Table 2.

Combined pathogenic allele frequency for HC genes in the 1000 Genomes Project (1000G), Exome Sequencing Project (ESP), and Exome Aggregation Consortium (ExAc) datasets

Gene	1000G	ESP6500	ExAc	Geographical distribution
HFE (p.Cys282Tyr)	0.013	0.048	0.0324	Highest prevalence in Northern Europe
HFE (non-p.Cys282Tyr)	0.001	0.0002	0.000307
HJV		0.00074	0.000316	Highest prevalence in Southern Asia
TFR2	0.0004	0.0003	0.000102	Most frequent among non-Finnish European populations
HAMP	0.0002		0.0000165	Several populations
SLC40A1	0.0008	0.0009	0.00034	Several populations (highest prevalence among Africans)

Modified from Wallace and Subramaniam.¹⁹