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. 2024 Apr 29;19(4):e0302147. doi: 10.1371/journal.pone.0302147

The cross-sectional association of parental psychosocial status with children’s Body Mass Index z-score and the mediating role of children’s energy balance behaviors - the ABCD Study

Meredith L Overman 1,2,3,4,*, Tanja Vrijkotte 4,5, Yolanda M Sánchez Castro 3,4, Margreet W Harskamp-van Ginkel 4,5, Monica Hunsberger 6, Carry M Renders 4,7, Stef P J Kremers 1,2, Mai J M Chinapaw 3,4
Editor: Henri Tilga8
PMCID: PMC11057752  PMID: 38683830

Abstract

Objective

Investigate the cross-sectional association between the psychosocial status of mothers and fathers and the BMI z-scores of their 10 to 12-year-old children. Explore whether this association is mediated by children’s diet, physical activity, screen time and sleep. Analyze the moderating effect of the educational levels of both the mother and father on the association.

Design

In a cross-sectional study design, children’s height and weight were measured following a standardized protocol. Parents completed the validated Depression Anxiety and Stress questionnaire, while diet quality, sports participation, time spent in bed and screen time were assessed through child-report using previously validated questions.

Participants

The data for this study were obtained from the Amsterdam Born Children and their Development study, involving children aged 10 to 12 years and both of their parents (N = 1315).

Results

The majority, 80%, of the parents were highly educated and born in the Netherlands, and 68% of the children had a healthy BMI. Maternal or paternal psychosocial status was not significantly associated with children’s BMI z-score (maternal β -0.0037; 95% CI: -0.008 to 0.0007, paternal β 0.0028; 95% CI: -0.007 to 0.002). Screen time mediated the association between paternal psychosocial status and children’s BMI z-score (β = 0.010, 95% CI: 0.002; 0.020). Children’s diet, physical activity, and sleep did not mediate the association between paternal psychosocial status and children’s BMI z-score. Parental educational level was not a moderator.

Conclusions

This research is unique in including four energy balance behaviors and including both mothers and fathers’ psychosocial status. Children withfathers experiencing poorer psychosocial status engaged in more screen time which partly explained their higher BMI z-score.

1. Introduction

Childhood overweight and obesity are global public health issues. Behavioral determinants of overweight and obesity are the consumption of energy dense food and beverages, lack of physical activity, lack of sleep and excessive screen time [1–5]. These behaviors are, in turn, influenced by the interplay between environmental and individual factors [6]. Parents are part of their children’s social environment and influence above mentioned energy balance behaviors, for example, through parenting practices and creating a more or less healthy home environment [7].

Previous research found that parental psychosocial status, defined as the interplay between depression, anxiety and stress levels, was associated with childhood energy balance behaviors [7–11] or BMI [7,12,13]. Children, whose parents had a higher stress level, had less opportunities for physical activity than children with less stressed parents [14]. Furthermore, higher levels of parental stress has been associated with lower TV restrictions for children [14,15]. Maternal, depressive symptoms have been associated with children’s sleep/wake problems and paternal depressive symptoms with shorter time in bed of children and fewer sleep minutes [16]. Zarychta, et al. [9] found that higher levels of parental depression were associated with higher levels of child BMI, which was mediated by physical activity. Shankardass et al. [11], found that higher physical activity and higher parental education partially explained the relationship between parental stress and preadolescent BMI.

No previous studies have examined the interplay between depression, anxiety and stress, of both mother and father separately in relation to children’s energy balance behaviors and BMI z-score. Although both mother and father play a pivotal role in guiding their children to a healthy diet, physical activity, and sleep [17], childhood obesity research has predominantly focused on the mother’s role [18–20]. Therefore, the current study explores the independent association of both maternal and paternal psychosocial status with children’s BMI z-score. Furthermore, we examined whether this association was mediated by children’s dietary intake, sports participation, time in bed and screen time. As parents with higher levels of education tend to have children with healthier energy balanced-behaviors [21,22] and lower BMI, we also examined the potential moderating (i.e. effect modifying) role of parental educational level.

We hypothesized that increased parental depression, anxiety and stress, whether experienced by the mother or father, would be associated with increased BMI z-scores in their children. Further, we hypothesized that this association is partly mediated by children’s dietary intake, sports participation, time in bed and screen time. Finally, we hypothesized that the association between parental psychosocial status and children’s energy balance-related behavior is stronger among children from parents with a lower educational level.

2. Methods

2.1 Study design

We utilized cross-sectional data from phase 4 of the Amsterdam Born Children and their Development (ABCD) study collected in 2015. The ABCD study is a prospective ongoing population-based cohort study that examines the association between maternal lifestyle, health, psychosocial and environmental circumstances during pregnancy, and children’s health at birth and later in life (http://www.abcd-study.nl/). Details about the ABCD study, including its design, conceptual framework and measurements have been described previously [23]. Phase 4 of the ABCD study focused on children 10 to 12 years old and both their parents.

