Figure 3. Increased expression of multiple blood transcription modules (BTMs) at V2D2 is predictive of higher anti-spike IgG at V2D7.

Of 30 enriched BTMs at V2D2, increased expression of 18 BTMs is predictive of increased anti-spike IgG at V2D7 (p<0.05, FDR-corrected), controlling for SARS-CoV-2 history. Predictive pathways include innate immune, antigen presentation, and T cell pathways. The eigengenes (A) and linear models (B) for three example BTMs are shown.