Abstract.
The Trk family of neurotrophin receptors plays essential roles in cell fate specification, survival, growth, and differentiation. Their expression patterns are complex and dynamically regulated under many physiological and pathological conditions. However, the molecular mechanisms that control their tissue-specific expression are largely unknown. In this report, we review current knowledge about the transcriptional regulation of Trk receptors.
Keywords. Transcription, neurotrophin, TrkA, TrkB, TrkC, Klf7, Brn3a, Runx1, Runx3, Wt1, HF-1b, CREB, NeuroD, Ngn1, Ngn2, C-Jun, T3R
Footnotes
Received 13 July 2006; received after revision 9 October 2006; accepted 24 November 2006