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. 1982 Dec;14(2):78–81. doi: 10.1007/BF00200171

Reaction of the leukocytes of melanoma patients and control donors, including pregnant women, with melanoma- and fetus-derived materials

Alistair J Cochran 1,✉, Gaye Todd 2, David M Hart 3, Lindsay J A Morrison 2, Rona M MacKie 4
PMCID: PMC11039166  PMID: 6965229

Abstract

Using a one-stage capillary leukocyte migration inhibition assay, we examined peripheral blood leukocytes from 97 patients with malignant melanoma, 194 pregnant women, and 123 non-pregnant donors for their reactivity with materials from fetal and melanomatous tissues. As in previous studies, we found melanoma extracts selectively to inhibit melanoma patients' leukocytes. First-trimester fetal extracts also selectively inhibited melanoma patients' leukocytes, suggesting their cross-reactivity with melanoma-derived antigens. We could not localize the source of the inhibitory materials within the fetuses. We found no evidence that pregnant women were selectively immunized to fetal or melanoma extracts, regardless of their parity or the stage of their pregnancy.

Keywords: Melanoma, Pregnant Woman, Cancer Research, Melanoma Patient, Inhibition Assay

References

  • 1.Alexander P. Foetal “antigens” in cancer. Nature. 1972;235:137. doi: 10.1038/235137a0. [DOI] [PubMed] [Google Scholar]
  • 2.Avis P, Lewis MG. Tumor-associated fetal antigens in human tumors. J Natl Cancer Inst. 1973;51:1063. doi: 10.1093/jnci/51.3.1063. [DOI] [PubMed] [Google Scholar]
  • 3.Baldwin RW, Price MR. Nature and expression of tumor antigens associated with experimental animals and human tumors. Ann Clin Biochem. 1976;13:488. doi: 10.1177/000456327601300146. [DOI] [PubMed] [Google Scholar]
  • 4.Bendixen G, Søborg M. A leukocyte migration technique for in vitro detection of cellular (delayed-type) hypersensitivity in man. Dan Med Bull. 1969;16:1. [PubMed] [Google Scholar]
  • 5.Castro JE, Hunt R, Lance EM, Medawar PB. Implications of fetal antigen theory for fetal transplantation. Cancer Res. 1974;34:2055. [PubMed] [Google Scholar]
  • 6.Cochran AJ. Man, cancer and immunity. London New York: Academic Press; 1978. [Google Scholar]
  • 7.Cochran AJ, Spilg WGS, MacKie RM, Thomas CE. Post-operative depression of tumor-directed cell-mediated immunity in patients with malignant disease. Br Med J. 1972;IV:67. [PMC free article] [PubMed] [Google Scholar]
  • 8.Coggin JH, Anderson NG. Cancer differentiation and embryonic antigens. Some central problems. Adv Cancer Res. 1974;19:105. doi: 10.1016/s0065-230x(08)60053-6. [DOI] [PubMed] [Google Scholar]
  • 9.Giuliano AE, Irie RF, Morton DL. Oncofetal antigen-I (OFA-I): Relative antigenicity on melanoma cells. Cancer Immunol Immunother. 1981;10:243. [Google Scholar]
  • 10.Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965;122:467. doi: 10.1084/jem.122.3.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Goldberg EH, Tokuda S. Immunological enhancement of sarcoma I by antibody to fetal antigens in syngeneic mice. Transplantation. 1976;21:263. doi: 10.1097/00007890-197603000-00013. [DOI] [PubMed] [Google Scholar]
  • 12.Gorczynsky RM. Response of tumor-related and normal lymphocytes to antigens on fibroblasts from embryos of varying age. Br J Cancer. 1978;37:786. doi: 10.1038/bjc.1978.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Hersey P, Morgan G, Stone DE, McCarthy WH, Milton GW. Previous pregnancy as a protective factor against death from melanoma. Lancet. 1977;I:451. doi: 10.1016/s0140-6736(77)91943-2. [DOI] [PubMed] [Google Scholar]
  • 14.Irie RF, Giuliano AE, Morton DL. Oncofetal antigen: A tumor-associated fetal antigen immunogenic in man. J Natl Cancer Inst. 1979;63:367. [PubMed] [Google Scholar]
  • 15.Irie RF, Irie K, Morton DL. A membrane antigen common to human cancer and fetal brain tissues. Cancer Res. 1976;36:3510. [PubMed] [Google Scholar]
  • 16.Jones PC, Sze LL, Liu PY, Morton DL, Irie RF. Prolonged survival for melanoma patients with elevated IgM antibody to oncofetal antigen. J Natl Cancer Inst. 1981;67:249. [PubMed] [Google Scholar]
  • 17.Levin L, McHardy JE, Curling OM, Hudson CN. Tumor antigenicity in ovarian cancer. Br J Cancer. 1975;32:152. doi: 10.1038/bjc.1975.144. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Matzku S, Zoller M, Ikinger U, Price MR. Organ-related and malignancy-associated reactivity of cancer patients' leukocytes: A leukocyte migration study with tumor and fetal extracts. Br J Cancer. 1979;39:516. doi: 10.1038/bjc.1980.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Ross CE, Cochran AJ, Hoyle DE, Grant RM, MacKie RM. Formalinized tumor cells in the leukocyte migration inhibition test. Clin Exp Immunol. 1975;22:126. [PMC free article] [PubMed] [Google Scholar]
  • 20.Siebert E, Sorg C, Happle R, Macher E. Membrane antigens of human malignant melanoma. III. Specificity of human sera reacting with cultured melanoma cells. Int J Cancer. 1977;19:172. doi: 10.1002/ijc.2910190206. [DOI] [PubMed] [Google Scholar]
  • 21.Sikora K, Stern P, Lennox E. Immunoprotection by embryonal carcinoma cells for methylcholanthrene-induced murine sarcomas. Nature. 1977;269:813. doi: 10.1038/269813a0. [DOI] [PubMed] [Google Scholar]
  • 22.Shaw HM, Milton GW, Farago G, McCarthy WH. Endocrine influences on survival from malignant melanoma. Cancer. 1978;42:669. doi: 10.1002/1097-0142(197808)42:2<669::aid-cncr2820420238>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  • 23.Van Furth R, Adinolfi M. Synthesis of the foetal alpha1-globulin in man. Nature. 1969;222:1296. doi: 10.1038/2221296a0. [DOI] [PubMed] [Google Scholar]
  • 24.Viza D. Human leukemoembryonic antigens. In: Anderson NG, Coggin JH, editors. Embryonic and fetal antigens in cancer, vol 1. Springfield, VA: Department of Commerce; 1971. p. 13. [Google Scholar]
  • 25.Wells SA, Burdick JF, Christiansen C, Kethcham AS, Adkins PC. Demonstration of tumor-associated delayed cutaneous hypersensitivity reactions in patients with lung cancer and in patients with carcinoma of the cervix. Natl Cancer Inst Monogr. 1973;37:197. [PubMed] [Google Scholar]
  • 26.Wilson NIL, Ross CE, MacKie RM, Cochran AJ. A study of the immunology of non-malignant melanocytic lesions. Cancer Immunol Immunother. 1979;6:27. [Google Scholar]

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