This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by the Central Committee on Research Involving Human Subjects in The Netherlands; the medical ethics review committees of the Academic Medical Center, Amsterdam; the VU University Medical Center Amsterdam; and the Registration Committee of the Municipality of Amsterdam. The Ethics approval numbers for the different parts of the ABCD-study are: (1) Pregnancy questionnaire: METC AMC 02/039#02.17.392; (2) Questionnaires and health check at age 5–6: METC AMC 02/039#07.17.1039; (3) Questionnaires and health check at age 11–12: METC AMC 2015_154#B2015655a.

Written informed consent was obtained from each mother upon enrollment in the study and again at age 5, as part of preventive health monitoring by the ministry of health. Additionally, written informed consent was obtained from the child starting at age 12 and participating fathers.

The study has been reported in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology–Nutritional Epidemiology (STROBE-nut) guidelines for nutritional epidemiological research guidelines [24].

2.2 Study population

In 2002 and 2003, all pregnant women in Amsterdam were invited to participate in the ABCD study during their first appointment with the obstetrician. Subsequently, mothers were asked for permission to track their child’s development by sending invitations every five years. In relation to phase 4, the first questionnaire was filled out on March 5th, 2015, and the father questionnaire (the most recent one) was filled out by May 21st, 2017. Physical measurements were taken during this follow-up period.

Phase 4 marked the first-time fathers were invited to participate. In total, 3018 children, 2997 mothers, and 2264 fathers completed a questionnaire (Fig 1). Data on BMI were obtained from ABCD’s physical examination [23] or if unavailable the Amsterdam Youth Health Care data. Mother-father-child trios with complete data for both parents and child were included. We included all parents who filled in the mother and father’s questionnaire, regardless of whether they were the biological parent or not. Our study does not include children with same sex parents or from single households. The final sample size included 1315 mother-father-child trios.

Fig 1. ABCD phase 4 data selection.

Fig 1

2.3 Measurements

2.3.1 Children’s Body Mass Index (BMI) z-score

Children’s height and weight were measured according to a standardized protocol by trained nurses at the Youth Health Care center (n = 1503), or the ABCD health check (n = 590). In case both measurements were available, the ABCD measurement was used since it was closest to the questionnaire data. Each Child’s Body Mass Index was calculated (BMI z-score; calculated as weight (kg)/height (m2)) and converted into BMI z-scores, using age and sex adjusted reference tables [25].

2.3.2 Parental psychosocial status

Both mother and father completed the validated Depression Anxiety and Stress questionnaire (DASS-21) with 21 items regarding their feelings and behaviors related to psychological issues [26]. Depression was assessed with questions such as “I did not experience any positive feeling”, Anxiety, with questions such as, “I experience breathing difficulty (e.g., excessively rapid breathing, breathlessness in the absence of physical exertion)” and for stress, questions such as “I found it difficult to relax” were included. The questions were answered on a four-level scale, from (almost) never (0) to very often (3). We computed a total score of the DASS 21 including all three psychopathologies per parent. Since depression, anxiety and stress are correlated moderately high, using the total parental psychosocial status score gives a general impression of parental psychological status [26,27]. The total score ranges from 0 to 63, from no to severe psychological distress.

2.4 Potential mediators

All energy balance-related behaviors were assessed by child report.

2.4.1 Diet quality score

The ABCD study selected relevant items from existing questionnaires to assess children’s food intake [28,29]. The dietary intake questionnaire covers four food groups: fruits (excluding juice), vegetables, snacks (e.g. biscuit, candy, chocolate, crisps) and sugar-sweetened beverages (SSBs) (i.e. fruit juice, soft drinks). Fruit and vegetable intake were assessed in servings per day. Snack intake was assessed in portions per day. Children were asked how many glasses of SSBs they drank on average during a school day and a weekend day. For each food group, the number of servings per day was divided into quartiles. Each quartile was rated 1 to 4. Based on that, a total Diet Quality Score was calculated. The minimum score was four representing an unfavorable consumption of SSB, snacks, fruits and vegetables. The maximum score was sixteen representing a favorable consumption of SSB, snacks, fruits and vegetables. Missing scores were imputed if at least two dietary components were available. The calculation of the Diet Quality Score is in line with a study conducted as part of the broader ABCD study [30].

