 | BPG |
| ENSG00000115641 | 17.0194508009153 | 0.0110685012966746 | 0.552391837873705 | 1.0526762753976E-29 | BPG |
| ENSG00000060558 | 13.75 | 0.0266218044809461 | 0.550616755318472 | 0.00025669154956774 | BPG |
| ENSG00000147065 | 29.0869916509561 | 0.0240709907229761 | 0.53654301642417 | 8.11287354734939E-30 | BPG |
| ENSG00000110427 | 36.6200578592093 | 0.0122666642572542 | 0.532060599558595 | 0.00291374882581983 | BPG |
| ENSG00000159200 | 13.9405684754522 | 0.0441669320419815 | 0.529082695095812 | 7.08904757466765E-07 | BPG |
| ENSG00000116120 | 13.2267732267732 | 0.0344536764202843 | 0.528875755953478 | 0.00805916733707207 | BPG |
| ENSG00000162419 | 27.9619805481874 | 0.00685307479690918 | 0.525155335489124 | 0.00223599875365847 | BPG |
| ENSG00000167670 | 21.763859832636 | 2.73646856659351E-07 | 0.521039303621415 | 0.000147383634918683 | BPG |
| ENSG00000005884 | 22.8070175438597 | 0.0402615281928553 | 0.513443633410088 | 3.7351721134188E-23 | BPG |
| ENSG00000171488 | 17.1157687795288 | 3.2058714522525E-07 | 0.513239813177653 | 0.00114332064975316 | BPG |
| ENSG00000073712 | 12.5 | 0.0341240726600526 | 0.512037234330269 | 1.28218578484813E-07 | BPG |
| ENSG00000137309 | 15.2883630986236 | 0.00729589058035453 | 0.511487559636413 | 4.36463899514817E-15 | BPG |
| ENSG00000125731 | 17.948717948718 | 0.0396708027087845 | 0.509667175183969 | 0.00391499527626842 | BPG |
| ENSG00000196792 | 12.5 | 0.0439863781029824 | 0.507954281998884 | 0.0461085059867358 | BPG |
| ENSG00000101773 | 27.5862068965517 | 0.0387651384224958 | 0.506702061037264 | 1.17953929546148E-06 | BPG |
| ENSG00000134686 | 11.9293924466338 | 0.0319547070303023 | 0.49406131874452 | 5.10831089048732E-11 | BPG |
| ENSG00000125454 | 16.9843160611475 | 0.0163651212626911 | 0.494043665158886 | 0.00543931724489655 | BPG |
| ENSG00000285901 | 11.6166587674845 | 0.0444463457358793 | 0.485665901665924 | 0.00265331917593365 | BPG |
| ENSG00000075702 | 23.7220969376083 | 3.0737873482305E-10 | 0.484470132810983 | 0.0150733519063799 | BPG |
| ENSG00000039560 | 13.9867156739778 | 0.00138145335108338 | 0.483171930628531 | 6.66514055683011E-11 | BPG |
| ENSG00000168970 | 11.4285714285714 | 0.0459755722858929 | 0.48275764039426 | 0.0452815641249222 | BPG |
| ENSG00000100023 | 12.4508215690812 | 0.0133970134671646 | 0.482668327207678 | 0.0105207229595894 | BPG |
| ENSG00000132334 | 12.1472244811903 | 0.0474686841805455 | 0.475178385333266 | 7.6377217442228E-05 | BPG |
| ENSG00000073282 | 11.9007689143436 | 0.048546782398754 | 0.473557736578936 | 0.00196863331449595 | BPG |
| ENSG00000177706 | 17.7135047693423 | 0.00787495879534455 | 0.471523213919535 | 5.28191185180264E-07 | BPG |
| ENSG00000100065 | 26.4326432643264 | 0.0191484913378948 | 0.470268230654617 | 3.15996374866782E-08 | BPG |
| ENSG00000198042 | 17.7547169811321 | 0.0232281921397903 | 0.468902336950411 | 8.33417033982992E-09 | BPG |
| ENSG00000173530 | 10.1123595505618 | 0.0384166465261006 | 0.468398314663583 | 0.000143462486375593 | BPG |
| ENSG00000137478 | 15.511611030479 | 1.51079661917468E-05 | 0.46837326134002 | 0.00725447648208387 | BPG |
| ENSG00000171132 | 24.9302501536861 | 0.0160456878041116 | 0.468248157279246 | 0.0072417886941382 | BPG |
| ENSG00000149177 | 10.7246688919996 | 0.00630639306502788 | 0.467617414400212 | 0.0446129236346782 | BPG |
| ENSG00000113643 | 10.2938593409682 | 0.00576526528660252 | 0.46607475129958 | 0.0101843122334553 | BPG |
| ENSG00000109320 | 15.1220905326289 | 0.00163633849319427 | 0.460363788572407 | 6.35552267042898E-06 | BPG |
| ENSG00000134775 | 12.1574777154176 | 0.00829919587995446 | 0.459090918425327 | 3.0528769923768E-05 | BPG |
| ENSG00000169851 | 21.8632075471698 | 0.0431605350915495 | 0.453708983530555 | 5.70757756837102E-06 | BPG |
| ENSG00000259316 | 23.1493553527452 | 0.00128148450740161 | 0.451443145707578 | 0.0297853829323746 | BPG |
| ENSG00000128050 | 14.9583297534152 | 0.0158462688766661 | 0.451141139038848 | 5.93185210126709E-16 | BPG |
| ENSG00000179958 | 14.7819042555885 | 2.14522521012426E-05 | 0.44825768623875 | 3.09507657388312E-08 | BPG |
| ENSG00000157551 | 11.5706200154361 | 0.0419093860693028 | 0.447594054452798 | 0.00230304213579688 | BPG |
| ENSG00000163866 | 23.685580426861 | 0.049655105392165 | 0.44323975577384 | 0.000258724968656793 | BPG |
| ENSG00000196793 | 11.978766501362 | 0.0460453262119517 | 0.435328215579876 | 0.00221912060149269 | BPG |
| ENSG00000135763 | 16.8818129661503 | 0.0302759054994361 | 0.433984742554527 | 6.53126311486347E-08 | BPG |
| ENSG00000092969 | 11.648993391732 | 0.0210412227946416 | 0.432025567700634 | 1.3965214654066E-08 | BPG |
| ENSG00000081181 | 15.3088177871695 | 0.0430246629965016 | 0.431315577801243 | 0.0498940329939293 | BPG |
| ENSG00000148459 | 14.4086021505376 | 0.048742111856042 | 0.429364974832301 | 0.0433078449692255 | BPG |
| ENSG00000051180 | 16.4885639295088 | 0.0420749503776668 | 0.427558428562299 | 3.10366858073935E-05 | BPG |
| ENSG00000113119 | 14.2857142857143 | 0.0395734332048679 | 0.424497828527911 | 0.02981061954876 | BPG |
| ENSG00000100311 | 27.8616120721384 | 3.50691882283434E-07 | 0.424012807497665 | 8.81366769431761E-06 | BPG |
| ENSG00000126261 | 13.347296451442 | 0.000867938947185886 | 0.421711643478361 | 3.50063286508391E-07 | BPG |
| ENSG00000155903 | 13.953488372093 | 0.0018964907491042 | 0.42148143218127 | 0.0102460084903322 | BPG |
| ENSG00000120254 | 10.3525152439024 | 0.00242563790018186 | 0.416225112127262 | 3.11356337626985E-05 | BPG |
| ENSG00000126215 | 18.6881263285758 | 0.0047041318130588 | 0.416095969642456 | 2.96320540656788E-06 | BPG |
| ENSG00000159131 | 20 | 0.0337146988601268 | 0.414334455978619 | 1.40212757091001E-07 | BPG |
| ENSG00000197903 | 11.3590263691684 | 1.80362232316675E-09 | 0.410538463717116 | 7.24747897837557E-06 | BPG |
| ENSG00000166949 | 19.5793163891323 | 0.00299223158104252 | 0.410357367727777 | 6.43088240364512E-15 | BPG |
| ENSG00000100504 | 11.4035087719298 | 0.0278155256641892 | 0.405476621878327 | 3.69273681550957E-06 | BPG |
| ENSG00000189306 | 15.6716417910448 | 0.00152601710196405 | 0.404623362222909 | 0.000214579136064702 | BPG |
| ENSG00000139083 | 19.1780821917808 | 0.00773957494205465 | 0.400130877301734 | 7.7711291486059E-05 | BPG |
| ENSG00000184445 | 10.5769230769231 | 0.00114852995589866 | 0.397728662866405 | 9.03292391205679E-06 | BPG |
| ENSG00000105202 | 10.0411123165648 | 0.0330650395447605 | 0.395966085873695 | 6.31028858614087E-11 | BPG |
| ENSG00000156787 | 12.1844018914281 | 0.0393350703880211 | 0.395736943319907 | 4.74318720256828E-05 | BPG |
| ENSG00000053747 | 10.6796116504854 | 0.0249529707542088 | 0.395144257913057 | 7.61837371152048E-10 | BPG |
| ENSG00000115355 | 13.1376409522105 | 0.0487519118431527 | 0.391856276845191 | 0.00256243902236652 | BPG |
| ENSG00000013573 | 24.5015576323988 | 0.00653446009730904 | 0.390982972113944 | 5.35715606980235E-06 | BPG |
| ENSG00000180198 | 14.5269770879527 | 0.00763746153955366 | 0.385403936585871 | 1.18342807408686E-09 | BPG |
| ENSG00000115946 | 11.3475177304965 | 0.00367585685707775 | 0.385224026927863 | 0.000480076541409388 | BPG |
| ENSG00000012048 | 13.0100374175922 | 0.00926282151959503 | 0.381249185822562 | 2.9090055172466E-05 | BPG |
| ENSG00000160294 | 14.3973673385438 | 0.0219556763363379 | 0.381127688585386 | 0.044429515549183 | BPG |
| ENSG00000173744 | 11.8819776714513 | 0.00871363348299071 | 0.379563150298012 | 0.00111750633730919 | BPG |
| ENSG00000119969 | 17.910447761194 | 0.00623376601063658 | 0.379206507287822 | 0.000129620391717274 | BPG |
| ENSG00000111145 | 10.3885590933621 | 0.0252251574384709 | 0.378221079492621 | 0.000425935635161594 | BPG |
| ENSG00000276043 | 15.2073732718894 | 3.37152560029063E-05 | 0.377966627324228 | 1.13351188388114E-08 | BPG |
| ENSG00000131759 | 15.3109619686801 | 0.045316903961093 | 0.376819201869858 | 0.000596980581262559 | BPG |
| ENSG00000020426 | 33.2469029098243 | 0.0497208468729494 | 0.372042127924171 | 0.0012578498521631 | BPG |
| ENSG00000072110 | 27.020202020202 | 0.0420260837507448 | 0.36814862841075 | 2.13959571937118E-10 | BPG |
| ENSG00000169299 | 15.2948717948718 | 0.00130471132303523 | 0.366885877093739 | 0.000144955318663788 | BPG |
| ENSG00000174501 | 11.8978243978244 | 0.0228953502973815 | 0.36513259345253 | 0.00490678291116583 | BPG |
| ENSG00000154743 | 11.0578174381855 | 0.0153407685857562 | 0.360511380098629 | 0.00516434764538364 | BPG |
| ENSG00000143514 | 16.5490338683284 | 6.71877076986303E-10 | 0.35881789621363 | 2.17092794895104E-06 | BPG |
| ENSG00000111424 | 11.2359550561798 | 0.0317962645934882 | 0.358662099457706 | 0.00294175959312844 | BPG |
| ENSG00000108559 | 17.9736352881528 | 0.0417143548284744 | 0.358475087047095 | 4.28853145568068E-09 | BPG |
| ENSG00000197971 | 17.0625 | 0.0140844301130111 | 0.357679336817535 | 3.79081187181759E-06 | BPG |
| ENSG00000151693 | 11.0769230769231 | 0.000658666735123762 | 0.354638036216122 | 4.57279940276897E-06 | BPG |
| ENSG00000143228 | 14.4578313253012 | 0.0208397804233328 | 0.352493102853737 | 0.0200404463308018 | BPG |
| ENSG00000140854 | 13.9843332739897 | 9.17285896260538E-05 | 0.351879441055567 | 0.00121403316807806 | BPG |
| ENSG00000129514 | 12.5007845352413 | 0.00577489664804183 | 0.351208674792523 | 0.000144498645147243 | BPG |
| ENSG00000111716 | 18.602383531961 | 0.0119289900082757 | 0.349363197618885 | 7.78544029694051E-09 | BPG |
| ENSG00000171960 | 11.9368414184582 | 0.0104242592834035 | 0.347761011385615 | 0.000726796975151203 | BPG |
| ENSG00000165244 | 12.4912016088487 | 3.86317235533345E-06 | 0.34696056772625 | 3.9169520938833E-05 | BPG |
| ENSG00000080823 | 10.9767692453966 | 0.00130393296666201 | 0.344892675250566 | 0.00398579795922971 | BPG |
| ENSG00000172175 | 10.8527394935162 | 0.0194774047441644 | 0.341152662152261 | 0.0324220388410544 | BPG |
| ENSG00000159259 | 10.5882352941176 | 0.0489008832325082 | 0.340424438504752 | 0.00145586742134146 | BPG |
| ENSG00000159128 | 25.1612903225806 | 0.0485527510449985 | 0.337842993482334 | 7.27318213579374E-05 | BPG |
| ENSG00000110047 | 24.1612461485793 | 0.00150776844036724 | 0.334528870269943 | 0.000109902689365428 | BPG |
| ENSG00000197063 | 11.8755328218244 | 0.0493378159714684 | 0.334400889337693 | 5.31922911707779E-05 | BPG |
| ENSG00000221968 | 21.5480150809492 | 0.031818947144702 | 0.334384137494428 | 0.00343241815016781 | BPG |
| ENSG00000179115 | 11.0260946483857 | 0.0294813144269249 | 0.334306506654892 | 4.75012410699513E-05 | BPG |
| ENSG00000115163 | 11.7391304347826 | 0.00059433024365012 | 0.332183719875603 | 0.00177234839493096 | BPG |
| ENSG00000213024 | 14.8489314664701 | 0.0235226165595666 | 0.331862529986476 | 0.045445417558425 | BPG |
| ENSG00000111252 | 16.9539752922486 | 0.00573589684459279 | 0.33125115813949 | 3.52825565234949E-05 | BPG |
| ENSG00000145819 | 14.3424599233934 | 0.00230343250039912 | 0.330677158225405 | 0.00536155887245511 | BPG |
| ENSG00000102144 | 10.3479853479854 | 0.011765225239976 | 0.330116832106607 | 2.36274902194076E-07 | BPG |
| ENSG00000140859 | 15.2478537801163 | 0.00284421553068667 | 0.330101558567158 | 0.000308947762721306 | BPG |
| ENSG00000185238 | 15.3594273530308 | 0.000471869346833329 | 0.329647926677459 | 9.70284664586077E-05 | BPG |
| ENSG00000196535 | 19.5542652207326 | 0.00197961366255126 | 0.328931310926499 | 0.0123758316344305 | BPG |
| ENSG00000173200 | 15.7881024750326 | 0.00412154700403832 | 0.328436881055434 | 0.0279958714637936 | BPG |
| ENSG00000062038 | 10.9421972381767 | 0.00574831964808328 | 0.328215850647634 | 2.00014818397733E-10 | BPG |
| ENSG00000092853 | 11.5196078431373 | 0.012374369365079 | 0.327634213232578 | 0.000642703698649307 | BPG |
| ENSG00000145216 | 15.7894736842105 | 0.0471230922301574 | 0.327626700219808 | 0.00607568903684875 | BPG |
| ENSG00000077348 | 15.830964073404 | 0.00108924937474028 | 0.326243984244442 | 0.0280479451978743 | BPG |
| ENSG00000137656 | 10.2321516774953 | 0.00452774440080063 | 0.325524575166875 | 0.00429430569035293 | BPG |
| ENSG00000076248 | 14.6496976872014 | 0.0407787165171559 | 0.32454088468853 | 4.47249577241696E-06 | BPG |
| ENSG00000136237 | 22.4313725490196 | 0.012350922476546 | 0.321138596741079 | 4.02880506756189E-05 | BPG |
| ENSG00000104852 | 12.5020698791191 | 0.0227116726783726 | 0.320980373575367 | 0.0272299406051771 | BPG |
| ENSG00000104626 | 20.1738473167045 | 0.0483717092209023 | 0.319384146212676 | 0.00182257271468747 | BPG |
| ENSG00000165304 | 12 | 0.020179851199169 | 0.319129648728101 | 2.3370565052397E-05 | BPG |
| ENSG00000214113 | 21.1263579188107 | 0.000236248660011793 | 0.31875051786639 | 0.0469611212957108 | BPG |
| ENSG00000138442 | 33.6170212765958 | 0.032344777797837 | 0.318574659777552 | 4.27600892666218E-05 | BPG |
| ENSG00000186871 | 19.3867020492408 | 0.0102955415871951 | 0.318210088479527 | 0.000680436735418216 | BPG |
| ENSG00000107954 | 25.7726558407543 | 0.00123449997198655 | 0.313660478903761 | 0.000112848217085662 | BPG |
| ENSG00000049541 | 10.2450498225206 | 0.000400881435876873 | 0.31359405800916 | 0.0156478701318847 | BPG |
| ENSG00000122359 | 11.6279069767442 | 0.00253084737125586 | 0.312801510270879 | 0.000137209904272935 | BPG |
| ENSG00000179262 | 22.7272727272727 | 0.0383036857631157 | 0.309587279210015 | 0.0168093082757781 | BPG |
| ENSG00000166451 | 15.7765303394814 | 0.0013292853894967 | 0.306754469098701 | 0.000145665072772221 | BPG |
| ENSG00000105486 | 11.1876709446665 | 0.03642502559154 | 0.30478296776648 | 0.0373791119128896 | BPG |
| ENSG00000104835 | 11.9350282485876 | 0.00336520016079593 | 0.303755348840111 | 0.0495039185082071 | BPG |
| ENSG00000160072 | 11.7262922619128 | 0.0355442426299282 | 0.300394933337722 | 0.0255083618535847 | BPG |
| ENSG00000139618 | 10.8834244080146 | 0.0381891489049431 | 0.300036654668547 | 0.017616581598741 | BPG |
| ENSG00000284776 | 23.1168831168831 | 2.49177149563819E-08 | 0.299726261915365 | 0.00257452786653715 | BPG |
| ENSG00000164251 | 12.5490196078431 | 3.12802531249179E-05 | 0.299055569030699 | 2.62346645158704E-07 | BPG |
| ENSG00000132153 | 13.6713422949542 | 0.000190494073763039 | 0.298366594115216 | 0.00132106509958911 | BPG |
| ENSG00000168528 | 11.71875 | 0.0350619244037604 | 0.293679877382671 | 0.00272649456575734 | BPG |
| ENSG00000153179 | 11.509215637656 | 0.00487777271105144 | 0.292518165356911 | 7.62622000548776E-07 | BPG |
| ENSG00000133119 | 23.297342192691 | 0.024796155868454 | 0.290809071935399 | 0.000710793479083628 | BPG |
| ENSG00000171943 | 10.7947212855418 | 0.0281433704455951 | 0.289910858011574 | 0.0146448175451878 | BPG |
| ENSG00000127080 | 11.6788321167883 | 0.0118293720940106 | 0.289688322543739 | 0.00095971556272434 | BPG |
| ENSG00000127824 | 26.4705882352941 | 0.0319767800481153 | 0.289521638774619 | 1.71137376219558E-05 | BPG |
| ENSG00000178409 | 10.7233589673167 | 0.000688602871074047 | 0.2883218952718 | 0.00811924789522798 | BPG |
| ENSG00000125821 | 23.1168831168831 | 2.49177149563819E-08 | 0.284006254468088 | 0.00304151597190549 | BPG |
| ENSG00000129911 | 24.0011750881316 | 0.0109134199611343 | 0.283108845996834 | 0.0165962119775145 | BPG |
| ENSG00000197586 | 10.8916207611058 | 0.0240152796463978 | 0.281801266632194 | 0.000165273603573787 | BPG |
| ENSG00000120992 | 12.068653815733 | 0.0467686393144206 | 0.281043679407856 | 0.00312991441616504 | BPG |
| ENSG00000131373 | 21.502698215027 | 0.0348851228680506 | 0.280466355713528 | 0.026673189701079 | BPG |
| ENSG00000183856 | 14.939120560217 | 0.00353857287210456 | 0.279732061639544 | 5.33521552830561E-05 | BPG |
| ENSG00000074201 | 15.3724062113508 | 0.000714746368067523 | 0.278172389751471 | 0.00542221796366029 | BPG |
| ENSG00000179889 | 11.6279069767442 | 0.0234358092629859 | 0.27721334100356 | 0.0196164217673316 | BPG |
| ENSG00000103202 | 10.2702702702703 | 0.00299211581336382 | 0.276504211136244 | 0.0291270972475958 | BPG |
| ENSG00000198055 | 17.5735294117647 | 0.0360027243666033 | 0.276497268169316 | 0.00122532365132121 | BPG |
| ENSG00000129422 | 12.9141960237182 | 0.00353438535321241 | 0.273855899087307 | 0.00271216328064717 | BPG |
| ENSG00000163293 | 36.5049751243781 | 0.0114068205386867 | 0.272023189061049 | 0.0270981163833197 | BPG |
| ENSG00000124171 | 11.4952359930839 | 0.030251961845611 | 0.270512585386815 | 3.33325787602703E-05 | BPG |
| ENSG00000159921 | 16.6319740120478 | 0.0247102650373921 | 0.268776922763959 | 0.0157864714181887 | BPG |
| ENSG00000001497 | 12.0453190220632 | 0.0233246031741301 | 0.268705941554237 | 0.00102904917257424 | BPG |
| ENSG00000103121 | 15.7765303394814 | 0.0013292853894967 | 0.267698066293964 | 0.016451034700755 | BPG |
| ENSG00000135932 | 12.251837394407 | 0.0156600904910185 | 0.267400192087818 | 4.11766224712256E-06 | BPG |
| ENSG00000169021 | 19.7987405852574 | 0.0331848943325761 | 0.266995356380579 | 9.14558067484257E-05 | BPG |
| ENSG00000105011 | 12.962962962963 | 0.00398196380955524 | 0.265799661790176 | 0.000169594915789348 | BPG |
| ENSG00000184967 | 13.373809622822 | 0.000941887320689719 | 0.265344566520995 | 0.0469442423787682 | BPG |
| ENSG00000101255 | 10.6708140393795 | 0.00346186997238993 | 0.265331770942825 | 8.46152401667505E-06 | BPG |
| ENSG00000159322 | 30.5180533751962 | 0.0276939285224039 | 0.264849727499511 | 0.031358037477596 | BPG |
| ENSG00000169393 | -25.3085083351375 | 0.00854580724472204 | -3.16992500144231 | 0.0182157396451062 | BPG |
| ENSG00000005108 | -22.2422494592646 | 0.0203653725257178 | -3.12553088208386 | 1.24596404142175E-06 | BPG |
| ENSG00000115738 | -27.2559410725594 | 9.52294042593639E-09 | -3.01016459334895 | 4.18756231129654E-60 | BPG |
| ENSG00000140279 | -17.3963133640553 | 0.0439791706564696 | -3 | 0.0192457689020148 | BPG |
| ENSG00000179044 | -11.8119658119658 | 0.0011790794908365 | -2.75488750216347 | 0.0455889340587114 | BPG |
| ENSG00000198673 | -21.1428571428571 | 0.0368537626321193 | -2.67807190511264 | 0.0262071277264242 | BPG |
| ENSG00000165568 | -14.2735042735043 | 0.0119260335280958 | -2.32192809488736 | 0.0490441201507172 | BPG |
| ENSG00000144218 | -34.3563902885937 | 0.0334977985633422 | -2.17791779219585 | 1.12979214761745E-05 | BPG |
| ENSG00000132854 | -22.8348649401281 | 2.62412424405558E-05 | -2.14498791765084 | 5.70477130980723E-25 | BPG |
| ENSG00000214860 | -14.752079166228 | 0.0357688651189397 | -1.9831261814356 | 0.0106317837925749 | BPG |
| ENSG00000122367 | -34.6323529411765 | 0.0106724369520212 | -1.85561009066482 | 0.00523883401102577 | BPG |
| ENSG00000124766 | -28.7427162707306 | 0.0305691015210822 | -1.70659194512269 | 4.71764749310228E-08 | BPG |
| ENSG00000170871 | -11.2102325960324 | 0.0447876537542586 | -1.66699826958717 | 4.56446949371295E-10 | BPG |
| ENSG00000145526 | -28.7231848184819 | 0.0150508507436879 | -1.61598939634178 | 0.00646044956681184 | BPG |
| ENSG00000184588 | -30.9081527347781 | 0.0464620728183575 | -1.6000299488101 | 3.46814360898919E-07 | BPG |
| ENSG00000177679 | -26.0307692307692 | 0.00289766189866405 | -1.59991284218712 | 0.0138522073197324 | BPG |
| ENSG00000171847 | -16.6869638885947 | 0.0292778679893094 | -1.5722514489716 | 0.0291208044305836 | BPG |
| ENSG00000198734 | -14.3318587177867 | 0.0345038617590958 | -1.56021583838547 | 8.38227320628895E-21 | BPG |
| ENSG00000176399 | -24.8348017621145 | 0.000673263816959103 | -1.53343220008107 | 0.00119524778946158 | BPG |
| ENSG00000170962 | -26.6187050359712 | 0.0089555471845991 | -1.46948528330122 | 0.00328843491383136 | BPG |
| ENSG00000096006 | -15.7666894509 | 0.0375840981055877 | -1.46733200672105 | 0.000154999070643722 | BPG |
| ENSG00000117318 | -22.5806451612903 | 9.36255404736851E-06 | -1.45691426106468 | 9.98591828088862E-70 | BPG |
| ENSG00000187634 | -32.1937321937322 | 0.0194393818625017 | -1.362232804096 | 4.32371894143658E-05 | BPG |
| ENSG00000164292 | -16.8253968253968 | 0.0489389998905521 | -1.32775695358668 | 2.06829375217998E-43 | BPG |
| ENSG00000110693 | -22.723094096789 | 0.00434170059540129 | -1.3112016882943 | 0.00661793779747204 | BPG |
| ENSG00000031081 | -23.1221590909091 | 3.85163478790826E-05 | -1.30618535834161 | 0.0136161269955364 | BPG |
| ENSG00000283765 | -18.060221475675 | 0.0201026712084086 | -1.27105142340771 | 0.00121867914175793 | BPG |
| ENSG00000183307 | -44.8542805100182 | 0.0122239033285652 | -1.25779775746765 | 0.0201283284961805 | BPG |
| ENSG00000126882 | -11.474980351061 | 0.0431523638296012 | -1.25375659224578 | 1.32638827271431E-05 | BPG |
| ENSG00000125378 | -17.9442875805976 | 0.00159035617570787 | -1.22239242133645 | 0.00421868324091519 | BPG |
| ENSG00000022267 | -11.410411622276 | 0.0396008506303448 | -1.17523880133878 | 3.55852677638216E-33 | BPG |
| ENSG00000167080 | -11.4236928221097 | 0.0144869300714228 | -1.16753048630192 | 2.32961544138755E-06 | BPG |
| ENSG00000187720 | -19.4477791116447 | 0.0219138227172992 | -1.13814629276965 | 0.012520318473065 | BPG |
| ENSG00000143341 | -19.5062850219597 | 0.0402301439644637 | -1.13670923392942 | 6.97523100767761E-36 | BPG |
| ENSG00000255690 | -11.6808149405772 | 0.0189770213776895 | -1.12810482574769 | 0.00330599810212225 | BPG |
| ENSG00000112902 | -11.6916269571137 | 0.00115469564699574 | -1.11393198503502 | 1.05408010797426E-37 | BPG |
| ENSG00000172348 | -14.8290188558645 | 0.0136130268570052 | -1.09019780897158 | 0.0423127348056044 | BPG |
| ENSG00000123364 | -10.5263157894737 | 0.000314566514861363 | -1.08318591161621 | 1.69242220698737E-23 | BPG |
| ENSG00000068781 | -15.7183499288763 | 0.00516409946365694 | -1.07635088613011 | 0.00551621832195923 | BPG |
| ENSG00000125845 | -11.3027843053479 | 0.00789415268806258 | -1.07397404155579 | 5.18332620110209E-18 | BPG |
| ENSG00000187867 | -12.8241040005746 | 0.0116382197911919 | -1.0630097975258 | 0.023188149041441 | BPG |
| ENSG00000135063 | -17.3875054609 | 0.0406662819530852 | -1.05169323418149 | 0.00332636281879902 | BPG |
| ENSG00000123407 | -10.9556347791642 | 0.0142153062123272 | -1.0221957461142 | 2.21399677099899E-11 | BPG |
