ERRATUM
Volume 61, no. 7, e00428-23, 2023, https://doi.org/10.1128/jcm.00428-23. Table 2 should appear as shown in this erratum. Data in the last four columns were misaligned.
Table 3: The column heading “Clarithromyci MIC” should read “Clarithromycin MIC.” The following should be added to footnote b: “erm (55)P, plasmid erm (55).”
TABLE 2.
Clinical and laboratory information on 10 clarithromycin-+resistant (MIC, ≥16 µg/ml) PCR erm (55)P-positive isolates (one per patient) and 6 erm (55)-negative isolates with an intermediate clarithromycin MIC (4 µg/mL) of Mycobacterium chelonaea
| Organism and patient no. | Age (yrs) | Geographic location | Strain | Culture dateb | Source | Colony morphology | Clarithromycin MIC (µg/mL) | 23S rRNA mutation | PCR result erm (55)P |
erm (55)P aa sequence | PCR result | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3-day | Extended (days) | erm (55)T | erm (55)C | ||||||||||
| M. chelonae, resistantc | |||||||||||||
| 1 | 54 | OH | 18:60630 | 6/27/2018 | Tissue, ankle wound | Smooth on 7H10, rough irregular edges on TSA | >16 | NA | - | - | 82% | + | - |
| 2 | 74 | WA | 18:62378 | 10/31/2018 | Nasal septal cartilage | Rough on TSA or 7H10 | 1 | (5), (8) 16, >16 | - | + | 100% | - | - |
| 3 | 83 | KY | 19:64973 | 2/27/2019 | Hand | Slightly smooth to smooth granular on 7H10, smooth intermediate with irregular edges on TSA | 2 | (6) >16 | - | + | 100% | - | - |
| 4 | 5 | MA | 20:67831 | 3/13/2020 | BAL | Smooth on TSA, rough on 7H10 | 4 | (4), (5) 8, 16 | - | + | 100% | - | - |
| 4 | 5 | MA | 20:68529 | 3/13/2020 | BAL | Smooth on TSA or 7H10 | 0.25 | (14) 1d | - | - | NA | - | - |
| 5 | 69 | PA | MC6 22:74950 | 8/28/2020 | Leg | Smooth on TSA or 7H10 | 1 | >16 (x3) | - | + | 100% | - | - |
| 6 | 71 | NC | 20:69984 | 12/3/2020 | Synovial fluid | Smooth on TSA, smooth irregular edges on 7H10 | >16 | NA | - | - | 86% | - | + |
| 7 | 75 | MA | 21:70135 | 12/23/2020 | Great toe pus | Smooth on TSA, smooth irregular edges on 7H10 | 2 | (4) >16 | - | + | 100% | - | - |
| 8 | 55 | IA | 21:70968 | 3/5/2021 | Leg | Smooth on TSA, smooth irregular edges on 7H10 | 16 | (4) >16 | - | - | 86% | - | + |
| 9 | 49 | MA | 21:71627 | 5/6/2021 | Knee biopsy | Rough on TSA or 7H10 | 2 | (6) >16 | - | + | 100% | - | - |
| 10 | 25 | AL | 21:73373 | 6/16/2021 | Sputum | Smooth on TSA, smooth irregular edges on 7H10 | >16 | NA | - | - | 82% | + | - |
| M. chelonae, intermediatee | |||||||||||||
| 1 | 34 | NY | 21:71445 | 4/16/2021 | Soft tissue, foot | Smooth on TSA, irregular edges on 7H10 | 0.5 | 4 | NA | - | NA | - | - |
| 2 | 60 | MA | 21:73597 | 9/30/2021 | Sputum | Smooth irregular edges on TSA or 7H10 | 0.12 | 4 | NA | - | NA | - | - |
| 3f | 62 | TX | 21:74200 | 11/26/2021 | Skin | Smooth on TSA, smooth irregular edges on 7H10 | 0.25, 0.5 | 4, 4 | NA | - | NA | - | - |
| 4 | 76 | NY | MC4 22:74948 | 2021 | Sputum | Smooth on TSA or 7H10 | 0.5, 0.5 | 4, 4 | NA | - | NA | - | - |
| 5 | 9 | PA | MC8 22:74954 | 2021 | Abdominal wound | Smooth on TSA, rough on 7H10 | 0.5, 0.25 | 8, 4 | NA | - | NA | - | - |
| 6 | 54 | MO | 22:74477 | 2/11/2022 | Cornea | Smooth on TSA or 7H10 | 0.5 | 4 | NA | - | NA | - | - |
The 10 resistant isolates (from 10 patients) were isolated in Laboratory A or B. Symbols and abbreviations: NA, not applicable; -, negative; 7H10, Middlebrook 7H10 agar; TSA, trypticase soy agar; BAL, bronchoalveolar lavage; aa, amino acids; erm (55)P, plasmid erm; erm (55)T, chromosome on a transposon (55.3); erm (55)C, chromosome not on a transposon (55.2).
Isolates are presented in chronological order of isolation.
Resistant (MIC ≥16 µg/mL; n = 10 patients); also includes one clarithromycin-susceptible isolate from mixed culture (number 4).
Susceptible to clarithromycin (same patient as 20:67831).
Intermediate (MIC = 4 µg/mL; n = 6 isolates from patients).
Same patient had two isolates.