2.4.2 Sports participation

Sports participation included the items "do you practice any sport?", "If yes, how many hours do you practice this sport per week? (including training and matches)". If the child played more than one organized sport the same question was repeated up to three times. Based on these items, a MET-score was calculated by multiplying the total hours of sports participation with the metabolic equivalent for that sport [31]. If the child reported more than one sport, the same procedure was followed and then added up to obtain a final score.

2.4.3 Time in bed

For time in bed children answered the following questions: “At what time do you usually go to bed?" and "At what time do you usually get up?" separately for school days and weekends. The average time in bed on a school day was multiplied by 5 and the average time in bed on the weekends was multiplied by two. Subsequently, we calculated the average number of hours spent in bed.

2.4.4 Screen time

Screen time included two questions: "How long do you usually watch TV in your spare time, per day?" and "How long do you usually use a computer, game console, tablet, mobile, and laptop, per day?". These questions were answered separately for school days and weekends. The average screen time on a school day was multiplied by 5 and the average screen time on the weekends was multiplied by two. Following that, we computed the average number of hours of screen time.

2.5 Moderator—maternal and paternal education

Mothers and fathers self-reported their highest level of education, which we categorized as low (primary school/technical secondary education or lower vocational secondary school), medium (degree in higher vocational secondary education/academic secondary education/intermediate vocational education) or high (degree in higher vocational education/university).

2.6 Covariates

In the respective analyses, the place of birth of the mother or father (Netherlands, Other Western, Non-western country) served as a covariate. Parental BMI was calculated as weight (kg)/height (m2) from self-reported data.

2.7 Statistical analyses

The final analysis includes complete mother-father-child trios and was performed using IBM SPSS package version 26.0 (SPSS Inc., Armonk, NY, USA). Covariates were organized in a DAG using DAGGity and a minimal adjustment set was identified: parental BMI; and DASS score of the other parent; (see Figs 2 and 3) [32]. First, we examined the association of maternal and paternal psychosocial status, respectively, with child’s BMI z-score using linear regression (total effect). Second, we performed a multivariable mediation analysis including the potential mediators: diet quality score, sports participation, time in bed and screen time using model 4 of the PROCESS macro with 5000 bootstrap samples for calculating 95% confidence intervals [33]. Multiple mediation models separate the direct and indirect effect of X and Y through the different mediators, with the condition of no causal influence between mediators. Both models were adjusted for place of birth of the parent, parent BMI and the counter parent’s psychosocial status. In the final step, we conducted tests for moderated mediation, with the educational level of the respective parent serving as the moderator (i.e. effect modifier) in the association between parental psychosocial status and the potential mediators. In case of a significant interaction between parental psychosocial status and educational level (p<0.10), we performed a stratified mediation analysis using model 8 of Andrew Hayes [34]. Hayes moderated mediation analysis works through conditional processing analysis. Hayes’ methods combined the estimation of the direct and indirect effects of parental educational level on children’s BMI z-score, through the proposed mediators followed by an inferential test for such indirect effects. We did not adjust for multiple testing but instead report effect sizes, confidence intervals, and p-values of all performed analyses to enable readers using their own judgment about the relevance of the observed associations. Furthermore, in this study, we consider mediation even if the association between the main exposure and outcomes is not statistically significant, as mediation analyses provide a more complete picture of associations by explaining working mechanisms [35].

Fig 2. Association between maternal psychosocial status and child BMI including moderation by maternal educational level and mediation by energy balance behaviors.

Fig 2

Fig 3. Association between paternal psychosocial status and child BMI including moderation by paternal educational level and mediation by energy balance behaviors.

Fig 3

3. Results

Table 1 presents the characteristics of the study sample. In total, 1315 mother-father-child trios had complete data on children’s BMI z-score, dietary intake, sports participation, time in bed and screen time. The mean BMI z-score of the children was -0.27 and 10% of the children had overweight. The mean diet quality score was 8.3 ranging from 4 to 16. With regard to sports participation, the mean value was 28.6 MET/hours per week. The mean hours in bed were 10.5, and mean screen time 3.1 hours per day, ranging from 1 to 10 hours per day. Twenty-three percent of the mothers and 45% of the fathers had overweight. Furthermore, 81% of the mothers and 75% of the fathers had a high educational level. The mean psychosocial status score was 11.3 for mothers and 10.7 for fathers.

Table 1. Characteristics of children, their mothers and fathers: Amsterdam born children and their development cohort study.

