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. 2024 Apr 24;103:105100. doi: 10.1016/j.ebiom.2024.105100

Fig. 4.

Fig. 4

Comparison of SARS-CoV-2-specific and off-target in vitro immune responses following BNT162b2 and ChAdOx1-S vaccination. Forest plots depicting adjusted geometric mean ratios (GMR) and 95% confidence intervals for the effect of COVID-19 vaccine type on (a) serum IgG (n = 225) (b) iSARS-induced (n = 76–110) and (c and d) BCG (n = 37–115), C. albicans (n = 71–115), E. coli (n = 21–115), S. aureus (n = 70–115) and R848 (n = 24–115) -induced whole blood cytokine and chemokine responses 28 days after the second vaccination dose (V2). (c and d) A sub-set of (c) 7 chemokines and (d) 6 cytokines/growth factors are depicted, data for all cytokine–stimulant pairs are available in Supplementary Table S6. GMR > 1.0 indicates responses that were higher for BNT162b2-vaccinated compared to ChAdOx1-S-vaccinated participants. Abbreviations: BCG, bacille Calmette Guérin; GMR, geometric mean ratio; Ig, immunoglobulin; iSARS, γ-irradiated SARS-CoV-2; R848, resiquimod; RBD, receptor binding domain.