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. 2024 Apr 17;19(4):e0300470. doi: 10.1371/journal.pone.0300470

Short-term health effects of an urban regeneration programme in deprived neighbourhoods of Barcelona

Xavier Bartoll-Roca 1,2,*, María José López 1,2,3,4, Katherine Pérez 1,2,3, Lucía Artazcoz 1,2,3,4, Carme Borrell 1,2,3,4
Editor: Angela Mendes Freitas5
PMCID: PMC11023398  PMID: 38630702

Abstract

Urban regeneration programmes are interventions meant to enhance the wellbeing of residents in deprived areas, although empirical evidence reports mixed results. We evaluated the health impact of a participatory and neighbourhood-wide urban regeneration programme, Pla de Barris 2016–2020, in Barcelona. A pre-post with a comparison group study design. Using data from a cross-sectional survey performed in 2016 and 2021. The health outcomes analysed were mental health, alcohol and psychotropic drug use, perceived health status, physical activity and obesity. Depending on the investment, two intervention groups were defined: moderate- and high-intensity intervention groups. The analysis combined difference-in-difference estimation with an inverse weighting derived from a propensity score to reduce potential biases. The impact of the intervention in percentages and its confidence interval were estimated with a linear probability model with clustered adjusted errors. The intervention had a positive impact on health outcomes in women in the high-intensity intervention group: a reduction of 15.5% in the relative frequency of those experiencing poor mental health, and of 21.7% in the relative frequency of those with poor self-perceived health; and an increase of 13.7% in the relative frequency of those doing physical activity. No positive impact was observed for men, but an increase of 10.3% in the relative frequency of those using psychotropic drugs in the high-intensity intervention group. This study shows positive short-term effects of the urban regeneration programme Pla de Barris 2016–2020 on health outcomes in women in the high-intensity intervention group. These results can guide future interventions in other areas.

Introduction

Urban regeneration programmes are complex interventions aimed at enhancing wellbeing in disadvantaged communities [1]. Looking for long-term advances, policy-makers are changing the focus of these programmes to improving the built and social environments [2]. This way, regeneration can encompass a broad range of policy sectors, from housing, public spaces and mobility, to social services, information technologies and economy. Moreover, social problems tend to be spatially distributed in an unequal way, which can make urban programmes more suitable than traditional sector programmes [3]. An unequal provision of resources among individuals and social groups in an urban environment can lead to health inequalities. Comprehensive urban regeneration programmes aim to facilitate access to and availability of a wide range of these resources. Therefore, it is expected that urban regeneration programmes comprising a greater diversity of interventions will favour access to dispositional resources and provide wider options for a better life. Finally, urban regeneration programmes can be seen as public health interventions that potentially improve the wellbeing of recipients and indirectly benefit the entire population [4, 5].

Previous literature reported that good built and social environments are associated with desirable social and health outcomes, like social cohesion and physical activity, and inversely associated with others like overweight and alcohol abuse [6, 7]. However, when individual characteristics are taken into consideration, the literature found mixed evidence for urban regeneration programmes to improve wellbeing [1, 8], especially for mental health [911]. The variability in results could be due to the heterogeneity of the interventions and different methodological threads. In particular: changes in population composition (e.g., gentrification), non-observed confounding factors, and previous trends; and different analyses (short- or long-term effects) [1, 12]. Despite variability, several studies found evidence for urban regeneration programmes to improve wellbeing in different situations: when citizens participate in them [13], in areas of high-intensity intervention [1416], and among citizens residing in the intervention area for a long time [17].

Urban regeneration programmes have been implemented in Europe since the early 90’s under the Urban pilot projects 1990–1993, and more decisively with the URBAN programmes (1994–2006). In this context, the Catalonia Neighbourhood’s Law (Law 2/2004) was designed to improve living conditions in the most disadvantaged neighbourhoods, mainly through town planning interventions. In Barcelona city, these urban regeneration programmes have been associated with improvements in self-perceived health, mainly among low-income citizens [18]. Therefore, in 2016, the city council promoted a new urban regeneration programme, “Pla de Barris (PdB) 2016–2020”. PdB was a multicomponent, comprehensive, intersectoral, and community engagement programme with a total budget of 150 million euros implemented in 16 disadvantaged neighbourhoods with a total population of 225,631 people in 2016. It aimed to decrease inequalities by involving citizens in the development of projects that addressed the built and social environments. It was assumed that the benefits of the intervention would be neighbourhood-wide, and not restricted to participants.

The objective of our study was to assess the impact of the PdB urban regeneration programme on wellbeing in deprived neighbourhoods of Barcelona, characterised by lower indicators in terms of income, education level, residential vulnerability indices, higher unemployment rates, a higher percentage of the foreign population and material deprivation. To achieve this, we assessed selected health outcomes and health-related behaviours through routine health survey data in a pre-post design with a comparison group. To overcome some methodological limitations mentioned above, a differentiation was made between the moderate and high-intensity intervention neighbourhoods according to the amount of investment per inhabitant. The difference-in-difference method with reweighting was applied to reduce possible bias in socio-economic characteristics between the comparison and intervention groups in the pre- and post-intervention periods.

Materials and methods

The intervention Pla de Barris (PdB)

The programme is a multicomponent, comprehensive intersectoral and community engagement programme aimed at improving living conditions in the most disadvantaged neighbourhoods. The total budget was of 150 million € (m€), of which 105 m€ were for inversion, 35 m€ were for services and 10 m€ were for overheads. The four components include: i) social rights: 277 actions with a budget of 27,8 m€ for the improvement of cohesion, promotion of culture and sports, attention to social services, housing and health, information technology and equipment; ii) education: 165 actions and 33,3 m€ devoted to schools and literacy education; iii) economy: 149 actions and 9,5 m€ in commerce, social economy and employment; iv) urban ecology: 122 actions and 70 m€ in public space, mobility and green areas.

It would be impossible to give an account of all of the 713 actions. The following are examples: intervention in schools by recruiting 160 social and health service professionals to reinforce the emotional education of pupils and families in the school environment; a childcare service was offered, mainly used by single-parent families, providing more than 11.2 thousand services; digital training courses were held; extending occupational training and developing disused ground floors for commercial purposes; bus lines were inaugurated to areas that are difficult to access; rehabilitation of vulnerable housing was carried out in defense of the right to decent housing; various adaptations of public space and the opening of green spaces with a gender perspective; the refurbishment and opening of open-access sports facilities. As 64 of the total 713 actions were strictly in the health sector, the assumption in this research is that the health benefits of an intervention in health determinants outside the health sector spill over to the entire population.

The participation of the neighbours has been sought to be carried out not only in the phases of diagnosis and definition of the objectives and actions but also during the follow-up and management.

Design, study population and sources of information

This study has a quasi-experimental design, comparing the group of the 16 intervened neighbourhoods with a comparison group. Because of the variation in budget across neighbourhoods (335.8 to 2048.7 € per inhabitant), a distinction was made between moderate- and high-intensity interventions on the basis of the median of 727.6 € per inhabitant. Such distinction is also motivated by an interest in studying a possible dose-response effect.

The neighbourhoods of the comparison group were selected among the ones that were most similar to the intervened ones in terms of socioeconomic characteristics, such as household disposable income, percentage of people with primary education or less, unemployment, rate of people attending social services, and household overcrowding. With a Cronbach’s alpha of 0.9, a summary index was computed with the first principal components. The 17 neighbourhoods with the lowest scores (apart from the ones in the intervention group) were selected to form the comparison group (with a population of 302,270 in 2016).