  N Mean (SD)
Children
Age, years 1315 11.4 (0.7)
BMI z-score 1315 -0.27 (1.0)
BMI categorical Underweight 289 22%
Normal weight 891 67.8%
Overweight 135 10.3%
Time in Bed (Hrs/24 hours) 1315 10.5 (0.5)
Diet Quality Score (4–16 Pts) 1315 8.3 (2.2)
Screen Time (Hrs/day) 1315 3.1 (1.4)
Sport Participation (MET hours/week) 1315 28.6 (14.9)
Sex Girls 659 50.1%
Mother
Place of birth Netherlands 1133 86.2%
Other Western Country 84 6.4%
Other Non-Western Country 98 7.5%
Mother BMIa Underweight 31 2.4%
Normal weight 977 74.3%
Overweight 307 23.3%
Psychosocial Status (0–63 Pts) 1315 11.3 (11.2)
Educational Level Low and Medium 246 18.7%
High 1069 81.3%
Father
Place of birth Netherlands 1135 86.3%
Other Western Country 66 5.0%
Other Non-Western Country 114 8.7%
Father BMIa Underweight 5 0.4%
Normal weight 719 54.7%
Overweight 591 44.9%
Psychosocial Status (0–63 Pts) 1315 10.7 (11.6)
Educational Level
Low and Medium 320 24.3%
High 995 75.7%

aBMI = Body Mass Index.

3.1 Multiple mediation analysis

Tables 2 and 3 present the association of maternal and paternal psychosocial status, respectively with children’s BMI z-score, and potential mediation by children’s diet, sports participation, time in bed, and screen time. Neither maternal psychosocial status (β -0.0037; 95% CI: -0.008 to 0.0007) nor paternal psychosocial status (paternal β 0.0028; 95% CI: -0.007 to 0.002) were significantly associated with children’s BMI z-score. Maternal psychosocial status was not significantly associated with any of the four energy balance behaviors. Poorer paternal psychosocial status was associated with more screen time (β 0.009; 95% CI: 0.003 to 0.016), but not with the other energy balance behaviors. Three out of four mediators were significantly associated with BMI-z-score, although associations were small: less time in bed (β -0.126; 95% CI: -0.216 to -0.036), a higher diet quality score (β 0.046; 95% CI: 0.023 to 0.688) and more screen time (β 0.090; 95% CI: 0.056 to 0.128) were associated with a higher BMI-z-score. Screen time was a significant mediator of the association between paternal psychosocial status and children’s BMI z-score (a*b: β = 0.010 (95% CI: 0.002; 0.020). No other significant mediation effects were found. Parental educational level did not moderate the association between parental psychosocial status and children’s energy balance-related behaviors.

Table 2. The association between maternal psychosocial status and child BMI z-score and potential multiple mediation by energy balance behaviors (n = 1315).

  Maternal PSa → Mediator Mediator → BMIb z-score Mediation →
Mediator a-path (bootstrapped 95% CI) b-path (bootstrapped 95% CI) (a x b) (bootstrapped 95% CI)
Time in bed β = -0.0001 (95% CI: -0.0028; 0.0026) β = -0.126 (95% CI: -0.216; -0.036) β = 0.0001 (95% CI: -0.0038; 0.0045)
Diet quality score β = 0.004 (95% CI: -0.007; 0.014) β = 0.046 (95% CI: 0.023; 0.688) β = 0.002 (95% CI: -0.004; 0.008)
Screen Time β = -0.002 (95% CI: -0.009; 0.005) β = 0.090 (95% CI: 0.052; 0.128) β = -0.002 (95% CI: -0.010; 0.005)
Sport participation β = -0.053 (95% CI: -0.126; 0.020) β = 0.002 (95% CI: -0.001; 0.006) β = -0.001 (95% CI: -0.005; 0.001)
indirect effect β = -0.0016 (95% CI: -0.012; 0.009)
direct effect (maternal PS → BMI z-score) β = -0.0036 (95% CI:-0.008; 0.001)
Total Effect β = -0.0037 (95% CI:-0.008; 0.0007)

aPS = psychosocial status

bBMI = Body Mass Index.

Full model adjusted for Paternal BMI, Maternal BMI, Paternal psychosocial status, place of birth of the parent.

Bold indicates a significant association.

Table 3. The association paternal psychosocial status and child BMI z-score and potential multiple mediation by energy balance behaviors (n = 1315).

  Paternal PSa → Mediator Mediator → BMIb z-score Mediation
Mediator a-path (bootstrapped 95% CI) b-path (bootstrapped 95% CI) (a x b) (bootstrapped 95% CI)
Time in bed β = -0.0001 (95% CI:-0.0027; 0.0025) β = -0.126 (95% CI: -0.216; -0.036) β = 0.0002 (95% CI: -0.0046; 0.0049)
Diet quality score β = -0.009 (95% CI:-0.019; 0.002) β = 0.046 (95% CI: 0.023; 0.688) β = -0.005 (95% CI: -0.011; 0.001)
Screen Time β = 0.009 (95% CI: 0.003; 0.016) β = 0.090 (95% CI: 0.052; 0.128) β = 0.010 (95% CI: 0.002; 0.020)
Sport participation β = -0.046 (95% CI: -0.116; 0.025) β = 0.002 (95% CI: - 0.001; 0.006) β = -0.001 (95% CI: -0.005; 0.001)
indirect effect β = 0.0038 (95% CI: -0.008; 0.016)
direct effect (paternal PS → BMI z-score) β = -0.0031 (95% CI: -0.007; 0.001)
Total Effect β = 0.0028 (95% CI: -0.007; 0.002)

aPS = psychosocial status

bBMI = Body Mass Index.