| ENSG00000178826 | -12.3389400190416 | 0.0314189626104258 | -1.00938081120952 | 1.33830789090272E-22 | BPG |
| ENSG00000197183 | -18.7180988179232 | 5.05701304476227E-05 | -0.987198717776908 | 0.0149582145196133 | BPG |
| ENSG00000198246 | -11.7647058823529 | 0.0188313265083686 | -0.985032424402025 | 4.50193522132467E-16 | BPG |
| ENSG00000130720 | -21.4462659380692 | 0.00488164898792484 | -0.948385892392463 | 0.0284975232744333 | BPG |
| ENSG00000115425 | -18.5714285714286 | 0.00683444399629947 | -0.94727689644708 | 0.0299146981065191 | BPG |
| ENSG00000130303 | -28.1553015372487 | 2.47925168599852E-07 | -0.941000038982854 | 1.31028864997261E-05 | BPG |
| ENSG00000169239 | -46.286231884058 | 0.0364241250009795 | -0.931574858989118 | 0.0130880099341582 | BPG |
| ENSG00000181638 | -19.5980542754736 | 0.0055229125237 | -0.899639693651051 | 0.000113364332831388 | BPG |
| ENSG00000243244 | -13.4214394599303 | 0.0460770585806583 | -0.890223773079601 | 6.82444981046458E-15 | BPG |
| ENSG00000151623 | -27.6649369903632 | 0.0397955454574244 | -0.888830624063527 | 2.85802238792563E-05 | BPG |
| ENSG00000146197 | -45.2380952380952 | 0.00908276863868429 | -0.880701071627657 | 0.0107350099427185 | BPG |
| ENSG00000274070 | -11.5542845675296 | 0.0262921135672129 | -0.880634915716104 | 3.61509000218277E-26 | BPG |
| ENSG00000101265 | -16.1462650824353 | 0.0466807612174442 | -0.874007233794735 | 7.77066568488902E-16 | BPG |
| ENSG00000128591 | -41.7447306791569 | 0.033855976152254 | -0.864883069086945 | 0.000120766630439194 | BPG |
| ENSG00000165029 | -22.8506787330317 | 0.0434195105580634 | -0.86291825524471 | 0.000454633977955596 | BPG |
| ENSG00000078018 | -10.7717569786535 | 0.00396620119435979 | -0.856913044052906 | 0.00025794820431816 | BPG |
| ENSG00000146859 | -21.2696586114308 | 0.020578924497702 | -0.84633481531018 | 0.00169353470872061 | BPG |
| ENSG00000135837 | -13.4615384615385 | 0.0364112534338288 | -0.841914617768189 | 4.39815806229496E-30 | BPG |
| ENSG00000088002 | -19.2363636363636 | 0.0244052415164296 | -0.82505692379106 | 0.0298353550538748 | BPG |
| ENSG00000134627 | -19.2347990081375 | 0.00457463014138334 | -0.822461814447813 | 0.00844870159173753 | BPG |
| ENSG00000164506 | -38.9090909090909 | 7.65818641689538E-06 | -0.811913700700874 | 8.39113318714483E-09 | BPG |
| ENSG00000174827 | -13.8363659498664 | 0.0341624646108137 | -0.807564997782899 | 6.86717565483119E-11 | BPG |
| ENSG00000173145 | -13.6073641997813 | 0.0496578294314864 | -0.799516105316538 | 1.15159101940154E-05 | BPG |
| ENSG00000164442 | -10.0267379679144 | 0.0279776618927646 | -0.795281537660393 | 6.31202055193831E-21 | BPG |
| ENSG00000135925 | -21.9082719082719 | 0.0254991791510193 | -0.793619226035631 | 4.80751055745182E-06 | BPG |
| ENSG00000066468 | -10.2743271221532 | 0.0360674862820247 | -0.79071950242535 | 7.93144139610672E-21 | BPG |
| ENSG00000185352 | -27.4216524216524 | 0.00144885499699453 | -0.79007693062577 | 0.0447431224531728 | BPG |
| ENSG00000049283 | -12.5091575091575 | 0.0154280889548072 | -0.788195343774151 | 0.00132370874713995 | BPG |
| ENSG00000147883 | -17.9003588416924 | 3.30391091025144E-05 | -0.78473424255227 | 7.41560338748809E-22 | BPG |
| ENSG00000186472 | -11.34996582365 | 0.0305643480187316 | -0.77420499444271 | 2.61961422751016E-06 | BPG |
| ENSG00000073060 | -25.6318407960199 | 0.0328814878548733 | -0.772455864688409 | 1.76586173067377E-31 | BPG |
| ENSG00000176809 | -11.1764705882353 | 0.000514175858907286 | -0.763084655130088 | 0.000800654523769907 | BPG |
| ENSG00000063180 | -21.0976523476523 | 0.0222779988761963 | -0.755016874448972 | 0.00844328231083494 | BPG |
| ENSG00000170477 | -11.7304189435337 | 0.0269448063337879 | -0.742503777707636 | 1.3230872226162E-08 | BPG |
| ENSG00000132530 | -28.827519379845 | 0.00370560489179961 | -0.739203265142935 | 1.31129592238285E-06 | BPG |
| ENSG00000253910 | -11.9346222128117 | 0.0414994203111755 | -0.72950014391964 | 0.0396713817830189 | BPG |
| ENSG00000196872 | -21.8078218078218 | 0.00380004619688595 | -0.727960780904998 | 1.35353238986487E-09 | BPG |
| ENSG00000126217 | -35.85729339154 | 0.000935043160388676 | -0.721570218766501 | 5.08518675875215E-07 | BPG |
| ENSG00000165861 | -11.4021931140219 | 0.00763535184916297 | -0.720961014729347 | 7.00257301272694E-09 | BPG |
| ENSG00000078804 | -10.8225108225108 | 0.00928397592980438 | -0.719263592432747 | 1.32150632916988E-06 | BPG |
| ENSG00000196159 | -14.8936170212766 | 0.0471818011006502 | -0.717525713342523 | 1.86638251549598E-07 | BPG |
| ENSG00000256223 | -16.3728567978749 | 0.0174051731046039 | -0.715820262853991 | 0.000393372988416042 | BPG |
| ENSG00000120093 | -25.3233687841334 | 1.01612381858311E-12 | -0.714467624516055 | 0.0242160980884065 | BPG |
| ENSG00000137261 | -29.2911943203939 | 0.0306274405863407 | -0.70626879694329 | 0.00736742878448766 | BPG |
| ENSG00000113448 | -23.7878787878788 | 0.0277146558900479 | -0.705491592161748 | 4.54141174788106E-07 | BPG |
| ENSG00000182580 | -13.1755341432761 | 0.0401831561820508 | -0.704544116473825 | 0.00558262764757869 | BPG |
| ENSG00000154265 | -11.7605910899313 | 0.000789266764691025 | -0.704077083584603 | 1.45827370046656E-06 | BPG |
| ENSG00000134030 | -17.2413793103448 | 0.0440574659353242 | -0.703735064599572 | 0.00423651266925635 | BPG |
| ENSG00000153113 | -12.8383413219479 | 0.00247776438292905 | -0.703518178232066 | 1.42459864428974E-14 | BPG |
| ENSG00000064787 | -13.652989821883 | 0.0244339815607894 | -0.696607856550066 | 4.6594488010428E-06 | BPG |
| ENSG00000138764 | -34.7946725860155 | 0.000333173550939385 | -0.695928088181486 | 2.71937010624573E-14 | BPG |
| ENSG00000188026 | -14.1176470588235 | 0.0459663762263134 | -0.694037324976346 | 0.023738157713412 | BPG |
| ENSG00000196417 | -22.0108950878182 | 0.0120084340558698 | -0.690451059239939 | 0.00048897912138809 | BPG |
| ENSG00000130635 | -17.720207253886 | 0.0492072592643873 | -0.685198409708279 | 1.26290044816402E-26 | BPG |
| ENSG00000163071 | -17.8918650793651 | 0.000238225772485735 | -0.68326457433296 | 0.0160637005422413 | BPG |
| ENSG00000162616 | -10.1658977127712 | 0.00489225511347078 | -0.677964365696175 | 4.80260658941897E-12 | BPG |
| ENSG00000150347 | -13.3711042556557 | 0.000279912881808571 | -0.668489279530708 | 1.18874074373337E-26 | BPG |
| ENSG00000239704 | -49.5726495726496 | 0.00319349673251791 | -0.667424660913131 | 0.0143437957934638 | BPG |
| ENSG00000196227 | -16.7942942942943 | 0.00329264008508148 | -0.662382727403818 | 3.58986363598043E-10 | BPG |
| ENSG00000146350 | -20.1736542954448 | 3.35326970164892E-05 | -0.653262229789643 | 0.00944152725963259 | BPG |
| ENSG00000120784 | -29.6452328159645 | 0.0186782132873125 | -0.651513693629762 | 0.0146042259180537 | BPG |
| ENSG00000186806 | -26.4183561213264 | 0.00983045396353613 | -0.649858302947994 | 0.00754359177228354 | BPG |
| ENSG00000158321 | -24.1720883887228 | 0.028801593296161 | -0.648265082629678 | 0.00534070540002623 | BPG |
| ENSG00000004399 | -11.0782295419455 | 0.0466824666406132 | -0.643196863834183 | 0.00186187396969658 | BPG |
| ENSG00000167720 | -14.0460174285277 | 0.0121783610214339 | -0.638444830991933 | 0.00499040741340259 | BPG |
| ENSG00000166473 | -18.6415415735122 | 0.0140373551765548 | -0.637980883020648 | 0.0350745435774593 | BPG |
| ENSG00000161328 | -16.1817226890756 | 0.0456827331161719 | -0.626321530482211 | 0.0311368727613035 | BPG |
| ENSG00000105357 | -21.8991534781008 | 0.033635003674445 | -0.620745655468585 | 2.7355022608927E-18 | BPG |
| ENSG00000110975 | -11.6666666666667 | 0.0378117878869766 | -0.620411336725446 | 0.00614008621027657 | BPG |
| ENSG00000121281 | -31.036531036531 | 0.000108395658331335 | -0.620078087582796 | 0.00134564043630872 | BPG |
| ENSG00000198682 | -12.2528100018032 | 0.000145080197988415 | -0.618563904087295 | 1.88074343089455E-10 | BPG |
| ENSG00000181035 | -17.948717948718 | 1.1243993955062E-06 | -0.613645255425247 | 0.00752603927024964 | BPG |
| ENSG00000249437 | -10.4472025216706 | 0.0191099409923715 | -0.600838259722475 | 0.000312463160490006 | BPG |
| ENSG00000119280 | -22.9323308270677 | 0.00448911230662707 | -0.598855003274603 | 4.87658245333588E-05 | BPG |
| ENSG00000081189 | -18.8919888401754 | 0.0458657425156468 | -0.592175990953731 | 1.68981299065485E-05 | BPG |
| ENSG00000142798 | -21.5303215303215 | 0.0231716063266128 | -0.5899034146544 | 8.21742467592223E-12 | BPG |
| ENSG00000148180 | -22.0766831773986 | 0.00333445198565143 | -0.58507858029968 | 1.02616245712461E-21 | BPG |
| ENSG00000151117 | -30.5263157894737 | 0.000159722311744359 | -0.57831922709054 | 1.52621139350365E-05 | BPG |
| ENSG00000163406 | -17.7479892761394 | 0.00255182037669778 | -0.577405149543082 | 0.0121769142274754 | BPG |
| ENSG00000152284 | -18.9802631578947 | 0.0164930267945575 | -0.573347871818441 | 0.00169316922396989 | BPG |
| ENSG00000181555 | -18.7059993878176 | 0.00642328434364566 | -0.57045000701778 | 0.000633772036520459 | BPG |
| ENSG00000132825 | -16.7942942942943 | 0.00329264008508148 | -0.567278581158528 | 3.64112288296977E-08 | BPG |
| ENSG00000214960 | -25 | 0.016295176120114 | -0.566616208240501 | 0.000191551711513297 | BPG |
| ENSG00000116117 | -57.8347578347578 | 0.00293279455643258 | -0.565110565625496 | 0.00619843887025926 | BPG |
| ENSG00000179240 | -21.3538363982245 | 0.0341784248396807 | -0.562569888678666 | 0.000174515953525452 | BPG |
| ENSG00000139173 | -25.6965174129353 | 0.0437445774727228 | -0.561479359762611 | 0.00409511772182182 | BPG |
| ENSG00000185261 | -20.0123757094696 | 0.020052417848434 | -0.553253640993819 | 0.0362478930997127 | BPG |
| ENSG00000020181 | -12.7834293418311 | 0.032356879366654 | -0.546427899302171 | 0.00983148706722227 | BPG |
| ENSG00000114805 | -19.3918531267929 | 0.0108898114101458 | -0.543298174118273 | 0.00195123896760484 | BPG |
| ENSG00000197050 | -18.4495021337127 | 0.0198866741668744 | -0.538866086131702 | 0.00624942651321243 | BPG |
| ENSG00000184012 | -18.1991879627418 | 0.00597710816950326 | -0.534540606687861 | 2.80433524861581E-05 | BPG |
| ENSG00000266074 | -17.8296049500238 | 0.00673064892733957 | -0.532013620772197 | 0.00290890178605587 | BPG |
| ENSG00000137710 | -17.024154589372 | 0.0194503531162814 | -0.509881553601421 | 1.19794881274545E-11 | BPG |
| ENSG00000286185 | -25.5740107474353 | 0.0442468970760671 | -0.508549385201989 | 0.0233281012293291 | BPG |
| ENSG00000168952 | -27.0041227668346 | 0.0361783351821684 | -0.506001358375646 | 0.000757715658056192 | BPG |
| ENSG00000065717 | -19.2005157962605 | 0.0465447514310898 | -0.505023206478345 | 0.030178121078624 | BPG |
| ENSG00000128881 | -14.7619047619048 | 0.0307063695905693 | -0.503303250321294 | 0.000699512661491251 | BPG |
| ENSG00000288611 | -27.1107196097032 | 4.90113226319831E-12 | -0.502383281415895 | 0.00136437218092605 | BPG |
| ENSG00000197321 | -14.9425287356322 | 0.0469346695243425 | -0.501773106156611 | 5.87968999963141E-08 | BPG |
| ENSG00000004468 | -17.7096492080459 | 0.010110582357382 | -0.498784546838366 | 2.88191330173453E-19 | BPG |
| ENSG00000031003 | -12.6666666666667 | 0.0165147742367946 | -0.498416665958258 | 1.62058029177946E-05 | BPG |
| ENSG00000185442 | -32.776171924092 | 0.00749766036878492 | -0.488240690456756 | 0.000221616026621544 | BPG |
| ENSG00000010810 | -13.6842105263158 | 0.0191245606116734 | -0.486449571915371 | 0.000413551472221232 | BPG |
| ENSG00000133056 | -40.8445576993083 | 0.000905019819790039 | -0.48630858030407 | 6.28258786955604E-06 | BPG |
| ENSG00000111335 | -11.1763191763192 | 0.0235768105093155 | -0.485212793338396 | 4.18687964443166E-14 | BPG |
| ENSG00000137941 | -15.3955260171827 | 0.00014539576338224 | -0.483014293094851 | 0.005048594733699 | BPG |
| ENSG00000155621 | -11.3020890206718 | 0.015856947109812 | -0.47892536403238 | 0.00239940453361955 | BPG |
| ENSG00000185630 | -42.9711751662971 | 0.00600531248549614 | -0.476626525138652 | 4.68402347442217E-06 | BPG |
| ENSG00000166387 | -21.7245146650979 | 0.0443533343534964 | -0.475296219553436 | 0.0011843075479458 | BPG |
| ENSG00000104687 | -11.4678899082569 | 0.0348851228680506 | -0.464375020256106 | 6.97868723476842E-05 | BPG |
| ENSG00000182621 | -14.1242265587815 | 0.0189228623228636 | -0.460113840733944 | 0.00511236354729573 | BPG |
| ENSG00000126016 | -35.2063492063492 | 0.0276634704800075 | -0.459114019287442 | 0.000389295435109945 | BPG |
| ENSG00000107864 | -28.9068825910931 | 0.0209329546065706 | -0.458141001249102 | 0.0326818098866569 | BPG |
| ENSG00000136295 | -11.6443959640033 | 0.0323485301149538 | -0.458073580642192 | 0.000508698691512146 | BPG |
| ENSG00000165072 | -19.0677025527192 | 0.000339771897715373 | -0.45645563299263 | 1.97166067202811E-06 | BPG |
| ENSG00000171604 | -18.9543197074715 | 4.1729471859855E-08 | -0.453648847676855 | 1.39816502664685E-06 | BPG |
| ENSG00000035862 | -15.7889507154213 | 0.0468290151418606 | -0.451158553185102 | 4.78852687458916E-18 | BPG |
| ENSG00000151690 | -14.4205594598319 | 0.0104011052091819 | -0.449636871552875 | 0.000999885078613307 | BPG |
| ENSG00000186350 | -19.2988014150694 | 0.0017111929157375 | -0.448057242810654 | 1.55132841468133E-14 | BPG |
| ENSG00000129933 | -15.0412087912088 | 0.0317264087153831 | -0.444759038098622 | 0.0374773939660338 | BPG |
| ENSG00000119771 | -31.5789473684211 | 0.0321213640771322 | -0.44461773449381 | 0.000411429515895675 | BPG |
| ENSG00000118777 | -22.9389788293898 | 0.000234720797535922 | -0.442408470794975 | 6.46795535036693E-06 | BPG |
| ENSG00000117114 | -20 | 0.0261546286341399 | -0.441252757186227 | 0.000523087175169761 | BPG |
| ENSG00000135596 | -24.2690058479532 | 0.0273177882292688 | -0.439942841041666 | 0.00918029544146054 | BPG |
| ENSG00000053254 | -20.0134027120782 | 0.038465108119542 | -0.439027674185821 | 1.53454946009585E-08 | BPG |
| ENSG00000137642 | -11.5808823529412 | 0.0216307609026432 | -0.436013456287618 | 7.68304029801625E-11 | BPG |
| ENSG00000004766 | -11.4812063586391 | 0.0415076545920972 | -0.435199538758269 | 0.0165862605250558 | BPG |
| ENSG00000173269 | -21.638418079096 | 0.0451104664416307 | -0.434535907955739 | 0.00346600064214692 | BPG |
| ENSG00000060656 | -14.5128849780012 | 0.0235178287141165 | -0.430759874289997 | 0.00126382471978609 | BPG |
| ENSG00000024422 | -26.7651080120317 | 8.74869238951487E-07 | -0.430742625234609 | 0.0292165467312493 | BPG |
| ENSG00000263001 | -12.4821415143996 | 4.13774880745456E-05 | -0.427605769403905 | 1.30049770019362E-15 | BPG |
| ENSG00000174938 | -31.3690169840453 | 0.00566139896404944 | -0.427578762750185 | 0.00943681282532973 | BPG |
| ENSG00000122042 | -11.3924050632911 | 0.0453494958684685 | -0.426135208162175 | 6.74272007444918E-06 | BPG |
| ENSG00000159882 | -11.1559109843844 | 0.00349377912991324 | -0.423414847816786 | 0.0126593449204417 | BPG |
| ENSG00000076067 | -10.172441069451 | 0.0322621422851104 | -0.422942697364189 | 0.000138197954281027 | BPG |
| ENSG00000111110 | -16.2162162162162 | 0.0427487766122153 | -0.422821207581922 | 7.20801592208993E-13 | BPG |
| ENSG00000119772 | -23.7141148325359 | 0.0163957352760807 | -0.421826664941483 | 1.21514223997701E-08 | BPG |
| ENSG00000114904 | -10.8284048255516 | 0.0241379586403085 | -0.420381720055679 | 4.72687968962056E-06 | BPG |
| ENSG00000213626 | -20.530703202377 | 0.000146032484618759 | -0.414439738739572 | 9.3078793953285E-09 | BPG |
| ENSG00000107485 | -27.8860569715142 | 0.0301130999882541 | -0.413948336504497 | 1.75626784325988E-05 | BPG |
| ENSG00000104447 | -12.250554323725 | 0.0017224362480735 | -0.411834331696803 | 1.05945304519687E-12 | BPG |
| ENSG00000105289 | -26.3516583371195 | 0.00243834530570209 | -0.41174610474983 | 0.00268329936508764 | BPG |
| ENSG00000196189 | -19.8748299319728 | 0.0351914032748957 | -0.411650094480343 | 0.000186204771936961 | BPG |
| ENSG00000076554 | -11.3150813486933 | 0.0464255898730151 | -0.408729640831393 | 0.000156010695767343 | BPG |
| ENSG00000184384 | -16.7614498028511 | 0.0197342494549712 | -0.40859384701675 | 1.90834843581944E-08 | BPG |
| ENSG00000106799 | -12 | 0.01330417194986 | -0.407774072780301 | 0.000280359663905417 | BPG |
| ENSG00000021826 | -23.6842105263158 | 0.0462736889243597 | -0.405337418500074 | 0.00616383842515306 | BPG |
| ENSG00000005187 | -17.038789025544 | 0.0153436175619191 | -0.403418416012008 | 0.0448865535404382 | BPG |
| ENSG00000133943 | -14.8343361013044 | 0.00591261719440728 | -0.403301391227878 | 0.000100742003170586 | BPG |
| ENSG00000011028 | -21.595015576324 | 0.0171678013900045 | -0.402874720298177 | 9.42467032388253E-07 | BPG |
| ENSG00000127663 | -33.6503623188406 | 0.00171051555895984 | -0.401869868853929 | 2.86929099910416E-05 | BPG |
| ENSG00000141570 | -11.2593052109181 | 0.0144163128036595 | -0.400763699039544 | 0.00755259880380841 | BPG |
| ENSG00000275395 | -26.265664160401 | 0.00777188474259746 | -0.399832627667512 | 0.00313125281698433 | BPG |
| ENSG00000103126 | -21.3554987212276 | 0.000201394510843982 | -0.398908443869134 | 1.94566970403727E-05 | BPG |
| ENSG00000140836 | -33.0721003134796 | 0.0420168370380255 | -0.398451891606571 | 9.35526164448217E-08 | BPG |
| ENSG00000118257 | -23.2538713615627 | 0.00139916562865624 | -0.398420727705338 | 0.000143402070040823 | BPG |
| ENSG00000172493 | -21.3652535729361 | 0.0372534055870424 | -0.38972945200723 | 0.0234032173352906 | BPG |
| ENSG00000090020 | -19.2743288590604 | 0.015861808311544 | -0.388856683389991 | 0.000518778442434831 | BPG |
| ENSG00000053108 | -34.5943673812526 | 0.0253805519864271 | -0.387579503772093 | 0.0424531936840138 | BPG |
| ENSG00000138759 | -11.5113137944056 | 0.0337883711297745 | -0.387473859671809 | 0.0257016002817308 | BPG |
| ENSG00000140396 | -10.8151549942595 | 0.0360233343840566 | -0.386742552310836 | 0.000239083816398964 | BPG |
| ENSG00000137145 | -18.2248096730855 | 0.00508177320801475 | -0.383559267805676 | 1.10343356270823E-08 | BPG |
| ENSG00000033800 | -10.8055262849783 | 3.62593955542093E-05 | -0.38191478078331 | 4.91471783275079E-07 | BPG |
| ENSG00000067208 | -10.2189781021898 | 0.00498029617865129 | -0.381634341011633 | 0.0143609651949742 | BPG |
| ENSG00000149571 | -35.1841820151679 | 0.0322340724629596 | -0.38124062832878 | 0.00038268469644075 | BPG |
| ENSG00000148411 | -18.2267749911692 | 0.0311200040968892 | -0.380991780541891 | 0.000130763088080944 | BPG |
| ENSG00000166263 | -22.2222222222222 | 0.00924873499321939 | -0.380744321724967 | 0.000418729852976832 | BPG |
| ENSG00000108370 | -20.2324224448118 | 0.0224885565269278 | -0.376513232652959 | 0.0357246871062311 | BPG |
| ENSG00000177425 | -30.9791332263242 | 0.0290104230584578 | -0.374495972949755 | 0.00621084614505039 | BPG |
| ENSG00000071909 | -27.1900269541779 | 0.026966427274738 | -0.373123857545449 | 0.0344094454284773 | BPG |
| ENSG00000147852 | -10.9904673331783 | 0.0499202989198112 | -0.370732125655407 | 8.07912484025131E-06 | BPG |
| ENSG00000213463 | -18.4473929236499 | 0.000409714520048529 | -0.369621388831842 | 0.0117890081504949 | BPG |
| ENSG00000183111 | -14.1414141414141 | 0.0234289623507625 | -0.369058181807338 | 0.000887079686645829 | BPG |
| ENSG00000103544 | -15.7894736842105 | 0.0135107886884008 | -0.368911930402233 | 0.00796346489599808 | BPG |
| ENSG00000142065 | -15.5963302752294 | 0.00642989573367869 | -0.368867317845923 | 0.0061016352497874 | BPG |
| ENSG00000000971 | -18.6928104575163 | 0.0381543097810529 | -0.368156784815649 | 0.00829744213311694 | BPG |
| ENSG00000196498 | -26.3157894736842 | 0.00716785210795178 | -0.365364917610353 | 0.0024253152303974 | BPG |
| ENSG00000167930 | -25.9743954480797 | 0.0132126767562927 | -0.364788396824613 | 0.000160436626026178 | BPG |
| ENSG00000164463 | -29.6296296296296 | 0.0116456414843442 | -0.36011128877525 | 2.00051018268182E-08 | BPG |
| ENSG00000149932 | -22.6774193548387 | 0.0147586695726215 | -0.359641098179801 | 0.00798093556666294 | BPG |
| ENSG00000133121 | -24.5989304812834 | 0.0362428273664653 | -0.359284458342618 | 3.70422379108297E-06 | BPG |
| ENSG00000163430 | -26.4274497487437 | 2.06667236117478E-12 | -0.357847922538527 | 4.99082827647821E-16 | BPG |
| ENSG00000165813 | -13.3241758241758 | 0.0234969527049207 | -0.35652546997289 | 8.29764421380416E-05 | BPG |
| ENSG00000048707 | -27.2341597796143 | 0.00733359766974552 | -0.355910194316597 | 0.00460082542307338 | BPG |
| ENSG00000115419 | -12.2636856814072 | 0.00233942838867749 | -0.3534824267315 | 0.000700021903309769 | BPG |
| ENSG00000168769 | -11.8910939806462 | 0.00924277200859742 | -0.352781048803786 | 0.000226578959147252 | BPG |
| ENSG00000144036 | -10.1010101010101 | 0.0415913214659878 | -0.351100145352023 | 1.30393720844209E-07 | BPG |
| ENSG00000090905 | -10.5896368883818 | 0.0144273051946461 | -0.347832227062783 | 0.000471463587356345 | BPG |
| ENSG00000112983 | -13.0574767469592 | 4.72308756925635E-06 | -0.347495648150863 | 6.32052916426757E-05 | BPG |
| ENSG00000035664 | -12.7271804244086 | 0.0333961822126745 | -0.347029855464279 | 0.000251558833382371 | BPG |
| ENSG00000011347 | -19.7648728083511 | 0.000716431069673398 | -0.346753803485244 | 0.000132820027074002 | BPG |
| ENSG00000145743 | -12.4588744588745 | 0.0312074337643093 | -0.345848057083885 | 0.00115791649628188 | BPG |
| ENSG00000185621 | -12.5049648435403 | 0.00644783960827106 | -0.342887713523009 | 0.00947313600986688 | BPG |
| ENSG00000054267 | -10.4492959974688 | 0.025373302489601 | -0.342210031447351 | 5.14097041637532E-05 | BPG |
| ENSG00000078687 | -15.5804849162746 | 0.0198389185083253 | -0.341871086716868 | 0.00112924317517576 | BPG |
| ENSG00000109618 | -29.5842345590002 | 0.0300916586865236 | -0.339962017717625 | 0.00326955308091664 | BPG |
| ENSG00000126705 | -26.0695011188627 | 4.62071581198193E-05 | -0.336920809362834 | 3.74083405840874E-06 | BPG |
| ENSG00000187498 | -10.4905764966741 | 0.0192200266176312 | -0.336870943565742 | 1.33866133734124E-06 | BPG |
| ENSG00000078114 | -32.7096774193548 | 0.0160013884423327 | -0.336614795442298 | 3.31483817017941E-07 | BPG |