We used the data collected by the Public Health Agency of Barcelona and the city council from the Barcelona Health Surveys (BHS) of 2016 and 2021 (respectively, the first year of the intervention and the year after the end of it). The BHS is a routine official survey with the objective of understanding the health of the adult population (>14 years old) and its determinants that is planned every five years. As a small fraction of the intervention was carried out in 2016, we consider that there was insufficient time for any effects to have occurred. The sampling design of the BHS consists of 4000 randomly selected men and women distributed among the 10 districts and 73 neighbourhoods of Barcelona. The sample size was computed to achieve a precision of ± 2% for the whole city and ±6% for the 10 districts. Interviews were conducted face-to-face by trained professionals using computer-assisted personal interviewing. Non-respondents are substituted by individuals in the same quotas (by sex, age group and neighbourhood) until the objective sample is reached. The final sample size for the 16 neighbourhoods in the intervention group and the 17 neighbourhoods in the control group was 558 men and 603 women in 2016 and 559 men and 601 women in 2021, which represents a precision of ± 3% for the 33 neighbourhoods analysed. All computations included sample weights to restore representativeness; moreover, potential bias among intervention and comparison groups in 2016 and 2021 was corrected by reweighting with the inverse of the propensity score.

Variables

On the basis of previous literature, we focused on a range of health outcomes and health-related behaviours potentially related to urban regeneration programmes: psychosocial distress (mental health, use of psychotropic drugs, and alcohol abuse), self-perceived health status, physical activity, and obesity.

Mental health was measured with the General Health Questionnaire-12 (GHQ-12), which measures psychosocial distress with 12 items. Such items are added up to an index in the range 0–12 and then dichotomized: having a score of 3 or more means having poor or not-good mental health (reference category).

Use of psychotropic drugs was defined as having consumed at least 1 drug among antidepressants, tranquillizers, or sleeping pills in the last two days (reference category).

Alcohol abuse was measured according to the amount of alcohol consumed, the type of drink, and the frequency of consumption. Participants were categorized as risky drinkers or moderate/non-drinkers (reference category). Moreover, drinking five or more alcoholic beverages on a single occasion was considered risky consumption [19].

Self-perceived health status was reported in five categories and then dichotomized: “excellent”, “very good”, and “good” were classified as good health status (reference category), and “fair” and “poor” as poor health status.

Physical activity during leisure time was reported on the basis of the International Physical Activity Questionnaire (IPAQ). It was classified according to the energy required, its duration, and its frequency. Finally, it was dichotomized into moderate and intense activity and low-intensity activity (reference category) [19].

Obesity was evaluated on the basis of self-reported weight and height and categorised according to the cut-off points recommended by the WHO. Overweight, normal weight, and underweight were classified as non-obesity (reference category).

The propensity score was computed with the following covariates: sex; age group (15–34 as the reference category, 36–64, and 65 and above); occupational social class (manual as the reference category and non-manual); employment situation (employed, unemployed, and others); origin (autochthonous and foreign-born); and population turnover (having been living in the neighbourhood for 6 years or less, or having been living there for more than 6 years).

Statistical analysis

To identify the potential effect of PdB on health outcomes and health-related behaviours, we used differences-indifferences (DiD) combined with a propensity score and an inverse probability weighting. DiD is a widely used method to assess the effectiveness of public health interventions and it represents a growing area of methodological development [20]. It consists in deducing the effect of the intervention from the difference between the observed evolution after the intervention and the estimated evolution without the intervention. The latter is assumed to be equal to the observed evolution of the comparison group. In our study, we used a linear probability model to estimate the age-adjusted effect with 95% confidence intervals in percentages.

The attribution of causality in DiD is threatened by two factors: a non-parallel evolution between intervention and comparison groups prior to intervention and a different compositional evolution between the two groups. However, it has been suggested that these biases can be substantially reduced with a propensity score [21]. In our case, a probability was computed based on selected demographic and socioeconomic covariates (age, occupational social class, origin, and employment status). It was assumed that the selected covariates were not affected by the intervention. Then, a final score was computed with the inverse of the probability previously obtained along with the sampling weights.

Finally, the linear probability model estimation of the DiD incorporates these new weights. To account for individuals sharing neighbourhoods’ characteristics, we applied clustered robust standard errors. All computations were stratified by gender. To check if results were maintained in case the comparison group changed, we performed a sensitivity analysis that included the 28 neighbourhoods of low- and middle-income.

Population turnover

To assess compositional changes in the populations of the comparison and intervention neighbourhoods during the intervention, we compared the distribution by age group, sex, and educational level. Data were obtained from the official register of inhabitants from the city council for the years 2016 and 2021. We also checked differences in the number of years living in the neighbourhood before and after applying the propensity score.

Results

The most frequent sociodemographic characteristics both of men and women in the intervention and comparison groups were the following: being 35- to 64-year-old, being employed in manual occupations, being autochthonous, and having been living for more than 6 years in the neighbourhood. In 2016, before the intervention, there was higher unemployment among men and more foreign-born men and women in the intervention groups (Table 1). After intervention, there were differences in age among women and in country of birth among men between the comparison and intervention groups. These differences were removed after weighting data derived from the propensity score for the pre-intervention and post-intervention period (S1 Table 1 in S1 File). Table 1 also shows no population turnover (gentrification) in the sample according to the number of years living in the neighbourhood. This was confirmed by the official population registration data: there were no differences by sex or age group between 2016 and 2021, and the education level improved at a common rate both in the comparison and the intervention groups (S1 Table 2 in S1 File).

Table 1. Characteristics of the study population stratified by sex and group.

Barcelona, 2016 and 2021.

2016 2021
Men Women Men Women
Comparison N = 321 Moderate intensity N = 177 High intensity N = 60 Comparison N = 348 Moderate intensity N = 184 High intensity N = 71 Comparison N = 308 Moderate intensity N = 199 High intensity N = 52 Comparison N = 351 Moderate intensity N = 179 High intensity N = 71
Age
15–34 25.1 31.1 22.9 26.0 27.0 18.3 25.9 36.4 27.5 24.8 33.0 34.0
35–64 54.3 51.9 51.1 45.2 49.8 58.8 54.2 51.6 54.9 49.3 44.0 54.5
+65 20.6 17.0 26.0 28.8 23.2 22.9 19.9 12.0 17.6 25.9 23.0 11.5
p-valuea 0.420 0.244 0.061 0.037
Occupational social class
Non-manual 16.1 12.0 7.4 15.1 11.9 14.2 20.7 22.1 13.6 22.6 19.6 15.2
Manual 81.5 85.6 85.1 83.0 84.7 84.3 77.9 74.7 86.4 75.7 75.9 82.1
Missing 2.4 2.4 7.5 1.9 3.4 1.5 1.4 3.2 0.0 1.7 4.5 2.7
p-value 0.100 0.677 0.367 0.366
Employment situation
Employed 53.2 55.8 45.5 45.1 49.9 45.3 55.4 57.1 55.0 49.9 49.4 54.7
Unemployed 9.0 16.8 18.2 7.9 10.0 13.6 11.1 15.0 14.0 9.6 10.2 8.8
Others 36.5 26.0 31.9 45.9 39.6 41.1 33.1 27.2 30.9 40.3 39.5 35.0
Missing 1.3 1.4 4.4 1.1 0.5 0.0 0.4 0.7 0.0 0.2 0.9 1.5
p-valuea 0.020 0.531 0.591 0.935
Country of origin
Autochthonous 72.3 58.2 76.9 72.8 59.6 74.6 70.1 55.3 68.9 72.1 66.5 65.6
Foreign born 27.7 41.5 24.1 27.2 40.4 25.4 29.6 44.7 31.1 27.7 33.5 34.4
Missing 0 0.3 0.0 0 0 0 0.3 0.0 0.0 0.2 0.0 0.0
p-valuea 0.005 0.006 0.002 0.285
Population turnover
≤6 years 19.2 18.7 13.7 14.8 19.7 12.5 24.2 27.6 30.2 22.3 23.7 24.7
>6 years 80.4 80.0 84.9 85.2 80.3 87.5 75.4 72.4 69.8 77.7 75.3 75.3
Missing 0.4 1.3 1.4 0 0 0 0.4 0.0 0.0 0.0 1.0 0.0
p-valuea 0.473 0.507 0.557 0.856

ain bold significance of p-values <0.05 of across comparison and intervention groups.

