Skip to main content
Cancer Immunology, Immunotherapy : CII logoLink to Cancer Immunology, Immunotherapy : CII
. 1985 Feb;19(1):43–45. doi: 10.1007/BF00199310

In vivo immunization against autologous glioblastoma-associated antigens

Arnold E Eggers 1,, Lila Tarmin 1, Eugenia T Gamboa 1
PMCID: PMC11039155  PMID: 3844974

Abstract

A glioblastoma patient was immunized in vivo with a mixture of autologous and homologous glioblastoma cells coupled to adjuvant peptide and cord-factor analog. Immune activity of peripheral blood lymphocytes was measured in a short-term 51chromium-release assay against autologous tumor target cells. The patient developed direct cell-mediated cytotoxicity against tumor-associated antigens, which appeared to be T-cell mediated.

Keywords: Peptide, Cancer Research, Target Cell, Immune Activity, Blood Lymphocyte

References

  • 1.Apuzzo MLJ, Mitchell MS. Immunological aspects of intrinsic glial tumors. J Neurosurg. 1981;55:1. doi: 10.3171/jns.1981.55.1.0001. [DOI] [PubMed] [Google Scholar]
  • 2.Bloom HJG, Peckham MJ, Richardson AE, Alexander PA, Payne PM. Glioblastoma multiforme: A controlled trial to assess the value of specific active immunotherapy in patients treated by radical surgery and radiotherapy. Br J Cancer. 1973;27:253. doi: 10.1038/bjc.1973.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Dick SJ, Macchi B, Papazoglou S, Oldfield EH, Kornblith PL, Smith BH, Gately MK. Lymphoid cell-glioma interaction enhances cell coat production by human gliomas: novel suppressor mechanism. Science. 1983;220:739. doi: 10.1126/science.6220469. [DOI] [PubMed] [Google Scholar]
  • 4.Eggers AE, Tarmin L, Ginsburg S. Use of covalently bound adjuvant peptide to increase tumor immunogenicity. Cancer Immunol Immunother. 1982;12:167. [Google Scholar]
  • 5.Eggers AE, Tarmin L. In vitro immunization against autologous glioblastoma cells coupled to adjuvant peptide. J Neurol Sci. 1984;63:147. doi: 10.1016/0022-510x(84)90191-6. [DOI] [PubMed] [Google Scholar]
  • 6.Eggers AE, Tarmin L, Ginsburg S. Use of covalently bound cord factor analog to increase tumor immunogenicity. J Biol Resp Mod. 1984;3:413. [PubMed] [Google Scholar]
  • 7.Harvey L, Fox M. Transferral of malignancy as a complication of organ transplantation: an insuperable problem? J Clin Pathol. 1981;34:116. doi: 10.1136/jcp.34.2.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 8.Lederer E, Adam A, Ciorbaru R, Petit JF, Wietzerbin J. Cell walls of mycobacteria and related organisms: Chemistry and immunostimulant properties. Mol Cell Biochem. 1975;7:87. doi: 10.1007/BF01792076. [DOI] [PubMed] [Google Scholar]
  • 9.Mahaley MS. Handbook of cancer immunology. New York: Garland Publishing; 1978. The immunobiology of human brain tumors; p. 399. [Google Scholar]
  • 10.Mahaley MS, Bigner DD, Dudka LF, Wilds PR, Williams DN, Boudin TW, Whitaker JN, Bynum JN. Immunobiology of primary intracranial tumors, Part 7: Active immunization of patients with anaplastic human glioma cells: a pilot study. J Neurosurg. 1983;59:201. doi: 10.3171/jns.1983.59.2.0201. [DOI] [PubMed] [Google Scholar]
  • 11.Ommaya AK. Immunotherapy of gliomas: a review. Adv Neurol. 1976;15:337. [PubMed] [Google Scholar]
  • 12.Ponten J, MacIntyre EH. Long-term culture of normal and neoplastic human glia. Acta Path Microbiol Scand. 1968;74:465. doi: 10.1111/j.1699-0463.1968.tb03502.x. [DOI] [PubMed] [Google Scholar]

Articles from Cancer Immunology, Immunotherapy : CII are provided here courtesy of Springer

RESOURCES