Full model covariates: Paternal BMI, Maternal BMI, Maternal psychosocial status, place of birth of the parent.

Bold indicates a significant association.

4. Discussion

This cross-sectional study provides insight into the association between maternal psychosocial status and children’s BMI z-score, independently from paternal psychosocial status and vice versa. Parental psychosocial status was not significantly associated with children’s energy balance behaviors nor their BMI z-score. However, time in bed, dietary quality and screen time were significantly associated with children’s BMI z-score. Only screen time appeared a significant mediator in the association between paternal psychosocial status and children’s BMI z-score. Children of fathers with 10 points higher psychosocial score had 5 min/day more screen time, and children with 1 hour/day more screen time had 0.09 points higher BMI z-score. Parental educational level did not moderate the association between parental psychosocial status and children’s energy balance-related behaviors.

Most parents in the current study were highly educated (81% of the mothers and 76% of the fathers). Since higher educated parents tend to have fewer psychosocial complaints this may explain the lack of significant associations,. Moreover, children from highly educated parents tend to engage in more physical activity, less screen time, have a higher intake of fruit, vegetables [21,22] and a lower BMI [36]. Previous studies found that children from parents with low levels of anxiety and stress were also more likely to engage in healthy habits. In our sample we indeed found a significant association between parental psychosocial status and screen time.

The sample characteristics reflect that our sample was relatively healthy. For example, most parents had normal levels of psychosocial status according to the DASS-21 score [26]. Similarly, the four energy balance behaviors were on average in line with WHO recommendations [1].

Regarding the association between parental psychosocial status and children’s BMI, our findings are in line with Walton et al. [14] who found no significant association between parental stress and children’s BMI z-score either. Other studies found a significant association of parental depression or stress, with children’s BMI [7,9,11–13]. Regarding the association between parental psychosocial status, and energy balance-related behaviors, results of previous studies are inconsistent. Parks et al. found no significant association between parent’s stressors or parent-perceived stress and children’s physical activity. Consistent with our findings, neither of these studies found an association between parental stress and dietary intake of the children [10,37]. El Sheikh [16] found that higher parental depressive symptoms was associated with sleep/awake problems and shorter time in bed, which was contrary to our findings. Some studies found that higher stress levels of parents were associated with lower physical activity, less screen time restrictions and higher sedentary behavior [10,14,15]. Less rules and restrictions can result in more screen-based or sedentary behaviors among children [15,38]. In our study, screen time was indeed a mediator in the association between paternal psychosocial status and BMI z-score.

In line with previous literature, less time in bed and more screen time were associated with higher child BMI z-scores [1,2,4,5]. Contrary to our hypothesis and previous literature, we found that children with a better diet quality score had a higher BMI z-score. This might be explained by children’s social desirable answering [39]. Peer influence, body image concerns and diet intake become more relevant for pre-adolescences, resulting in under and over reporting of dietary behaviors [40]. Another explanation may be that children with a higher BMI z-score are more conscious of their dietary behaviors or parents may set more rules to prevent further increases in the BMI z-score. Sport participation was not significantly associated with children’s BMI z-score. One explanation may be that we did not include all types of physical activity contributing to energy expenditure such as active transport or outdoor play.

4.1 Strengths and limitations

A major strength and distinctive aspect of our study is that we have data on the psychosocial status of both mothers and fathers. In research fathers are often underrepresented. Another major strength is the substantial sample size. 1,315 mother-father-child trios is more than in other comparable studies on the association between the psychosocial status of mothers or fathers and the BMI of their children [7,9,10,12]. Moreover, height and weight of the children were measured by trained personnel according to standardized procedures. BMI remains a valuable screening tool, especially at the population level, to identify individuals potentially at risk of being overweight or underweight. We used the BMI z-score i.e. BMI adjusted for age and sex of the child. However, it is important to acknowledge that BMI also has limitations. BMI lacks precision in distinguishing between muscle and fat mass and our reference values were not specific for ethnicity. Although sports participation is not a perfect measure of overall physical activity, organized sports participation is associated to overall moderate to vigorous physical activity as well as compliance with physical activity guidelines [41,42]. In addition, we did not consider parents’ dietary habits and physical activity. Hence, our understanding of shared family dynamics related to energy balance behaviors is limited. Furthermore, we used frequently used validated questionnaires, enabling comparison with previous studies. However, this study utilized the Diet Quality Score to assess the consumption of fruits, vegetables, snacks, and sugar-sweetened beverages which has not been validated to date. However, the Diet Quality Score includes pivotal elements of children’s dietary pattern that have been shown to be associated with future health [28,29]. Moreover, this self-report of energy balance behaviors may suffer from recall bias and social desirable answering, which might have led to over- and underreporting. This can be considered a limitation. Furthermore, the cross-sectional design of the ABCD study prohibits conclusions regarding a temporal causal relationship between variables. Another limitation is that we did not include data from households with single parents or with same-sex parents. Moreover, we lacked information on biological parenthood. Nonetheless, despite these limitations, this research is unique in including four energy balance behaviors and including both mothers and fathers psychosocial status.