Table 2 shows the results of the intervention on selected outcomes from the DiD weighted regression. High-intensity intervention significantly reduced the relative frequency of women with poor mental health by 15.5% with respect to the comparison group. In the high-intensity intervention group, the frequency of women with poor self-perceived health was significantly reduced by 21.7%, and the frequency of women doing moderate and intense physical activity significantly increased by 13.7%. For these two indicators, the improvement was mainly due to the favourable evolution of the high-intensity intervention group. Finally, the frequency of women with obesity significantly decreased (9.7%), but alcohol abuse increased (5.8%) in the moderate-intensity intervention group; however, these results were not significant in the sensitivity analysis (S1 Table 3 in S1 File).

Table 2. Health outcomes and health-related behaviours in the study population stratified by sex and group.

Barcelona, 2016 and 2021.

Men Women
Type of intervention Pre-2016a Post-2021a Post-Pre DiDb (p-value) c Pre-2016a Post-2021a Post-Pre DiDb (p-value) c
Poor mental health Comparison 22.9 23.9 1.0 - 22.5 33.9 11.4 -
Moderate 19.7 27.2 7.5 6.5 (0.472) 31.0 33 2.0 -9.4 (0.153)
High 17.2 22.6 5.4 4.4 (0.658) 43.9 39.8 -4.1 -15.5 (0.020)
Psychotropic drug use Comparison 13.7 9.2 -4.5 - 19.6 21.4 1.8 -
Moderate 9.5 14.0 4.5 9.0 (0.057) 24.0 24.7 0.7 -1.1 (0.935)
High 6.0 11.8 5.8 10.3 (0.029) 24.9 14.1 -10.8 -12.6 (0.205)
Alcohol abuse Comparison 11.3 14.4 3.1 - 6.8 5.9 -0.9 -
Moderate 9.3 13.0 3.7 0.6 (0.924) 4.0 8.9 4.9 5.8 (0.043)
High 9.9 10.4 0.5 -2.6 (0.691) 6.0 6.3 0.3 1.2 (0.786)
Poor health perception Comparison 20.1 22.9 2.8 - 25.8 28.3 2.5 -
Moderate 14.1 24.0 9.9 7.1 (0.311) 26.8 27.4 0.6 -1.9 (0.865)
High 20.0 22.4 2.4 -0.4 (0.899) 43.0 23.8 -19.2 -21.7 (0.012)
Moderate and intense physical activity Comparison 34.0 31.7 -2.3 - 24.1 21 -3.1 -
Moderate 33.9 33.6 -0.3 2.0 (0.865) 15.3 18.8 3.5 6.6 (0.213)
High 31.7 33.7 2.0 4.3 (0.726) 7.5 18.1 10.6 13.7 (0.025)
Obesity Comparison 16.1 18.8 2.7 - 14.6 21.2 6.6 -
Moderate 19.9 21.1 1.2 -1.5 (0.834) 21.0 17.9 -3.1 -9.7 (0.022)
High 17.2 12.4 -4.8 -7.5 (0.329) 20.9 25.7 4.8 -1.8 (0.706)

aPrevalences/100.

bdifference-in-difference estimated by linear regressions adjusted by age and weighted data by the inverse of the propensity score.

cin bold significance of p-value<0.05.

Regarding men, the only significant result was an increase of 10.3% in the frequency of those using psychotropic drugs in the high-intensity intervention group. This result was due to a drop in the comparison group, while the two intervention groups showed a parallel ascending trend.

Discussion

This study found a positive impact of urban regeneration programmes on mental health, self-perceived health, and physical activity among women in the high-intensity intervention group.

Apart from the amount invested, citizen participation also seemed to favour the effectiveness of our intervention [13, 15, 16]. The improvements in women’s health but not in men’s may be related to many factors. First, women participated more than men in the actions of the PdB. Indeed, women in the most deprived neighbourhoods are usually less included in the labour market and so tend to have more free time. In addition, in order to reconcile work and family life, female workers often choose jobs close to home or part-time [22]; therefore, they might spend more time in their neighbourhoods and be more sensitive to the impact of an urban regeneration programme than men [23]. Moreover, women in the intervention groups showed worse health outcomes at pre-intervention than men, leaving more room for improvement.

An improvement in mental health was previously detected among different populations in other urban regeneration programmes: among women of the high-intensity intervention group in the neighbourhood-wide intervention ‘District Approach’ in the Netherlands [23]; among men and women in the programme ‘GoWell’ in Glasgow [14]; in deprived areas in Wales, without differentiation by gender [17]. Moreover, in our study, indicators related to psychological distress and physical health status move in the same favourable direction among women. In the Spanish context, previous research has also found effects of benefits (on preventable causes of mortality) in areas of higher investment intensity where two or more urban regeneration programmes overlap [24, 25]. In general, although wide-neighbourhood intervention programmes and citizen participation seem to benefit mental health in areas of high-intensity intervention, the evidence is not clear. For instance, the evaluation of the participatory ‘New Deal for Communities’ intervention in England found no overall effect on mental health, except for most disadvantaged groups [26], neither in the area of intervention in Glasgow [2], nor in the urban regeneration in Northern Ireland [27], nor in the ‘Well London’ project [14].

Self-perceived health status is a less studied outcome. There is weak evidence for its improvement in the ‘Neighbourhood Law’ for 2006–2011 in Barcelona [18] and in the neighbourhood renewal programme in Northern Ireland [25]. No effect on self-perceived health status was observed neither in the greening space intervention in the context of the ‘District Approach’ in the Netherlands [28], nor in the ‘Neighbourhood Renewal Strategy’ in Australia, except for the small subgroup involved in the partnership activities [29]. In our case, the reduction in poor self-perceived health among women is consistent with the reduction in poor mental health; both pre-intervention frequencies evolved downward.

The effects of the interventions on physical activity have been shown to depend on citizen participation [30], and the quality, safety, and civility of urban green spaces [31]. Even though our evaluation makes no distinction between actions undertaken for these different areas of action, we observed an overall improvement in physical activity among women in the high-intensity intervention group. In fact, physical activity and obesity move in the same direction in favour of the intervention for both sexes, even though they are not all statistically significant. In our case, as in a previous study, more walkable public spaces may have been the cause of the improvement in overall health [32].

The increase in the use of psychotropic drugs by men in the high-intensity group was an unexpected result; however, it was driven by a drop in the comparison group. This result contrasts with the null effects found in Denmark for the years 2015 to 2020 [33], and with the favourable evolution of residents in urban regeneration areas in Andalusia (Spain) during the years 2008 to 2015 [34]. We must bear in mind that during the years under study, there have also been two relevant circumstances. On the one hand, the long-lasting effects of the economic crisis during 2016 and the emergence of the COVID-19 pandemic in early 2020. Both events have led to a worsening of mental-related health problems, especially among the male population during the economic crisis and among young adult women during the lockdown of COVID-19. It is difficult to identify to what extent both crises may have differentially affected our comparison and intervention groups and through which mechanisms. If this were the case, it would be a limitation of our research. There is evidence of oscillations in health inequalities during both crises, but in the medium term, they translate into the persistence of inequalities [35, 36]. For this reason, we believe that the effects of both crises on the different evolution of health status between the intervention and control groups are small. In any case, the effects of the intervention must be interpreted depending on the contextual characteristics of the neighbourhoods.

