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. 2009 Oct 1;11(10):885–888. doi: 10.1016/j.jfms.2009.04.002

HER-2/neu (c-erbB-2) oncoprotein in hyperplastic endometrial polyps detected in two cats

Deniz Misirlioglu 1, Deniz Nak 2, Musa Ozgur Ozyigit 3, Yavuz Nak 4, Ahmet Akkoc 5
PMCID: PMC11135513  PMID: 19560383

Abstract

The presence of HER-2/neu (c-erbB-2) oncoprotein, oestrogen-α receptor (ER), and progesterone receptor (PR) in hyperplastic endometrial polyps (EPs) of two cats with cystic endometrial hyperplasia-pyometra (CEH-P) complex was investigated. Immunohistochemistry assay for ER, PR and c-erbB-2 oncoprotein in the glandular and stromal tissue of the EPs was performed. ER and c-erbB-2 immunoreactivity was observed in the glandular epithelium of the EPs whereas PR immunoreactivity was detected only in the stromal fibroblasts. The c-erbB-2 oncoprotein may play a role with the ER in the pathogenesis of the hyperplastic EPs, although the role of this oncoprotein in the pathogenesis of EPs has yet to be determined.

Contributor Information

Deniz Misirlioglu, Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey  denizy@uludag.edu.tr.

Deniz Nak, Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey.

Musa Ozgur Ozyigit, Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey.

Yavuz Nak, Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey.

Ahmet Akkoc, Department of Pathology, Faculty of Veterinary Medicine, Uludag University, 16059 Gorukle, Bursa, Turkey.

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