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ATP binds nucleic-acid-binding pockets of FUS and TDP-43 RRM domains. (a) (I) Superimposition of FUS RRM (purple), TDP-43 RRM1 (blue), and RRM2 (yellow) with secondary structures labeled. (II)–(VI) ATP/AMP/PPP complexes of FUS RRM domain. (b) ATP complexes of TDP-43 RRM1 and RRM2 domains.
