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. 2024 Mar 20;628(8007):424–432. doi: 10.1038/s41586-024-07182-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Plots show the log2-transformed fold change in metabolite level between treatment arms by the -log10(p-value). Points indicate individual metabolites colored by their metabolic categorization. Dotted lines indicate the threshold of significant gene expression, defined as log2-transformed fold change ≥ 0.58 and ≤ −0.58 (vertical lines) and a -log10(p-value) ≥ 1.30 (horizontal line). Statistical analysis performed on natural log-transformed values using one-sided T-test. b, Clustered heatmap of top fifty metabolites across study arms. Dendrogram groups individual samples by similarity of metabolite profile. Bar color for each sample indicates treatment arm, vehicle control (grey), Fna C1-treated (green), or Fna C2-treated (lavender). c, Schematic of glutathione metabolic pathway. d, Plot demonstrates the ratio between oxidized (GSSG) and reduced (GSH) glutathione levels for each treatment arm, vehicle control (grey), Fna C1-treated (green), or Fna C2-treated (lavender); n = 4 mice per arm. Data is plotted as mean ± s.e.m. Statistical analysis performed using one-way ANOVA. e, Schematic of eicosanoid metabolic pathway.