| ENSG00000257923 | -33.3935561577838 | 0.0140879640094156 | -0.333068652492565 | 7.22255658121801E-05 | BPG |
| ENSG00000118898 | -24.1774151092393 | 1.67516345394496E-05 | -0.332136872186805 | 1.43092872225816E-06 | BPG |
| ENSG00000108840 | -12 | 0.0125161345866882 | -0.330166204586187 | 8.37847751568423E-06 | BPG |
| ENSG00000090615 | -25.3346855983773 | 5.86662883997356E-06 | -0.326546834385105 | 0.00245668100546887 | BPG |
| ENSG00000124788 | -22.4137931034483 | 0.000301981434417419 | -0.3247633955855 | 5.48725590404673E-18 | BPG |
| ENSG00000169967 | -11.4583333333333 | 0.0339287737679039 | -0.324675795510129 | 2.87816468590847E-08 | BPG |
| ENSG00000148400 | -12.2994652406417 | 0.0327847423666243 | -0.322624320288574 | 0.00334632511147991 | BPG |
| ENSG00000168143 | -20.8005249343832 | 0.0224423004027622 | -0.321704369207935 | 0.000648834340912548 | BPG |
| ENSG00000158828 | -13.0841121495327 | 0.00836764608199518 | -0.32169317290553 | 0.000252368264090229 | BPG |
| ENSG00000091622 | -10.3234914246238 | 0.0437409493308147 | -0.319576087235189 | 0.0257875483845378 | BPG |
| ENSG00000167755 | -37.6623376623377 | 0.00152676786261716 | -0.318421604149615 | 1.12887892117129E-06 | BPG |
| ENSG00000196975 | -10.4037267080745 | 0.0005631525966545 | -0.318322994090514 | 0.000476234545672557 | BPG |
| ENSG00000196935 | -12.5095492742552 | 0.0312581984774442 | -0.317212837258018 | 6.26141169093279E-06 | BPG |
| ENSG00000105810 | -17.3458725182863 | 0.0154453795157378 | -0.316635644920549 | 0.0001567758234917 | BPG |
| ENSG00000179912 | -10.8843537414966 | 0.00435216859219888 | -0.315746578471056 | 0.000874410459462611 | BPG |
| ENSG00000112144 | -12.3076923076923 | 0.0352358160993718 | -0.313903923802541 | 0.00138892875889279 | BPG |
| ENSG00000196628 | -26.4150943396226 | 0.00159773648008419 | -0.313420129875148 | 3.28353137619013E-05 | BPG |
| ENSG00000175155 | -10.767405236335 | 0.0492552564194126 | -0.313192706891764 | 0.00257815783289071 | BPG |
| ENSG00000131149 | -72.3484848484848 | 6.02086208344641E-07 | -0.312479031368485 | 8.88086989224702E-05 | BPG |
| ENSG00000173402 | -17.3076923076923 | 0.00259101568638736 | -0.311495771507253 | 6.72980902479292E-07 | BPG |
| ENSG00000172817 | -13.0865201372126 | 0.0148212401623412 | -0.310860790984529 | 0.000193135720485011 | BPG |
| ENSG00000033122 | -15.1976099351714 | 0.0443638347308002 | -0.306925931548116 | 0.00649183678214571 | BPG |
| ENSG00000188064 | -12.2101449275362 | 0.0219575344210156 | -0.30632285680212 | 0.00403868260498254 | BPG |
| ENSG00000145431 | -11.3122820427077 | 0.0245549610355889 | -0.304810542546114 | 0.0331405587117779 | BPG |
| ENSG00000168795 | -10.063648762746 | 0.035655980992928 | -0.304780788272944 | 0.00124804558314024 | BPG |
| ENSG00000152104 | -19.5183486238532 | 0.0186903174950322 | -0.304201627678951 | 9.3801020593915E-09 | BPG |
| ENSG00000171517 | -10.7142857142857 | 0.030254997250585 | -0.303203453090096 | 0.027909916119053 | BPG |
| ENSG00000148498 | -25.6010171058715 | 0.00121364071948905 | -0.302775645054516 | 0.000599403897821241 | BPG |
| ENSG00000109654 | -37.5 | 0.0341617113401962 | -0.301685799799022 | 0.0170642350636622 | BPG |
| ENSG00000107104 | -10.3243861338469 | 0.0431702429948203 | -0.300742764996734 | 0.00633350140038271 | BPG |
| ENSG00000130844 | -39.983164983165 | 4.16525166325114E-10 | -0.300668723482284 | 0.00719998180056289 | BPG |
| ENSG00000217128 | -11.6228070175439 | 0.0495363996427847 | -0.298728320110066 | 9.04052804294962E-05 | BPG |
| ENSG00000091157 | -13.7931034482759 | 0.0109254916292158 | -0.297059220774465 | 0.0374840228006454 | BPG |
| ENSG00000144306 | -17.2854441575341 | 0.00559347748568485 | -0.293767533373402 | 0.0228695802793786 | BPG |
| ENSG00000146648 | -15.6407144095717 | 0.037114166441291 | -0.293703786413115 | 2.29989877751664E-08 | BPG |
| ENSG00000013288 | -20.1121794871795 | 0.00270720181302578 | -0.293473449710851 | 0.000421015976627107 | BPG |
| ENSG00000075568 | -21.9716494845361 | 0.0419162189190783 | -0.293035982058586 | 0.0302709234446858 | BPG |
| ENSG00000163701 | -11.1111111111111 | 0.0356666493579973 | -0.292553492753849 | 0.0388021610140557 | BPG |
| ENSG00000105426 | -19.0459067481721 | 0.0115227968479095 | -0.29136312889229 | 9.61011029442332E-06 | BPG |
| ENSG00000142784 | -15.6462585034014 | 0.0170921943617 | -0.291309926911496 | 0.000705471601159669 | BPG |
| ENSG00000213694 | -15.9353471118177 | 0.000600072464513817 | -0.289866885655064 | 0.00708301690362163 | BPG |
| ENSG00000119711 | -20.3245942571785 | 0.00640464663479342 | -0.289825497682747 | 0.0011433293486166 | BPG |
| ENSG00000124587 | -10.219068956933 | 0.0480419481129848 | -0.289260874309599 | 0.0126463946039842 | BPG |
| ENSG00000122779 | -23.0899830220713 | 0.0338399491511729 | -0.286905809452637 | 0.0312074493440943 | BPG |
| ENSG00000133424 | -29.8483736854977 | 0.00295502009273725 | -0.285218427692496 | 0.0188359404674102 | BPG |
| ENSG00000164073 | -15.3201571890892 | 0.0150902906467985 | -0.283527577697872 | 0.0348579282153239 | BPG |
| ENSG00000196743 | -15.7559198542805 | 0.00253350944854052 | -0.28258280221177 | 0.00252542188050536 | BPG |
| ENSG00000133983 | -18.4473929236499 | 0.000409714520048529 | -0.28200331050987 | 0.0264347269628561 | BPG |
| ENSG00000137802 | -29.5496991076987 | 0.045919863933346 | -0.279574081983723 | 6.17422330703431E-07 | BPG |
| ENSG00000177426 | -16.8514136992784 | 0.0019906890357851 | -0.279003057669837 | 4.43854792534203E-05 | BPG |
| ENSG00000139266 | -26.486915146709 | 2.18453721103963E-13 | -0.277918279325949 | 0.0404238161915395 | BPG |
| ENSG00000183018 | -15.8710730314158 | 0.0303798945817675 | -0.275184263619617 | 0.0380516157947918 | BPG |
| ENSG00000125637 | -19.8146513680494 | 0.0255341249935498 | -0.272566168006445 | 0.0497067351784928 | BPG |
| ENSG00000197757 | -11.0945824396319 | 0.0237079682771938 | -0.271302021817394 | 0.0131892309227297 | BPG |
| ENSG00000177853 | -11.0696612105063 | 0.00840131928524951 | -0.268605858957599 | 0.0290459942156785 | BPG |
| ENSG00000054965 | -15 | 0.0466784626955542 | -0.267963637356679 | 0.000293100155619997 | BPG |
| ENSG00000148842 | -11.4588050599281 | 0.0266352962539337 | -0.267695783203657 | 0.00377595052802898 | BPG |
| ENSG00000123636 | -28.1315458734814 | 0.0140819601108139 | -0.267416852462943 | 0.011351823485927 | BPG |
| ENSG00000126858 | -12.2970639032815 | 0.000516604023102541 | -0.266499681624815 | 0.0311298311886331 | BPG |
| ENSG00000162434 | -20 | 0.033302838632579 | -0.263612329451374 | 4.94379178207903E-08 | BPG |
| ENSG00000243708 | 11.4285714285714 | 0.0459755722858929 | -10.2086408085582 | 0.0303914223244126 | BNG |
| ENSG00000285791 | 11.6889326831308 | 2.58663260106533E-05 | -5.32192809488736 | 0.0444464233284871 | BNG |
| ENSG00000284686 | 15.2453424298085 | 0.0142705765108504 | -4.56478461878353 | 0.0159534725530422 | BNG |
| ENSG00000284554 | 20.4896907216495 | 0.0239166953197774 | -2.88452278258007 | 0.0161004908719089 | BNG |
| ENSG00000141052 | 23.4808612440191 | 0.0332321208951147 | -2.84130225398094 | 0.00445823481164802 | BNG |
| ENSG00000198673 | 34.2760180995475 | 0.0471210718080951 | -2.67807190511264 | 0.0262071277264242 | BNG |
| ENSG00000166509 | 23.8829833203699 | 0.000107100204342874 | -2.44166733916145 | 9.2409671837753E-10 | BNG |
| ENSG00000172346 | 13.8792102206736 | 0.0338485749067207 | -2.30666133823405 | 0.00785735661929826 | BNG |
| ENSG00000055163 | 18.4180790960452 | 0.0478510307688422 | -2.2829339632715 | 0.0165454370593668 | BNG |
| ENSG00000144218 | 26.7397628104721 | 0.0231025020147638 | -2.17791779219585 | 1.12979214761745E-05 | BNG |
| ENSG00000085741 | 21.8053804119378 | 0.0099531998749705 | -1.96578428466209 | 0.000496517358048221 | BNG |
| ENSG00000122367 | 14.6890216261722 | 0.000179835622794449 | -1.85561009066482 | 0.00523883401102577 | BNG |
| ENSG00000159450 | 11.9856933865753 | 0.0244013429886495 | -1.85414913353655 | 0.00369912599429018 | BNG |
| ENSG00000170871 | 20.7547169811321 | 0.0356584465615654 | -1.66699826958717 | 4.56446949371295E-10 | BNG |
| ENSG00000145526 | 27.8409090909091 | 0.0265871205051091 | -1.61598939634178 | 0.00646044956681184 | BNG |
| ENSG00000184588 | 21.6815809097688 | 0.0320487792308055 | -1.6000299488101 | 3.46814360898919E-07 | BNG |
| ENSG00000177679 | 27.6068965517241 | 0.0141703113104466 | -1.59991284218712 | 0.0138522073197324 | BNG |
| ENSG00000115844 | 19.5057536313903 | 0.023166417767195 | -1.4723706743448 | 0.00193013004584154 | BNG |
| ENSG00000134516 | 22.2453646981949 | 0.0240135392868345 | -1.41503749927884 | 0.018051969347599 | BNG |
| ENSG00000137834 | 11.8944143630664 | 0.0161432184490245 | -1.4039992278264 | 1.34050871745801E-05 | BNG |
| ENSG00000164292 | 19.9233716475096 | 0.0364557999486495 | -1.32775695358668 | 2.06829375217998E-43 | BNG |
| ENSG00000110693 | 20.5844828001252 | 0.0214335484821773 | -1.3112016882943 | 0.00661793779747204 | BNG |
| ENSG00000031081 | 11.8811881188119 | 0.0285139918378 | -1.30618535834161 | 0.0136161269955364 | BNG |
| ENSG00000104081 | 14.6915584415584 | 0.0266766311662972 | -1.28504761764604 | 2.89295613727264E-29 | BNG |
| ENSG00000179869 | 14.2641077523658 | 0.036012662655069 | -1.27077305420077 | 2.96061122587694E-26 | BNG |
| ENSG00000183307 | 32.9376854599407 | 7.37254582691034E-06 | -1.25779775746765 | 0.0201283284961805 | BNG |
| ENSG00000125378 | 23.908804559772 | 0.0141634247950583 | -1.22239242133645 | 0.00421868324091519 | BNG |
| ENSG00000187720 | 13.1598457888494 | 8.52728379619754E-05 | -1.13814629276965 | 0.012520318473065 | BNG |
| ENSG00000143341 | 17.9016221873365 | 0.0235758336459982 | -1.13670923392942 | 6.97523100767761E-36 | BNG |
| ENSG00000112902 | 27.8081467113384 | 0.0190729888469772 | -1.11393198503502 | 1.05408010797426E-37 | BNG |
| ENSG00000050628 | 29.1620207564971 | 0.0142390504680928 | -1.11103131238874 | 0.0159352652065548 | BNG |
| ENSG00000164125 | 11.1111111111111 | 0.0114068205386867 | -1.0994888016056 | 2.13172674056113E-29 | BNG |
| ENSG00000172348 | 35.0877192982456 | 0.0256081938719352 | -1.09019780897158 | 0.0423127348056044 | BNG |
| ENSG00000166147 | 36.1985472154964 | 0.0302694806912422 | -1.07480383893417 | 5.03157126804725E-30 | BNG |
| ENSG00000168477 | 24.7942386831276 | 0.000309416960514426 | -1.07297944535711 | 4.18654241470581E-09 | BNG |
| ENSG00000227051 | 19.4767441860465 | 0.00156131261208117 | -1.06558834162758 | 0.0116318181984038 | BNG |
| ENSG00000204947 | 10.9382151029748 | 0.0400885775398988 | -1.05794734920928 | 0.00408853581326887 | BNG |
| ENSG00000178026 | 29.3280632411067 | 0.0436981213068628 | -1.03963178689293 | 0.0125500731349175 | BNG |
| ENSG00000130701 | 12.666383460776 | 0.0374981214266512 | -1.03652587602511 | 0.00215566552074285 | BNG |
| ENSG00000069702 | 13.8827838827839 | 0.0270751116053932 | -1.02537178970831 | 1.85966982990304E-10 | BNG |
| ENSG00000168916 | 13.0047371982856 | 0.00666888599889314 | -1.02291693739155 | 0.0298227184961054 | BNG |
| ENSG00000116039 | 21.7977019301523 | 0.0182959230355484 | -1.01495034146597 | 0.00147837289196474 | BNG |
| ENSG00000157502 | 10.7212071629852 | 0.0298875776396145 | -0.99885817561045 | 1.63962018298735E-17 | BNG |
| ENSG00000097096 | 11.0371346956713 | 0.0175081999482966 | -0.996406735275991 | 1.53173247911141E-18 | BNG |
| ENSG00000197183 | 15.8699862994284 | 0.0248089139195588 | -0.987198717776908 | 0.0149582145196133 | BNG |
| ENSG00000204103 | 12.66446797431 | 0.000520207556120523 | -0.979535897440284 | 0.0445563180502833 | BNG |
| ENSG00000182263 | 13.5664335664336 | 0.0044007150689271 | -0.97480591784075 | 3.43643082167393E-14 | BNG |
| ENSG00000111799 | 16.685280321644 | 0.0328568094477351 | -0.951255666148583 | 1.60507703090466E-13 | BNG |
| ENSG00000146477 | 18.4911717495987 | 0.0194503531162814 | -0.936947829464703 | 0.000353422946928915 | BNG |
| ENSG00000177076 | 15.863840719332 | 0.0144405638821234 | -0.929610672108602 | 3.49843978402604E-12 | BNG |
| ENSG00000126803 | 10.5054798516481 | 0.00219758317404919 | -0.927718158319253 | 1.22276845523072E-24 | BNG |
| ENSG00000114166 | 17.0500560006892 | 0.0188813032991278 | -0.926874802389804 | 2.55900871212831E-07 | BNG |
| ENSG00000167183 | 13.1452244989363 | 0.0112001369917942 | -0.921163842447899 | 1.5003407140692E-08 | BNG |
| ENSG00000185432 | 13.8783109080139 | 0.04153131178274 | -0.918437760189343 | 1.3451990699202E-10 | BNG |
| ENSG00000178568 | 37.0017128620367 | 2.62446043121715E-21 | -0.888968687611259 | 0.0032937298473144 | BNG |
| ENSG00000151623 | 11.9830450223393 | 0.0156272601196254 | -0.888830624063527 | 2.85802238792563E-05 | BNG |
| ENSG00000245848 | 28.8480263650663 | 0.000588322424264537 | -0.882292014433902 | 1.19753165707245E-06 | BNG |
| ENSG00000150893 | 12.7647612756328 | 0.0193133285667364 | -0.867784804610925 | 2.03480136814508E-10 | BNG |
| ENSG00000165029 | 15.7516412595972 | 0.0429688266413051 | -0.86291825524471 | 0.000454633977955596 | BNG |
| ENSG00000078018 | 18.6377708978328 | 0.0267348110796337 | -0.856913044052906 | 0.00025794820431816 | BNG |
| ENSG00000087085 | 20.9770114942529 | 0.0099341108704103 | -0.841770332190061 | 0.000518237003680987 | BNG |
| ENSG00000104205 | 10.0578466131741 | 8.69490707846433E-06 | -0.837798814548365 | 1.07967548935029E-05 | BNG |
| ENSG00000088002 | 41.5165165165165 | 0.0104801422938026 | -0.82505692379106 | 0.0298353550538748 | BNG |
| ENSG00000185924 | 11.3515115589804 | 0.0318484916420642 | -0.797562185039193 | 0.000271873678644402 | BNG |
| ENSG00000066468 | 31.0344827586207 | 0.00473328658620488 | -0.79071950242535 | 7.93144139610672E-21 | BNG |
| ENSG00000185352 | 15.4640921409214 | 0.0361105332861815 | -0.79007693062577 | 0.0447431224531728 | BNG |
| ENSG00000125848 | 14.0999692559951 | 0.0314930098693842 | -0.786090105274825 | 0.0237497881247026 | BNG |
| ENSG00000168453 | 16.1601597160603 | 0.0167552169351298 | -0.752291325395042 | 0.00224328328413343 | BNG |
| ENSG00000011201 | 34.5980126467931 | 0.040528242942424 | -0.750374039136391 | 5.83095093384214E-05 | BNG |
| ENSG00000176182 | 16.4007826021522 | 0.00102380692089381 | -0.741364058063724 | 0.0382622065004552 | BNG |
| ENSG00000139998 | 13.5398054397459 | 0.0302652271862405 | -0.73884967913656 | 3.44175359709653E-16 | BNG |
| ENSG00000253910 | 16.2661776264082 | 0.00844151005684433 | -0.72950014391964 | 0.0396713817830189 | BNG |
| ENSG00000196872 | 12.6008851861494 | 0.0459907985460533 | -0.727960780904998 | 1.35353238986487E-09 | BNG |
| ENSG00000126217 | 18.4417245158933 | 0.0478245948927844 | -0.721570218766501 | 5.08518675875215E-07 | BNG |
| ENSG00000165861 | 17.776590937102 | 2.8745872305254E-07 | -0.720961014729347 | 7.00257301272694E-09 | BNG |
| ENSG00000256223 | 18.1818181818182 | 0.0247394474772389 | -0.715820262853991 | 0.000393372988416042 | BNG |
| ENSG00000120093 | 14.7095375722543 | 0.0307865686470777 | -0.714467624516055 | 0.0242160980884065 | BNG |
| ENSG00000108984 | 17.728667038483 | 0.00475059817701297 | -0.710175082739545 | 5.01107261444136E-23 | BNG |
| ENSG00000137261 | 23.0116648992577 | 0.0417311399068192 | -0.70626879694329 | 0.00736742878448766 | BNG |
| ENSG00000113448 | 38.8888888888889 | 0.0445643717437885 | -0.705491592161748 | 4.54141174788106E-07 | BNG |
| ENSG00000143126 | 16.9444444444444 | 0.0291129750811605 | -0.704692138332153 | 2.74246450392245E-05 | BNG |
| ENSG00000134030 | 12.3072875559063 | 0.000780194592826204 | -0.703735064599572 | 0.00423651266925635 | BNG |
| ENSG00000153113 | 21.9307394036636 | 0.00374511905818774 | -0.703518178232066 | 1.42459864428974E-14 | BNG |
| ENSG00000179348 | 24.1163561656628 | 6.70182429095373E-08 | -0.699514617089266 | 1.00020068482785E-07 | BNG |
| ENSG00000064787 | 15.4477430029768 | 0.019433423253655 | -0.696607856550066 | 4.6594488010428E-06 | BNG |
| ENSG00000188026 | 36.2956810631229 | 0.0129326007149464 | -0.694037324976346 | 0.023738157713412 | BNG |
| ENSG00000221890 | 18.7572590011614 | 0.0308096453721258 | -0.690795412733281 | 0.0176007089136136 | BNG |
| ENSG00000196417 | 11.4957264957265 | 0.0125211169053565 | -0.690451059239939 | 0.00048897912138809 | BNG |
| ENSG00000130635 | 26.9356597600872 | 0.0271574565142418 | -0.685198409708279 | 1.26290044816402E-26 | BNG |
| ENSG00000111913 | 30.7936507936508 | 0.0414896056053475 | -0.670840335881557 | 0.000101763314920898 | BNG |
| ENSG00000150347 | 14.9859943977591 | 0.0440225685517479 | -0.668489279530708 | 1.18874074373337E-26 | BNG |
| ENSG00000116711 | 14.0571532580997 | 0.0297904753033027 | -0.667339028324238 | 0.0283734297613091 | BNG |
| ENSG00000196227 | 12.1661315424197 | 0.0106092170610959 | -0.662382727403818 | 3.58986363598043E-10 | BNG |
| ENSG00000002016 | 14.5918688937914 | 0.00312863804951235 | -0.655096958010198 | 0.00272596416552348 | BNG |
| ENSG00000146350 | 23.3137254901961 | 0.0146677698628851 | -0.653262229789643 | 0.00944152725963259 | BNG |
| ENSG00000145536 | 17.1686274509804 | 0.0427584023858685 | -0.64965904943743 | 2.45479952909829E-05 | BNG |
| ENSG00000158321 | 27.5966018087147 | 0.0101861074494865 | -0.648265082629678 | 0.00534070540002623 | BNG |
| ENSG00000171219 | 12.258064516129 | 0.00894773991707233 | -0.643572286500509 | 4.99326325232002E-17 | BNG |
| ENSG00000004399 | 15.4077540106952 | 0.0417624266596511 | -0.643196863834183 | 0.00186187396969658 | BNG |
| ENSG00000166473 | 41.9574468085106 | 0.0183894814151029 | -0.637980883020648 | 0.0350745435774593 | BNG |
| ENSG00000066382 | 14.5661819919448 | 0.0154570820713063 | -0.63786558271762 | 0.00347335684687682 | BNG |
| ENSG00000165124 | 11.3423575860124 | 0.0380101767330406 | -0.63523570720238 | 0.000592958316482939 | BNG |
| ENSG00000223573 | 29.0424725656918 | 6.20881894139791E-09 | -0.630849959762384 | 2.28917372212143E-09 | BNG |
| ENSG00000105357 | 11.5917067463928 | 0.0014517892392665 | -0.620745655468585 | 2.7355022608927E-18 | BNG |
| ENSG00000110975 | 16.7147730254526 | 0.00872311460033196 | -0.620411336725446 | 0.00614008621027657 | BNG |
| ENSG00000121281 | 13.0323989807062 | 0.0342477469741301 | -0.620078087582796 | 0.00134564043630872 | BNG |
| ENSG00000198682 | 10.4387656702025 | 0.00204118703000595 | -0.618563904087295 | 1.88074343089455E-10 | BNG |
| ENSG00000188153 | 11.5046244078502 | 0.025660119822895 | -0.616462780545589 | 5.88521426071701E-15 | BNG |
| ENSG00000181035 | 22.9144289294665 | 0.0147254762161582 | -0.613645255425247 | 0.00752603927024964 | BNG |
| ENSG00000005469 | 10.3174603174603 | 0.000499992831155057 | -0.609148687022231 | 3.42678393928905E-06 | BNG |
| ENSG00000075461 | 15.342989017985 | 0.00304300349665309 | -0.605155649192202 | 2.28866368636362E-12 | BNG |
| ENSG00000167861 | 11.7043294290795 | 0.00136830639884553 | -0.600339911716719 | 1.51057836248098E-06 | BNG |
| ENSG00000104936 | 10.3047080299292 | 0.0360010218041492 | -0.597332951997686 | 4.00855123499364E-10 | BNG |
| ENSG00000198691 | 22.6515151515152 | 0.0493777709424798 | -0.587156714134073 | 0.000809594934608358 | BNG |
| ENSG00000138336 | 16.9651741293532 | 0.0482494140512625 | -0.587007426706185 | 0.000973023962220727 | BNG |
| ENSG00000148180 | 23.2778604949207 | 3.57611619264839E-09 | -0.58507858029968 | 1.02616245712461E-21 | BNG |
| ENSG00000164309 | 18.1738618461881 | 0.00164648726654438 | -0.584962500721158 | 0.0173490350620861 | BNG |
| ENSG00000165434 | 12.3711340206186 | 0.0445444711611503 | -0.584708169289755 | 1.25825478046189E-10 | BNG |
| ENSG00000198846 | 21.2872559095581 | 0.0153427691333421 | -0.578938713093386 | 0.00289858288076006 | BNG |
| ENSG00000152284 | 10.675049351987 | 0.0459654025511792 | -0.573347871818441 | 0.00169316922396989 | BNG |
| ENSG00000181555 | 20.5492050978846 | 0.00757578203996778 | -0.57045000701778 | 0.000633772036520459 | BNG |
| ENSG00000139973 | 19.6004700352526 | 0.0305810605288159 | -0.570187148040758 | 0.00480345245979799 | BNG |
| ENSG00000147912 | 12.7404413500118 | 0.00303259312325178 | -0.569771393690503 | 0.00602492513846353 | BNG |
| ENSG00000214960 | 14.1791044776119 | 0.000599946846525298 | -0.566616208240501 | 0.000191551711513297 | BNG |
| ENSG00000243317 | 32.6256043725037 | 0.0311519672052956 | -0.56636438224004 | 0.0104549849382166 | BNG |
| ENSG00000116117 | 25.4728492983526 | 0.000960434321705651 | -0.565110565625496 | 0.00619843887025926 | BNG |
| ENSG00000090238 | 15.1902643933778 | 0.0213139948134366 | -0.556120748810073 | 0.0493146928859833 | BNG |
| ENSG00000185261 | 31.9214131218457 | 0.0314674697603723 | -0.553253640993819 | 0.0362478930997127 | BNG |
| ENSG00000020181 | 12.4230657780354 | 0.001966428225144 | -0.546427899302171 | 0.00983148706722227 | BNG |
| ENSG00000128567 | 18.8532110091743 | 0.0182896877761265 | -0.544534074812149 | 0.000147772976409115 | BNG |
| ENSG00000120925 | 12.5353906074451 | 0.0196933918755241 | -0.539247164748559 | 0.000736410991429054 | BNG |
| ENSG00000197050 | 18.374307233196 | 0.000119040562611568 | -0.538866086131702 | 0.00624942651321243 | BNG |
| ENSG00000114423 | 23.9495798319328 | 0.0431958123249209 | -0.535465534932059 | 1.7576048201707E-08 | BNG |
| ENSG00000134321 | 13.6886005560704 | 0.00997575625153228 | -0.522870156352437 | 7.04810893304969E-05 | BNG |
| ENSG00000241489 | 24.2486554887694 | 0.00550099733479635 | -0.522263595350611 | 0.00027164275856533 | BNG |
| ENSG00000137070 | 12.0733953849137 | 0.0318905841876695 | -0.521952703195358 | 0.0424631435708416 | BNG |
| ENSG00000166689 | 24.5501775807919 | 0.00388073994598053 | -0.516848119489151 | 1.81992158020414E-08 | BNG |
| ENSG00000119686 | 14.484126984127 | 0.0332429167482642 | -0.51377490313628 | 0.00213204060595649 | BNG |
| ENSG00000137710 | 28.6331500392773 | 0.0389255987511811 | -0.509881553601421 | 1.19794881274545E-11 | BNG |
| ENSG00000128881 | 14.2607313195549 | 0.0119137103769155 | -0.503303250321294 | 0.000699512661491251 | BNG |
| ENSG00000127955 | 41.9444444444444 | 0.0354275939892162 | -0.503216922792406 | 8.94381266527608E-08 | BNG |
