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. 2024 Apr 8;14(6):2544–2559. doi: 10.7150/thno.93269

Figure 4.

Figure 4

Pkd1 deletion in Ctsk+ PSPCs showed impaired fracture healing and diminished responsiveness to mechanical unloading. A Representative micro-CT images of fractured femurs from Pkd1f/f and Pkd1-Ctsk-CKO mice treated with ground and HU at 7dpf and 14 dpf. B The callus index of fractured femurs from Pkd1f/f and Pkd1-Ctsk-CKO mice treated with ground and HU at 14 dpf. (n = 6). C-E Safranin O staining showed the cartilage callus formation and woven bone area from Pkd1f/f and Pkd1-Ctsk-CKO mice treated with ground and HU at 7 dpf and 14 dpf (n = 6). Scale bar indicates 200 μm. F, G Representative images of OCN immunohistochemical staining with analysis of number of osteoblasts (n = 6). Arrows indicate OCN positive cells. Data are shown as mean ± SD. *p < 0.05, ***p < 0.001 and **** p < 0.0001. ns, no significance.