Of the lessons learned about intervention design, the excessive number of interventions rather than focusing on the most determinant ones in each area of action is noteworthy. Second, participation is uneven across neighbourhoods and is lower in the most deprived neighbourhoods. It is therefore necessary to implement a plan to strengthen the capacity for collective action in these neighbourhoods.

This study has several limitations. Caution should be exercised when interpreting the results causally. Even though we used comparison areas and propensity score to make the distributions of population features between comparison and intervention groups comparable, threads of causality could arise if other factors affect both groups differently in previous trends or during the intervention. If the health indicators between the intervention and control groups did not move in parallel in the previous periods, this would imply that factors other than the intervention were at work and the results obtained could not be attributed to the intervention. For example, if the lasting effects of the 2008 economic crisis had affected the intervention group more severely than the control group. This could have further worsened their health indicators in 2016. In such a case, these indicators would tend to return to normal in 2021, and the improvement would not be attributable to the intervention. Another circumstance that could occur is that the intervention itself has changed the social context, and therefore the observed improvements in health cannot be attributed to the intervention. However, we believe that these effects, even if they exist, should be limited and not compromise the overall results. A low sample size is another limitation, especially in the high-intervention group, which does not allow for the analysis of the impact on health inequalities or the testing of heterogeneous results among socioeconomic groups within neighbourhoods. It was not possible to assess if the effect among participants was greater because of the lack of data. Finally, the time when to study the impact of an intervention represents a controversial issue: on the one hand, it may take time to change health behaviours, such as dietary habits or obesity; on the other hand, the impact of the interventions may decay and confounding factors may increase with time. For example, limited results were found in the ‘New Deal for Communities’ intervention within 3.5 years after the intervention, but no results were found after 6 years [26], nor in the ‘District Approach’ intervention [37]. Therefore, for our intervention, a long-term evaluation will be needed to see if the positive health outcomes are sustained over time.

This study also has several strengths. First, it adds evidence to the impact of regeneration programmes on health outcomes and health-related behaviours, an area where evidence is still scarce. Second, the different surveys make it possible to have numerous comparable health outcomes in the two periods and will allow a long-term evaluation. Third, the quasi-experimental design with a comparison group helps to minimise the threats to the internal validity of the study. Finally, the analysis used propensity score to reduce potential biases from possible failure to meet the parallel assumption and diminish the potential compositional change between comparison and intervention groups during the period.

Our results can be useful to implement urban regeneration programmes in other areas. In particular, we derived several lessons from them. First, urban planning practice can probably do better to integrate insights from public health, explicitly establishing the links between the built environment and health outcomes. Second, under budgetary constraints, actions should be designed to concentrate resources on the target population or areas with worse living conditions within neighbourhoods where there is more room for improvement. Third, a specific strategy to target men is needed. Fourth, a qualitative study to report on the perceptions and experiences of local residents could play a pivotal role in strengthening the study’s ability to establish a more robust causal link between the regeneration programme and the observed positive health outcomes. Finally, the re-assessment of urban regeneration programmes at different times would make it possible to disentangle if the impact observed is maintained in the long term.

Conclusions

This study shows positive short-term effects of the urban regeneration programme Pla de Barris 2016–2020 on health outcomes in women in the high-intensity intervention group. These results can guide future interventions in other areas.

Supporting information

S1 File

(DOCX)

pone.0300470.s001.docx (21.4KB, docx)

Data Availability

The Barcelona Health Survey (BHS) forms part of the statistical actions of interest to the Generalitat de Catalunya and is included in the Annual Statistical Action Programme (PAAE) under the registration number: 05-03-24. The ESB 2021 is anonymous and confidential, in accordance with Law 6/2007, of 17 July, which regulates the preparation and publication of surveys and opinion polls in Catalonia. On the other hand, the confidentiality of the data is guaranteed in accordance with Organic Law 3/2018 on the Protection of Personal Data and the guarantee of digital rights. Therefore, it is assured that the information obtained from the questionnaires will be used exclusively in the field of health. According to the regulation, access to the data is on direct request to the administration (Public Health Agency of Barcelona) upon request by accredited research groups, under the clause of non-transfer to third parties. Therefore, access to the data is not allowed without their consent and subrogated access is not possible. On legal grounds, data is only accessible upon request from the official administrative source to the address info@aspb.cat.

Funding Statement

The author(s) received no specific funding for this work.

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Decision Letter 0

Angela Mendes Freitas

4 Dec 2023

PONE-D-23-31700Short-term health effects of an urban regeneration programme in deprived neighbourhoods of BarcelonaPLOS ONE

Dear Dr. Bartoll,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

==============================

ACADEMIC EDITOR: In light of both reviewers opinion and considering their comments, the article needs to address various aspects, from survey/data limitations to the sound discussion of results. It is strongly recommended to address all comments and questions raised in order to be accepted for publication, as it was considered a very important study.

==============================

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

Reviewer #3: Yes

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2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: No

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4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

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5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: An exhaustive description on the renewable solutions adopted is needed

1. The study presents the results of original research. Yes

2. Results reported have not been published elsewhere. Yes

3. Experiments, statistics, and other analyses are performed to a high technical standard and are described in sufficient detail. Yes

4. Conclusions are presented in an appropriate fashion and are supported by the data. Yes

5. The article is presented in an intelligible fashion and is written in standard English. Yes

6. The research meets all applicable standards for the ethics of experimentation and research integrity. Yes

7. The article adheres to appropriate reporting guidelines and community standards for data availability. Yes

Reviewer #2: This paper reports on the impact of an urban regeneration programme in Barcelona. The results confirm results of previous studies in other countries of a modest impact among women in particular. I do have multiple questions, however, relating to the validity and interpretation of the results:

1 . I could not find information on non-respons on the survey. It seems that 4000 people have been approached (per sexe?), and around 600 participated. Right? This implies a response rate of 15%, which is extremely low. I would like to see information on the selectiveness of the response, as this might bias the results.

2. I miss information on the socio-economic characteristics at neighbourhoodlevel. What is the level of deprivation here? This information is also useful in relation to my first point: is the survey representative for the population at stake?

3. What exactly does the programme entail? The authors state that they could not describe all activities, which I of course do understand. As a reader, however, I have no clue as to what the content of the programme was. E.g. classified as ‘economy’: how substantial have these been? How many people have been reached. And did the programme also entail housing renovations for example? If policymakers want to base their decisions on studies like this, they need information as what activities/programmes are needed to achieve this result.

4. Related to the previous question: what exactly was the budget per neighbourhood? Is it 28 million in total, distributed across 16 neighbourhoods, over 4 years? It seems a relatively small amount per neighbourhood, also depending of course on how many people live in a neighbourhood, what determines the amount of money spent per person. A similar question relates to the difference between moderate and high intensity districts. Is this a relevant difference?

5. The authors emphasize the positive results among women in high intensity districts. However, 2 of the positive effects occur in low intensity districts. So is there really a difference?

6. Some of the results seem odd, and need to be discussed. E.g.

-reduction in obesity among women in moderate intensity disricts, as compared to increase in high intensity districs.

-the prevalence of poor health perception in women in high intensity district is extremely high (43%), which could probably explain the observed decrease.

-the observed increase in drug use among men in intervention districts.

7. An important weakness is the absence of trend data. The authors use two time points, which might bias the results. This should at least be mentioned in the discussion section.

