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. 2024 Mar 20;628(8007):424–432. doi: 10.1038/s41586-024-07182-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — Fna C1 and Fna C2 detection in stool metagenomic data from previously published independent cohorts from patients with CRC and healthy controls plotted by individual cohorts. Left plot shows the effect sizes for Fna C1 and Fna C2 calculated across all samples (CRC n = 627, healthy control n = 619) using a meta-analysis of standardized mean differences and a random effects model on MetaPhlAn4⁶³ species-level genome bins (SGB) abundances. Right plot shows the effect sizes for Fna C1 and Fna C2 calculated using the same approach but with samples where Fna C1 co-occurred with Fna C2 excluded (CRC n = 596, healthy control n = 616). Data is plotted as mean ± s.e.m. Statistical significance assessed by Wald test, two-sided. All p-values are corrected via the Benjamini-Yakuteli method.