Table 3.
Associations of maternal weight group and insulin resistance or beta cell function.
| Beta Maternal Weight | SE Maternal Weight | P(t) Maternal Weight | R-Squared | Model p (F) | |
|---|---|---|---|---|---|
| Models of Static Indices at Birth | |||||
| Model Set 1: Outcome HOMA2-IR | |||||
| Model 1a: Birth HOMA2-IR ~ Maternal Weight Group | 0.15 | 0.10 | 0.14 | 0.02 | 0.14 |
| Model 1b: Birth HOMA2-IR ~ Maternal Weight Group + Pregnancy Weight Gain | 0.15 | 0.10 | 0.14 | 0.02 | 0.32 |
| Model 1c: Birth HOMA2-IR ~ Maternal Weight Group + Education | 0.16 | 0.10 | 0.10 | 0.04 | 0.08 |
| Model 1d: Birth HOMA2-IR ~ Maternal Weight Group + 2nd trimester GCT glucose | 0.20 | 0.10 | 0.05 | 0.03 | 0.15 |
| ,Model 1e: Birth HOMA2-IR ~ Maternal Weight Group + Birth HOMA2-B | −0.05 | 0.07 | 0.49 | 0.53 | <0.0001 |
| Model Set 2: Outcome HOMA2-B | |||||
| Model 2a: Birth HOMA2-B ~ Maternal Weight Group | 0.27 | 0.10 | 0.007 | 0.05 | 0.007 |
| Model 2b: Birth HOMA2-B ~ Maternal Weight Group + Pregnancy Weight Gain | 0.28 | 0.10 | 0.007 | 0.06 | 0.02 |
| Model 2c: Birth HOMA2-B ~ Maternal Weight Group + Education | 0.29 | 0.10 | 0.004 | 0.07 | 0.01 |
| Model 2d: Birth HOMA2-B ~ Maternal Weight Group + 2nd trimester GCT glucose | 0.35 | 0.10 | 0.0005 | 0.1 | 0.002 |
| Model 2e: Birth HOMA2-B ~ Maternal Weight Group + Birth HOMA2-IR | 0.17 | 0.07 | 0.02 | 0.55 | <0.0001 |
| Models of Static Indices at 7 months | |||||
| Model Set 3: Outcome HOMA2-IR | |||||
| Model 3a: HOMA2-IR ~ Maternal Weight Group | 0.20 | 0.13 | 0.11 | 0.02 | 0.11 |
| Model 3b: HOMA2-IR ~ Maternal Weight Group + Pregnancy Weight Gain | 0.20 | 0.13 | 0.12 | 0.03 | 0.18 |
| Model 3c: HOMA2-IR ~ Maternal Weight Group + Education | 0.16 | 0.13 | 0.20 | 0.02 | 0.20 |
| Model 3d: HOMA2-IR ~ Maternal Weight Group + 2nd trimester GCT glucose | 0.22 | 0.13 | 0.09 | 0.03 | 0.17 |
| Model 3e: HOMA2-IR~ Maternal Weight Group +HOMA2-B | −0.02 | 0.06 | 0.66 | 0.82 | <0.0001 |
| Model 3f: HOMA2-IR~ Maternal Weight Group +Birth HOMA2-B | 0.25 | 0.13 | 0.05 | 0.03 | 0.11 |
| Model Set 4: Outcome HOMA2-B | |||||
| Model 4a: HOMA2-B~ Maternal Weight Group | 0.14 | 0.07 | 0.05 | 0.03 | 0.048 |
| Model 4b: HOMA2-B~ Maternal Weight Group + Pregnancy Weight Gain | 0.14 | 0.07 | 0.05 | 0.03 | 0.10 |
| Model 4c: HOMA2-B~ Maternal Weight Group + Education | 0.12 | 0.07 | 0.10 | 0.03 | 0.16 |
| Model 4d: HOMA2-B~ Maternal Weight Group + GCT glucose | 0.14 | 0.07 | 0.06 | 0.03 | 0.15 |
| Model 4e: HOMA2-B~ Maternal Weight Group + HOMA2-IR | 0.04 | 0.03 | 0.21 | 0.82 | <0.0001 |
| Model 4f: HOMA2-B ~ Maternal Weight Group + Birth HOMA2-IR | 0.15 | 0.07 | 0.04 | 0.03 | 0.11 |
| Models of Dynamic Indices at 7 Months | |||||
| Model 5a: Insulinogenic Index~ Maternal Weight Group | 0.12 | 0.12 | 0.31 | 0.009 | 0.31 |
| Model 5b: Insulinogenic Index~ Maternal Weight Group + HOMA2-IR | 0.09 | 0.11 | 0.44 | 0.17 | <0.0001 |
| Model 5c: Disposition Index ~ Maternal Weight Group | 0.02 | 0.13 | 0.87 | 0.0002 | 0.87 |
| Model 5d: Disposition Index ~ Maternal Weight Group + HOMA2-IR | 0.08 | 0.11 | 0.48 | 0.31 | <0.0001 |
Legend Table 3. Log-transformed values for HOMA2-IR, HOMA2-B, insulinogenic, and disposition indices were used in all models. Maternal weight group was modeled as a categorical variable of 3 levels (2 df). Abbreviations: GCT, glucose challenge test.