Genome sequence analysis of Klebsiella pneumoniae strains VH1‐2 and 18622. (A) Species, sources, and chromosome sizes of the CRKP isolates. (B) Comparison of plasmids pCRKP18622‐KPC, pVH1‐2‐KPC, and p112298‐KPC. (C) Circular comparison of plasmid pVH1‐2‐VIR, pCRKP18622‐VIR, and pCRKP18622‐2. The plasmid pVH1‐2‐VIR located at the innermost circle was used as the reference plasmid to perform sequence alignment with BLASTn by the BRIG software. Genetic regions associated with virulence are highlighted in cyan. (D) Linear alignment of complete plasmid sequences of pR210‐2‐CTX, pCRKP18622‐2, and pRes_C2051_ESBL. Genes are denoted by arrows and colored based on function classification. Shaded regions denote shared regions of homology (95% nucleotide identity). (E) Linear alignment of complete plasmid sequences of pVir‐CR‐HvKP4, pCRKP18622‐VIR, and pKP70‐2.