4.2 Recommendations

We observed a significant association between paternal psychosocial status and screen time, and between screen time and children’s BMI z-score. However, more research is needed to confirm and further explain the association between paternal psychosocial status and children’s BMI z-score through screen time. Future research should be carried out in more diverse, at risk groups in order to understand how parental psychosocial status might affect children’s BMI z-score through energy balance-related behaviors.

5. Conclusion

In conclusion, children with fathers experiencing poorer psychosocial status engaged in more screen time which partly explained a higher BMI z-score. We found no other mediating effects of energy balance behaviors, and there were no other significant associations between parental psychosocial status and children’s BMI z-score.

Supporting information

S1 Checklist

(DOCX)

pone.0302147.s001.docx (53.2KB, docx)
S1 Table. STROBE-nut: An extension of the STROBE statement for nutritional epidemiology.

(DOCX)

pone.0302147.s002.docx (34KB, docx)

Acknowledgments

The authors thank all participating mothers, fathers and their children for their time and involvement in the ABCD cohort study. In addition, we thank Roel Hermans, PhD, who provided valuable feedback on the manuscript in an early stage.

Data Availability

Due to ethical considerations, the individual data from the ABCD study cannot be deposited in a public repository. This decision is guided by the need to protect the privacy and confidentiality of the study participants. The data contains potentially identifying or sensitive information about the participants, and releasing it publicly could breach their privacy rights. The ABCD data are owned by the Amsterdam University Medical Centers, location AMC in Amsterdam, The Netherlands. Any researcher can request the data by submitting a general publication proposal form to the ABCD Project Team as outlined at https://www.amc.nl/web/abcd-studie-2/abcd-studie/voor-onderzoekers-.htm under section use of data (Dutch: Gebruik van data), by email: abcd@amsterdamumc.nl. The ABCD Project Team will check proposals for compatibility with the general objectives, ethical approvals and informed consent forms of the ABCD study, that are in line with the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants approved by the Central Committee on Research Involving Human Subjects in The Netherlands; the medical ethics review committees of the Academic Medical Center, Amsterdam; the VU University Medical Center Amsterdam; and the Registration Committee of the Municipality of Amsterdam. There are no other restrictions to obtaining the data and all data requests will be processed in the same manner.

Funding Statement

This research is part of the Lifestyle Innovations Based on Youth Knowledge and Experience (LIKE) program and is supported by a grant from the Netherlands Cardiovascular Research Initiative: an initiative with support of the Dutch Heart Foundation, ZonMw, CVON2016‐07 LIKE, and Sarphati Amsterdam. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Decision Letter 0

Henri Tilga

10 Dec 2023

PONE-D-23-29554The association of parental psychosocial status with children’s Body Mass Index and the mediating role of children’s energy balance behaviors - the ABCD StudyPLOS ONE

Dear Dr. Overman,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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Henri Tilga, PhD

Academic Editor

PLOS ONE

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Additional Editor Comments:

The Reviewers have provided several useful comments to increase the quality of this manuscript. Please carefully follow all the comments made by the Reviewers and revise the manuscript accordingly.

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: No

Reviewer #2: No

**********

2. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: No

Reviewer #2: No

**********

3. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

Reviewer #2: No

**********

4. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

Reviewer #2: No

**********

5. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Dear PLOS ONE editor and authors

I've commented on the manuscript for improving readability.

General comments

The main issue with this manuscript is that statistical analyses do not match the study's aim, and the results do not support the authors' conclusion. I've described the reasons below.

Title

1. I prefer using "The cross-sectional association of ..." instead of " The association of ...".

Abstract

2. Please indicate the results of mediation analyses on children’s diet, physical activity, and sleep.

Introduction

3. I disagree that educational level serves as a potential mediator. Parent educational levels are just a confounder, not a mediator. Current psychological stress never causes low socio-economic status.