Reviewer #3: The manuscript entitles "Short-term health effects of an urban regeneration programme in deprived neighborhoods of Barcelona" is interesting and makes a significant contribution to this research field in Spain. However, I believe that before being accepted for publication, the authors should address a series of revisions that I consider important:

1. In the introduction, the authors make the following statement regarding the spatial distribution of social problems and the suitability of urban regeneration projects in neighborhoods with a high density of immigrant population: "especially in immigrant-dense neighbourhoods, which can make urban programmes more suitable than traditional sector programmes." I believe that this assumption deserves a better argumentative development, an explanation of why these types of problems can be more effectively addressed through urban regeneration.

2. The researchers conduct a limited review of the existing literature and overlook the consideration of previous studies published in Spain on the subject. For example, they omit studies that specifically illustrated potential effects in areas of high intervention intensity (confluence of two or more project-based areas).

Moya, A. R. Z., & Yáñez, C. J. N. (2017). Impact of area regeneration policies: Performing integral interventions, changing opportunity structures and reducing health inequalities. J Epidemiol Community Health, 71(3), 239-247

Even the existence of relevant prospective studies published is dismissed by stating that "there is a lack of longitudinal studies.

Rodgers, S. E., Heaven, M., Lacey, A., Poortinga, W., Dunstan, F. D., Jones, K. H., ... & Lyons, R. A. (2014). Cohort profile: the housing regeneration and health study. International journal of epidemiology, 43(1), 52-60.

Smith, N. R., Clark, C., Fahy, A. E., Tharmaratnam, V., Lewis, D. J., Thompson, C., ... & Cummins, S. (2012). The Olympic Regeneration in East London (ORiEL) study: protocol for a prospective controlled quasi-experiment to evaluate the impact of urban regeneration on young people and their families. BMJ open, 2(4), e001840.

Nygaard, S. S., Jorgensen, T. S. H., Wium-Andersen, I. K., Brønnum-Hansen, H., & Lund, R. (2023). Is urban regeneration associated with antidepressants or sedative medication users: a registry-based natural experiment. J Epidemiol Community Health, 77(4), 237-243.

Cummins, S., Clark, C., Lewis, D., Smith, N., Thompson, C., Smuk, M., ... & Eldridge, S. (2018). The effects of the London 2012 Olympics and related urban regeneration on physical and mental health: the ORiEL mixed-methods evaluation of a natural experiment. Public Health Research, 6(12).

Zapata-Moya, Á. R., Martín-Díaz, M. J., & Viciana-Fernández, F. J. (2021). Area-Based Policies and Potential Health Benefits: A Quasi-Experimental Cohort Study in Vulnerable Urban Areas of Andalusia (Spain). Sustainability, 13(15), 8169.

3. In the introduction, the authors refer to the lack of prospective studies as a factor that raises a number of weaknesses in studies on the health impact of urban regeneration programs, and mention specifically the following (Changes in the composition of the population; Failure to consider confounding factors and Previous trends). Although the methodological effort made by the researchers to develop a quasi-experimental approach is commendable, the cross-sectional nature of the data used does not allow in any case to overcome the three limitations mentioned above, especially the risk of attributing effects to the intervention without controlling for the population change that occurred before and after the intervention, as well as the study of previous trends in the most vulnerable neighborhoods. Combining the quasi-experimental method with the individual-level propensity score technique is an alternative to try to reduce these risks; however, the specialized literature indicates that there is a greater population change in neighborhoods intervened by urban regeneration programs. The researchers try to show that these differences in population change are not operating in their analyses, but I believe they should acknowledge that having only two cross-sectional sampling points does not allow for a categorical assertion of the non-existence of effects due to the population change motivated by the interventions.

4. In addition to the limitations mentioned, there are external factors (the 2008 economic crisis and subsequent recovery, which some studies place from 2016 onward) that could be affecting the results, especially in those more vulnerable neighborhoods, as there could be a r"regression to the mean effect" after a greater worsening of the main outcomes in the crisis phase. This could be happening especially among women, as the authors indicate; these showed worse health outcomes than men before the intervention, and therefore, there would be more possibility of a tendency (beyond the intervention) to improve, a "regression to the mean effect" among a particularly vulnerable group in a context of vulnerability. To rule out this alternative explanation for the main findings of the study, trends in these indicators should be explored jointly in intervened and control neighborhoods whenever possible.

5. It is also important to mention another external factor that could influence the results in some way: since the COVID-19 crisis and lockdown occurred in 2020, the researchers should at least comment on how this could be impacting the potential effects found on mental health, self-perception of health among women, and alcohol consumption. Similarly, with the increase in the use of psychotropic drugs among men.

6. Regarding these external factors, the researchers in the discussion section point out as a strength of the study that "Indeed, any other contextual factor affecting the results at the city level should be equally affecting all the groups studied." In my opinion, this is a risky statement, as there is no guarantee that the impact of the economic crisis, as well as its recovery period, and even the COVID-19 crisis (as external factors) will have a similar effect among all city groups and all neighborhoods. Also, the potential impacts of the programs on health could be conditioned by the differential effects of the economic crisis.

Zapata Moya, Á. R., & Navarro Yáñez, C. J. (2021). Urban regeneration policies and mental health in a context of economic crisis in Andalusia (Spain). Journal of Housing and the Built Environment, 36, 393-405.

7. In a more nuanced interpretation, I think it is essential to recognize, especially in the discussion of the article, the potential for conditional effects of the intervention depending on the contextual characteristics of the neighborhoods.

8. Regarding mental health, the researchers choose to dichotomize the scale variable from a score of 3, considering that from this score onwards, there is a risk to mental health. I believe that this necessitates a more detailed explanation and references from reputable sources to support the authors' decision.

9. The explanation for why only positive effects are observed among women refers to a conventional argument that rests on the idea that women have greater exposure to community life in the neighborhood and, therefore, to the interventions of these projects. Perhaps the discussion could be enriched if the authors delve deeper into this matter and are able to reference various explanatory pathways (which may be complementary) from the perspective of the sociology of health.

Regarding the style of presenting information and the article's wording, I find it suitable for publication after addressing the points and suggestions made earlier.

**********

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Reviewer #1: No

Reviewer #2: No

Reviewer #3: No

**********

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PLoS One. 2024 Apr 17;19(4):e0300470. doi: 10.1371/journal.pone.0300470.r002

Author response to Decision Letter 0


4 Feb 2024

PONE-D-23-31700

Short-term health effects of an urban regeneration programme in deprived neighbourhoods of Barcelona

We are grateful for the opportunity to address the issues raised by the reviewers, which undoubtedly improve the content of the article. In the following text we answer the reviewers' comments point by point. Corrections and modifications have been incorporated into the main manuscript in red and supressed text in change control.

Reviewers' comments and author’s responses:

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

Reviewer #2: Partly

Reviewer #3: Yes

RESPONSE:

In the following we comment on the changes made in accordance with the reviewers' recommended changes.________________________________________

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

Reviewer #2: Yes

Reviewer #3: Yes

________________________________________

3. Have the authors made all data underlying the findings in their manuscript fully available?

The requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: No

RESPONSE:

We have extended the explanation of data availability in the cover letter. (There are legal restrictions)

The Barcelona Health Survey (BHS) forms part of the statistical actions of interest to the Generalitat de Catalunya and is included in the Annual Statistical Action Programme (PAAE) under the registration number: 05-03-24. The BHS 2021 is anonymous and confidential, in accordance with Law 6/2007, of 17 July, which regulates the preparation and publication of surveys and opinion polls in Catalonia. On the other hand, the confidentiality of the data is guaranteed in accordance with Organic Law 3/2018 on the Protection of Personal Data and the guarantee of digital rights. Therefore, it is assured that the information obtained from the questionnaires will be used exclusively in the field of health. According to the regulation, access to the data is on direct request to the administration (Public Health Agency of Barcelona) upon request by accredited research groups, under the clause of non-transfer to third parties. Therefore, access to the data is not allowed without their consent and subrogated access is not possible. Data is only accessible upon request from the official administrative source to the Public Health Agency of Barcelona address info@aspb.cat.

