Table 2.
Composition of CS/DS isomers in the colon.
| % CS/DS isomers (mean ± SEM) | Controls | IBD at Dx | IBD in CR | p-value | ||
|---|---|---|---|---|---|---|
| Control vs IBD at Dx | Control vs IBD in CR | IBD at Dx vs. IBD in CR | ||||
| CS-A (4S) | 76.5 ± 0.7 | 70.1 ± 0.5 | 77.6 ± 0.5 | p < 0.0001 | p = 0.51 | p < 0.0001 |
| CS-C (6S) | 18.1 ± 0.8 | 21.5 ± 0.6 | 16.6 ± 0.5 | p = 0.0027 | p = 0.33 | p < 0.0001 |
| CS-O (0S) | 2.7 ± 0.4 | 2.9 ± 0.2 | 2.2 ± 0.1 | p = 0.94 | p = 0.12 | p = 0.0099 |
| CS-E (4S6S) | 1.5 ± 0.2 | 4.9 ± 0.4 | 2.6 ± 0.2 | p < 0.0001 | p = 0.12 | p < 0.0001 |
| DS (2S4S) | 1.2 ± 0.11 | 0.6 ± 0.05 | 1.0 ± 0.04 | p < 0.0001 | p = 0.0215 | p < 0.0001 |
| Avg. # sulfates per CS/DS | 0.999 ± 0.011 | 1.027 ± 0.021 | 1.015 ± 0.014 | p < 0.0001 | p = 0.0194 | p = 0.0357 |
Relative percentages of colonic CS/DS isomers among control patients (Control), patients with IBD at diagnosis (IBD at Dx), and patients with IBD in clinical remission (IBD in CR).