Table 3.
Different H. pylori OMPs, their given names, receptors, and roles in gastric disorders.
| OMP | Also Known as | Receptor | PU | GC | GA | DU | MALT | Reference(s) |
|---|---|---|---|---|---|---|---|---|
| Cag A | Cytotoxicity in associated gene | Epithelial cell | ✓ | ✓ | EPIYAD/C | - | ✓ | [54] |
| Cag L | ||||||||
| Vac A | Vacuolating cytotoxin | RPTP-α | VacAs1m1 VacAs2m2 |
VacAs1m1 | VacAs1m1 | - | - | [43,54] |
| RPTP-β | ||||||||
| Lipids | ||||||||
| Heparin sulphate | ||||||||
| Sphingomyelin | ||||||||
| Fibronectin | ||||||||
| Β2-integrin | ||||||||
| EGFR | ||||||||
| Hop B/C | Alp A/B | Laminin | - | - | - | - | - | [190,191] |
| Collagen IV | ||||||||
| Hop H | Oip A | Not known | ✓ | ✓ | - | ✓ | [54,88,91] | |
| Hop P | Sab A | sLex | - | - | - | - | ✓ | [58] |
| sLea | ||||||||
| Hop S | Bab A | sLeb | Bab A2 | ✓ | ✓ | - | - | [54] |
| A, B, O blood group | ||||||||
| Hop Q | - | CEACAMs | - | ✓ | - | - | - | [121] |
Abbreviations: PU, peptic ulcer; GC, gastric cancer; GA, gastric adenocarcinoma; DU, duodenal ulcer; MALT, mucosa-associated lymphoid tissue; sLe, sialyl-Lewis; EGFR, epidermal growth factor receptor; ✓, genopositive.