________________________________________

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

Reviewer #3: Yes

RESPONSE:

A second revision of the manuscript has been carried out by an expert translator.

________________________________________

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: An exhaustive description on the renewable solutions adopted is needed

1. The study presents the results of original research. Yes

2. Results reported have not been published elsewhere. Yes

3. Experiments, statistics, and other analyses are performed to a high technical standard and are described in sufficient detail. Yes

4. Conclusions are presented in an appropriate fashion and are supported by the data. Yes

5. The article is presented in an intelligible fashion and is written in standard English. Yes

6. The research meets all applicable standards for the ethics of experimentation and research integrity. Yes

7. The article adheres to appropriate reporting guidelines and community standards for data availability. Yes

Reviewer #2: This paper reports on the impact of an urban regeneration programme in Barcelona. The results confirm results of previous studies in other countries of a modest impact among women in particular. I do have multiple questions, however, relating to the validity and interpretation of the results:

1 . I could not find information on non-respons on the survey. It seems that 4000 people have been approached (per sexe?), and around 600 participated. Right? This implies a response rate of 15%, which is extremely low. I would like to see information on the selectiveness of the response, as this might bias the results.

We have introduced changes that hopes it makes this issue easier to follow. We have added information that the 4000 people interviewed from the 10 Districts refer also to the 73 neighbourhoods of Barcelona. We added information on quotes: by sex, age group and neighbourhood. As stated in the main text, non-response is supplemented by interviewing substitutes with the same characteristics until the target sample of 4000 cases for the whole Barcelona is reached, the resulting sample after the substitutions is comparable to the original sample design. Therefore, the response rate it is not 15%, there is no non-response. We have made it clearer that the analysed sample (from the 4000 cases for the whole BCN) corresponds to the subsample of the 16 neighbourhoods of the intervention group and the 17 neighbourhoods of the control group, which represents a precision of ± 3% for the 33 neighbourhoods analysed.

2. I miss information on the socio-economic characteristics at neighbourhood level. What is the level of deprivation here? This information is also useful in relation to my first point: is the survey representative for the population at stake?

We have introduced a paragraph detailing the characteristics of these vulnerable neighbourhoods:

“[These neighbourhoods are] … characterised by poor indicators in terms of income, education level, residential vulnerability indices and higher unemployment rates, higher percentage of the foreign population and material deprivation”

We also have added information in the Methods section on the accuracy of estimates. The subsample for the 33 neighbourhoods analysed is representative with a precision of ± 3%.

3. What exactly does the programme entail? The authors state that they could not describe all activities, which I of course do understand. As a reader, however, I have no clue as to what the content of the programme was. E.g. classified as ‘economy’: how substantial have these been? How many people have been reached. And did the programme also entail housing renovations for example? If policymakers want to base their decisions on studies like this, they need information as what activities/programmes are needed to achieve this result.

In the introduction there is a general idea regarding the aim of the urban regeneration programmes. We have added a summary sentence about the general goal of the intervention at the beginning of the intervention comment “… aimed at improving living conditions in the most disadvantaged neighbourhoods”.

Also, we give examples of relevant type of intervention. As examples of economic interventions, we already included increase the employability through “extending occupational training” or improving economic environment though “developing disused ground floors for commercial purposes”. Regarding housing rehabilitation, we already make explicit “rehabilitation of vulnerable housing was carried out”.

More information on the programme can be found on the web on some links below. However, we are reluctant to cite in the text because these links easily can change and become obsolete. Moreover, as the intervention progress, the information on these links is renewed and become obsolete easily. If it is a real problem we could add the general information link: https://www.pladebarris.barcelona/

Other links are:

Current population assessment: https://www.barcelona.cat/infobarcelona/en/tema/city-council/the-neighbourhood-plan-has-a-positive-impact-on-65-of-residents-in-23-neighbourhoods_1266510.html

Regarding housing interventions: https://www.barcelona.cat/infobarcelona/en/tema/city-council/the-neighbourhood-plan-allocates-over-21-million-euros-to-decent-housing-initiatives_920128.html).

More information about the specific activities related to the COVID-19 pandemics: (https://www.barcelona.cat/infobarcelona/en/tema/city-council/the-neighbourhood-plan-has-a-positive-impact-on-65-of-residents-in-23-neighbourhoods_1266510.html)

Regarding the intervention as accomplishing good practice by the city council (https://www.coe.int/eu/web/interculturalcities/-/barcelona-s-neighbourhood-plan),

4. Related to the previous question: what exactly was the budget per neighbourhood? Is it 28 million in total, distributed across 16 neighbourhoods, over 4 years? It seems a relatively small amount per neighbourhood, also depending of course on how many people live in a neighbourhood, what determines the amount of money spent per person. A similar question relates to the difference between moderate and high intensity districts. Is this a relevant difference?

Thanks for the question. More details on the implementation can be found in the Catalan language document https://www.pladebarris.barcelona/, is not English-translated and difficult to navigate so not worth to refer to in the main text.

The paper already states that the total amount is 150 million €, of which 105 m€ were for inversion, 35 m€ were for services and 10 m€ were for overheads. We have moved this sentence to the beginning of the paragraph to avoid misunderstanding.

We have shown the total expenditure per capita in the neighbourhoods because we believe it is a good measure for the reader, and easily comparable with other common indicators such as income per capita or salary. So that, in the main text it is explicit the amount of investment in euros by inhabitant in the range of “335.8 to 2048.7 € per inhabitant”, which is not a negligible amount by Spanish standards, considering also that it comes from a local administration. Precisely, given the wide range between these magnitudes makes sense the distinction by intensity in €/hab. More resources were allocated to the most depressed areas in need of greater investment, hence the differentiation into high intensity and moderate intensity interventions.

5. The authors emphasize the positive results among women in high intensity districts. However, 2 of the positive effects occur in low intensity districts. So is there really a difference?

We definitely believe that it is very convenient to keep the difference. One reason is conceptual: to allow ex-ante for intensity/dose effect. The second, is that previous literature that found results make the differentiation, this literature is commented in the discussion. Third, a very consistent association is observed for women (5 out of the 6 results analysed while only 1 for households).

6. Some of the results seem odd, and need to be discussed. E.g.

-reduction in obesity among women in moderate intensity disricts, as compared to increase in high intensity districs.

-the prevalence of poor health perception in women in high intensity district is extremely high (43%), which could probably explain the observed decrease.

-the observed increase in drug use among men in intervention districts.

We also have stated the initial worse level of health status among women and interpreted as there are more room for improvement as in here: “Moreover, women in the intervention groups showed worse health outcomes at pre-intervention than men, leaving more room for improvement”.

Following the reviewer suggestion, we have added as a limitation the possible case of ‘regression to mean’: “For example, if the lasting effects of the 2008 economic crisis had affected the intervention group more severely than the control group, this could have further worsened their health indicators in 2016. In such a case, these indicators would tend to return to normal in 2021 and the improvement would not be attributable to the intervention.”

We have also extended the comments regarding the increase in drug use among men: “This result contrasts with the null effects found in Denmark for the years 2015 to 2020 (Nygaard 2023), and with the favourable evolution of residents in urban regeneration areas in Andalusia (Spain) during the years 2008 to 2015 (Zapata-Moya 2021). We must bear in mind that during the years under study, there have also been two relevant circumstances. On the one hand, the long-lasting effects of the economic crisis during 2016 and the emergence of the COVID-19 pandemic in early 2020. Both events have led to a worsening of mental-related health problems, especially among the male population during the economic crisis and among young adult women during the lockdown of COVID-19. There is evidence of oscillations in health inequalities during both crises, but in the medium term, they translate into the persistence of inequalities35 36. For this reason, we believe that the effects of both crises on the different evolution of health status between the intervention and control groups are small. In any case, the effects of the intervention must be interpreted depending on the contextual characteristics of the neighbourhoods.”

