Table 4.

Average percentage composition of statistically significant (ANOVA test) intestinal microbiota genera and species in CRC-induced animals for the four cohorts studied. Asterisks indicate the level of significant difference compared to the control cohort. Cohort 1: PBS administration; Cohort 2: quercetin administration; Cohort 3: luteolin administration; Cohort 4: xanthohumol administration. Asterisks indicate statistically significant differences (* p < 0.05; ** p < 0.005; *** p < 0.0005; **** p < 0.0001).

Genus	Cohort 1 (%)	Cohort 2 (%)	Cohort 3 (%)	Cohort 4 (%)
Muribaculum	0.24	0.37 ***	0.56 ****	0.44 ****
Bilophila	0.18	0.29	0.80 ***	0.49
Christensenellaceae R-7	0.76	0.27	0.08 **	0.66
Clostridia UCG-014	4.37	3.64	1.88 **	4.94
Eubacterium xylanophilum group	1.40	0.71 *	0.31 **	0.69 *
Uncultured (Oscillospiraceae)	3.99	4.84	6.06 *	4.72
Uncultured (Ruminococcaceae)	0.45	0.46	1.27 ****	0.98 **
“Candidatus Saccharimonas”	0.35	2.06 **	1.07	1.28
Parasutterella	0.01	0.02	0.03	0.16 *
Turicibacter	0.77	0.46	0.07 **	0.40
Gastranaerophilales	0.20	0.25	0.22	0.71 *
Uncultured (Erysipelotrichaceae)	0.02	0.13 *	0.06	0.02
Species
Bacteroides sp.	0.23	0.27	1.45 **	1.04
Eubacterium sp.	0.06	0.33	0.30	0.58 *
Coprostanoligenes group
UCG-005 metagenome	0.05	0.13 *	0.08	0.08