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. 2023 Sep 28;109(5):1348–1358. doi: 10.3324/haematol.2023.283178

Figure 4.

Figure 4.

MI-2 induces apoptosis and cell cycle arrest in B-cell acute lymphoblastic leukemia cell lines. (A) Apoptotic induction quantified by flow cytometry using Annexin-V staining in the shown cell lines following treatment with 0-1 mM of MI-2 for 48 hours (h). (B) Immunoblot showing the change in expression of c-PARP in B-cell acute lymphoblastic leukemia (B-ALL) cell lines following treatment with 0-2 mM of MI-2 for 48 h. (C) Changes in cell cycle quantified by flow cytometry using propidium iodide staining in the shown cell lines following treatment with 0-1 mM of MI-2 for 48 h. *P<0.05, **P< 0.01, ***P<0.001. ns: not significant. Error bars represent Standard Error of Mean.