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. Author manuscript; available in PMC: 2024 Apr 11.
Published in final edited form as: Glia. 2023 Jun 7;71(9):2285–2303. doi: 10.1002/glia.24423

FIGURE 7. Decrease of N1 peak following adult-onset sulfatide depletion.

FIGURE 7.

(ai) Compound action potential (CAP) recordings demonstrate comparable and robust N1 and N2 peaks between the CTL and CST-cKO mice 3-months PI. (aii) Quantification of the ratio of N1/N2 from ascending stimulus currents in the CTL and CSTcKO mouse at 3-months PI shows no significant difference between genotypes. (bi) By 6-months PI CSTcKO mice present with a reduced N1 peak and (bii) a significant reduction in the N1/N2 ratio between cKO and CTL mice. (ci) By 11-months PI, N1 peaks were not observed in the CST cKO mice but N2 peaks were spared. (cii) The loss of the N1 peak resulted in further separation of N1/N2 ratios between CTL and CSTcKO mice at 11-months PI with the ratios being zero due to loss of N1 peak. Analyzed using a 2-way ANOVA. ****p < .0001.