Table 5.

Factors independently associated with a CVD history.

Univariate Analysis				Multivariate Analysis
Variables	OR	95%CI	p Value	OR	95%CI	p Value
Age	1.051	1.020–1.082	<0.001
Sex (male)	0.238	0.109–0.519	<0.001	0.266	0.114–0.619	0.002
Duration of diabetes	1.000	1.000–1.000	0.001	1.000	1.000–1.000	0.02
Hypertension history	5.318	2.872–9.846	<0.001	4.685	2.443–8.986	<0.001
FIB-4 > 1.3	2.118	1.144–3.923	0.017	1.835	0.920–3.659	0.085

CVD: cardiovascular disease; OR: odds ratio; CI: confidence interval. Although age was significantly associated with a history of CVD in the univariate analysis, it was not included in the multivariate one. This was done to avoid multicollinearity issues, as FIB-4 is per se an age-dependent factor: [Age (years) × AST (U/L)/[PLT(109/L) × ALT1/2 (U/L)] [23].