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. 1998 Sep 5;317(7159):682. doi: 10.1136/bmj.317.7159.682a

Long term follow up of children with recurrent abdominal pain

Definition of recurrent abdominal pain was not applied

Ishaq Abu-Arafeh 1
PMCID: PMC1113851  PMID: 9728012

Editor—Large longitudinal studies of children with recurrent abdominal pain, such as the one Hotopf et al conducted, are needed. Current knowledge is limited, and studies on the long term follow up of patients with recurrent abdominal pain should fill the gaps. Hotopf et al have addressed this important subject by trying to answer two questions, as the title of their paper indicates.1 The prevalence of recurrent abdominal pain in their cohort (2%) was lower than that reported in cross sectional studies (8-12%).2,3 This suggests problems with the collection and reliability of the data.

Hotopf et al’s first question was, “Why do children have chronic abdominal pain?” Their study was not, however, designed to answer this question. They did not have enough information and did not look for any to help them identify possible causes of abdominal pain. The subjects of the study were identified from a cohort born in 1946, and the information was collected at the ages of 7, 11, and 15. The information could not be verified by further questioning, and Apley’s definition of recurrent abdominal pain was not applied.2 Hotopf et al described the abdominal pain as recurrent, persistent, and chronic, but interchangeably, which added to the confusion and lack of conviction about the condition in question. Although there is no unifying definition that applies to all cases of recurrent abdominal pain in children, the children were treated as if they were a homogeneous group.

Hotopf et al’s second question related to what happens to children with recurrent abdominal pain when they grow up. Without a proper definition of recurrent abdominal pain, their conclusions could be true for any non-specific painful condition. Although Hotopf et al’s conclusions are useful to describe any child with recurrent ache and pain of unidentifiable cause, they are not specific to recurrent abdominal pain as described and defined by Apley.

References

  • 1.Hotopf M, Carr S, Mayou R, Wadsworth M, Wessely S. Why do children have chronic abdominal pain, and what happens to them when they grow up? Population based cohort study. BMJ. 1998;316:1196–1200. doi: 10.1136/bmj.316.7139.1196. . (18 April.) [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 2.Apley J, Naish N. Recurrent abdominal pains: a field survey of 1000 school children. Arch Dis Child. 1958;33:165–170. doi: 10.1136/adc.33.168.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Abu-Arafeh I, Russell G. Prevalence and clinical features of abdominal migraine compared with those of migraine headache. Arch Dis Child. 1995;72:413–417. doi: 10.1136/adc.72.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
BMJ. 1998 Sep 5;317(7159):682.

Authors’ reply

Matthew Hotopf 1,2,3,4, S Wessely 1,2,3,4, Siobhan Carr 1,2,3,4, Richard Mayou 1,2,3,4, M Wadsworth 1,2,3,4

Editor—Abu-Arafeh points out the importance of long term follow up of children with recurrent abdominal pain. This was our motive in presenting a long (21 year), large (n=3637), population based prospective cohort study of children with functional abdominal pain. Most of Abu-Arafeh’s comments relate to the fact that we were unable to use a definition for recurrent abdominal pain that was first used some years after our study had started.1-1 We do not think, however, that this reduces the validity of our findings.

Firstly, Apley’s definition, like definitions of most other functional somatic symptoms, is arbitrary. The main reason for using it is that other studies have done so, but there are no other reasons to think that it represents a unique clinical entity; it is a means of labelling a common clinical problem. Secondly, contrary to Abu-Arafeh’s assertion, we did explore other causes for chronic pain in the children by assessing their hospital records from the age of 0-15. Thirdly, the outcome we used is probably a more severe category than recurrent abdominal pain as defined by Apley. We believe that it is likely that the children whom we identified would have met Apley’s criteria. Our definition may not have captured Apley’s notion of recurrent abdominal pain precisely, but this is offset by the fact that our sample was population based and therefore less prone to systematic biases than studies based purely in clinical settings.

Funding is unlikely to become available nowadays to follow up such a large cohort of children over such a long time, and even if it did, one would have to wait many years for the results. We believe that, in the meantime, the main findings of our paper—that children with persistent abdominal pain come from families with high rates of physical illness and are at increased risk of later anxiety and depression—are useful to help us understand the causes and outcome of functional somatic symptoms in childhood.

References

  • 1-1.Apley J, Naish N. Recurrent abdominal pains: a field study of 1000 school children. Arch Dis Child. 1957;33:165–170. doi: 10.1136/adc.33.168.165. [DOI] [PMC free article] [PubMed] [Google Scholar]

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