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. 2024 May 19;14(5):289. doi: 10.3390/metabo14050289

Table 3.

Significantly changed pathways in livers of rats drinking purified water.

Total in Pathway Hits Raw P FDR Impact Enriched Compounds KEGG Link
Aminoacyl–tRNA biosynthesis 67 15 2.49 × 10−8 2.02 × 10−6 0.333 Asparagine, Histidine, Glutamine, Glycine, Aspartic acid, Serine, Methionine, Valine, Alanine, Lysine, Leucine, Tryptophan, Tyrosine, Proline, Glutamic acid http://www.genome.jp/kegg-bin/show_pathway?rno00970/C00152%09DeepSkyBlue/C00135%09DeepSkyBlue/C00064%09DeepSkyBlue/C00037%09DeepSkyBlue/C00049%09DeepSkyBlue/C00065%09DeepSkyBlue/C00073%09DeepSkyBlue/C00183%09DeepSkyBlue/C00041%09DeepSkyBlue/C00047%09DeepSkyBlue/C00123%09DeepSkyBlue/C00078%09DeepSkyBlue/C00082%09DeepSkyBlue/C00148%09DeepSkyBlue/C00025%09DeepSkyBlue (accessed on 18 May 2024)
Nitrogen metabolism 9 4 3.05 × 10−4 6.64 × 10−3 0.444 Glutamic acid, Glutamine, Histidine, Glycine http://www.genome.jp/kegg-bin/show_pathway?rno00910/C00025%09DeepSkyBlue/C00064%09DeepSkyBlue/C00135%09DeepSkyBlue/C00037%09DeepSkyBlue (accessed on 18 May 2024)
Alanine, aspartate, and glutamate metabolism 24 6 3.21 × 10−4 6.64 × 10−3 0.640 Aspartic acid, Alanine, Glutamic acid, GABA, Glutamine, Asparagine http://www.genome.jp/kegg-bin/show_pathway?rno00250/C00049%09DeepSkyBlue/C00041%09DeepSkyBlue/C00025%09DeepSkyBlue/C00334%09DeepSkyBlue/C00064%09DeepSkyBlue/C00152%09DeepSkyBlue (accessed on 18 May 2024)
Arginine and proline metabolism 44 8 3.28 × 10−4 6.64 × 10−3 0.265 Glutamine, Ornithine, Aspartic acid, Glutamic acid, Proline, 4-Hydroxyproline, Guanidoacetic acid, GABA http://www.genome.jp/kegg-bin/show_pathway?rno00330/C00064%09DeepSkyBlue/C00077%09DeepSkyBlue/C00049%09DeepSkyBlue/C00025%09DeepSkyBlue/C00148%09DeepSkyBlue/C01157%09DeepSkyBlue/C00581%09DeepSkyBlue/C00334%09DeepSkyBlue (accessed on 18 May 2024)
Histidine metabolism 15 4 2.73 × 10−3 4.42 × 10−2 0.308 Glutamic acid, Histidine, Aspartic acid, 1-Methylhistidine http://www.genome.jp/kegg-bin/show_pathway?rno00340/C00025%09DeepSkyBlue/C00135%09DeepSkyBlue/C00049%09DeepSkyBlue/C01152%09DeepSkyBlue (accessed on 18 May 2024)
Biosynthesis of unsaturated fatty acids 42 6 6.91 × 10−3 9.32 × 10−2 0 DPA, Arachidonic acid, Dihomo-gamma-linolenic acid, DHA, EPA, alpha-Linolenic acid http://www.genome.jp/kegg-bin/show_pathway?rno01040/C16513%09DeepSkyBlue/C00002%09DeepSkyBlue/C03242%09DeepSkyBlue/C06429%09DeepSkyBlue/C06428%09DeepSkyBlue/C06427%09DeepSkyDeep (accessed on 18 May 2024)
Butanoate metabolism 20 4 8.27 × 10−3 9.45 × 10−2 0.222 3-Hydroxybutyric acid, GABA, Glutamic acid, Butyric acid http://www.genome.jp/kegg-bin/show_pathway?rno00650/C01089%09DeepSkyBlue/C00003%09DeepSkyBlue/C00025%09DeepSkyBlue/C00246%09DeepSkyBlue (accessed on 18 May 2024)
Glycine, serine, and threonine metabolism 32 5 9.34 × 10−3 9.45 × 10−2 0.432 Serine, Guanidoacetic acid, Glycine, Sarcosine, 5-Aminolevulinic acid http://www.genome.jp/kegg-bin/show_pathway?rno00260/C00065%09DeepSkyBlue/C00581%09DeepSkyBlue/C00037%09DeepSkyBlue/C00213%09DeepSkyBlue/C00430%09DeepSkyBlue (accessed on 18 May 2024)