Table 1.
Phenotypic studies of compounds 6 and 7 against Leishmania amazonensis and their toxicity profile
| Compound | EC50 (μm)AF | EC50 (μm)IA | CC50 (μm)PMM | SIAF | SIIA | CC50 (μm) Hep G2 |
|---|---|---|---|---|---|---|
| 6 | 10.78 ± 0.80 | 4.57 ± 0.08 (P = 0.027)a | >500 | >46 | >109 | >160 |
| 7 | 13.12 ± 1.70 | 9.19 ± 0.68 | >500 | >38 | >54 | >160 |
| Miltefosine | 4.37 ± 0.11 | 13.30 ± 3.03a | 169.69 ± 5.07 | >38 | >12 | – |
AF, amastigote forms of L. amazonensis (LTB0016 strain) purified from animal lesions; IA, intracellular forms in peritoneal macrophages; SI, selective index.
EC50 is reported as mean and s.d. values.
a
Statistical analysis was performed with GraphPad prism v.9.1.2 by ordinary ANOVA test.