| ENSG00000197321 | 21.9171814230153 | 0.036646900840191 | -0.501773106156611 | 5.87968999963141E-08 | BNG |
| ENSG00000268043 | 22.653156300955 | 0.00400317217342186 | -0.501256784016834 | 0.0182883160391524 | BNG |
| ENSG00000107099 | 39.5915678524374 | 0.0195055406073874 | -0.499845887083205 | 0.00208375996312581 | BNG |
| ENSG00000004468 | 12.1951219512195 | 0.038467462223309 | -0.498784546838366 | 2.88191330173453E-19 | BNG |
| ENSG00000083123 | 22.5 | 0.0245859854332828 | -0.498464583649882 | 0.000340419237867412 | BNG |
| ENSG00000031003 | 26.6564318034906 | 0.0217127474516512 | -0.498416665958258 | 1.62058029177946E-05 | BNG |
| ENSG00000183044 | 17.5899742930591 | 0.000384657817382759 | -0.497226809344069 | 8.54488863773884E-05 | BNG |
| ENSG00000124467 | 23.8176470588235 | 0.0417943093826968 | -0.495318902553343 | 0.00473377315997699 | BNG |
| ENSG00000177303 | 25.5813953488372 | 0.0360479555471996 | -0.491974622256619 | 8.7489021015237E-06 | BNG |
| ENSG00000111961 | 26.078431372549 | 0.0407504283176384 | -0.491236856643731 | 2.48976492107798E-14 | BNG |
| ENSG00000185442 | 23.3378317588844 | 0.00174367822635544 | -0.488240690456756 | 0.000221616026621544 | BNG |
| ENSG00000010810 | 14.9159663865546 | 0.0425652235144658 | -0.486449571915371 | 0.000413551472221232 | BNG |
| ENSG00000111335 | 19.5384615384615 | 0.0471474911149716 | -0.485212793338396 | 4.18687964443166E-14 | BNG |
| ENSG00000114770 | 13.9481413009138 | 0.028967058065351 | -0.484076384162012 | 4.02271054341108E-08 | BNG |
| ENSG00000137941 | 11.8190079877553 | 0.0193456625379411 | -0.483014293094851 | 0.005048594733699 | BNG |
| ENSG00000149260 | 43.8095238095238 | 0.0222437844825907 | -0.47822513286538 | 0.0144181754674735 | BNG |
| ENSG00000105492 | 15.9129901960784 | 0.0318828061877183 | -0.478047296804645 | 0.00855673971982164 | BNG |
| ENSG00000072858 | 25.8367856908003 | 0.0271064512377889 | -0.47669201719264 | 0.0434660969166838 | BNG |
| ENSG00000185630 | 15.2542372881356 | 0.0443172927303969 | -0.476626525138652 | 4.68402347442217E-06 | BNG |
| ENSG00000166387 | 17.7108639863131 | 0.0295489808875449 | -0.475296219553436 | 0.0011843075479458 | BNG |
| ENSG00000124942 | 24.7691201681137 | 0.00103131086256605 | -0.474392536230519 | 3.09603368050903E-14 | BNG |
| ENSG00000008323 | 37.6282649253731 | 2.50661784039429E-14 | -0.466707226346571 | 0.00140380214213413 | BNG |
| ENSG00000138303 | 11.7647058823529 | 0.00199813755820777 | -0.462618563812952 | 0.000191896181673512 | BNG |
| ENSG00000125266 | 16.3265306122449 | 0.0460499274278431 | -0.462355578124758 | 2.7748334758846E-16 | BNG |
| ENSG00000182621 | 13.279334858637 | 0.0225777427225306 | -0.460113840733944 | 0.00511236354729573 | BNG |
| ENSG00000126016 | 16.5492777379367 | 0.00849881594750249 | -0.459114019287442 | 0.000389295435109945 | BNG |
| ENSG00000107864 | 12.2122403144301 | 0.0301314363561356 | -0.458141001249102 | 0.0326818098866569 | BNG |
| ENSG00000136295 | 13.7074829931973 | 0.000491213772379682 | -0.458073580642192 | 0.000508698691512146 | BNG |
| ENSG00000171604 | 27.7815405455329 | 0.00294096172983806 | -0.453648847676855 | 1.39816502664685E-06 | BNG |
| ENSG00000150556 | 37.5 | 0.0109836286899308 | -0.453179487183903 | 0.00172366138067641 | BNG |
| ENSG00000035862 | 18.5524520315241 | 0.0351743704365662 | -0.451158553185102 | 4.78852687458916E-18 | BNG |
| ENSG00000137414 | 10.5544440485652 | 0.00423248406173437 | -0.447689697432434 | 4.30843512142587E-05 | BNG |
| ENSG00000174456 | 14.3014604574263 | 0.0149410499960918 | -0.44752315950708 | 0.03598620057456 | BNG |
| ENSG00000129493 | 11.0504201680672 | 0.0144470729314065 | -0.446655711835727 | 0.00778447877637807 | BNG |
| ENSG00000196967 | 16.2420841567734 | 0.00025867693432669 | -0.445467129297523 | 0.000224181365577937 | BNG |
| ENSG00000129933 | 14.3144922384169 | 0.000432568102183404 | -0.444759038098622 | 0.0374773939660338 | BNG |
| ENSG00000119771 | 17.2413793103448 | 0.0388262077612964 | -0.44461773449381 | 0.000411429515895675 | BNG |
| ENSG00000121989 | 15.3653095370887 | 0.0302234057665656 | -0.444528795988244 | 1.64215148130686E-05 | BNG |
| ENSG00000118777 | 19.0268065268065 | 0.00898381918638679 | -0.442408470794975 | 6.46795535036693E-06 | BNG |
| ENSG00000117114 | 21.8518518518519 | 0.0258821518569486 | -0.441252757186227 | 0.000523087175169761 | BNG |
| ENSG00000170365 | 12.5051419169066 | 0.00956966372760876 | -0.43934074696144 | 0.00396074346888895 | BNG |
| ENSG00000053254 | 27.9874213836478 | 0.040395061954745 | -0.439027674185821 | 1.53454946009585E-08 | BNG |
| ENSG00000115616 | 12.036010811021 | 0.0492387190359769 | -0.436445306227521 | 0.000115162802536429 | BNG |
| ENSG00000177694 | 23.8667282714718 | 0.00987326807617852 | -0.431558175834021 | 1.29491578718345E-09 | BNG |
| ENSG00000024422 | 27.6158623984711 | 0.0168033859609324 | -0.430742625234609 | 0.0292165467312493 | BNG |
| ENSG00000263001 | 12.9596402622718 | 0.0185269299019678 | -0.427605769403905 | 1.30049770019362E-15 | BNG |
| ENSG00000104497 | 10.2733785822021 | 0.00730893312706585 | -0.424642558756677 | 0.0219969817122393 | BNG |
| ENSG00000076067 | 10.9556397409263 | 0.0059602672720826 | -0.422942697364189 | 0.000138197954281027 | BNG |
| ENSG00000111110 | 16.977466977467 | 0.000540722238095916 | -0.422821207581922 | 7.20801592208993E-13 | BNG |
| ENSG00000213626 | 29.9457994579946 | 0.0377276764664726 | -0.414439738739572 | 9.3078793953285E-09 | BNG |
| ENSG00000172667 | 23.7246963562753 | 0.0474848655744828 | -0.412851266035975 | 0.00143250843933229 | BNG |
| ENSG00000105289 | 15.5648592072388 | 0.0110678259799135 | -0.41174610474983 | 0.00268329936508764 | BNG |
| ENSG00000135643 | 14.565610429156 | 0.0489006771605987 | -0.410376121908981 | 0.0023753800622474 | BNG |
| ENSG00000160325 | 12.0906136052402 | 0.0447524194044426 | -0.410122008864727 | 0.0327554626240886 | BNG |
| ENSG00000115904 | 15.9753456605031 | 0.00622289236958857 | -0.409262861652211 | 2.21354668124224E-06 | BNG |
| ENSG00000198551 | 25.9259259259259 | 0.0263223587684373 | -0.408793558121986 | 0.0144574112408487 | BNG |
| ENSG00000099139 | 17.3040667923512 | 0.0260782817068225 | -0.408740260817638 | 2.0345655513523E-11 | BNG |
| ENSG00000076554 | 30.1587301587302 | 0.026989458289609 | -0.408729640831393 | 0.000156010695767343 | BNG |
| ENSG00000184384 | 34.2731829573935 | 0.0457754145078931 | -0.40859384701675 | 1.90834843581944E-08 | BNG |
| ENSG00000152409 | 13.0952380952381 | 0.0089475018307773 | -0.406334623724234 | 1.81980304651701E-06 | BNG |
| ENSG00000185115 | 14.1691106321331 | 0.0486297174163698 | -0.406285025269877 | 0.0471767784504365 | BNG |
| ENSG00000133943 | 17.6787148594378 | 0.0024986162549337 | -0.403301391227878 | 0.000100742003170586 | BNG |
| ENSG00000011028 | 23.8768638768639 | 2.49177149563819E-08 | -0.402874720298177 | 9.42467032388253E-07 | BNG |
| ENSG00000127663 | 16.3120567375887 | 0.00199479787932435 | -0.401869868853929 | 2.86929099910416E-05 | BNG |
| ENSG00000275395 | 40.1215805471125 | 0.0161209738470805 | -0.399832627667512 | 0.00313125281698433 | BNG |
| ENSG00000140836 | 22.0262096774194 | 0.01353803363207 | -0.398451891606571 | 9.35526164448217E-08 | BNG |
| ENSG00000197121 | 13.3465608465608 | 0.000216837614926441 | -0.398127720768761 | 6.40513117712682E-05 | BNG |
| ENSG00000147394 | 14.7713025567546 | 1.37389673771049E-05 | -0.393895478184056 | 0.00012655160829566 | BNG |
| ENSG00000198624 | 15.3837342497136 | 0.0312565681270824 | -0.391493449347894 | 0.019092758640645 | BNG |
| ENSG00000172493 | 24.3243243243243 | 0.0326834339365618 | -0.38972945200723 | 0.0234032173352906 | BNG |
| ENSG00000090020 | 16.4556962025316 | 0.0416009438220768 | -0.388856683389991 | 0.000518778442434831 | BNG |
| ENSG00000112079 | 10.1827411167513 | 0.0100171189668929 | -0.388199801705896 | 1.09379010875715E-07 | BNG |
| ENSG00000138759 | 36 | 0.04992950805686 | -0.387473859671809 | 0.0257016002817308 | BNG |
| ENSG00000109323 | 12.2641509433962 | 0.0069510470048547 | -0.386464027629376 | 0.00155007758709338 | BNG |
| ENSG00000124006 | 19.0433862433862 | 0.0322288314190479 | -0.386068098767428 | 1.87116592734966E-06 | BNG |
| ENSG00000140044 | 10.7904578132204 | 9.33890316296523E-09 | -0.381947673579412 | 0.0233492939076747 | BNG |
| ENSG00000067208 | 10.6948341310447 | 0.0370695915488687 | -0.381634341011633 | 0.0143609651949742 | BNG |
| ENSG00000149571 | 15.7046791818436 | 0.0421796299620546 | -0.38124062832878 | 0.00038268469644075 | BNG |
| ENSG00000166263 | 15.625 | 0.00714785082935721 | -0.380744321724967 | 0.000418729852976832 | BNG |
| ENSG00000074621 | 37.2177055103884 | 0.0430195524117608 | -0.376969458445324 | 0.0400580722604868 | BNG |
| ENSG00000008300 | 24.3827160493827 | 0.00848287737033332 | -0.376563351464209 | 0.0234887642424702 | BNG |
| ENSG00000108370 | 17.6969178082192 | 0.000780062895708609 | -0.376513232652959 | 0.0357246871062311 | BNG |
| ENSG00000071909 | 12.0548116240597 | 0.0490054769874261 | -0.373123857545449 | 0.0344094454284773 | BNG |
| ENSG00000064655 | 16.4221364221364 | 0.018160735094327 | -0.370785409945289 | 0.000286216813915154 | BNG |
| ENSG00000147852 | 15.3964923393642 | 0.0338694660141525 | -0.370732125655407 | 8.07912484025131E-06 | BNG |
| ENSG00000103544 | 44.0711462450593 | 0.0137093219337725 | -0.368911930402233 | 0.00796346489599808 | BNG |
| ENSG00000142065 | 21.0619133402863 | 0.00758559471411506 | -0.368867317845923 | 0.0061016352497874 | BNG |
| ENSG00000166295 | 22.4340175953079 | 0.00231052665483842 | -0.36854278853606 | 0.00529971793428787 | BNG |
| ENSG00000196498 | 27.3656480505796 | 0.00165568906695835 | -0.365364917610353 | 0.0024253152303974 | BNG |
| ENSG00000107105 | 12.0634920634921 | 0.0487293089605174 | -0.365260396902254 | 0.00142528327132613 | BNG |
| ENSG00000110628 | 11.7507099547164 | 0.00605011299301495 | -0.364197318260097 | 0.0233052964014367 | BNG |
| ENSG00000145246 | 10.9188034188034 | 0.0460646211045671 | -0.36064904708903 | 0.0135260007232632 | BNG |
| ENSG00000164463 | 17.8451178451178 | 0.0115418200671948 | -0.36011128877525 | 2.00051018268182E-08 | BNG |
| ENSG00000197852 | 16.42166344294 | 0.0328002414526065 | -0.358070903678058 | 0.0463281393522118 | BNG |
| ENSG00000165813 | 16.8224299065421 | 0.00315028103681137 | -0.35652546997289 | 8.29764421380416E-05 | BNG |
| ENSG00000048707 | 14.821083172147 | 0.0443046839021289 | -0.355910194316597 | 0.00460082542307338 | BNG |
| ENSG00000146411 | 12.3137254901961 | 0.0111360967257588 | -0.353548977358163 | 0.000126067031609596 | BNG |
| ENSG00000110987 | 30.0347222222222 | 0.0421845647585318 | -0.353265409587902 | 0.000559485941448659 | BNG |
| ENSG00000111271 | 10.6666666666667 | 0.008468668423606 | -0.353001616041892 | 0.00560907003355677 | BNG |
| ENSG00000173960 | 16.7713039566587 | 0.0483843564132747 | -0.352925140306958 | 0.0394304539177195 | BNG |
| ENSG00000168769 | 12.5748502994012 | 0.000650725986752801 | -0.352781048803786 | 0.000226578959147252 | BNG |
| ENSG00000130702 | 11.1639672292068 | 0.0372983683188233 | -0.35203751427251 | 2.20623970839814E-08 | BNG |
| ENSG00000183354 | 12.8326330532213 | 0.0355388940157917 | -0.351864288021866 | 0.0148775505018936 | BNG |
| ENSG00000166025 | 11.875 | 0.00620759228648224 | -0.34809950931572 | 1.15937311348668E-16 | BNG |
| ENSG00000090905 | 33.4425155584671 | 0.0422728274876238 | -0.347832227062783 | 0.000471463587356345 | BNG |
| ENSG00000149639 | 18.4732335027705 | 0.0195307265727982 | -0.347636760659084 | 0.00218329338042741 | BNG |
| ENSG00000035664 | 43.3962264150943 | 0.000533581462920669 | -0.347029855464279 | 0.000251558833382371 | BNG |
| ENSG00000145743 | 11.3872941770235 | 0.0352501512573267 | -0.345848057083885 | 0.00115791649628188 | BNG |
| ENSG00000075651 | 12.3397435897436 | 0.0465276148281672 | -0.345786234742914 | 1.02844545122384E-06 | BNG |
| ENSG00000173230 | 10.5312229614822 | 0.0101047746531274 | -0.344274253793976 | 4.53886715903854E-06 | BNG |
| ENSG00000054267 | 10.2189781021898 | 0.0141196697095234 | -0.342210031447351 | 5.14097041637532E-05 | BNG |
| ENSG00000115464 | 11.1111111111111 | 0.00133219128075895 | -0.340616368337588 | 0.00164951387603357 | BNG |
| ENSG00000109618 | 33.179167665149 | 8.41930404674389E-16 | -0.339962017717625 | 0.00326955308091664 | BNG |
| ENSG00000108389 | 10.154017148301 | 0.00553242265274357 | -0.33699162338449 | 0.000125906890521743 | BNG |
| ENSG00000187498 | 11.733746130031 | 0.0385511399220718 | -0.336870943565742 | 1.33866133734124E-06 | BNG |
| ENSG00000078114 | 21.1104684788895 | 0.0469928272245415 | -0.336614795442298 | 3.31483817017941E-07 | BNG |
| ENSG00000134326 | 10.0901813475147 | 0.00955467281308764 | -0.335910517196568 | 0.00768797119644126 | BNG |
| ENSG00000176438 | 10.1892605633803 | 0.0159761741102653 | -0.334560161543612 | 0.000737954103415541 | BNG |
| ENSG00000257923 | 19.1239316239316 | 1.45731709371131E-05 | -0.333068652492565 | 7.22255658121801E-05 | BNG |
| ENSG00000101871 | 40.4761904761905 | 0.0426934459761882 | -0.33158031456629 | 8.68758160318984E-05 | BNG |
| ENSG00000169905 | 25.7142857142857 | 0.0267363003963852 | -0.331359426161868 | 5.53490215236054E-14 | BNG |
| ENSG00000187098 | 19.5980861244019 | 8.05235237869731E-10 | -0.330412292260139 | 0.00634727754168873 | BNG |
| ENSG00000108840 | 13.2352941176471 | 0.000480223775456203 | -0.330166204586187 | 8.37847751568423E-06 | BNG |
| ENSG00000205336 | 45.4459203036053 | 0.00752186156988445 | -0.326567818510395 | 0.00273947706529407 | BNG |
| ENSG00000124788 | 25.7575757575758 | 0.0428322856458021 | -0.3247633955855 | 5.48725590404673E-18 | BNG |
| ENSG00000138468 | 19.6808510638298 | 0.0363634312739796 | -0.324452496302909 | 0.000842061722170376 | BNG |
| ENSG00000119661 | 10.5009584002487 | 0.0198710131539813 | -0.324146817715437 | 0.00244892770308636 | BNG |
| ENSG00000158828 | 22.5434024038254 | 9.48818804503089E-07 | -0.32169317290553 | 0.000252368264090229 | BNG |
| ENSG00000133059 | 30.0466355762825 | 0.0489887123582783 | -0.320621897386737 | 0.00023545527539353 | BNG |
| ENSG00000130723 | 11.3976750473101 | 0.000134696004589683 | -0.320040985343096 | 0.000129242633673824 | BNG |
| ENSG00000196352 | 10.062893081761 | 0.00946448639676561 | -0.319753723653023 | 0.00103987762735318 | BNG |
| ENSG00000082641 | 18.8746438746439 | 0.0413984951095962 | -0.319310869004695 | 3.66328560649142E-11 | BNG |
| ENSG00000213995 | 14.047976011994 | 0.0421140380563497 | -0.318859345969839 | 0.00917522191680684 | BNG |
| ENSG00000141736 | 11.1019736842105 | 0.015707575378512 | -0.318638706904216 | 1.01759720474176E-05 | BNG |
| ENSG00000196628 | 18.9379132532125 | 0.026628993901866 | -0.313420129875148 | 3.28353137619013E-05 | BNG |
| ENSG00000131149 | 41.1764705882353 | 0.0493532022723004 | -0.312479031368485 | 8.88086989224702E-05 | BNG |
| ENSG00000178234 | 11.5294961448808 | 0.00659775491842036 | -0.31233732557587 | 0.0444075334779666 | BNG |
| ENSG00000168056 | 19.5390805999268 | 0.00454352205309947 | -0.310082881286277 | 0.000214762739461813 | BNG |
| ENSG00000033122 | 29.625590694293 | 0.00210695325158986 | -0.306925931548116 | 0.00649183678214571 | BNG |
| ENSG00000112304 | 20.0174825174825 | 0.0351743704365662 | -0.306243573211412 | 0.0463949995660573 | BNG |
| ENSG00000008083 | 10.0729517396184 | 0.0140092913501159 | -0.305704155228222 | 0.00520773838098378 | BNG |
| ENSG00000152104 | 17.8128950695322 | 0.0289165706469852 | -0.304201627678951 | 9.3801020593915E-09 | BNG |
| ENSG00000156976 | 62.4045331362405 | 1.64036524813892E-26 | -0.303223827036908 | 0.000173375292214423 | BNG |
| ENSG00000148498 | 18.2381959126145 | 0.039148232419445 | -0.302775645054516 | 0.000599403897821241 | BNG |
| ENSG00000167972 | 29.97150997151 | 0.046054661618327 | -0.302562770020427 | 0.0175183932548747 | BNG |
| ENSG00000109654 | 22.3880597014925 | 0.0312572030696368 | -0.301685799799022 | 0.0170642350636622 | BNG |
| ENSG00000107104 | 10.1918216694849 | 4.13774880745456E-05 | -0.300742764996734 | 0.00633350140038271 | BNG |
| ENSG00000130844 | 27.687969924812 | 0.00390442314567267 | -0.300668723482284 | 0.00719998180056289 | BNG |
| ENSG00000185585 | 11.5521003818876 | 0.0392453693308722 | -0.299045268650416 | 7.43191486234675E-05 | BNG |
| ENSG00000217128 | 12.0838262633091 | 0.0017609206903326 | -0.298728320110066 | 9.04052804294962E-05 | BNG |
| ENSG00000099260 | 10.8910891089109 | 0.0353811040563858 | -0.298592047217847 | 0.000424285345172563 | BNG |
| ENSG00000091157 | 13.1028368794326 | 0.0484770918475124 | -0.297059220774465 | 0.0374840228006454 | BNG |
| ENSG00000140416 | 17.6034134584066 | 0.000754540256215715 | -0.296072693115342 | 7.8888780545974E-08 | BNG |
| ENSG00000088280 | 13.6121812511466 | 0.0043559525569461 | -0.295958148559171 | 3.52360850016329E-05 | BNG |
| ENSG00000196267 | 18.834768250973 | 0.0114164686143015 | -0.295920444805625 | 0.0101731668155433 | BNG |
| ENSG00000204217 | 24.3243243243243 | 0.00155707895508587 | -0.294392145198983 | 8.00814045879748E-08 | BNG |
| ENSG00000118816 | 17.7777777777778 | 0.0459158478090898 | -0.293827410959701 | 0.000793611995264555 | BNG |
| ENSG00000146648 | 21.6057812677819 | 0.0164588521031709 | -0.293703786413115 | 2.29989877751664E-08 | BNG |
| ENSG00000075568 | 14.4736842105263 | 0.028405831268229 | -0.293035982058586 | 0.0302709234446858 | BNG |
| ENSG00000105426 | 23.3977172958736 | 0.00158843839337624 | -0.29136312889229 | 9.61011029442332E-06 | BNG |
| ENSG00000142784 | 12.641432367221 | 2.75713514771609E-08 | -0.291309926911496 | 0.000705471601159669 | BNG |
| ENSG00000115468 | 24.9363327674024 | 0.012367393390153 | -0.290583721544564 | 0.0401381507632302 | BNG |
| ENSG00000119912 | 14.340675671213 | 0.0223871948498093 | -0.288796061228694 | 0.0179505502465591 | BNG |
| ENSG00000214655 | 13.1659836065574 | 0.0357874542093045 | -0.288774708212451 | 0.00266065262221928 | BNG |
| ENSG00000162825 | 14.2034333025851 | 0.00666121923321421 | -0.286100015751736 | 0.0198036139611593 | BNG |
| ENSG00000133424 | 39.5833333333333 | 0.0244052415164296 | -0.285218427692496 | 0.0188359404674102 | BNG |
| ENSG00000184677 | 27.8225806451613 | 0.0381796105921428 | -0.285200061636264 | 0.0330078205932338 | BNG |
| ENSG00000116005 | 31.1556603773585 | 2.10459449932301E-07 | -0.28407646921438 | 0.000921125149288969 | BNG |
| ENSG00000165240 | 10.3479853479854 | 0.011765225239976 | -0.28314719196807 | 7.80285429525471E-09 | BNG |
| ENSG00000133983 | 39.5604395604396 | 0.0414994516121064 | -0.28200331050987 | 0.0264347269628561 | BNG |
| ENSG00000151553 | 18.560074801309 | 0.0421356350946662 | -0.280613980013202 | 0.00535868165740882 | BNG |
| ENSG00000186448 | 20.9177489177489 | 0.000190407930326322 | -0.279901421655579 | 0.0243344047039009 | BNG |
| ENSG00000139266 | 11.5023275497249 | 0.0251514349771169 | -0.277918279325949 | 0.0404238161915395 | BNG |
| ENSG00000164855 | 17.4666035744185 | 0.00378786634448218 | -0.268774379016911 | 0.0101022767524733 | BNG |
| ENSG00000054965 | 28.4817875726967 | 0.0118905351512364 | -0.267963637356679 | 0.000293100155619997 | BNG |
| ENSG00000148842 | 28.0701754385965 | 0.0148914319157164 | -0.267695783203657 | 0.00377595052802898 | BNG |
| ENSG00000123636 | 12.257053291536 | 0.0303309564762876 | -0.267416852462943 | 0.011351823485927 | BNG |
| ENSG00000115170 | 12.5139206377117 | 0.0109195293972354 | -0.267382852871544 | 0.0370125180568233 | BNG |
| ENSG00000133639 | 18.9965359258018 | 0.0137735837044225 | -0.267168024889054 | 0.0028996243944354 | BNG |
| ENSG00000126858 | 19.9737532808399 | 0.0103436202041154 | -0.266499681624815 | 0.0311298311886331 | BNG |
| ENSG00000112855 | 11.1111111111111 | 0.0274407754224659 | -0.264771736543482 | 0.0349592186244644 | BNG |
| ENSG00000162434 | 11.1013986013986 | 0.0400147705940586 | -0.263612329451374 | 4.94379178207903E-08 | BNG |
| ENSG00000140379 | -13.0602240896359 | 0.0419869667954231 | 7.75933340719466 | 0.0367406623189661 | BNG |
| ENSG00000102445 | -22.4608590927338 | 0.0136717844177114 | 7.1632303488683 | 0.0201523496528516 | BNG |
| ENSG00000198626 | -30.4647160068847 | 0.0317766894353491 | 5.4374053123073 | 0.0297721172788166 | BNG |
| ENSG00000273217 | -11.6228070175439 | 0.0495363996427847 | 5.32192809488736 | 0.0445013525732622 | BNG |
| ENSG00000186603 | -10.4218502246818 | 1.74723393165367E-06 | 4.88264304936184 | 0.00562268869170042 | BNG |
| ENSG00000167772 | -20.6896551724138 | 0.026213853591628 | 2.89710009241571 | 3.24861125698761E-10 | BNG |
| ENSG00000288520 | -18.5674522845575 | 0.0293128390705597 | 2.7004397181411 | 0.0288626152504842 | BNG |
| ENSG00000152953 | -25.4347826086957 | 0.0389556921466233 | 2.32192809488736 | 0.0352806015308715 | BNG |
| ENSG00000163359 | -18.6857721812129 | 0.00839883744965913 | 2 | 0.0453917622597636 | BNG |
| ENSG00000197641 | -11.5761478163494 | 0.00503948227834267 | 1.92619869958988 | 1.92719648884193E-25 | BNG |
| ENSG00000205403 | -15.8402203856749 | 0.0062625386976592 | 1.68182403997374 | 0.0124171144084143 | BNG |
| ENSG00000138675 | -13.9705882352941 | 0.00218543164097531 | 1.58496250072116 | 0.00663087291080351 | BNG |
| ENSG00000178726 | -11.8489223129544 | 0.00199516551116929 | 1.52281005197375 | 2.48269726859935E-30 | BNG |
| ENSG00000154678 | -19.3846556690233 | 0.0433527558360389 | 1.39854937649027 | 0.0282987501155144 | BNG |
| ENSG00000130164 | -11.0260942983035 | 0.0115934255677052 | 1.38476472870143 | 1.68437434910057E-68 | BNG |
| ENSG00000138944 | -37.8117457763475 | 0.0169445660029793 | 1.37586690199816 | 0.00219311995651581 | BNG |
| ENSG00000197646 | -12.0122574055158 | 0.0251916789947428 | 1.36950657725287 | 4.76360889303288E-20 | BNG |
| ENSG00000163485 | -17.520151730678 | 0.00250341105617622 | 1.34513548604869 | 0.0424124417976442 | BNG |
| ENSG00000188001 | -21.5264586160109 | 0.00189270004090834 | 1.33763299559323 | 1.51293275212706E-05 | BNG |
