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. 1994 Jan;39(1):49–52. doi: 10.1007/BF01517180

Local bacillus Calmette-Guérin therapy for bovine vulval papilloma and carcinoma

F W G Hill 1, V P M G Rutten 2,✉, M H Hoyer 1, W R Klein 3, J W Koten 4, P A Steerenberg 5, E J Ruitenberg 2,6, W Den Otter 4,5
PMCID: PMC11038630  PMID: 8044826

Abstract

Thirty cows from a pedigree Friesian dairy herd with bovine vulva papilloma and carcinoma were treated by intralesional injections of live bacillus Calmette-Guérin (BCG). This treatment induced total regression of all of six carcinomas. Whilst, after treatment, limited regression was also observed in advanced papillomas, BCG has little or no effect on the early stages of papillomas. This is the first study of BCG therapy in this type of cancer.

Key words: Immunotherapy, BCG, Bovine vulval papilloma-carcinoma

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