Table 2. Events and Hazard Ratios for Adverse Cardiovascular Outcomes by V142I Carrier Status.
| Outcomes | No./total (%) | Absolute difference, % (95% CI) | Hazard ratio (95% CI)a,b | P value | |
|---|---|---|---|---|---|
| V142I noncarrier events | V142I carrier events | ||||
| HF hospitalization | 2373/22 584 (10.5) | 134/754 (17.8) | 7.3 (4.5 to 10.0) | 1.84 (1.54 to 2.20) | <.001 |
| All-cause death | 8744/22 584 (38.7) | 329/754 (43.6) | 4.9 (1.3 to 8.5) | 1.27 (1.13 to 1.42) | <.001 |
| HF hospitalization or all-cause death | 9290/22 584 (41.1) | 355/754 (47.1) | 5.9 (2.3 to 9.6) | 1.31 (1.18 to 1.46) | <.001 |
| By HF typec | |||||
| HFrEF hospitalization | 740/21 599 (3.4) | 57/721 (7.9) | 4.5 (2.5 to 6.5) | 2.47 (1.87 to 3.26) | <.001 |
| HFpEF hospitalization | 722/21 599 (3.3) | 32/721 (4.4) | 1.1 (−0.4 to 2.6) | 1.43 (0.99 to 2.05) | .054 |
Abbreviations: HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction.
a
Models adjusted for interactions between study genotyping platform and the first 10 principal components and stratified by age, sex, and the genotyping platform.
b
No proportional hazards violations were detected.
c
ARIC participants did not have HF events adjudicated (including ejection fraction) until 2005, leading to different participant numbers for HFrEF and HFpEF events compared with other events.