| ENSG00000285816 | -15.6369183829138 | 0.0239049278657468 | 1.29972421516298 | 1.68350938440851E-07 | BNG |
| ENSG00000177374 | -21.5589376667475 | 0.00445208163839317 | 1.24285652389617 | 0.0138731645825835 | BNG |
| ENSG00000090339 | -10.6666666666667 | 0.0410133958281216 | 1.22517486200778 | 1.17341214937116E-27 | BNG |
| ENSG00000104368 | -34.1463414634146 | 0.0182409938245087 | 1.1794767156618 | 4.32168441024132E-39 | BNG |
| ENSG00000169991 | -17.1866447728517 | 0.0158204811842248 | 1.15497288407955 | 1.9806121954697E-32 | BNG |
| ENSG00000175505 | -27.9661016949153 | 1.06348633808996E-05 | 1.13024667675028 | 7.38979815808529E-11 | BNG |
| ENSG00000196639 | -15.4970760233918 | 0.00090947165898245 | 1.12687176584051 | 2.79229839886979E-11 | BNG |
| ENSG00000196083 | -36.3636363636364 | 0.000249970412403766 | 1.1188160178939 | 1.91714465012516E-34 | BNG |
| ENSG00000107957 | -18.655090765588 | 0.043587140391366 | 1.10378045790299 | 5.22642208471637E-05 | BNG |
| ENSG00000167914 | -19.7192513368984 | 0.00810848185643203 | 1.0790715709912 | 0.00212095639712 | BNG |
| ENSG00000124496 | -11.9527769853635 | 0.00548776059044123 | 1.05475976867859 | 9.74227997345186E-09 | BNG |
| ENSG00000134107 | -20.5533596837945 | 0.0102286108939419 | 1.01740704590947 | 5.59821544185794E-34 | BNG |
| ENSG00000112096 | -15.7002858309514 | 0.0276978683819853 | 1.00829655641631 | 0.0277179645543597 | BNG |
| ENSG00000136026 | -20.8110516934046 | 5.06625982084557E-06 | 0.981140972748685 | 0.000121641120032545 | BNG |
| ENSG00000137936 | -11.6054875787913 | 0.0387043048384392 | 0.940973373349762 | 1.93812440346207E-27 | BNG |
| ENSG00000125730 | -12.3979591836735 | 0.000755350080859917 | 0.940197017497937 | 1.10578488599274E-13 | BNG |
| ENSG00000142634 | -25.2007557864903 | 0.0255231120152627 | 0.908622445824029 | 4.92613125327356E-49 | BNG |
| ENSG00000182326 | -12.3648537401899 | 0.0273998846984687 | 0.878141657126903 | 3.79553006148258E-05 | BNG |
| ENSG00000111700 | -51.4193548387097 | 0.00599089375902751 | 0.867939147909315 | 0.0025682878525908 | BNG |
| ENSG00000129521 | -35.8974358974359 | 0.00643442018997199 | 0.84358980503217 | 2.59806804251617E-05 | BNG |
| ENSG00000075131 | -13.2420091324201 | 0.0289563274100958 | 0.816530118457942 | 0.00474497942871165 | BNG |
| ENSG00000114541 | -14.0845070422535 | 0.034354834947395 | 0.815747086313056 | 1.42922170794235E-22 | BNG |
| ENSG00000127507 | -23.5303617571059 | 0.00980477148159086 | 0.810338780496422 | 0.000547643416920011 | BNG |
| ENSG00000172927 | -16.2748744136993 | 0.0160248077870733 | 0.808903709153095 | 0.00348914353770542 | BNG |
| ENSG00000174640 | -20.5257054503286 | 0.029565719454343 | 0.800012946716431 | 0.00209466071836222 | BNG |
| ENSG00000156299 | -17.5735294117647 | 0.0277298044419221 | 0.792603966282472 | 5.65041318074885E-06 | BNG |
| ENSG00000088727 | -18.2795698924731 | 0.0496766885347703 | 0.787318886643381 | 0.0218939732192762 | BNG |
| ENSG00000105137 | -11.5606936416185 | 0.00939974597671166 | 0.786429083203057 | 0.000279118337134963 | BNG |
| ENSG00000128965 | -18.6904761904762 | 0.000282827758537118 | 0.782165860625856 | 1.505866464105E-06 | BNG |
| ENSG00000103546 | -11.6170689719897 | 0.0154089401089322 | 0.758806642705791 | 0.0418443211370969 | BNG |
| ENSG00000123358 | -25.8726647000983 | 0.0130489763385992 | 0.737561626003184 | 5.9249188956385E-06 | BNG |
| ENSG00000138829 | -31.6725352112676 | 0.0372853032268371 | 0.713477241243836 | 0.0417689085213096 | BNG |
| ENSG00000102743 | -18.4110885733604 | 0.00457691456434629 | 0.707392478782857 | 0.00209427175210604 | BNG |
| ENSG00000157557 | -22.9957805907173 | 0.017203962372102 | 0.694034680852988 | 1.74996558874179E-33 | BNG |
| ENSG00000034152 | -18.8859520313265 | 0.0167888007588856 | 0.693086631049928 | 5.24816371136761E-05 | BNG |
| ENSG00000213397 | -27.1225071225071 | 0.00434588003696628 | 0.689932060322699 | 0.000404367736333311 | BNG |
| ENSG00000131746 | -10.5288590604027 | 0.0264465832690492 | 0.678937554055473 | 5.60206611487306E-12 | BNG |
| ENSG00000165799 | -24.1837299391256 | 0.00857990103345192 | 0.678071905112639 | 0.0177003751106127 | BNG |
| ENSG00000142089 | -11.331290432414 | 5.65365659019406E-05 | 0.673593087060183 | 1.29781289919547E-25 | BNG |
| ENSG00000184408 | -38.2692307692308 | 9.49729224589839E-06 | 0.667424660913128 | 0.0384781428522723 | BNG |
| ENSG00000126091 | -21.6867469879518 | 0.00889633435336452 | 0.626850897011178 | 0.00839083915114877 | BNG |
| ENSG00000143322 | -26.9976498237368 | 0.000254774068165335 | 0.617742991222575 | 1.13702174725912E-26 | BNG |
| ENSG00000127666 | -13.0050658561297 | 0.00325853898090201 | 0.617666665793861 | 2.82406615980706E-06 | BNG |
| ENSG00000154217 | -23.3516483516484 | 0.0493895123654999 | 0.615899482470343 | 0.000662697989781469 | BNG |
| ENSG00000112159 | -23.3950694531348 | 0.0108221249561433 | 0.610708775591004 | 0.00592967658047154 | BNG |
| ENSG00000104419 | -23.7073170731707 | 0.049221174709303 | 0.609880299095611 | 1.42913107270399E-30 | BNG |
| ENSG00000182010 | -17.0862470862471 | 0.0355002358593476 | 0.597418933145846 | 1.36143320589088E-07 | BNG |
| ENSG00000107937 | -16.5659543109801 | 2.71661545092223E-06 | 0.597234370126258 | 1.09995147692887E-07 | BNG |
| ENSG00000119681 | -19.1963826944815 | 0.00719070703708989 | 0.595560346860678 | 1.84681312504672E-05 | BNG |
| ENSG00000128294 | -29.5713229859571 | 0.000142543647709696 | 0.59321592735501 | 0.0345827448979271 | BNG |
| ENSG00000154655 | -33.4452064789143 | 0.00390173354630116 | 0.59183345241 | 1.03930323127386E-06 | BNG |
| ENSG00000165650 | -16.3934426229508 | 0.0378421421189818 | 0.579453598291972 | 0.0453755163033109 | BNG |
| ENSG00000140945 | -54.1404612159329 | 6.28268106238419E-05 | 0.574978412148533 | 0.00366332390862918 | BNG |
| ENSG00000131941 | -10.5882516781327 | 0.0184141127143809 | 0.573258396588686 | 1.74407845148977E-14 | BNG |
| ENSG00000136492 | -11.7223083063342 | 0.0117767722940519 | 0.572251448971601 | 2.26692368906575E-07 | BNG |
| ENSG00000166444 | -42.5475687103594 | 0.0295866997565394 | 0.56545984417481 | 4.99627819602438E-09 | BNG |
| ENSG00000156113 | -17.9012547914687 | 0.0127279978159161 | 0.562791119722535 | 0.0227562050853387 | BNG |
| ENSG00000159110 | -14.3515151515151 | 0.00553207872317444 | 0.562541206013363 | 0.0121492862435441 | BNG |
| ENSG00000113318 | -17.8626289225368 | 0.00157714237650006 | 0.562313761775957 | 0.000273593476721578 | BNG |
| ENSG00000142185 | -42.8235294117647 | 0.0245087649772323 | 0.561438218660123 | 0.0293332076847108 | BNG |
| ENSG00000050820 | -20.3125 | 0.0271861387486728 | 0.556139137843372 | 4.24342943708694E-08 | BNG |
| ENSG00000115641 | -24.035964035964 | 0.0339725594017967 | 0.552391837873705 | 1.0526762753976E-29 | BNG |
| ENSG00000060558 | -13.6 | 0.00601386696065428 | 0.550616755318472 | 0.00025669154956774 | BNG |
| ENSG00000147065 | -19.4475138121547 | 0.0241049580541904 | 0.53654301642417 | 8.11287354734939E-30 | BNG |
| ENSG00000160214 | -12.9454545454545 | 0.0390164434434383 | 0.535814851392069 | 1.07390707704074E-05 | BNG |
| ENSG00000162419 | -12.7713474557764 | 0.0319921945269321 | 0.525155335489124 | 0.00223599875365847 | BNG |
| ENSG00000167670 | -11.6883116883117 | 0.0192095726179785 | 0.521039303621415 | 0.000147383634918683 | BNG |
| ENSG00000171488 | -12.2956730769231 | 0.0172368472444858 | 0.513239813177653 | 0.00114332064975316 | BNG |
| ENSG00000073712 | -16.9811320754717 | 0.0408786639650407 | 0.512037234330269 | 1.28218578484813E-07 | BNG |
| ENSG00000196792 | -31.4427103159497 | 0.000199788774540287 | 0.507954281998884 | 0.0461085059867358 | BNG |
| ENSG00000050165 | -16 | 0.049872192771084 | 0.507308499457133 | 1.72938165941866E-06 | BNG |
| ENSG00000171453 | -13.2422402159244 | 0.0269713990389909 | 0.50397390606564 | 1.80289167441687E-05 | BNG |
| ENSG00000147689 | -10.2777205394143 | 0.0296131818152576 | 0.498448488864361 | 2.63996760589321E-05 | BNG |
| ENSG00000134686 | -11.2458193979933 | 0.0490807313383056 | 0.49406131874452 | 5.10831089048732E-11 | BNG |
| ENSG00000065534 | -26.1363636363636 | 4.58581903515231E-05 | 0.492937258882307 | 0.00489440648365668 | BNG |
| ENSG00000123130 | -31.9319319319319 | 0.0018567584274336 | 0.489750774803252 | 0.00176615938851862 | BNG |
| ENSG00000275740 | -15.503581963759 | 0.0453593619314214 | 0.487931412162827 | 0.00587654338965406 | BNG |
| ENSG00000156398 | -18.8524590163934 | 0.000348784129373148 | 0.487008729785849 | 0.0128476275418884 | BNG |
| ENSG00000285901 | -12.202502379981 | 0.00468928631103516 | 0.485665901665924 | 0.00265331917593365 | BNG |
| ENSG00000039560 | -12.9437229437229 | 0.0263720785924747 | 0.483171930628531 | 6.66514055683011E-11 | BNG |
| ENSG00000100023 | -22.8361871673974 | 0.00133219128075895 | 0.482668327207678 | 0.0105207229595894 | BNG |
| ENSG00000182484 | -20.2096926023306 | 0.0481433701401008 | 0.48255939531705 | 0.0492338919447914 | BNG |
| ENSG00000132334 | -10.0267752552016 | 0.0242987932391369 | 0.475178385333266 | 7.6377217442228E-05 | BNG |
| ENSG00000083454 | -14.9709934735315 | 0.0364912699901172 | 0.474966356535059 | 0.036003407428261 | BNG |
| ENSG00000076003 | -11.8291944276196 | 0.0218100885442315 | 0.473426901781583 | 1.34801366061123E-12 | BNG |
| ENSG00000177706 | -13.3480709381021 | 2.24772238051684E-13 | 0.471523213919535 | 5.28191185180264E-07 | BNG |
| ENSG00000100065 | -20.1939115929942 | 0.0130722284127865 | 0.470268230654617 | 3.15996374866782E-08 | BNG |
| ENSG00000173530 | -21.7687985014718 | 2.8140664777479E-05 | 0.468398314663583 | 0.000143462486375593 | BNG |
| ENSG00000137478 | -24.3654822335025 | 1.64835961175456E-10 | 0.46837326134002 | 0.00725447648208387 | BNG |
| ENSG00000171132 | -21.3210296260321 | 0.0256886794368254 | 0.468248157279246 | 0.0072417886941382 | BNG |
| ENSG00000149177 | -10.7919678714859 | 0.00278325904974516 | 0.467617414400212 | 0.0446129236346782 | BNG |
| ENSG00000185215 | -22.6086956521739 | 0.0223192198423381 | 0.466484134892728 | 5.69006853725303E-12 | BNG |
| ENSG00000103187 | -11.2068965517241 | 0.0387775128062209 | 0.46390663278 | 2.51230178927757E-17 | BNG |
| ENSG00000134013 | -18.2029598308668 | 0.0190547132705856 | 0.462967204381542 | 4.76544917479903E-12 | BNG |
| ENSG00000141682 | -10.1941747572816 | 0.00214392520301642 | 0.462655005004157 | 1.81835401657973E-05 | BNG |
| ENSG00000134775 | -15.8536585365854 | 0.0272829985423177 | 0.459090918425327 | 3.0528769923768E-05 | BNG |
| ENSG00000188677 | -24.9844564541585 | 0.000168636053320139 | 0.45812961249548 | 0.0430808758707585 | BNG |
| ENSG00000240053 | -12.7484296158995 | 0.0296606338382643 | 0.455843715666729 | 0.0294401639525279 | BNG |
| ENSG00000160799 | -40.3155818540434 | 1.69713921674551E-06 | 0.452833529552961 | 0.00501376556672779 | BNG |
| ENSG00000109861 | -12.7042483660131 | 0.0431789067221677 | 0.448219439704906 | 4.16593315448456E-10 | BNG |
| ENSG00000157551 | -12.9955514265807 | 0.00753561613606589 | 0.447594054452798 | 0.00230304213579688 | BNG |
| ENSG00000197498 | -13.6572622779519 | 0.0123223125411247 | 0.447023051589182 | 0.00184985462302071 | BNG |
| ENSG00000196776 | -11.6533425279246 | 0.00849214239415063 | 0.437581426271295 | 0.000188816039026614 | BNG |
| ENSG00000197417 | -19.751056964842 | 4.01914267959484E-11 | 0.432638130125041 | 0.0169974449289784 | BNG |
| ENSG00000092969 | -12.7301640441915 | 0.0319446080797506 | 0.432025567700634 | 1.3965214654066E-08 | BNG |
| ENSG00000148459 | -31.8840579710145 | 0.00568478148180565 | 0.429364974832301 | 0.0433078449692255 | BNG |
| ENSG00000162433 | -11.2694811599921 | 0.00173237839008872 | 0.425793896102561 | 4.5580052209163E-08 | BNG |
| ENSG00000101546 | -10.7843137254902 | 0.0418187681953032 | 0.423722096644087 | 0.00495092158758691 | BNG |
| ENSG00000120254 | -11.3635157369566 | 0.0402595578220733 | 0.416225112127262 | 3.11356337626985E-05 | BNG |
| ENSG00000165689 | -12.2080440996325 | 1.88001695122534E-05 | 0.414491747412722 | 2.01925319811362E-07 | BNG |
| ENSG00000166949 | -12.8427912028238 | 0.0166308090053364 | 0.410357367727777 | 6.43088240364512E-15 | BNG |
| ENSG00000139343 | -16.9364413656437 | 0.00648669118839666 | 0.408633088879767 | 0.000641235169794379 | BNG |
| ENSG00000166068 | -13.5135135135135 | 0.0351743704365662 | 0.40489548885823 | 0.000120660653415139 | BNG |
| ENSG00000105928 | -11.1111111111111 | 0.035093062877173 | 0.40377048746052 | 4.22656711665809E-06 | BNG |
| ENSG00000141076 | -14.051533802869 | 0.0280107819608233 | 0.401002142074746 | 4.02203339977718E-15 | BNG |
| ENSG00000156787 | -29.8706240487062 | 0.0468147702659847 | 0.395736943319907 | 4.74318720256828E-05 | BNG |
| ENSG00000170379 | -32.4734249416645 | 0.0170665902919789 | 0.394768901772857 | 0.0271338669211037 | BNG |
| ENSG00000146232 | -14.0488110137672 | 0.00474973349274566 | 0.392149770861626 | 0.00332674089463065 | BNG |
| ENSG00000079337 | -14.4724556489262 | 0.0405054892640396 | 0.390891411947141 | 0.0064912127527941 | BNG |
| ENSG00000113356 | -10.45280468574 | 0.0174053941207476 | 0.390375445044573 | 0.0389512379357209 | BNG |
| ENSG00000126602 | -10.4268292682927 | 0.00276913810072556 | 0.38577551135716 | 1.82359994148375E-09 | BNG |
| ENSG00000132470 | -11.2192569335427 | 0.00310423617780924 | 0.383379173420695 | 4.30403166435463E-06 | BNG |
| ENSG00000012048 | -16.2792058516196 | 2.78883070497941E-05 | 0.381249185822562 | 2.9090055172466E-05 | BNG |
| ENSG00000173744 | -14.4028520499109 | 0.000202174864163991 | 0.379563150298012 | 0.00111750633730919 | BNG |
| ENSG00000276043 | -20.8995584988963 | 0.0126091804239962 | 0.377966627324228 | 1.13351188388114E-08 | BNG |
| ENSG00000104998 | -31.9047619047619 | 0.00809423555363895 | 0.377373601776779 | 0.00378313393633686 | BNG |
| ENSG00000020426 | -13.6842105263158 | 0.0110742001662289 | 0.372042127924171 | 0.0012578498521631 | BNG |
| ENSG00000109519 | -11.2951807228916 | 0.0396862905145413 | 0.37164683450387 | 0.000248352981138557 | BNG |
| ENSG00000117411 | -17.4176805078022 | 0.0164899944153455 | 0.370426330875051 | 5.04544077240487E-06 | BNG |
| ENSG00000072110 | -21.177245601798 | 0.00391150829143861 | 0.36814862841075 | 2.13959571937118E-10 | BNG |
| ENSG00000143324 | -18.1824882075472 | 9.45950789324614E-06 | 0.366843989575849 | 3.25957742537955E-05 | BNG |
| ENSG00000174501 | -20.0966962127317 | 0.0310230617351151 | 0.36513259345253 | 0.00490678291116583 | BNG |
| ENSG00000132434 | -27.9419609516697 | 0.0393749617732968 | 0.363383323510468 | 0.0187163147277958 | BNG |
| ENSG00000185344 | -27.9569892473118 | 3.86317235533345E-06 | 0.361820822010875 | 0.0321913603940228 | BNG |
| ENSG00000198742 | -16.2399969659043 | 0.00501008174211403 | 0.360277274531718 | 0.000538983577484304 | BNG |
| ENSG00000151693 | -25.9456333140544 | 2.19912826474313E-05 | 0.354638036216122 | 4.57279940276897E-06 | BNG |
| ENSG00000156795 | -38.0377358490566 | 0.0144869300714228 | 0.343348146097523 | 0.00551779589047665 | BNG |
| ENSG00000077150 | -12.6892461370376 | 0.0306893423114589 | 0.3412428507965 | 3.37086858397517E-05 | BNG |
| ENSG00000108021 | -22.2047389855609 | 0.00106602646373337 | 0.339704174053552 | 0.000135551547207724 | BNG |
| ENSG00000119408 | -61.0294117647059 | 2.8440811599222E-06 | 0.338972363751516 | 0.00265932587383534 | BNG |
| ENSG00000197063 | -15.2279763580073 | 0.00842915807812787 | 0.334400889337693 | 5.31922911707779E-05 | BNG |
| ENSG00000180730 | -20.8983251564879 | 7.90954011912372E-07 | 0.333836788722445 | 0.00201645424663414 | BNG |
| ENSG00000111252 | -11.7093023255814 | 0.00998741143562405 | 0.33125115813949 | 3.52825565234949E-05 | BNG |
| ENSG00000145819 | -10.7178340784898 | 0.0396605018365575 | 0.330677158225405 | 0.00536155887245511 | BNG |
| ENSG00000196535 | -11.4600972797694 | 0.0161093684855209 | 0.328931310926499 | 0.0123758316344305 | BNG |
| ENSG00000162613 | -17.3644474948524 | 0.0324067530449809 | 0.328447709136984 | 3.13022134509149E-06 | BNG |
| ENSG00000062038 | -13.4920634920635 | 0.0238922126161395 | 0.328215850647634 | 2.00014818397733E-10 | BNG |
| ENSG00000092853 | -15.9663865546218 | 0.0125512798926505 | 0.327634213232578 | 0.000642703698649307 | BNG |
| ENSG00000092470 | -29.1854072963518 | 0.0296202538605799 | 0.326458938833974 | 0.0020964526533321 | BNG |
| ENSG00000186314 | -17.1071438989528 | 0.0231358749611893 | 0.326345262946965 | 0.0329328808988499 | BNG |
| ENSG00000166166 | -10.68524970964 | 0.0192164922708738 | 0.325728283849324 | 0.0136212340309268 | BNG |
| ENSG00000196550 | -12.6049933383537 | 0.013463315146511 | 0.323951510423659 | 0.00514137736104517 | BNG |
| ENSG00000104852 | -10.1283636828863 | 0.0139631200255514 | 0.320980373575367 | 0.0272299406051771 | BNG |
| ENSG00000165304 | -18.1269162872805 | 0.000643598541175108 | 0.319129648728101 | 2.3370565052397E-05 | BNG |
| ENSG00000214113 | -12.5010029687876 | 0.0156887342030493 | 0.31875051786639 | 0.0469611212957108 | BNG |
| ENSG00000138442 | -13.8278388278388 | 0.0213187887833145 | 0.318574659777552 | 4.27600892666218E-05 | BNG |
| ENSG00000112972 | -16.1152949614488 | 0.0126838220569589 | 0.315001497982013 | 0.000188738979456314 | BNG |
| ENSG00000169180 | -13.2955936352509 | 0.000849752872498409 | 0.314632885879975 | 0.00135627094179664 | BNG |
| ENSG00000049541 | -12.280701754386 | 0.0169546622797692 | 0.31359405800916 | 0.0156478701318847 | BNG |
| ENSG00000132676 | -11.035419452049 | 0.0245033065121283 | 0.312063598061888 | 0.000208407937187256 | BNG |
| ENSG00000141526 | -23.1404958677686 | 0.00261240939848165 | 0.311619739598562 | 0.000591786040639583 | BNG |
| ENSG00000126698 | -25.1425106124924 | 0.00166587580328008 | 0.306617549211211 | 5.18237372697286E-05 | BNG |
| ENSG00000114480 | -10.9884201819686 | 0.0223217340619718 | 0.306344199668908 | 0.00604581620290016 | BNG |
| ENSG00000120539 | -19.3901132968829 | 0.00343396625615726 | 0.305597893946784 | 0.00455858021237978 | BNG |
| ENSG00000105486 | -15.5844155844156 | 0.0453494958684685 | 0.30478296776648 | 0.0373791119128896 | BNG |
| ENSG00000131620 | -13.3653830413027 | 0.0252948591576672 | 0.303751434937819 | 0.00347391075687533 | BNG |
| ENSG00000254087 | -10.2983725135624 | 0.0488287796275528 | 0.300166838538387 | 3.02913127470451E-07 | BNG |
| ENSG00000035403 | -11.7315415508187 | 0.0441497518533752 | 0.299008368980096 | 6.87026731676217E-09 | BNG |
| ENSG00000083635 | -19.9529373580006 | 0.0381200922165914 | 0.29870686861847 | 0.0119954298989839 | BNG |
| ENSG00000004897 | -11.1111111111111 | 0.00478915076025825 | 0.295393259079194 | 0.00466842591071524 | BNG |
| ENSG00000050344 | -10.0816582914573 | 0.015707575378512 | 0.293012352905917 | 1.17008748072877E-05 | BNG |
| ENSG00000153179 | -21.377606263361 | 0.0203578875585219 | 0.292518165356911 | 7.62622000548776E-07 | BNG |
| ENSG00000160957 | -23.3835005574136 | 0.00101322585276091 | 0.290326906767959 | 0.0265100950636294 | BNG |
| ENSG00000163808 | -18.9340915718868 | 0.00301633219510026 | 0.289017609465231 | 0.0494132444071175 | BNG |
| ENSG00000178409 | -12.9095116307393 | 0.000364087446723097 | 0.2883218952718 | 0.00811924789522798 | BNG |
| ENSG00000175054 | -11.7296606644084 | 0.00106320574342346 | 0.287648371836303 | 0.0146795244446537 | BNG |
| ENSG00000173039 | -27.7398958591619 | 0.00656136475063831 | 0.285633241047627 | 0.0231883773624121 | BNG |
| ENSG00000150753 | -14.4251968503937 | 0.0218407491899384 | 0.284904189377523 | 1.84163220481641E-11 | BNG |
| ENSG00000107130 | -14.7435897435897 | 0.00549774755816806 | 0.281455174998768 | 0.000936775496395401 | BNG |
| ENSG00000100749 | -18.5744810744811 | 0.0250788833752389 | 0.280627114774547 | 0.00344286194449417 | BNG |
| ENSG00000183856 | -13.0434782608696 | 0.0401499412717785 | 0.279732061639544 | 5.33521552830561E-05 | BNG |
| ENSG00000175792 | -10.6004901960784 | 0.00203845771080645 | 0.279137832001109 | 0.000439440796344355 | BNG |
| ENSG00000074201 | -24.7899159663866 | 0.0403083767489215 | 0.278172389751471 | 0.00542221796366029 | BNG |
| ENSG00000184900 | -30.8723265153638 | 0.000377128553514499 | 0.273174201869466 | 0.000220867190177533 | BNG |
| ENSG00000105220 | -18.7007110536522 | 0.00212214059295916 | 0.272702090740145 | 0.00812206968916581 | BNG |
| ENSG00000163293 | -10.8718487394958 | 0.0497617848609876 | 0.272023189061049 | 0.0270981163833197 | BNG |
| ENSG00000131378 | -41.025641025641 | 0.00822190406098067 | 0.271778685197926 | 0.0160680013219797 | BNG |
| ENSG00000001497 | -16.4869398514258 | 0.0137608208710987 | 0.268705941554237 | 0.00102904917257424 | BNG |
| ENSG00000135932 | -13.8342133248755 | 0.000662445859206366 | 0.267400192087818 | 4.11766224712256E-06 | BNG |
| ENSG00000285077 | -15.7713467817686 | 0.045902210404969 | 0.266423004081944 | 0.0468961829118312 | BNG |
| ENSG00000156873 | -12.9756450446106 | 0.000127244227100649 | 0.265336666731864 | 0.031407509745278 | BNG |
| ENSG00000182022 | -14.7592262313075 | 0.00110428414136549 | 0.26444863953694 | 0.000757398141982721 | BNG |
2.5. MSCs promoting the demethylation of the transcription factor NGF and then upregulating KRT17 and FOXJ1
We predicted the transcription factor binding sequences of 66 genes whose methylation levels were negatively correlated with transcription levels in the promoter region and found that 9 genes were rich in transcription factor binding sequences (Table 7). Based on the gene expression correlation and sequence analyses, we selected 4 transcription factors to construct a map of the transcription factor and target gene interactions of MSCs to reverse TEC senescence via Cytoscape (Fig. 5A). In this network, NGF is the central regulatory factor, targeting 108 genes, including many antiaging-related motifs, such as KRT17, FOXJ1. The expression level of NGF was positively correlated with that of KRT17 and FOXJ1 (Pearson's r = 0.92 and 0.74, Fig. 5B). Indicating that promoter demethylation is closely related to the increase in mRNA expression during MSCs reversal of TEC ageing.