There is a decrease in obesity in all intervention groups for men and women compared to the control group, although only statistically significant for the moderate intensity group for women, which runs in favour of the intervention. This fact is congruent with the also increase in all interviewed group in physical activity. We have added: “In fact, physical activity and obesity move in the same direction in favor of the intervened groups of both sexes, even though they are not all statistically significant.”

7. An important weakness is the absence of trend data. The authors use two time points, which might bias the results. This should at least be mentioned in the discussion section.

We see the point of the reviewer. The BHS survey is routinely carried out every 5 years. Although we had a previous one for 2011, we decided not to include in this analysis to avoid introducing more noise into the data, as at this time it was affected by the financial crisis. However, we were aware that there may be trend problems (non-compliance with the hypothesis of parallel trends). For this reason, we have used the reweighting techniques to reduce possible biases between the intervention and comparison group before and after the intervention, as stated in the methodological section.

Following the reviewer recommendation, we have expanded on this and other related issues in the limitations section: “This study has several limitations. Caution should be exercised when interpreting the results causally. Even though we used comparison areas and propensity score to make the distributions of population features between comparison and intervention groups comparable, threads to causality could arise if other factors differently affect both groups in previous trends or during the intervention. If the health indicators between the intervention and control groups do not move in parallel in the previous periods. This would imply that factors other than the intervention are at work and the results obtained could not be attributed to the intervention. For example, if the lasting effects of the 2008 economic crisis had affected the intervention group more severely than the control group, this could have further worsened their health indicators in 2016. In such a case, these indicators would tend to return to normal in 2021 and the improvement would not be attributable to the intervention, which is known as regression to the mean. Another circumstance that could occur is that the intervention itself has changed the social context and therefore these observed improvements in health cannot be attributed to the intervention. However, we believe that these effects, even if they exist, should be limited and do not compromise the overall results.”

Reviewer #3: The manuscript entitles "Short-term health effects of an urban regeneration programme in deprived neighbourhoods of Barcelona" is interesting and makes a significant contribution to this research field in Spain. However, I believe that before being accepted for publication, the authors should address a series of revisions that I consider important:

1. In the introduction, the authors make the following statement regarding the spatial distribution of social problems and the suitability of urban regeneration projects in neighbourhoods with a high density of immigrant population: "especially in immigrant-dense neighbourhoods, which can make urban programmes more suitable than traditional sector programmes." I believe that this assumption deserves a better argumentative development, an explanation of why these types of problems can be more effectively addressed through urban regeneration.

Sector programmes only account for a dimension of the problem. –we are not referring on urban regeneration programs but integral urban regeneration programs which are designed to account for a wide range of problems, acting on not only physical environment but on the social environment with the aim to redistribution of territorial, social and territorial endowments (which has been conceptualised as the Fundamental Cause Theory (Link, B.G.; Phelan, J. Social conditions as fundamental causes of disease. J. Health Soc. Behav. 1995, 35, 80–94).

We make it explicit adding the following paragraph: “An unequal provision of resources among individuals and social groups in an urban environment can lead to health inequalities. Comprehensive urban regeneration programmes aim to facilitate access to and availability of a wide range of these resources. Therefore, it is expected that urban regeneration programmes comprising a greater diversity of interventions will favour access to dispositional resources and provide wider options for a better life”.

The reference to the immigrant population was not necessary and has been supressed.

2. The researchers conduct a limited review of the existing literature and overlook the consideration of previous studies published in Spain on the subject. For example, they omit studies that specifically illustrated potential effects in areas of high intervention intensity (confluence of two or more project-based areas).

Moya, A. R. Z., & Yáñez, C. J. N. (2017). Impact of area regeneration policies: Performing integral interventions, changing opportunity structures and reducing health inequalities. J Epidemiol Community Health, 71(3), 239-247

Even the existence of relevant prospective studies published is dismissed by stating that "there is a lack of longitudinal studies.

Rodgers, S. E., Heaven, M., Lacey, A., Poortinga, W., Dunstan, F. D., Jones, K. H., ... & Lyons, R. A. (2014). Cohort profile: the housing regeneration and health study. International journal of epidemiology, 43(1), 52-60.

Nygaard, S. S., Jorgensen, T. S. H., Wium-Andersen, I. K., Brønnum-Hansen, H., & Lund, R. (2023). Is urban regeneration associated with antidepressants or sedative medication users: a registry-based natural experiment. J Epidemiol Community Health, 77(4), 237-243.

Smith, N. R., Clark, C., Fahy, A. E., Tharmaratnam, V., Lewis, D. J., Thompson, C., ... & Cummins, S. (2012). The Olympic Regeneration in East London (ORiEL) study: protocol for a prospective controlled quasi-experiment to evaluate the impact of urban regeneration on young people and their families. BMJ open, 2(4), e001840.

Cummins, S., Clark, C., Lewis, D., Smith, N., Thompson, C., Smuk, M., ... & Eldridge, S. (2018). The effects of the London 2012 Olympics and related urban regeneration on physical and mental health: the ORiEL mixed-methods evaluation of a natural experiment. Public Health Research, 6(12).

Zapata-Moya, Á. R., Martín-Díaz, M. J., & Viciana-Fernández, F. J. (2021). Area-Based Policies and Potential Health Benefits: A Quasi-Experimental Cohort Study in Vulnerable Urban Areas of Andalusia (Spain). Sustainability, 13(15), 8169.

Thank you for noticing the issue and facilitating these important references. The statement "there is a lack of longitudinal studies” has been supressed; it was mean to say that retrospective studies are more common than prospective ones.

We have cited two papers from Moya & Yáñez, (2017) and Zapata-Moya 2021, precisely to reinforce the importance of integrated urban regeneration programs instead of sector programmes (even though it deals with mortality) and the paper from Nygaard to add (lack of) evidence on drug use.

We added the following texts in the discussion section:

“In the Spanish context, previous research has also found effects benefits (on preventable causes of mortality) in areas of higher investment intensity where two or more urban regeneration programmes overlap (Zapata-Moya 2017 impact; Zapata-Moya 2021).” … “This result contrasts with the null effects found in Denmark for the years 2015 to 2020 (Nygaard 2023), and with the favourable evolution of residents in urban regeneration areas in Andalusia (Spain) during the years 2008 to 2015 (Zapata-Moya 2021).”

We did not consider the papers from Smith, 2012; and Cummings, 2012; because they focus children from 11-12 years old, while we study the adult population above 14 years old (the population target has been added in methods). The same with Rodger’s paper that investigates effects on injuries, cardiovascular and respiratory conditions.

3. In the introduction, the authors refer to the lack of prospective studies as a factor that raises a number of weaknesses in studies on the health impact of urban regeneration programs, and mention specifically the following (Changes in the composition of the population; Failure to consider confounding factors and Previous trends). Although the methodological effort made by the researchers to develop a quasi-experimental approach is commendable, the cross-sectional nature of the data used does not allow in any case to overcome the three limitations mentioned above, especially the risk of attributing effects to the intervention without controlling for the population change that occurred before and after the intervention, as well as the study of previous trends in the most vulnerable neighborhoods. Combining the quasi-experimental method with the individual-level propensity score technique is an alternative to try to reduce these risks; however, the specialized literature indicates that there is a greater population change in neighborhoods intervened by urban regeneration programs. The researchers try to show that these differences in population change are not operating in their analyses, but I believe they should acknowledge that having only two cross-sectional sampling points does not allow for a categorical assertion of the non-existence of effects due to the population change motivated by the interventions.

