Fig. 1.
The sialyltransferase enzyme ST6GAL1 is upregulated in prostate cancer that has spread to the bone. (a) Immunohistochemistry analysis of a previously published 125 case tissue microarray (TMA)29 to compare ST6GAL1 levels in localised prostate cancer tumours and prostate cancer tissues presenting with metastasis to bone or lymph node (all biopsy samples were taken from the primary site). Further details for this cohort are provided in Supplementary Table S1. ST6GAL1 protein levels are 1.7-fold upregulated in patients with prostate cancer lymph node metastasis (unpaired t test, p = 0.1657) and 2.3-fold upregulated in patients with prostate cancer bone metastasis (unpaired t test, p = 0.0091). Scale bar is 100 μm.