Table 7.
Transcription factors correlate with target genes.
| TF | Gene | Score |
|---|---|---|
| ELL2 | TRIM7 | 4.465 |
| ELL2 | TRIM41 | 4.317 |
| ELL2 | HMGN4 | 3.913 |
| ELL2 | BORCS6 | 3.857 |
| ELL2 | ALOXE3 | 3.803 |
| ELL2 | ZNF184 | 3.755 |
| ELL2 | RNF207 | 3.587 |
| ELL2 | HES7 | 3.579 |
| ELL2 | H4C12 | 3.578 |
| ELL2 | AURKB | 3.566 |
| ELL2 | UBC | 3.538 |
| ELL2 | H4C8 | 3.514 |
| ELL2 | SDR39U1 | 3.409 |
| ELL2 | B4GALT3 | 3.336 |
| ELL2 | GBA | 3.3 |
| ELL2 | SHF | 3.265 |
| ELL2 | HARS2 | 3.246 |
| ELL2 | HARS1 | 3.242 |
| ELL2 | PPOX | 3.235 |
| ELL2 | USP21 | 3.14 |
| ELL2 | PQBP1 | 3.138 |
| ELL2 | H4C11 | 3.132 |
| ELL2 | ZMAT2 | 3.117 |
| ELL2 | H2AC11 | 3.113 |
| ELL2 | SRCIN1 | 3.098 |
| ELL2 | H2BC11 | 3.097 |
| ELL2 | TIMM17B | 3.093 |
| ELL2 | ANG | 3.084 |
| ELL2 | RPL22 | 3.082 |
| ELL2 | H2BC17 | 3.079 |
| ELL2 | CCDC77 | 3.075 |
| ELL2 | H2AC17 | 3.063 |
| ELL2 | H4C9 | 3.009 |
| ELL2 | RNASE4 | 3.003 |
| ELL2 | ZNF335 | 3.002 |
| ELL2 | HOXA5 | 2.98 |
| ELL2 | WDR13 | 2.958 |
| ELL2 | S100A13 | 2.946 |
| ELL2 | BDP1 | 2.942 |
| ELL2 | S100A1 | 2.935 |
| ELL2 | PIN1 | 2.91 |
| ELL2 | H2AC15 | 2.884 |
| ELL2 | HBP1 | 2.875 |
| ELL2 | LDHA | 2.875 |
| ELL2 | LOC105371063 | 2.872 |
| ELL2 | BAZ2A | 2.865 |
| ELL2 | CALM1 | 2.861 |
| ELL2 | DNAJA3 | 2.858 |
| ELL2 | LOC107985657 | 2.853 |
| ELL2 | BRMS1 | 2.844 |
| ELL2 | CCDC130 | 2.842 |
| ELL2 | H2BC15 | 2.837 |
| ELL2 | TMEM107 | 2.836 |
| ELL2 | KHK | 2.821 |
| ELL2 | ZBED9 | 2.818 |
| ELL2 | UFC1 | 2.793 |
| ELL2 | CSKMT | 2.774 |
| ELL2 | UBL5 | 2.772 |
| ELL2 | C11orf98 | 2.767 |
| ELL2 | H2BC9 | 2.748 |
| ELL2 | TMEM205 | 2.738 |
| ELL2 | TCEANC | 2.733 |
| ELL2 | RACK1 | 2.733 |
| ELL2 | H3C7 | 2.733 |
| ELL2 | DPP9 | 2.732 |
| ELL2 | B4GAT1 | 2.717 |
| ELL2 | FAM189B | 2.714 |
| ELL2 | RIN1 | 2.708 |
| ELL2 | CCDC159 | 2.707 |
| ELL2 | LBHD1 | 2.703 |
| ELL2 | UQCC3 | 2.7 |
| ELL2 | SLC25A35 | 2.699 |
| ELL2 | GCDH | 2.685 |
| ELL2 | ZNF775 | 2.685 |
| ELL2 | DISP3 | 2.682 |
| ELL2 | ALG3 | 2.679 |
| ELL2 | CORO7 | 2.675 |
| ELL2 | CORO7-PAM16 | 2.675 |
| ELL2 | WBP1 | 2.674 |
| ELL2 | NOD1 | 2.671 |
| ELL2 | MUC1 | 2.663 |
| ELL2 | NCOA3 | 2.661 |
| ELL2 | EEF1AKMT4 | 2.657 |
| ELL2 | EEF1AKMT4-ECE2 | 2.657 |
| ELL2 | H3C8 | 2.655 |
| ELL2 | INO80B | 2.643 |
| ELL2 | QRICH1 | 2.639 |
| ELL2 | INTS5 | 2.636 |
| ELL2 | BSDC1 | 2.635 |
| ELL2 | TP53I3 | 2.633 |
| ELL2 | BSG | 2.632 |
| ELL2 | IER3 | 2.631 |
| ELL2 | JUP | 2.629 |
| ELL2 | H3C12 | 2.624 |
| ELL2 | H2BC10 | 2.624 |
| ELL2 | SIRT4 | 2.616 |
| ELL2 | SCAMP3 | 2.609 |
| ELL2 | PSAP | 2.608 |
| ELL2 | HSPA6 | 2.607 |
| ELL2 | H4C2 | 2.605 |
| F2R | MTRNR2L1 | 0.888 |
| F2R | COL23A1 | 0.727 |
| F2R | LOC105378947 | 0.482 |
| F2R | TMEM242 | 0.481 |
| F2R | ARHGEF18 | 0.464 |
| F2R | LOC101060017 | 0.244 |
| F2R | PEX11G | 0.07 |
| F2R | CLK4 | 0.057 |
| F2R | OR4F16 | 0.046 |
| F2R | TEX45 | 0.039 |
| F2R | MMEL1 | 0.029 |
| F2R | POTEA | 0.026 |
| F2R | FRG2B | 0.013 |
| F2R | ZNF358 | 0.011 |
| F2R | ZDHHC14 | 0.009 |
| F2R | MCOLN1 | 0.007 |
| F2R | PNPLA6 | 0.003 |
| F2R | PRXL2B | 0.001 |
| F2R | HGSNAT | 0.001 |
| F2R | LOC107984841 | 0.001 |
| F2R | TTC34 | 0.001 |
| GMEB2 | UBE2M | 3.861 |
| GMEB2 | CHMP2A | 3.676 |
| GMEB2 | TAF6 | 3.455 |
| GMEB2 | CNPY4 | 3.448 |
| GMEB2 | MCM7 | 3.444 |
| GMEB2 | AP4M1 | 3.442 |
| GMEB2 | SRSF2 | 3.395 |
| GMEB2 | MFSD11 | 3.394 |
| GMEB2 | VPS52 | 3.39 |
| GMEB2 | RPS18 | 3.39 |
| GMEB2 | ZNF517 | 3.264 |
| GMEB2 | B3GALT4 | 3.233 |
| GMEB2 | RPL8 | 3.126 |
| GMEB2 | MOGS | 3.116 |
| GMEB2 | WBP1 | 3.081 |
| GMEB2 | MZF1 | 3.074 |
| GMEB2 | NAA80 | 3.062 |
| GMEB2 | HYAL3 | 3.062 |
| GMEB2 | HYOU1 | 2.977 |
| GMEB2 | LIN37 | 2.974 |
| GMEB2 | PROSER3 | 2.974 |
| GMEB2 | WDR74 | 2.969 |
| GMEB2 | TASOR | 2.929 |
| GMEB2 | HSPB6 | 2.92 |
| GMEB2 | TAF12 | 2.911 |
| GMEB2 | YIF1B | 2.909 |
| GMEB2 | MRPL53 | 2.894 |
| GMEB2 | C19orf33 | 2.879 |
| GMEB2 | NAA38 | 2.872 |
| GMEB2 | USP21 | 2.871 |
| GMEB2 | INO80B | 2.87 |
| GMEB2 | COPS6 | 2.866 |
| GMEB2 | CYB5D1 | 2.865 |
| GMEB2 | MBLAC1 | 2.855 |
| GMEB2 | DBP | 2.842 |
| GMEB2 | PSENEN | 2.84 |
| GMEB2 | TUSC2 | 2.835 |
| GMEB2 | U2AF1L4 | 2.824 |
| GMEB2 | SEC22C | 2.814 |
| GMEB2 | GLTPD2 | 2.804 |
| GMEB2 | CKS1B | 2.803 |
| GMEB2 | TRIM28 | 2.796 |
| GMEB2 | SHC1 | 2.793 |
| GMEB2 | KCNK6 | 2.786 |
| GMEB2 | CALR | 2.786 |
| GMEB2 | DHPS | 2.777 |
| GMEB2 | RAD23A | 2.776 |
| GMEB2 | SS18L2 | 2.776 |
| GMEB2 | TMEM88 | 2.764 |
| GMEB2 | ZNF34 | 2.763 |
| GMEB2 | PCSK4 | 2.755 |
| GMEB2 | PPOX | 2.74 |
| GMEB2 | REEP6 | 2.726 |
| GMEB2 | COG8 | 2.724 |
| GMEB2 | HYAL2 | 2.72 |
| GMEB2 | NIP7 | 2.718 |
| GMEB2 | RPL10 | 2.678 |
| GMEB2 | WDR46 | 2.674 |
| GMEB2 | PFDN6 | 2.673 |
| GMEB2 | UFC1 | 2.662 |
| GMEB2 | ZNF497 | 2.655 |
| GMEB2 | RASSF1 | 2.653 |
| GMEB2 | RPS2 | 2.651 |
| GMEB2 | H2BC6 | 2.65 |
| GMEB2 | RPL26 | 2.647 |
| GMEB2 | VPS11 | 2.646 |
| GMEB2 | ZNF837 | 2.645 |
| GMEB2 | RPS5 | 2.644 |
| GMEB2 | ZNF668 | 2.641 |
| GMEB2 | TP53I3 | 2.637 |
| GMEB2 | ZNF646 | 2.629 |
| GMEB2 | RXRB | 2.621 |
| GMEB2 | SLC39A7 | 2.62 |
| GMEB2 | HYAL1 | 2.614 |
| GMEB2 | H4C4 | 2.609 |
| GMEB2 | EID2 | 2.605 |
| GMEB2 | YDJC | 2.604 |
| GMEB2 | PSMB6 | 2.601 |
| GMEB2 | CDC37 | 2.6 |
| GMEB2 | TBCB | 2.6 |
| GMEB2 | H2AX | 2.592 |
| GMEB2 | NDUFB10 | 2.592 |
| GMEB2 | PIH1D1 | 2.592 |
| GMEB2 | ZBTB45 | 2.589 |
| GMEB2 | TRMT112 | 2.579 |
| GMEB2 | ZC3H4 | 2.577 |
| GMEB2 | FKBP2 / LOC114841035 | 2.575 |
| GMEB2 | LOC114841035 | 2.575 |
| GMEB2 | FOS | 2.575 |
| GMEB2 | POLR2I | 2.568 |
| GMEB2 | ALDH16A1 | 2.553 |
| GMEB2 | NUP155 | 2.552 |
| GMEB2 | IDE | 2.548 |
| GMEB2 | DCTPP1 | 2.548 |
| GMEB2 | STX5 | 2.545 |
| GMEB2 | MNT | 2.545 |
| GMEB2 | RSRP1 | 2.543 |
| GMEB2 | BICRA | 2.542 |
| GMEB2 | GNL1 | 2.542 |
| GMEB2 | SYF2 | 2.54 |
| METLL1 | METTL14 | 4.893 |
| METLL1 | C12orf57 | 1.67 |
| METLL1 | PTPN6 | 1.387 |
| METLL1 | TEX14 | 1.374 |
| METLL1 | LOC730183 | 1.057 |
| METLL1 | FBRS | 1.04 |
| METLL1 | SRCAP | 1.007 |
| METLL1 | EIF2B3 | 1 |
| METLL1 | TRMT2A | 0.999 |
| METLL1 | DNAJC11 | 0.999 |
| METLL1 | ARHGAP24 | 0.999 |
| METLL1 | CDCA5 | 0.998 |
| METLL1 | CLUAP1 | 0.998 |
| METLL1 | C7orf26 | 0.998 |
| METLL1 | NIPSNAP2 | 0.997 |
| METLL1 | ARHGEF2 | 0.997 |
| METLL1 | THEM6 | 0.997 |
| METLL1 | SLC45A4 | 0.997 |
| METLL1 | TAF12 | 0.996 |
| METLL1 | R3HCC1 | 0.995 |
| METLL1 | BAIAP2 | 0.995 |
| METLL1 | DRAP1 | 0.995 |
| METLL1 | POLR2I | 0.995 |
| METLL1 | ABHD16A | 0.995 |
| METLL1 | RAB37 | 0.995 |
| METLL1 | DHX16 | 0.994 |
| METLL1 | FOXP4 | 0.993 |
| METLL1 | AURKAIP1 | 0.993 |
| METLL1 | KRBA2 | 0.993 |
| METLL1 | SUPT4H1 | 0.993 |
| METLL1 | PPIL2 | 0.992 |
| METLL1 | KCTD5 | 0.992 |
| METLL1 | ZFPL1 | 0.992 |
| METLL1 | TMEM14B | 0.99 |
| METLL1 | DPP9 | 0.99 |
| METLL1 | RANBP1 | 0.99 |
| METLL1 | TMEM44 | 0.989 |
| METLL1 | SRI | 0.989 |
| METLL1 | NOTUM | 0.988 |
| METLL1 | SLC9A1 | 0.988 |
| METLL1 | PGK1 | 0.988 |
| METLL1 | LEMD1 | 0.987 |
| METLL1 | NDUFS8 | 0.987 |
| METLL1 | WDR74 | 0.987 |
| METLL1 | FAM83D | 0.986 |
| METLL1 | ZNF341 | 0.986 |
| METLL1 | POLG | 0.985 |
| METLL1 | SH2B1 | 0.984 |
| METLL1 | C11orf68 | 0.98 |
| METLL1 | LARP1 | 0.977 |
| METLL1 | TTI2 | 0.975 |
| METLL1 | POLDIP3 | 0.971 |
| METLL1 | CCDC200 | 0.968 |
| METLL1 | TBCB | 0.964 |
| METLL1 | LRP5 | 0.959 |
| METLL1 | PTK6 | 0.954 |
| METLL1 | SIRT4 | 0.945 |
| METLL1 | RAB27A | 0.898 |
| METLL1 | MTRNR2L1 | 0.893 |
| METLL1 | ZFPM1 | 0.861 |
| METLL1 | UCKL1 | 0.847 |
| METLL1 | SCIMP | 0.845 |
| METLL1 | KIF2C | 0.845 |
| METLL1 | FOXJ1 | 0.835 |
| METLL1 | NEU1 | 0.834 |
| METLL1 | ATN1 | 0.826 |
| METLL1 | ZFAND2A | 0.816 |
| METLL1 | PARP16 | 0.814 |
| METLL1 | TMEM107 | 0.812 |
| METLL1 | SEMA6A | 0.795 |
| METLL1 | RGS3 | 0.785 |
| METLL1 | OVOL3 | 0.781 |
| METLL1 | LY6G6F | 0.778 |
| METLL1 | LY6G6F-LY6G6D | 0.778 |
| METLL1 | LOC107986004 | 0.772 |
| METLL1 | CNOT3 | 0.76 |
| METLL1 | C16orf90 | 0.742 |
| METLL1 | ANKRD39 | 0.739 |
| METLL1 | PPARD | 0.731 |
| METLL1 | ABCC1 | 0.724 |
| METLL1 | GUCD1 | 0.721 |
| METLL1 | ABCA4 | 0.71 |
| METLL1 | TMEM262 | 0.707 |
| METLL1 | ARID3B | 0.703 |
| METLL1 | FGG | 0.702 |
| METLL1 | SNRPD3 | 0.696 |
| METLL1 | ZDHHC18 | 0.692 |
| METLL1 | SEMA4C | 0.685 |
| METLL1 | PTF1A | 0.683 |
| METLL1 | CLPTM1L | 0.674 |
| METLL1 | SOCS2 | 0.669 |
| METLL1 | SREBF1 | 0.655 |
| METLL1 | LMNB2 | 0.65 |
| METLL1 | ANKRD35 | 0.647 |
| METLL1 | PRR14 | 0.647 |
| METLL1 | RPL26 | 0.643 |
| METLL1 | ACSL4 | 0.62 |
| METLL1 | USP48 | 0.617 |
| METLL1 | ECM1 | 0.591 |
| METLL1 | NEU4 | 0.59 |
| NGF | ANTKMT | 7.618 |
| NGF | METRN | 7.608 |
| NGF | CCDC78 | 7.085 |
| NGF | LFNG | 7.027 |
| NGF | EFNA4 | 6.879 |
| NGF | NEMP1 | 6.673 |
| NGF | HAGHL | 6.654 |
| NGF | ZBTB42 | 6.594 |
| NGF | PAQR4 | 6.577 |
| NGF | EFNA3 | 6.555 |
| NGF | FBXL16 | 6.553 |
| NGF | NAB2 | 6.514 |
| NGF | KISS1R | 6.479 |
| NGF | R3HDM4 | 6.36 |
| NGF | AKT1 | 6.24 |
| NGF | SYTL1 | 6.211 |
| NGF | SH2B2 | 6.209 |
| NGF | NR1D1 | 6.18 |
| NGF | CALR | 6.143 |
| NGF | GADD45B | 6.138 |
| NGF | KREMEN2 | 6.116 |
| NGF | FIS1 | 6.101 |
| NGF | PHYHIP | 6.077 |
| NGF | PCNX3 | 6.07 |
| NGF | MAP3K11 | 6.069 |
| NGF | ARID3A | 6.051 |
| NGF | KIAA1522 | 6.046 |
| NGF | PPP1R14B | 6.019 |
| NGF | CHD4 | 5.991 |
| NGF | FKBP2 | 5.982 |
| NGF | FNDC11 | 5.965 |
| NGF | RAD23A | 5.959 |
| NGF | ABCB9 | 5.953 |
| NGF | OGFOD2 | 5.952 |
| NGF | LOC114841035 | 5.948 |
| NGF | TAS1R3 | 5.943 |
| NGF | PKMYT1 | 5.935 |
| NGF | TAPBP | 5.918 |
| NGF | RNF224 | 5.905 |
| NGF | PTH2 | 5.873 |
| NGF | NFIC | 5.872 |
| NGF | LRRC71 | 5.855 |
| NGF | RILP | 5.852 |
| NGF | CISH | 5.83 |
| NGF | SHMT2 | 5.827 |
| NGF | MAPKAPK3 | 5.827 |
| NGF | SCARF1 | 5.817 |
| NGF | CYSRT1 | 5.815 |
| NGF | MAPK12 | 5.811 |
| NGF | GFY | 5.81 |
| NGF | FARSA | 5.766 |
| NGF | SLC34A3 | 5.758 |
| NGF | RNF208 | 5.739 |
| NGF | LOC112267874 | 5.729 |
| NGF | ZBTB22 | 5.727 |
| NGF | ADAM15 | 5.698 |
| NGF | TTC9B | 5.682 |
| NGF | KCNN1 | 5.669 |
| NGF | INTS11 | 5.661 |
| NGF | CPTP | 5.66 |
| NGF | CLCF1 | 5.645 |
| NGF | SLC38A3 | 5.645 |
| NGF | AGPAT2 | 5.635 |
| NGF | ARL6IP4 | 5.634 |
| NGF | SP2 | 5.629 |
| NGF | OAZ1 | 5.624 |
| NGF | REXO1 | 5.623 |
| NGF | SERTAD1 | 5.619 |
| NGF | NOS3 | 5.617 |
| NGF | SERPINE1 | 5.611 |
| NGF | NENF | 5.603 |
| NGF | CLDN15 | 5.599 |
| NGF | HOXB4 | 5.598 |
| NGF | WDR24 | 5.595 |
| NGF | VASP | 5.592 |
| NGF | LBHD1 | 5.578 |
| NGF | UQCC3 | 5.577 |
| NGF | MAPK11 | 5.575 |
| NGF | PDE4A | 5.573 |
| NGF | SLC37A4 | 5.558 |
| NGF | GFER | 5.535 |
| NGF | NKX2-2 | 5.533 |
| NGF | MAPK7 | 5.531 |
| NGF | EHD2 | 5.524 |
| NGF | NOXO1 | 5.521 |
| NGF | B9D1 | 5.515 |
| NGF | SRMS | 5.501 |
| NGF | PLCB3 | 5.497 |
| NGF | GADD45GIP1 | 5.492 |
| NGF | ARHGAP45 | 5.464 |
| NGF | UCKL1 | 5.455 |
| NGF | KCNK7 | 5.447 |
| NGF | PLEC | 5.439 |
| NGF | PRKAR1B | 5.437 |
| NGF | SLC12A5 | 5.426 |
| NGF | ELFN1 | 5.416 |
| NGF | CLDN9 | 5.41 |
| NGF | SPINT2 | 5.409 |
| NGF | SECTM1 | 5.409 |
| NGF | NEUROG2 | 5.401 |
| NGF | CHTF18 | 3.653 |
| NGF | TRIM39 | 3.306 |
| NGF | KRT17 | 1.777 |
| NGF | PGF | 1.479 |
| NGF | FOXJ1 | 1.431 |
| NGF | KNTC1 | 1.3 |
| NGF | F2R | 1.202 |
| NGF | POLR3G | 1.012 |
| POLR3G | HMGN4 | 4.191 |
| POLR3G | ALOXE3 | 3.96 |
| POLR3G | HES7 | 3.844 |
| POLR3G | TRIM7 | 3.068 |
| POLR3G | SHF | 2.792 |
| POLR3G | TRIM41 | 2.5 |
| POLR3G | ANG | 2.233 |
| POLR3G | RNASE4 | 2.175 |
| POLR3G | BORCS6 | 1.997 |
| POLR3G | PGBD2 | 1.959 |
| POLR3G | ZNF184 | 1.944 |
| POLR3G | AGBL5 | 1.941 |
| POLR3G | TRIM55 | 1.933 |
| POLR3G | HSPA6 | 1.93 |
| POLR3G | DPP9 | 1.926 |
| POLR3G | POLR3E | 1.908 |
| POLR3G | LOC105375107 | 1.759 |
| POLR3G | POM121L2 | 1.755 |
| POLR3G | PLXDC1 | 1.678 |
| POLR3G | ABT1 | 1.652 |
| POLR3G | OR6S1 | 1.606 |
| POLR3G | UBC | 1.598 |
| POLR3G | H4C8 | 1.553 |
| POLR3G | AURKB | 1.529 |
| POLR3G | PER1 | 1.471 |
| POLR3G | LASP1 | 1.429 |
| POLR3G | TRIM27 | 1.36 |
| POLR3G | HJV | 1.349 |
| POLR3G | TMEM107 | 1.284 |
| POLR3G | PRSS16 | 1.28 |
| POLR3G | MPZL1 | 1.245 |
| POLR3G | H2BC17 | 1.05 |
| POLR3G | MDM4 | 1.032 |
| POLR3G | H2AC17 | 1.032 |
| POLR3G | OR2B2 | 1.026 |
| POLR3G | VAMP2 | 1.025 |
| POLR3G | CGB2 | 0.994 |
| POLR3G | KNL1 | 0.991 |
| POLR3G | TIA1 | 0.986 |
| POLR3G | ILF2 | 0.983 |
| POLR3G | PLEKHG2 | 0.982 |
| POLR3G | FBXO31 | 0.98 |
| POLR3G | DCT | 0.98 |
| POLR3G | POLG | 0.979 |
| POLR3G | SACM1L | 0.978 |
| POLR3G | PRMT5 | 0.978 |
| POLR3G | CCDC107 | 0.977 |
| POLR3G | LUC7L2 | 0.975 |
| POLR3G | RAB11A | 0.974 |
| POLR3G | BCAR3 | 0.974 |
| POLR3G | METTL26 | 0.973 |
| POLR3G | FMC1-LUC7L2 | 0.972 |
| POLR3G | NDUFS7 | 0.972 |
| POLR3G | LTA4H | 0.97 |
| POLR3G | TMEM259 | 0.969 |
| POLR3G | SLC27A4 | 0.968 |
| POLR3G | C8orf37 | 0.966 |
| POLR3G | B4GAT1 | 0.965 |
| POLR3G | PPP6R3 | 0.962 |
| POLR3G | FMC1 | 0.959 |
| POLR3G | FCGR3A | 0.958 |
| POLR3G | NCOA7 | 0.956 |
| POLR3G | RPL23 | 0.955 |
| POLR3G | SMARCC2 | 0.941 |
| POLR3G | PPEF1 | 0.936 |
| POLR3G | MYNN | 0.921 |
| POLR3G | ZMAT2 | 0.916 |
| POLR3G | H2BC13 | 0.905 |
| POLR3G | ZNF213 | 0.903 |
| POLR3G | TMPO | 0.891 |
| POLR3G | MTRNR2L1 | 0.888 |
| POLR3G | H2AC13 | 0.888 |
| POLR3G | H3C12 | 0.875 |
| POLR3G | ARL5C | 0.872 |
| POLR3G | PIK3C2B | 0.87 |
| POLR3G | ACTRT3 | 0.832 |
| POLR3G | RNASE12 | 0.827 |
| POLR3G | RS1 | 0.821 |
| POLR3G | BRMS1 | 0.811 |
| POLR3G | KRBA1 | 0.808 |
| POLR3G | FCGR3B | 0.806 |
| POLR3G | RNASE11 | 0.795 |
| POLR3G | TMEM214 | 0.789 |
| POLR3G | H3C10 | 0.781 |
| POLR3G | LOC101929805 | 0.742 |
| POLR3G | ZNF692 | 0.722 |
| POLR3G | C1QTNF6 | 0.719 |
| POLR3G | PSMA3 | 0.713 |
| POLR3G | CCDC115 | 0.709 |
| POLR3G | CNN2 | 0.707 |
| POLR3G | IMP4 | 0.705 |
| POLR3G | MCRIP2 | 0.704 |
| POLR3G | OR1F1 | 0.7 |
| POLR3G | CGB1 | 0.7 |
| POLR3G | ZFP36 | 0.685 |
| POLR3G | PLLP | 0.678 |
| POLR3G | PFAS | 0.674 |
| POLR3G | WFIKKN1 | 0.67 |
| POLR3G | CTC1 | 0.653 |
| POLR3G | H2BC10 | 0.652 |
| SVIL | H4C2 | 1.915 |
| SVIL | H3C6 | 1.817 |
| SVIL | H2BC8 | 1.813 |
| SVIL | H3C1 | 1.805 |
| SVIL | H2AC8 | 1.804 |
| SVIL | H4C1 | 1.795 |
| SVIL | PGBD3 | 1.77 |
| SVIL | H2AC12 | 1.58 |
| SVIL | H4C9 | 1.58 |
| SVIL | H2BC12 | 1.574 |
| SVIL | H3C2 | 1.569 |
| SVIL | H1-1 | 1.504 |
| SVIL | H2AC4 | 1.498 |
| SVIL | H3C3 | 1.482 |
| SVIL | H2BC3 | 1.427 |
| SVIL | H4C4 | 1.375 |
| SVIL | H2AC6 | 1.356 |
| SVIL | H2BC9 | 1.355 |
| SVIL | CROCC | 1.355 |
| SVIL | H2BC4 | 1.342 |
| SVIL | H3C7 | 1.298 |
| SVIL | H4C3 | 1.288 |
| SVIL | TMEM135 | 1.263 |
| SVIL | H2BC5 | 1.259 |
| SVIL | LUC7L2 | 1.25 |
| SVIL | FMC1-LUC7L2 | 1.244 |
| SVIL | FMC1 | 1.234 |
| SVIL | H1-3 | 1.178 |
| SVIL | GEMIN6 | 1.155 |
| SVIL | H4C7 | 1.153 |
| SVIL | SRSF7 | 1.153 |
| SVIL | H1-4 | 1.142 |
| SVIL | H1-6 | 1.137 |
| SVIL | TEX14 | 1.135 |
