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. 2024 Mar 20;628(8007):424–432. doi: 10.1038/s41586-024-07182-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — Plots of individual, characterized metabolites, with metabolic categories having > 10 significantly altered metabolites shown. Each plot shows the log2-transformed log change between Fna C2-treated mice compared to Fna C1-treated mice versus the log2-transformed log change between Fna C2-treated mice compared to control mice. Dashed lines indicate the threshold of significantly altered metabolites, defined as log2-transformed fold change (FC) ≥ 0.58 and ≤ −0.58. Upper right quadrant indicates metabolites that are significantly elevated in Fna C2-treated mice as compared to both Fna C1-treated and control mice. Lower left quadrant indicates metabolites that are significantly lower in Fna C2-treated mice as compared to both Fna C1-treated and control mice. Top metabolites in each of these quadrants are labeled.