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The FA proteins function in DNA damage repair. Eight of the FA proteins (namely FANCA, B, C, E, F, G, L, and M) form the FA core complex to mono-ubiquitinate two downstream FA proteins, FANCD2 and FANCI, upon DNA damage. The two then form a dimer to recruit other downstream FA proteins, such as FANCD1, FANCJ, and FANCN, to the damaged DNA and influence the DNA replication, cell-cycle control, and DNA repair processes.