| SVIL | MAK16 | 1.131 |
| SVIL | H4C8 | 1.12 |
| SVIL | TTI2 | 1.119 |
| SVIL | H4C5 | 1.104 |
| SVIL | TNFRSF10D | 1.088 |
| SVIL | H4C6 | 1.073 |
| SVIL | TIMM13 | 1.06 |
| SVIL | H2BC6 | 1.054 |
| SVIL | H3C4 | 1.053 |
| SVIL | H2AC7 | 1.053 |
| SVIL | H2BC7 | 1.052 |
| SVIL | CSDE1 | 1.052 |
| SVIL | NRAS | 1.044 |
| SVIL | TET1 | 1.031 |
| SVIL | CUEDC2 | 1.031 |
| SVIL | H2AC11 | 1.027 |
| SVIL | ZSCAN12 | 1.025 |
| SVIL | ALOXE3 | 1.022 |
| SVIL | FRG1 | 1.012 |
| SVIL | RPS27L | 1.011 |
| SVIL | H2BC11 | 1.01 |
| SVIL | PSMB6 | 1.009 |
| SVIL | COA6 | 1.009 |
| SVIL | EIF3E | 1.008 |
| SVIL | DSTYK | 1.007 |
| SVIL | MRPS35 | 1.005 |
| SVIL | MCOLN1 | 1.004 |
| SVIL | COX7A2 | 1.003 |
| SVIL | FBXW9 | 1.001 |
| SVIL | IST1 | 1 |
| SVIL | ACCS | 1 |
| SVIL | HSP90AB1 | 1 |
| SVIL | ANAPC15 | 1 |
| SVIL | UBB | 1 |
| SVIL | LRRC63 | 1 |
| SVIL | JMJD1C | 1 |
| SVIL | PHB | 1 |
| SVIL | EPG5 | 1 |
| SVIL | FUS | 1 |
| SVIL | PSMC2 | 1 |
| SVIL | SYNPO2 | 1 |
| SVIL | MNAT1 | 0.999 |
| SVIL | GOSR1 | 0.999 |
| SVIL | ITPR1 | 0.999 |
| SVIL | TDG | 0.999 |
| SVIL | FBXW7 | 0.999 |
| SVIL | EEF1A1 | 0.999 |
| SVIL | MTERF1 | 0.999 |
| SVIL | SF3A3 | 0.999 |
| SVIL | RABGAP1L | 0.999 |
| SVIL | NDUFAF1 | 0.999 |
| SVIL | RPL12 | 0.999 |
| SVIL | NSL1 | 0.999 |
| SVIL | JUNB | 0.999 |
| SVIL | COX14 | 0.999 |
| SVIL | LRRC37A3 | 0.999 |
| SVIL | EMC4 | 0.999 |
| SVIL | HNRNPA2B1 | 0.999 |
| SVIL | RPL7 | 0.999 |
| SVIL | RPS27 | 0.999 |
| SVIL | RPL10 | 0.998 |
| SVIL | HSPA1A | 0.998 |
| SVIL | DVL2 | 0.998 |
| SVIL | RPS6 | 0.998 |
| SVIL | MAGED1 | 0.998 |
| SVIL | ZNHIT6 | 0.998 |
| TOE1 | LOC101929601 | 3.499 |
| TOE1 | LOC101929627 | 3.235 |
| TOE1 | ZDHHC7 | 2.861 |
| TOE1 | RASA4 | 2.803 |
| TOE1 | ARID1A | 2.729 |
| TOE1 | PPP2R5B | 2.595 |
| TOE1 | ATG2A | 2.582 |
| TOE1 | MNT | 2.545 |
| TOE1 | MRPL48 | 2.493 |
| TOE1 | MCRIP2 | 2.47 |
| TOE1 | H2AX | 2.433 |
| TOE1 | TSEN34 | 2.422 |
| TOE1 | MBOAT7 | 2.407 |
| TOE1 | MFAP3L | 2.379 |
| TOE1 | MRPL44 | 2.347 |
| TOE1 | WDR90 | 2.338 |
| TOE1 | MRPL40 | 2.333 |
| TOE1 | HIRA | 2.314 |
| TOE1 | DPAGT1 | 2.295 |
| TOE1 | EIF2B5 | 2.221 |
| TOE1 | METTL26 | 2.206 |
| TOE1 | FGF9 | 2.193 |
| TOE1 | RGL2 | 2.168 |
| TOE1 | PYGO2 | 2.164 |
| TOE1 | HMBS | 2.156 |
| TOE1 | LOC101928120 | 2.155 |
| TOE1 | PBXIP1 | 2.141 |
| TOE1 | RTEL1 | 2.131 |
| TOE1 | SLC25A39 | 2.103 |
| TOE1 | VILL | 2.095 |
| TOE1 | NEU1 | 2.091 |
| TOE1 | TRIP6 | 2.088 |
| TOE1 | LOC107985728 | 2.088 |
| TOE1 | AMDHD2 | 2.084 |
| TOE1 | FZR1 | 2.072 |
| TOE1 | KIAA0513 | 2.029 |
| TOE1 | ACAP2 | 2.022 |
| TOE1 | SYTL1 | 2.017 |
| TOE1 | FUT1 | 2.014 |
| TOE1 | KIAA0586 | 2.01 |
| TOE1 | TIMM9 | 2.01 |
| TOE1 | GOLGA6L10 | 2.01 |
| TOE1 | CAMK1 | 1.993 |
| TOE1 | SAMD11 | 1.992 |
| TOE1 | UBC | 1.986 |
| TOE1 | NOTCH2NLA | 1.977 |
| TOE1 | RAB7A | 1.973 |
| TOE1 | C4orf47 | 1.97 |
| TOE1 | UFSP2 | 1.97 |
| TOE1 | AP3S1 | 1.961 |
| TOE1 | MCEE | 1.961 |
| TOE1 | TMEM250 | 1.959 |
| TOE1 | LRRC1 | 1.958 |
| TOE1 | P3H4 | 1.958 |
| TOE1 | KCNAB2 | 1.956 |
| TOE1 | NPHP4 | 1.956 |
| TOE1 | RBPJ | 1.955 |
| TOE1 | MPHOSPH10 | 1.952 |
| TOE1 | RAP2B | 1.951 |
| TOE1 | DNAAF3 | 1.95 |
| TOE1 | MRPL36 | 1.948 |
| TOE1 | DOHH | 1.947 |
| TOE1 | ERAP1 | 1.947 |
| TOE1 | RPS9 | 1.943 |
| TOE1 | SEPTIN2 | 1.941 |
| TOE1 | CITED2 | 1.941 |
| TOE1 | HDLBP | 1.94 |
| TOE1 | ATG12 | 1.94 |
| TOE1 | ZFAND6 | 1.937 |
| TOE1 | TDP1 | 1.936 |
| TOE1 | LNPEP | 1.935 |
| TOE1 | FAM72D | 1.931 |
| TOE1 | ZFP91 | 1.926 |
| TOE1 | ATP6V0C | 1.922 |
| TOE1 | EEF2 | 1.922 |
| TOE1 | TRIM65 | 1.919 |
| TOE1 | CCNT2 | 1.918 |
| TOE1 | C2 | 1.918 |
| TOE1 | EHMT2 | 1.918 |
| TOE1 | EFCAB11 | 1.916 |
| TOE1 | GANAB | 1.916 |
| TOE1 | ISOC2 | 1.914 |
| TOE1 | ANP32B | 1.914 |
| TOE1 | SLC12A9 | 1.913 |
| TOE1 | COMMD1 | 1.913 |
| TOE1 | NACC1 | 1.912 |
| TOE1 | YPEL5 | 1.911 |
| TOE1 | TRMT1 | 1.91 |
| TOE1 | FKBP10 | 1.906 |
| TOE1 | HSPG2 | 1.905 |
| TOE1 | INTS5 | 1.902 |
| TOE1 | ZMIZ1 | 1.901 |
| TOE1 | ARL5A | 1.9 |
| TOE1 | PLEKHA8 | 1.897 |
| TOE1 | COIL | 1.896 |
| TOE1 | MEIS1 | 1.894 |
| TOE1 | SRRT | 1.892 |
| TOE1 | GATD3B | 1.89 |
| TOE1 | FKBP14 | 1.885 |
| TOE1 | SRGAP2B | 1.883 |
| TRIM3 | Pde2a | 4.206 |
| TRIM3 | Ptp4a3 | 4.194 |
| TRIM3 | Erg | 4.052 |
| TRIM3 | Cxxc5 | 3.926 |
| TRIM3 | Rassf2 | 3.738 |
| TRIM3 | Chrna9 | 3.689 |
| TRIM3 | LOC115488942 | 3.652 |
| TRIM3 | Cbfa2t3 | 3.558 |
| TRIM3 | Cep250 | 3.508 |
| TRIM3 | Dnah7a | 3.483 |
| TRIM3 | Cerk | 3.431 |
| TRIM3 | Rac2 | 3.411 |
| TRIM3 | Plxnd1 | 3.384 |
| TRIM3 | Zbtb18 | 3.369 |
| TRIM3 | Laptm5 | 3.32 |
| TRIM3 | Adssl1 | 3.316 |
| TRIM3 | Pomgnt2 | 3.221 |
| TRIM3 | N4bp3 | 3.216 |
| TRIM3 | Smad3 | 3.206 |
| TRIM3 | Rmnd5b | 3.195 |
| TRIM3 | Iqcn | 3.182 |
| TRIM3 | Cd52 | 3.168 |
| TRIM3 | Cyth4 | 3.162 |
| TRIM3 | Jund | 3.161 |
| TRIM3 | Unc93b1 | 3.117 |
| TRIM3 | Tfap4 | 3.098 |
| TRIM3 | Sfi1 | 3.093 |
| TRIM3 | Ttpal | 3.091 |
| TRIM3 | Tpcn1 | 3.09 |
| TRIM3 | Eef2k | 3.078 |
| TRIM3 | Aldh3b1 | 3.075 |
| TRIM3 | Gm4832 | 3.061 |
| TRIM3 | Adgre5 | 2.984 |
| TRIM3 | Il2ra | 2.932 |
| TRIM3 | Fmnl1 | 2.896 |
| TRIM3 | Tfeb | 2.886 |
| TRIM3 | Wdfy4 | 2.886 |
| TRIM3 | Slamf6 | 2.88 |
| TRIM3 | Gm32211 | 2.862 |
| TRIM3 | Ddit4 | 2.849 |
| TRIM3 | Abca6 | 2.843 |
| TRIM3 | Aff1 | 2.837 |
| TRIM3 | Tpst2 | 2.816 |
| TRIM3 | Ky | 2.815 |
| TRIM3 | Lrmp | 2.787 |
| TRIM3 | Srl | 2.77 |
| TRIM3 | Irgc1 | 2.761 |
| TRIM3 | Ralgds | 2.76 |
| TRIM3 | AI467606 | 2.756 |
| TRIM3 | Ubxn11 | 2.733 |
| TRIM3 | Pacsin1 | 2.732 |
| TRIM3 | Snn | 2.707 |
| TRIM3 | Ackr2 | 2.699 |
| TRIM3 | Ppp1r18 | 2.686 |
| TRIM3 | Msh6 | 2.664 |
| TRIM3 | Akna | 2.662 |
| TRIM3 | Rgs8 | 2.657 |
| TRIM3 | Hdac7 | 2.647 |
| TRIM3 | Emid1 | 2.628 |
| TRIM3 | Fam129c | 2.613 |
| TRIM3 | Fgd2 | 2.599 |
| TRIM3 | 4930467E23Rik | 2.598 |
| TRIM3 | Gna15 | 2.598 |
| TRIM3 | Rilpl2 | 2.572 |
| TRIM3 | Inf2 | 2.569 |
| TRIM3 | Pxdn | 2.567 |
| TRIM3 | Scgb1a1 | 2.549 |
| TRIM3 | Gm19402 | 2.546 |
| TRIM3 | Amz2 | 2.529 |
| TRIM3 | H4c14 | 2.525 |
| TRIM3 | Cyth1 | 2.518 |
| TRIM3 | Nr4a1 | 2.509 |
| TRIM3 | Kcnj12 | 2.496 |
| TRIM3 | Cxcr4 | 2.495 |
| TRIM3 | Pxn | 2.491 |
| TRIM3 | Dgkd | 2.489 |
| TRIM3 | Enpp6 | 2.479 |
| TRIM3 | Cd79b | 2.475 |
| TRIM3 | Sike1 | 2.471 |
| TRIM3 | Cdh17 | 2.434 |
| TRIM3 | Nmrk1 | 2.427 |
| TRIM3 | Rbm17 | 2.421 |
| TRIM3 | Arap1 | 2.42 |
| TRIM3 | Ostf1 | 2.414 |
| TRIM3 | Tspear | 2.414 |
| TRIM3 | P2rx1 | 2.398 |
| TRIM3 | Rnase10 | 2.394 |
| TRIM3 | BC034090 | 2.387 |
| TRIM3 | Tex14 | 2.381 |
| TRIM3 | Ech1 | 2.378 |
| TRIM3 | Bex6 | 2.378 |
| TRIM3 | Asb2 | 2.373 |
| TRIM3 | Rbm38 | 2.373 |
| TRIM3 | Socs3 | 2.37 |
| TRIM3 | Cnn1 | 2.363 |
| TRIM3 | Pgls | 2.362 |
| TRIM3 | Kcnab2 | 2.361 |
| TRIM3 | Stambpl1 | 2.357 |
| TRIM3 | Lrrc32 | 2.348 |
| TRIM3 | Nrm | 2.344 |
Fig. 5.
MSCs induce NGF demethylation to regulate the expression of KRT17 and FOXJ1. A MSCs reverse the methylation of transcription factors and the regulatory network of target genes during TEC aging (orange triangles represent transcription factors, and blue circles represent target genes). B The transcription factor NGF was associated with the RNA-seq expression of the target genes KRT17 and FOXJ1 during the reversal of TEC senescence by MSCs. The horizontal coordinate represents the expression of the transcription factor NGF, and the ordinate represents the expression of the target gene. C The mRNA expression levels of demethylated NGF, KRT17 and FOXJ1 were analyzed via qPCR. D The expression of NGF was detected by immunofluorescence (400×). E The expression of the TEC proliferation marker Ki67 was detected by immunofluorescence (400×). F Regulatory role of decreased methylation of the NGF/KRT17/FOXJ1 axis in the MSC-mediated reversal of TEC senescence. The measured values represent the mean ± standard deviation (`X ± s) of three replicate experiments. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001).
Immunofluorescence analysis and RT‒qPCR further proved that NGF interacted with KRT17 and FOXJ1 (Fig. 5C and D). Functionally, NGF, KRT17 and FOXJ1 were mainly involved in the proliferation of epithelial cells. KI67 showed that the proliferation ability of ageing TECs increased after coculture with MSCs (Fig. 5E). In summary, these results suggest that MSCs demethylate the NGF gene of ageing TECs and promote the expression of KRT17 and FOXJ1, to promote the growth and proliferation of ageing TECs (Fig. 5F).
3. Materials and methods
3.1. Animal
Six macaque monkeys were purchased from Kunming Animal Laboratory Center, Chinese Academy of Sciences (Experimental Animal Production License No.: SCXK (Yunnan) K2017-0003), aged 22–28 years old, Weight 3.5–6.5 kg, normally raised in the Laboratory Animal Center of 920th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force (Laboratory animal license No.: SYXK (Military) 2017-0051) Laboratory animal studies were approved by the Theoretical Committee of the 920th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force, the approval number: 2020-034 (Section) −01.
3.2. MSCs
MSCs of macaque monkeys (BMMSCs) and human (UCMSCs) were derived from the stem cell Bank of the National and Local Joint Engineering Center for Stem Cell and Immune Cell Biomedical Technology affiliated with the 920th Hospital of the Joint Logistic Support Force. The BMMSCs and UCMSCs preserved in liquid nitrogen were rapidly thawed in warm water at 37 °C, normal saline was added, and the mixture was centrifuged at 2000 rpm for 3 min. The cells were resuspended in the DMEM/F12 culture medium containing 10% fetal bovine serum and inoculated in a culture bottle at a density of 5000/cm2, after which the DMEM/F12 culture medium was changed the next day. When the degree of cell fusion reached 85%, the cells were digested with trypsin containing 0.25% EDTA and passaged with DMEM/F12 culture medium. P4 generation BMMSCs and UCMSCs were used to determine their differentiation potential and surface markers, and the detailed methods used were described in our previous published article [19].
3.3. Cell injection
When the fusion degree of the cultured P4 MSCs generation was approximately 80%, the cells were digested and washed. They were diluted with 0.9% sterile sodium chloride solution at a concentration of 2 × 106 cells/ml. Macaque monkeys were randomly divided into two groups: the senescence model group (n = 3) and the senescence treatment group (n = 3), After the macaque monkeys in the treatment group were immobilized, MSCs were injected into the femoral vein at 1 × 107/kg per monkey once every other day 3 times, the senescence model group was infused with isovolumetric saline at the same time.
3.4. Thymus index measurement
Five months after the treatment, macaques in each group were fasted for 24 h. The body weight of the macaques in each group was measured (kg), and the monkeys were anesthetized with excess 3% sodium pentobarbital (1 kg/ml). The abdominal cavity was exposed, the rib cartilage on both sides was cut up to the upper margin of the thoracic cavity, and the thymus tissue was exposed below the heart. An electronic balance was used to weigh the mass (g) and calculate the thymus index of each monkey individually and the average value of each group was taken for statistical analysis. The calculation formula is as follows:
3.5. Thymus tissue HE staining
The thymus tissue was fixed in 4% paraformaldehyde solution for 24 h and then dehydrated and embedded in paraffin. The thickness of the sections was approximately 4 μm. After being treated with xylene-anhydrous ethanol-75% ethanol, the sections were sealed with neutral glue. Sections were observed and photographed with a Nikon microscope (NikonDS-U3, Nikon, Japan).
3.6. Determination of thymosin α and thymopoietin levels
Five months after cell injection, 5 ml of blood was collected from the femoral vein into a heparin tube and centrifuged at 2000 rpm for 10 min, after which the obtained serum was transferred to a microcentrifuge tube. The expression levels of thymosin α and thymopoietin in the serum were measured by ELISA kits (Millipore). The procedure was performed according to the reagent instructions. The absorbance (OD) of each well was measured at a wavelength of 450 nm in sequence. The measurement was carried out within 15 min after adding the termination solution. With the concentration of the standard product as the horizontal coordinate and the OD value as the vertical coordinate, a standard curve was drawn, and the corresponding concentration was determined according to the OD value of the sample multiplied by the dilution factor, which was the actual concentration of the sample.
3.7. Detection of P16 expression by immunofluorescence staining
The thymus tissue was fixed in 4% paraformaldehyde solution for 24 h and then dehydrated and embedded in paraffin. The thickness of the section was approximately 4 μm. Primary antibody Rabbit anti-monkey antibody P16 (Serviceebio:GB111143) was added for staining. FITC goat anti-rabbit was incubated at room temperature for 50 min, and the nuclei were restained with DAPI for 15 min. Finally, the sections were sealed with anti-fluorescence quenching sealant and photographed under a microscope (Nikon DS-U3, Nikon, Japan).
3.8. Immunohistochemical staining of the thymic epithelial cell-specific marker molecule CK14
Thymus tissue sections with a thickness of 4 μm were dewaxed in water for antigen repair and blocking of endogenous peroxidase. Primary antibody Mouse anti-monkey antibody CK14 antibody (Servicebio: GB12803-100) was used, and the second antibody was labeled with HRP. After incubation with the secondary antibody, the nuclei were stained with DAPI (Servicebio: G1012; DAPI dyeing: The slides were placed in PBS (pH 7.4) and washed by shaking on a decolorizing shaker 3 times for 5 min each. DAPI dye was added, and the samples were incubated at room temperature for 10 min in the dark. Sealing: The slide was placed in PBS (pH 7.4) and washed by shaking on the decolorizing 3 times for 5 min each. Anti-fluorescence quenching sealing tablets were used.). Sections were observed and photographed with a Nikon microscope (Nikon DS-U3, Nikon, Japan). The positive area signal was analyzed by ImageJ software (NIH, Bethesda, MD).
3.9. TECs
TEC (species: human) is a standard cell line obtained from Meisen CTCC, Catalogue No.: CTCC-004-0022p2. After the acquisition, DMEM/F12 medium containing 10%FBS was used in our laboratory for passage culture. The growth morphology of the cells was cobblestone. Meanwhile, EPCAM, a specific marker of high expression on the surface, was identified by immunofluorescence, which was consistent with the standard TEC reported in the literature, and the accuracy of the cells was confirmed (Supplementary Fig.1).
