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[Preprint]. 2024 May 26:2024.05.24.595804. [Version 1] doi: 10.1101/2024.05.24.595804

Table 3: Significant p values from one-way ANOVA (genotype) for male P30 Ts65Dn,Dyrk1afl/+,rtTA+,TetOCre+ (Ts65Dn × Dyrk1a+/dox-cre offspring) trabecular and cortical parameters.

All effect and interaction p values reported are adjusted using the Benjamini-Hochberg method. Welch’s t-test was performed to confirm ANOVA results when a significant Levene’s test occurred, indicating unequal variances between groups, and these p values are unadjusted. All p values from post hoc analyses are unadjusted.

BMD BV/TVǂ Tb.Th Tb.Sp Tb.N
Genotype 0.003 0.003 NS 0.003 0.003
Welch’s t-test N/A N/A N/A 0.001 N/A
Post Hoc Tukey Tukey N/A GH Tukey
Eu v. Eu,Dyrk1a +/dox-cre NS NS N/A NS NS
Eu v. