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. 1988 Jun;26(3):269–272. doi: 10.1007/BF00199940

Autologous antibodies to human bladder cancer

H Barton Grossman 1,✉, Gary Wedemeyer 1, Judith Stein 1
PMCID: PMC11038919  PMID: 3383207

Abstract

The autologous serologic reactivity of 13 patients with bladder cancer was evaluated using cell lines derived from each individual's own tumor as targets. Protein A and immune adherence assays were employed to determine antibody binding to the tumor targets at varying passage numbers. Autologous reactivity was found in 6 of the 13 cell lines tested. However, the titer was usually low regardless of the passage number. Seven autologous serum/cell line combinations were tested using both low and high passage cells as targets. In six of these combinations, the degree of antibody binding was similar with both low and high passage target cells. The incidence of autologous reactivity in the 12 patients with urothelial tumors was 50%.

Keywords: Cancer Research, Bladder Cancer, Target Cell, Antibody Binding, Tumor Target

Footnotes

This investigation was supported by PHS Grant number CA36933, awarded by the National Cancer Institute, DHHS.

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