Thank you for recognising the methodological efforts to overcome cros-sectional limitations.

We agree with the reviewer that results have to be taken with caution, as they cannot be simplistically attributed to the intervention. We have expanded the limitations suggested by the reviewer in this point 3 but also in point 4, with the following paragraph: “This study has several limitations. Caution should be exercised when interpreting the results causally. Even though we used comparison areas and propensity score to make the distributions of population features between comparison and intervention groups comparable, threads to causality could arise if other factors differently affect both groups in previous trends or during the intervention. If the health indicators between the intervention and control groups do not move in parallel in the previous periods, this would imply that factors other than the intervention are at work and the results obtained could not be attributed to the intervention. For example, if the lasting effects of the 2008 economic crisis had affected the intervention group more severely than the control group, this could have further worsened their health indicators in 2016. In such a case, these indicators would tend to return to normal in 2021 and the improvement would not be attributable to the intervention. Another circumstance that could occur is that the intervention itself has changed the social context, such as a process of gentrification, and therefore these improvements in health are observed and cannot be attributed to the intervention. However, we believe that these effects, even if they exist, should be limited and do not compromise the overall results.”

4. In addition to the limitations mentioned, there are external factors (the 2008 economic crisis and subsequent recovery, which some studies place from 2016 onward) that could be affecting the results, especially in those more vulnerable neighborhoods, as there could be a “regression to the mean effect" after a greater worsening of the main outcomes in the crisis phase. This could be happening especially among women, as the authors indicate; these showed worse health outcomes than men before the intervention, and therefore, there would be more possibility of a tendency (beyond the intervention) to improve, a "regression to the mean effect" among a particularly vulnerable group in a context of vulnerability. To rule out this alternative explanation for the main findings of the study, trends in these indicators should be explored jointly in intervened and control neighborhoods whenever possible.

We have grouped this topic with point 3 in order to highlight and expand on these limitations.

5. It is also important to mention another external factor that could influence the results in some way: since the COVID-19 crisis and lockdown occurred in 2020, the researchers should at least comment on how this could be impacting the potential effects found on mental health, self-perception of health among women, and alcohol consumption. Similarly, with the increase in the use of psychotropic drugs among men.

A paragraph on the potential lasting effects of the economic crisis and COVID-19 has been added with the with the recognition of conditionality of results:

“We must bear in mind that during the years under study, there have also been two relevant circumstances. On the one hand, the long-lasting effects of the economic crisis during 2016 and the emergence of the COVID-19 pandemic in early 2020. Both events have led to a worsening of mental-related health problems, especially among the male population during the economic crisis and among young adult women during the lockdown of COVID-19. It is difficult to identify to what extent both crises may have differentially affected our comparison and intervention group and through which mechanisms. If this were the case, it would be a limitation of our research. There is evidence of oscillations in health inequalities during both crises but in the medium term they translate into persistence of inequalities (Bartoll-Roca et al 2017; Martinez-Beneito et al., 2023). For this reason, we believe that the effects of both crises on the different evolution of health status between the intervention and control groups are of small amount.”

6. Regarding these external factors, the researchers in the discussion section point out as a strength of the study that "Indeed, any other contextual factor affecting the results at the city level should be equally affecting all the groups studied." In my opinion, this is a risky statement, as there is no guarantee that the impact of the economic crisis, as well as its recovery period, and even the COVID-19 crisis (as external factors) will have a similar effect among all city groups and all neighborhoods. Also, the potential impacts of the programs on health could be conditioned by the differential effects of the economic crisis.

Zapata Moya, Á. R., & Navarro Yáñez, C. J. (2021). Urban regeneration policies and mental health in a context of economic crisis in Andalusia (Spain). Journal of Housing and the Built Environment, 36, 393-405.

Certainly, this condition cannot be expected meet for sure and we have supressed the sentence. Regarding the potential effects of COVID-19, we refer to the added paragraph in point 5.

7. In a more nuanced interpretation, I think it is essential to recognize, especially in the discussion of the article, the potential for conditional effects of the intervention depending on the contextual characteristics of the neighborhoods.

We have added in the discussion the statement: “In any case, the effects of the intervention must be interpreted conditional on the contextual characteristics of the neighborhoods.”

8. Regarding mental health, the researchers choose to dichotomize the scale variable from a score of 3, considering that from this score onwards, there is a risk to mental health. I believe that this necessitates a more detailed explanation and references from reputable sources to support the authors' decision.

Different counting for Likert scales is possible for the GHQ-12. However, the coding (0, 0, 1,1) and dichotomization at the sum of 3 scores is widely used and a recommendation in the literature. Here you can find some examples:

Piccinelli M, Bisoffi G, Bon MG, Cunico L, Tansella M. Validity and test-retest reliability of the Italian version of the 12-item General Health Questionnaire in general practice: a comparison between three scoring methods. Compr Psychiatry. 1993 May-Jun;34(3):198-205

9. The explanation for why only positive effects are observed among women refers to a conventional argument that rests on the idea that women have greater exposure to community life in the neighborhood and, therefore, to the interventions of these projects. Perhaps the discussion could be enriched if the authors delve deeper into this matter and are able to reference various explanatory pathways (which may be complementary) from the perspective of the sociology of health.

Thank you for the suggestion. We see the point of the reviewer, but we would prefer to keep the current explanation in order to not exceed the limit of words of the manuscript.

Regarding the style of presenting information and the article's wording, I find it suitable for publication after addressing the points and suggestions made earlier.

________________________________________

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Reviewer #2: No

Reviewer #3: No

________________________________________

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Decision Letter 1

Angela Mendes Freitas

28 Feb 2024

Short-term health effects of an urban regeneration programme in deprived neighbourhoods of Barcelona

PONE-D-23-31700R1

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Reviewer #1: A general map of the city shall be adecuate to undestand some of the results shown. It is an interesting approach to a trendic topic nowadays.

A Planning Handbook has been recently publicated by Spanish Ministry of Health: "Guia para planificar ciudades saludables" 2020, (Fariña et al.,) may be it will be interesting to mention it in the introduction.

Reviewer #2: (No Response)

Reviewer #3: The authors have addressed most of the comments I have made, with the exception of the "explanatory" interpretations of why the results may be among women and not men. This is an issue of utmost interest that affects the differential benefits of "flexible resources" under root cause theory. I understand that the authors prefer not to go beyond words, but this is a scholarly effort worth considering, since it is an explanatory, rather than a descriptive challenge of potential differential impacts by gender.

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Acceptance letter

Angela Mendes Freitas

5 Apr 2024

PONE-D-23-31700R1

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    Data Availability Statement

    The Barcelona Health Survey (BHS) forms part of the statistical actions of interest to the Generalitat de Catalunya and is included in the Annual Statistical Action Programme (PAAE) under the registration number: 05-03-24. The ESB 2021 is anonymous and confidential, in accordance with Law 6/2007, of 17 July, which regulates the preparation and publication of surveys and opinion polls in Catalonia. On the other hand, the confidentiality of the data is guaranteed in accordance with Organic Law 3/2018 on the Protection of Personal Data and the guarantee of digital rights. Therefore, it is assured that the information obtained from the questionnaires will be used exclusively in the field of health. According to the regulation, access to the data is on direct request to the administration (Public Health Agency of Barcelona) upon request by accredited research groups, under the clause of non-transfer to third parties. Therefore, access to the data is not allowed without their consent and subrogated access is not possible. On legal grounds, data is only accessible upon request from the official administrative source to the address info@aspb.cat.


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