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[Preprint]. 2024 Mar 29:2024.03.28.587234. [Version 1] doi: 10.1101/2024.03.28.587234

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Figure 8. — The OB-domains of RPA are depicted along with the connecting disordered linkers. The XL-MS data suggest that the domains are compacted together and ssDNA is wrapped around this architecture. The domains are remodeled upon phosphorylation by Aurora kinase B at position Ser-384 in the RPA70 subunit. This modification releases the OB-F and wh domains and protein RPA interactions with other proteins. However, the wrapping of the ssDNA is not altered, but remodeling allows access to the ssDNA.