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. 2024 Mar 22;29(5-6):785–798. doi: 10.1007/s10495-024-01950-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — LIPUS regulates mouse articular cartilage through primary cilia. A COL II Cre;Ift88^fl/fl mice induced knockdown, mouse OA modeling and LIPUS intervention procedure; B Expression of ACAN, COL II, BIP, TUNEL and Primary cilia; ACAN aggrecan, COL II collagen II, BIP Immunoglobulin heavy chain binding protein, TUNEL TdT-mediated dUTP nick end labeling, KO Cartilage-Specific IFT88 Flox mice, N sham, NU sham + Low intensity pulsed ultrasound, OA osteoarthritis, OAU osteoarthritis + Low intensity pulsed ultrasound