4. In addition to the above comment, the authors appear to confuse mediation with effect modification. Please revise sentences in the introduction section distinguishing these concepts.

Materials and methods

5. If the dietary quality score has been validated, please refer to a corresponding paper. If not, please describe the limitation of nonvalidating in the discussion section.

6. Please explain why children's age and sex were not included as covariates.

7. In addition to comment 6, there can be other potential confounders. Referring to previous studies, please confirm covariates in this study are sufficient for analyses.

8. Paternal and maternal psychosocial status should be adjusted simultaneously. This is because mothers whose partners have poorer psychosocial status tend to exhibit worse psychosocial status, the effect of paternal psychosocial status can include maternal ones, and vice versa.

9. The authors have a typo, misspelling "SPSS" as "SPS."

Results

10. Because the main exposures were not significantly associated with the outcome, the interpretation of the subsequent mediator analyses is questionable. If such interpretation is permissible, the authors must cite supporting literature.

Discussion

11. The argument of this paper seems inconsistent with the results. Considering the lack of a significant association and the small beta from linear regression models, it would be accurate to conclude that there was no association between parental psychosocial status and children's Body Mass Index.

Reviewer #2: The authors investigated if there is an association between parental depression, anxiety, or stress symptoms are associated with their children’s (aged 10 - 12 years) body mass index (adjusted for age and sex). The study was performed using data from 1,315 children and their parents participating in the Amsterdam Born Children and their Development (ABCD) study.

Unfortunately, I cannot recommend this manuscript for publication as I firmly believe there are fundamental issues with the study measures used to assess diet quality and physical activity and the statistical analyses performed. Furthermore, the small sample size and lack of replication mean that the publication of these results would only contribute to the reproducibility problem and further erode the public’s trust in scientific research, without providing any positive impacts to the ABCD Study participants, the general public, or the medical and scientific communities.

Below I have provided a few general comments before listing my concerns with the study.

General comments:

• BMI is a different measurement to weight and using these terms interchangeably (for example in the short title) is both factually incorrect and misleading.

• The use of very long sentences throughout makes this manuscript hard to read.

• There are grammatical, nomenclature, and English language mistakes throughout the manuscript.

• It was not mentioned if adjustment for multiple testing was performed.

Concerns:

• The BMI mathematical formula was devised based on the average Western European man’s physical characteristics and does not (1) distinguish between excess body fat, bone mass, or musculature, (2) interpret the distribution of fat (which is a predictor of negative health outcomes such as type 2 diabetes and heart disease), and (3) cannot distinguish between sex, age, or ethnicity.

o The authors highlight that this is a muti-ethnic study, however, the BMI formula’s inability to distinguish between ethnicities has not been addressed in the study. Also age and sex adjusted reference tables were used to create the z-scores for the children, however, this was not done for the parents.

o Furthermore, there is an ever-growing body of evidence showing that BMI should not be used as a standalone tool for categorising individuals as overweight or obese (or getting a full overview of an individual’s overall health). Rather, multiple measures should be considered, including: body adiposity index, waist circumference, and waist-to-hip index.

• The dietary quality score used in the study does not include the five standard food groups. Therefore, a comprehensive overview of the child’s diet is not used by the study.

• The study only included sports participation as a measure of physical activity. This oversimplifies the possible physical activities the child could be performing on a regular basis, such as riding their bicycle or running. Furthermore, the parents’ diet or activity levels were not included, which is a massive limitation as shared family dynamic was not investigated.

• Although the study has data on full mother-father-child trios the analyses were performed on parent-child dyads. The authors state that: “We included all parents who filled in the mother and father’s questionnaire, regardless of whether they were the biological parent or not. Our study does not include children with same sex parents or from single households.”. I have concerns about the authors choice to conduct analyses separately for each parent, rather than looking at the complete family. Furthermore, sensitivity analyses should have been performed for non-biological relationships to disentangle the direct and indirect familial effects. Finally, the exclusion of children from households with single parents and same-sex couples prevents the results to be generalisable to the general population.

• The authors state “Another major strength is the considerable sample size.”, however, the study included only 1,315 mother-father-child trios. Given this small sample size, I have considerable concerns about the statistical power the study has to identify a true effect of parental psychosocial status with children’s BMI (or the potential study mediators: children’s diet, sports participation, time in bed, and screen time). Furthermore, no replication analyses were performed, therefore, no evidence that the findings are reliable and applicable to the population as a whole were provided.

Reviewer Confidential Comments to Editor

Unfortunately, I do not recommend this manuscript for publication as I believe there are fundamental issues with the study measures and statistical analyses. Furthermore, the sample size and lack of replication mean that the publication of these results would only contribute to the reproducibility problem and further erode the public’s trust in scientific research, without providing any positive impact to the ABCD Study participants, the general public, or the medical and scientific communities.

