Table 5.
Metaregression analyses to explore potential causes of heterogeneity among included studies
| Factor | Outcome | Effect of factor on outcome | Adjusted R2 (%) |
|---|---|---|---|
| Participants with past use of psychedelics (%) | Change in depression scores | Non-significant (P=0.38) | NA |
| Participants with past use of psychedelics (%) | Response rate | Significant (P=0.001)—each percentage increase point increase in past psychedelic use was associated with an increase of 6.0 points in response rates | 90.4 |
| Participants with previous use of psychedelics (%) | Remission rate | Significant (P=0.024)—each percentage increase point increase in past psychedelic use was associated with an increase of 3.9 points in remission rates | 98.0 |
| Female participants (%) | Change in depression scores | Non-significant (P=0.26) | NA |
| Female participants (%) | Response rate | Non-significant (P=0.35) | NA |
| Female participants (%) | Remission rate | Non-significant (P=0.25) | NA |
| Average participant’s age | Change in depression scores | Non-significant (P=0.43) | NA |
| Average participant’s age | Response rate | Significant (P=0.015)—each year increase in average age was associated with an increase of 0.13 points in response rates | 66.3 |
| Average participant’s age | Remission rate | Non-significant (P=0.16) | NA |
NA=not applicable.