3.10. Establishment and identification of the TEC ageing model and a coculture model of MSCs
Fourth-generation TECs were collected, the cell concentration was adjusted to 5 × 105 L-1, and 100 μL of cell suspension was inoculated in a 6-well culture plate. When the cell density was approximately 80%, 200 μmol/L H2O2 (China Nanguo Pharmaceutical Co., Ltd.) was added, and the cells were cocultured for 72 h. Fourth-generation MSCs were collected, the cell concentration was adjusted to 5 × 105 L-1, 100 μL of cell suspension was inoculated into the Transwell chamber, the Transwell chamber was embedded in the upper layer of the 6-well culture plate, and DMEM/F12 containing 10% fetal bovine serum was used for coculture of cells for 48 h.
3.11. SA-β-gal (senescence-associated β-galactosidase) staining
TECs were collected, washed with PBS once, operated according to the kit instructions (Solarbio, G1580), and observed under an ordinary optical microscope (ZEN2011), and the number of blue-positive cells in three visual fields was counted.
3.12. Expression level analysis of P21 and P16
TECs was collected for Western blotting analysis and lysed in RIPA buffer (Solarbio, China, Beijing). The total proteins of TEC cells were separated by Tris-Gly and 10% gel electrophoresis and then transferred to a nitrocellulose membrane. The cell membrane was blocked with 5% skim milk at room temperature for 1.5 h and then incubated with an antibody overnight. The next day, the membrane was washed with PBST and incubated for 30 min with horseradish peroxidase-labeled secondary antibody. Protein bands were detected after treatment with SuperSignal West Femto (Thermo Fisher Science, Waltham, MA, USA). Primary anti-rabbit anti-human P16 (1RV 1000, ab32503), P21 (1RV 1000, ab32351), SRC (1RV 300000 ab179473 ab109381), and ITGB3 (1RV 1000 ab179473) antibodies were obtained from Abcam. The primary anti-rabbit anti-human β-actin antibody (1RV 25000∼66009-1-Ig) and the secondary anti-HRP-Goat IgG antibody (1RV 1000, SA00001-2) were purchased from Proteintech.
3.13. Cell apoptosis assay
TUNEL staining was used to determine the apoptosis of TECs. TECs were collected, paraformaldehyde was fixed, the fixating solution was removed, 100 μl film breaking working solution was added, incubated at room temperature for 20 min, washed 3 times with PBS for 5 min each time, and buffer was added to cover the tissue for 10 min. Appropriate amounts of TDT enzyme and dUTP in the TUNEL kit were mixed with buffer at a 1:5:50 ratio. The slides were incubated for 2 h in an incubator at 37 °C, DAPI dye solution was added, the slides were incubated for 10 min at room temperature in the dark, and the slides were sealed with anti-fluorescence quenching tablet sealing agent. Microscopic photography: Sections were observed under a fluorescence microscope, and images were collected. DAPI emits blue light at 420 nm, while CY3 emits red light at 590 nm.
3.14. Observation of the cell substructure by fluoroscopic electron microscopy
TECs were collected, digested with 0.25% trypsin and made into a cell suspension. After washing with PBS, the cell precipitate was centrifuged and fixed for 4 h. After immersion in acetone, ultrathin sections of 80 nm were stained with uranium and lead, observed under a transmission electron microscope (Hitachi, HT7700), and photographed for image analysis.
3.15. Continuous observation of the morphology of cocultured TECs by a Nanolive 4D microscope
P4 generation TECs at a cell concentration of 5000/ml were added to a Nanolive 4D microscope petri dish, and then 1.5 ml DMEM/F12 (containing 10% fetal bovine serum) medium was added and mixed slowly; the medium was discarded after 24 h of culture. Then, DMEM/F12 containing 200 μmol/L H2O2 was added to treat the TECs for 72 h, after which the medium was discarded. Next MSCs at a P4 generation cell concentration of 5000 cells/ml were added and incubated for 48 h The Nanolive 4D microscope (Nikon Eclipse C1) was started and connected to the computer, the focal length was adjusted to take pictures under the appropriate field of vision for 48 h, and pictures were taken every 4 min.
3.16. DNA methylation and transcriptome sequencing
The TECs of MSCs were 1.3 × 107 in coculture and 1.2 × 107 in the induced senescence group. The cell precipitates were frozen in liquid nitrogen and stored at −80 °C for 24 h. Whole-genome methylation and transcriptome data were obtained by whole-genome methylation and transcriptome sequencing at Guangzhou Jidiao Biotechnology Co., Ltd (2009).
3.17. Analysis of DNA methylation sequencing data
The obtained clean data were mapped to the species reference genome using BSMAP software (version 2.90). The methylated cytosine level was then detected using a custom Perl script and assessed using the correction algorithm described by Lister R et al. The level of methylation was calculated based on the percentage of methylation of each sequence (CG, CHG, and CHH) in the entire genome, each chromosome, and different regions of the genome. To explain the changes in DNA methylation in TECs, methylation maps of the upstream 1 kb region and gene body were drawn according to the average methylation level of each window. Changes in GC content were screened according to the number of differentially methylated regions (DMRs) (≥5) and the absolute value of methylation ratio difference (≥0.1). The senescence genes were counted according to Gene Ontology Consortium.
3.18. RNA-seq analysis
The transcriptome database was analyzed by DESeq2 software, and the mRNAs satisfying the conditions of log2FC > 1.2 and P value < 0.05 were regarded as differentially expressed genes. The differentially expressed genes in ageing TECs and ageing TECs after coculture were counted and analyzed by gene function annotation.
3.19. Analysis of the relationship between gene methylation and transcriptional level
To calculate the correlation between gene methylation and transcription, the genes were divided into four groups according to the transcription level in RNA-seq data (FPKM ≤1 for no transcription, 1 < FPKM ≤10 for low transcription, 10 < FPKM ≤100 for medium transcription and FPKM >100 for high transcription). The Pearson correlation coefficients between upstream/gene body methylation levels and corresponding gene expression levels in TECs of the control, model and coculture groups were calculated.
3.20. Establishment of the transcription factor-methylation regulatory network
To explore the relationship between specific gene methylation and transcription factor binding, the TFs of ageing-related genes were predicted by CistromeDB, and the TF-DNA regulatory network was constructed by Cytoscape.
3.21. Enrichment analysis
Through the Gene Ontology database (GO item in http://www.geneontology.org/)), the number of genes in each item was calculated, and the GO items significantly enriched relative to the genomic background were defined by hypergeometric test. KEGG is the main public pathway-related database (http://www.kegg.jp/kegg/)).
3.22. Functional verification
3.22.1. Expression analysis of RAP1 signal pathway molecules RAP1, SRC and ITGB3
For Western blotting analysis, the primary anti-rabbit anti-human RAP1 (1RV 1000, ab14404), SRC (1RV 30000 ab179473 ab109381) and ITGB3 (1RV 1000 ab179473) were all obtained from Abcam, as described above.
3.22.2. Analysis of the relative expression of the ageing regulatory genes NGF, KRT17 and FOXJ1
Total RNA was extracted according to the production manual (Carlsbad Invitrogen Company, California) by RT-QPCR using TRIzol reagent. cDNA was amplified by reverse transcriptase (GoldenstarTM RT6, China) and random primers. According to the SYBR Green Master Mix specification (TsingKe Biotech Co., China), a CFX96TM Real-Time System (Applied 2720) was used for qPCR. The glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene was used as an internal control. Each experiment was repeated 3 times, and the gene expression level was normalized by the 2-T square method. All qPCR primers are listed in (Supplementary Table 1).
3.22.3. For immunofluorescence detection of NGF and KI67 expression
TECs were collected and fixed with paraformaldehyde, and the fixation solution was removed. Anti-mouse anti-human antibodies against Ki67 and NGF (1R1000 ∼ (th) ServiceBio) were added for staining. The nuclei at 15 min were restrained with CY3 goat anti-rabbit DAPI at room temperature for 50 min and then sealed with anti-fluorescence quenching sealant. Microscopic examination: The sections were observed under a fluorescence microscope, and images were collected (Nikon DS-U3, Nikon, Japan; DAPI UV excitation wavelength 380 nm, emission wavelength 420 nm, blue light; CY3 excitation wavelength 510–560 nm, emission wavelength 590 nm, red light). The number of positive cells was analyzed by ImageJ software (NIH, Bethesda, MD).
3.23. Statistical analysis
SPSS 21.0 statistical software was used for analysis, and the data are expressed as the mean ± standard deviation. A t-test was used to compare the two groups, and one-way analysis of variance (one-way ANOVA) was used to analyze the significance of differences among the three groups.
4. Discussion
Thymus aging weakens the immune system and other functions of the human body and is a progressive, multifactorial and complex biological process caused by serious damage to the microenvironment and integrity of the thymus matrix. MSC transplantation, as a new method for the treatment of thymus aging, has been proven to be effective and safe, and it has been proposed as a treatment to restore the structure and function of the thymus; for example, MSCs significantly increase the thymus index and improve the histological structure of the aging thymus [14]. Similarly, the structure was reconstructed, and the function of the aging thymus was improved after continuous MSC infusion [20]. However, in-depth research on this process in primates is lacking. Interestingly, we found that MSCs could regulate DNA methylation profiles to promote the division and proliferation of aging TECs, thereby improving the structure and function of the thymus in aging macaques.
Rhesus monkey belongs to non-human primates, whose genome sequencing is 93% similar to human genome, and the research results are more valuable for reference than other animals. In this study, we used elderly rhesus monkeys as a model to observe the effect of MSCs on thymus structure and function. To our surprise, our results showed that the volume of the thymus increased, the number of thymus lobules increased, the number of thymus epithelial cells and thymocytes increased, and the number of Hassall bodies and the amount of adipose tissue decreased. Moreover, the thymus index and the levels of thymosin α and thymopoietin in peripheral blood were decreased, the aging marker gene P16 was downregulated, and the TEC marker molecule CK14+ was upregulated after MSC treatment. These results implied that MSC treatment improved the structure and function of the thymus and promoted the regeneration of the thymic lobules.
The current consensus is that the therapeutic mechanism of MSCs involves its homing and strong paracrine functions [21,22]. Our results were consistent with previous studies showing that MSCs promote thymus regeneration by secreting various cytokines or differentiating into thymus tissue cells [23,24]. The above results suggest that MSC treatment improves the structure and function of the thymus in elderly rhesus monkeys.
As TECs are among the most important supporting cells of the thymus, their activity and quantity are crucial to the structural maintenance and function of this organ [25]. Therefore, we used human TECs as the research object, induced aging by H2O2, and observed the effect of intervention with MSCs. H2O2 is a small molecule that induce cell senescence due to oxidative stress caused by high levels of free radicals produced by the cell membrane, and increase the activity of SA-β-gal and expression of P16 and P21 [[26], [27], [28]], which were consisted with our results that the changes of TECs after treatment with 200 μmol/L H2O2 for 72 h. Interestingly, when senescent TECs were cocultured with MSCs in Transwell chambers for 48 h, the activity of SA-β-gal decreased, and P16 and P21 down-regulated, chromatin was evenly distributed, and autophagosomes were observed. Moreover, under a Nanolive 4D microscope, it was found that MSCs continuously secreted vesicular substances into ageing TECs, resulting in uniform distribution of TEC chromatin, appearance of intracellular autophagosomes and smaller cell morphology. These results suggested that MSCs would secrete vesicular substances improve the structure, and down-regulate ageing relative markers to reverse the ageing TECs.
DNA methylation plays an important role in regulating cell structure and function, but whether MSCs regulate DNA methylation to promote the division and proliferation of TECs has not been studied in depth [29,30]. Based on the analysis of the results of genome-wide methylation sequencing, it was found that the sites of methylation modification were mainly concentrated in CG loci, which was consistent with reports in mammals [31]. Then, we analyzed the methylation level of different positions of the gene and observed significant hypomethylation around the transcriptional start site, results showed that the methylation level of the gene body was higher than that of the adjacent region, and the methylation level decreased significantly after the transcriptional end site, indicating that the methylation level changed differently at different locations of the gene [32,33]. In addition, The results of differential methylation gene analysis between groups showed that 23 genes that inhibited cell growth and proliferation were methylated, and 37 genes that promoted cell growth and anti-inflammatory and antioxidant stress were demethylated in TECs after MSCs coculture, which indicated that methylation in the promoter region is one of the key mechanisms by which MSCs reverse TEC senescence.
It has been confirmed that DNA methylation in the gene promoter region can lead to gene silencing [32]. Our study revealed that the methylation of the ageing-promoting genes PDE5A, DUOX2, LAMP1 and SVIL in the promoter region leads to a decrease in the transcription level, while a decrease in the methylation level of the growth-promoting genes POLR3G, PGF, CHTF18, KRT17, FOXJ1, NGF, DYRK3, LRP8, CDT1, PRELID1, F2R, KNTC1 and TRIM3 leads to an increase in the transcription level. The Rap1 signaling pathway plays an important role in cell adhesion and integrin function in many cell types [34]. After coculture with MSCs, it activates the Rap1 signaling pathway, increases the expression of Rap1, SRC and ITGB3, promotes cell proliferation and facilitates resistance to apoptosis [[35], [36], [37]]. In the gene body region, although some studies have confirmed the effect of gene body DNA methylation on gene expression, the function of gene body DNA methylation is still poorly understood [38,39]. In our study, MSCs in the gene body region not only inhibited gene transcription but also promoted the transcription of some genes in the process of reversing TEC ageing.
DNA methylation in the promoter region prevents binding to transcription factors, leading to gene silencing [40]. Our research shows that NGF gene methylation inhibits the expression of KRT17 and FOXJ1, which highlights the regulatory mechanism of DNA methylation in the process of MSCs coculture with senescent TECs. Nerve growth factor NGF is reported to exist mainly in medullary epithelial cells of normal and regenerated thymic Hassall bodies, stimulating the activity and proliferation of mouse TECs in vitro [41,42]. Therefore, NGF may be a candidate regulatory gene in the process of MSCs coculture of ageing TECs. In addition, KRT17 and FOXJ1, as downstream regulators of NGF, are involved in epithelial cell development, but no studies describing the effects of these genes on TEC senescence have been published, so they may be new markers of TEC cell adhesion, cell proliferation and tissue development.
5. Conclusion
MSCtreatment significantly improved the morphology and structure of the thymus, reduced the expression level of aging markers, and promoted the activity of aging TECs to improve thymus structure and function. The mechanism by which MSCs promote thymus regeneration involves inhibition of the expression of senescence genes by inducing methylation in the promoter region of aging-related genes and inhibiting promoter methylation in cell growth- and differentiation-related genes to regulate their expression. Furthermore, MSCs upregulate KRT17 and FOXJ1 by increasing the expression of genes related to the RAP1 signaling pathway and regulate the demethylation of NGF genes to promote the proliferation of TECs.
Ethics approval and consent to participate
All experimental protocols were approved by the relevant committees of the 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army.
Consent for publication
Not applicable.
Availability of data and materials
All data generated or analyzed during this study are included in this published article. The datasets [GENERATED/ANALYZED] for this study can be found in the [https://www.jianguoyun.com/p/DTP_bNkQgbjoCxj36ZMFIAA] and GSA -gsa-human (HRA005210).
Funding
This work was supported by two major Science and Technology Special Projects of Yunnan Science and Technology Program (2018ZF001) and (202002AA100006), and Yunnan Province basic research project (202301AT070302). The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Authors’ contributions
XHP and XJW designed the study. ZLY, TC, XQZ, HJ, PH, LY, GPR performed the experiments and collected the data. ZLY wrote the manuscript. TC and ZXH assisted with the literature searches and revised the manuscript. All authors read and approved the final manuscript.
Declaration of competing interest
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Acknowledgments
We thank everyone on our team for assisting with the preparation of this manuscript.
Footnotes
Peer review under responsibility of the Japanese Society for Regenerative Medicine.
Appendix A
Supplementary data to this article can be found online at https://doi.org/10.1016/j.reth.2024.03.008.
Contributor Information
XiJun Wu, Email: 498682999@qq.com.
Xinghua Pan, Email: xinghuapankm@163.com.
Appendix A. Supplementary data
The following are the Supplementary data to this article:
Multimedia component 1
mmc1.docx (568.9KB, docx)
Multimedia component 2
mmc2.xlsx (8.8KB, xlsx)
References
- 1.Gao H., Cao M., Deng K., Yang Y., Song J., Ni M., et al. The lineage differentiation and dynamic heterogeneity of thymic epithelial cells during thymus organogenesis. Front Immunol. 2022;13 doi: 10.3389/fimmu.2022.805451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Sun S., Li J.Y., Nim H.T., Piers A., Ramialison M., Porrello E.R., et al. CD90 marks a mesenchymal Program in human thymic epithelial cells in vitro and in vivo. Front Immunol. 2022;13 doi: 10.3389/fimmu.2022.846281. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Garcia-Leon M.J., Mosquera M., Cela C., Alcain J., Zuklys S., Hollander G., et al. Abrogation of notch signaling in embryonic TECs impacts postnatal mTEC homeostasis and thymic involution. Front Immunol. 2022;13 doi: 10.3389/fimmu.2022.867302. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Wang H.X., Pan W., Zheng L., Zhong X.P., Tan L., Liang Z., et al. Thymic epithelial cells contribute to thymopoiesis and T cell development. Front Immunol. 2019;10:3099. doi: 10.3389/fimmu.2019.03099. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Gupta R., Gupta T., Kaur H., Sehgal S., Aggarwal A., Kapoor K., et al. Cytokeratin (CK5, CK8, CK14) expression and presence of progenitor stem cells in human fetal thymuses. Clin Anat. 2016;29:711–717. doi: 10.1002/ca.22736. [DOI] [PubMed] [Google Scholar]
- 6.Shichkin V.P., Felli M.P., Screpanti I., Antica M. Editorial: thymus function and aging: a focus on thymic epithelial cells. Front Immunol. 2022;13 doi: 10.3389/fimmu.2022.1003490. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Lancaster J.N., Keatinge-Clay D.E., Srinivasan J., Li Y., Selden H.J., Nam S., et al. Central tolerance is impaired in the middle-aged thymic environment. Aging Cell. 2022;21 doi: 10.1111/acel.13624. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Lepletier A., Chidgey A.P., Savino W. Perspectives for improvement of the thymic microenvironment through manipulation of thymic epithelial cells: a mini-review. Gerontology. 2015;61:504–514. doi: 10.1159/000375160. [DOI] [PubMed] [Google Scholar]
- 9.Tong Q.Y., Zhang J.C., Guo J.L., Li Y., Yao L.Y., Wang X., et al. Human thymic involution and aging in humanized mice. Front Immunol. 2020;11:1399. doi: 10.3389/fimmu.2020.01399. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Pan X.H., Chen Y.H., Yang Y.K., Zhang X.J., Lin Q.K., Li Z.A., et al. Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism. Aging (Albany NY) 2019;11:590–614. doi: 10.18632/aging.101762. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 11.Tian C., He J., An Y., Yang Z., Yan D., Pan H., et al. Bone marrow mesenchymal stem cells derived from juvenile macaques reversed ovarian ageing in elderly macaques. Stem Cell Res Ther. 2021;12:460. doi: 10.1186/s13287-021-02486-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 12.Yang Y.K., Li Y., Wang Y.Y., Ruan G.P., Tian C., Wang Q., et al. The effects of BMMSC treatment on lung tissue degeneration in elderly macaques. Stem Cell Res Ther. 2021;12:156. doi: 10.1186/s13287-021-02201-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 13.Yu Q., Tian C., Lv G., Kong Q., Li G., Zhu G., et al. Bone marrow mesenchymal stem cells derived from juvenile macaques reversed the serum protein expression profile in aged macaques. Curr Stem Cell Res Ther. 2023;18:391–400. doi: 10.2174/1574888X17666220429111218. [DOI] [PubMed] [Google Scholar]
- 14.Pan X.H., Lin Q.K., Yao X., Li Z.A., Cai X.M., Pang R.Q., et al. Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes. Aging (Albany NY) 2020;12:16899–16920. doi: 10.18632/aging.103594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Kan R.L., Chen J., Sallam T. Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation. Trends Genet. 2022;38:182–193. doi: 10.1016/j.tig.2021.06.014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16.Song J., VanBuskirk J.A., Merbs S.L. Regulation of opsin gene expression by DNA methylation and histone acetylation. Int J Mol Sci. 2022;23 doi: 10.3390/ijms23031408. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 17.Schubeler D. Function and information content of DNA methylation. Nature. 2015;517:321–326. doi: 10.1038/nature14192. [DOI] [PubMed] [Google Scholar]
- 18.Hale L.P., Neff J., Cheatham L., Cardona D., Markert M.L., Kurtzberg J. Histopathologic assessment of cultured human thymus. PLoS One. 2020;15 doi: 10.1371/journal.pone.0230668. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 19.Pan X.H., Huang X., Ruan G.P., Pang R.Q., Chen Q., Wang J.X., et al. Umbilical cord mesenchymal stem cells are able to undergo differentiation into functional islet-like cells in type 2 diabetic tree shrews. Mol Cell Probes. 2017;34:1–12. doi: 10.1016/j.mcp.2017.04.002. [DOI] [PubMed] [Google Scholar]
- 20.Liu G., Wang L., Pang T., Zhu D., Xu Y., Wang H., et al. Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1(-/-) mice. Cell Mol Immunol. 2014;11:275–284. doi: 10.1038/cmi.2013.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21.Abbaspanah B., Reyhani S., Mousavi S.H. Applications of umbilical cord derived mesenchymal stem cells in autoimmune and immunological disorders: from literature to clinical practice. Curr Stem Cell Res Ther. 2021;16:454–464. doi: 10.2174/1574888X16999201124153000. [DOI] [PubMed] [Google Scholar]
- 22.Liesveld J.L., Sharma N., Aljitawi O.S. Stem cell homing: from physiology to therapeutics. Stem Cell. 2020;38:1241–1253. doi: 10.1002/stem.3242. [DOI] [PubMed] [Google Scholar]
- 23.Selvasandran K., Makhoul G., Jaiswal P.K., Jurakhan R., Li L., Ridwan K., et al. A tumor necrosis factor-alpha and hypoxia-induced secretome therapy for myocardial repair. Ann Thorac Surg. 2018;105:715–723. doi: 10.1016/j.athoracsur.2017.09.005. [DOI] [PubMed] [Google Scholar]
- 24.Zhan Y., Wang L., Liu G., Zhang X., Yang J., Pan Y., et al. The reparative effects of human adipose-derived mesenchymal stem cells in the chemotherapy-damaged thymus. Stem Cell Dev. 2019;28:186–195. doi: 10.1089/scd.2018.0142. [DOI] [PubMed] [Google Scholar]
- 25.Owen D.L., Sjaastad L.E., Farrar M.A. Regulatory T cell development in the thymus. J Immunol. 2019;203:2031–2041. doi: 10.4049/jimmunol.1900662. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26.Giri S., Takada A., Paudel D., Yoshida K., Furukawa M., Kuramitsu Y., et al. An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment. Odontology. 2022;110:44–53. doi: 10.1007/s10266-021-00630-3. [DOI] [PubMed] [Google Scholar]
- 27.Lysek-Gladysinska M., Wieczorek A., Jozwik A., Walaszczyk A., Jelonek K., Szczukiewicz-Markowska G., et al. Aging-related changes in the ultrastructure of hepatocytes and cardiomyocytes of elderly mice are enhanced in ApoE-deficient animals. Cells. 2021;10 doi: 10.3390/cells10030502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 28.Zhu R.Z., Li B.S., Gao S.S., Seo J.H., Choi B.M. Luteolin inhibits H(2)O(2)-induced cellular senescence via modulation of SIRT1 and p53. Korean J Physiol Pharmacol. 2021;25:297–305. doi: 10.4196/kjpp.2021.25.4.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 29.Acharjee S., Chauhan S., Pal R., Tomar R.S. Mechanisms of DNA methylation and histone modifications. Prog Mole Biol Trans Sci. 2023;197:51–92. doi: 10.1016/bs.pmbts.2023.01.001. [DOI] [PubMed] [Google Scholar]
- 30.Zeng Y., Chen T. DNA methylation reprogramming during mammalian development. Genes. 2019;10 doi: 10.3390/genes10040257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 31.Mangelinck A., Mann C. DNA methylation and histone variants in aging and cancer. Inter Rev Cell Mole Biol. 2021;364:1–110. doi: 10.1016/bs.ircmb.2021.06.002. [DOI] [PubMed] [Google Scholar]
- 32.Mohd M.N., Aminullah L.F., Makpol S. Epigenetic changes and its intervention in age-related neurodegenerative diseases. Cell Mol Neurobiol. 2022;42:577–595. doi: 10.1007/s10571-020-00979-z. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 33.Soto-Palma C., Niedernhofer L.J., Faulk C.D., Dong X. Epigenetics, DNA damage, and aging. J Clin Invest. 2022;132 doi: 10.1172/JCI158446. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34.Shah S., Brock E.J., Ji K., Mattingly R.R. Ras and Rap1: a tale of two GTPases. Semin Cancer Biol. 2019;54:29–39. doi: 10.1016/j.semcancer.2018.03.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 35.Li H., Yu T., Ma Y., Wang H. [Expression of Laminin gene family in porcine pluripotent stem cells] Sheng Wu Gong Cheng Xue Bao. 2017;33:1304–1314. doi: 10.13345/j.cjb.170101. [DOI] [PubMed] [Google Scholar]
- 36.Li Y., Song Y., Li P., Li M., Wang H., Xu T., et al. Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-alpha-induced apoptosis in tumor-repopulating cells of melanoma. J ImmunoTher Cancer. 2020;8 doi: 10.1136/jitc-2019-000111. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 37.Salama Y., Heida A.H., Yokoyama K., Takahashi S., Hattori K., Heissig B. The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models. Blood Adv. 2020;4:1021–1037. doi: 10.1182/bloodadvances.2019001002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38.Sendzikaite G., Kelsey G. The role and mechanisms of DNA methylation in the oocyte. Essays Biochem. 2019;63:691–705. doi: 10.1042/EBC20190043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 39.Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., et al. Dynamic DNA methylation across diverse human cell lines and tissues. Genome Res. 2013;23:555–567. doi: 10.1101/gr.147942.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 40.Heberle E., Bardet A.F. Sensitivity of transcription factors to DNA methylation. Essays Biochem. 2019;63:727–741. doi: 10.1042/EBC20190033. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 41.Lee H.W., Kim S.M., Shim N.R., Bae S.K., Jung I.G., Kwak J.Y., et al. Expression of nerve growth factor is upregulated in the rat thymic epithelial cells during thymus regeneration following acute thymic involution. Regul Pept. 2007;141:86–95. doi: 10.1016/j.regpep.2006.12.015. [DOI] [PubMed] [Google Scholar]
- 42.Lee H.W., Na Y.J., Jung P.K., Kim M.N., Kim S.M., Chung J.S., et al. Nerve growth factor stimulates proliferation, adhesion and thymopoietic cytokine expression in mouse thymic epithelial cells in vitro. Regul Pept. 2008;147:72–81. doi: 10.1016/j.regpep.2008.01.004. [DOI] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
Video S1
3
Download video file (2MB, mp4)
Multimedia component 1
mmc1.docx (568.9KB, docx)
Multimedia component 2
mmc2.xlsx (8.8KB, xlsx)
Data Availability Statement
All data generated or analyzed during this study are included in this published article. The datasets [GENERATED/ANALYZED] for this study can be found in the [https://www.jianguoyun.com/p/DTP_bNkQgbjoCxj36ZMFIAA] and GSA -gsa-human (HRA005210).