**********

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Reviewer #1: No

Reviewer #2: No

**********

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PLoS One. 2024 Apr 29;19(4):e0302147. doi: 10.1371/journal.pone.0302147.r002

Author response to Decision Letter 0


11 Mar 2024

Subject: Re: PONE-D-23-29554 - Submission of Revised Manuscript

Dear Dr. Tilga and reviewers,

We appreciate the opportunity to revise and resubmit our manuscript. Thank you for taking the time to review our manuscript and for your valuable questions and feedback regarding the manuscript. We appreciate your thorough review and we have carefully reviewed the comments the academic editor and reviewers provided and addressed each point thoroughly in our revised submission.

I have uploaded the revised submission to the submission system and included the following items:

1. Response to reviewers: A detailed rebuttal letter addressing each point raised during the review process.

2. Revised Manuscript with Track Changes: A marked-up copy of the manuscript highlighting the changes made from the original version.

3. Manuscript: An unmarked version of the revised paper without tracked changes.

4. Strobenut: with revised page numbers and line numbers.

5. Revised Cover letter.

6. Figures, which were checked by PACE software.

We have also ensured that our financial disclosure statement and data availability is updated in the cover letter.

Thank you once again for your time and consideration.

Kind regards, also on behalf of the co-authors

Meredith L. Overman, MSc

Department of Health Promotion, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands.

m.overman@maastrichtuniversity.nl

Attachment

Submitted filename: Response to Reviewers.docx

pone.0302147.s003.docx (54.3KB, docx)

Decision Letter 1

Henri Tilga

28 Mar 2024

The cross-sectional association of parental psychosocial status with children’s Body Mass Index z-score and the mediating role of children’s energy balance behaviors - the ABCD Study

PONE-D-23-29554R1

Dear Dr. Overman,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

Within one week, you’ll receive an e-mail detailing the required amendments. When these have been addressed, you’ll receive a formal acceptance letter and your manuscript will be scheduled for publication.

An invoice will be generated when your article is formally accepted. Please note, if your institution has a publishing partnership with PLOS and your article meets the relevant criteria, all or part of your publication costs will be covered. Please make sure your user information is up-to-date by logging into Editorial Manager at Editorial Manager® and clicking the ‘Update My Information' link at the top of the page. If you have any questions relating to publication charges, please contact our Author Billing department directly at authorbilling@plos.org.

If your institution or institutions have a press office, please notify them about your upcoming paper to help maximize its impact. If they’ll be preparing press materials, please inform our press team as soon as possible -- no later than 48 hours after receiving the formal acceptance. Your manuscript will remain under strict press embargo until 2 pm Eastern Time on the date of publication. For more information, please contact onepress@plos.org.

Kind regards,

Henri Tilga, PhD

Academic Editor

PLOS ONE

Additional Editor Comments (optional):

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #1: All comments have been addressed

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #1: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #1: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #1: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #1: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #1: Dear PLOS ONE editor and authors

My apologies, it appears I have made several misreadings.

The authors have improved their manuscript, so I have no further comments.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #1: No

**********

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    S1 Checklist

    (DOCX)

    pone.0302147.s001.docx (53.2KB, docx)
    S1 Table. STROBE-nut: An extension of the STROBE statement for nutritional epidemiology.

    (DOCX)

    pone.0302147.s002.docx (34KB, docx)
    Attachment

    Submitted filename: Response to Reviewers.docx

    pone.0302147.s003.docx (54.3KB, docx)

    Data Availability Statement

    Due to ethical considerations, the individual data from the ABCD study cannot be deposited in a public repository. This decision is guided by the need to protect the privacy and confidentiality of the study participants. The data contains potentially identifying or sensitive information about the participants, and releasing it publicly could breach their privacy rights. The ABCD data are owned by the Amsterdam University Medical Centers, location AMC in Amsterdam, The Netherlands. Any researcher can request the data by submitting a general publication proposal form to the ABCD Project Team as outlined at https://www.amc.nl/web/abcd-studie-2/abcd-studie/voor-onderzoekers-.htm under section use of data (Dutch: Gebruik van data), by email: abcd@amsterdamumc.nl. The ABCD Project Team will check proposals for compatibility with the general objectives, ethical approvals and informed consent forms of the ABCD study, that are in line with the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants approved by the Central Committee on Research Involving Human Subjects in The Netherlands; the medical ethics review committees of the Academic Medical Center, Amsterdam; the VU University Medical Center Amsterdam; and the Registration Committee of the Municipality of Amsterdam. There are no other restrictions to obtaining the data and all data requests will be processed in the same manner.


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