Figure 2.

Schematic representation of the balance between oncogenic miRNAs and tumor-suppressor miRNAs. Downregulation of tumor-suppressor miRNAs could result in overexpression of oncogene mRNAs by reducing degradation. In turn, overexpression of oncogenic miRNAs could result in the downregulation of tumor-suppressor gene mRNAs by increasing mRNA degradation. Both processes have an impact on hallmarks of cancer such as cell proliferation, immortalization, and angioinvasion. The figure was created with BioRender.com.