Table 2.

Risk of Reaching Disability Milestones From MS Onset in LOMS Compared With That in AOMS

	Overall		RRMS		PPMS
	HR (95% CI)	Adjusted HRa (95% CI)	HR (95% CI)	Adjusted HRa (95% CI)	HR (95% CI)	Adjusted HRa (95% CI)
From MS onset to
EDSS 4	3.11b (2.61–3.71)	2.71c (2.22–3.30)	3.04b (2.47–3.73)	3.69b (2.97–4.58)	1.09c (0.76–1.57)	1.11c (0.75–1.65)
EDSS 6	3.80c (3.11–4.64)	2.67c (2.12–3.36)	2.99c (2.28–3.91)	3.61c (2.72–4.79)	1.68c (1.20–2.33)	1.67c (1.16–2.41)

Abbreviations: CI = confidence interval; EDSS = Expanded Disability Status Scale; MS = multiple sclerosis; PPMS = primary progressive multiple sclerosis; RRMS = relapsing-remitting multiple sclerosis.

^aAdjusted for sex, calendar year at MS onset, DMT exposure (none, both, modest, or high efficay) and initial disease course (RRMS or PPMS).

^bWeibull model.

^cCox PH model.