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Cellular and Molecular Life Sciences: CMLS logoLink to Cellular and Molecular Life Sciences: CMLS
. 2006 Feb 23;63(6):637–641. doi: 10.1007/s00018-005-5541-1

Functional interactions of protein kinase A and C in signalling networks: a recapitulation

E Maioli 1,, C Torricelli 1, V Fortino 1
PMCID: PMC11136383  PMID: 16501886

Abstract.

On the basis of evidence collected from the literature, we propose a general model by which protein kinase (PK) A and the different PKC isoforms can inversely affect cell growth. Molecular switches, which are able to direct the signal towards antiproliferative or mitogenic pathways, are the different isoforms of Raf and PKC. Conflicting data are also reported and discussed in an attempt to reconcile them.

Key words. PKA, Raf-1, Raf B, RKIP, PKC isoforms, ERKs, p21

Footnotes

Received 10 November 2005; received after revision 28 December 2005; accepted 3 January 2006


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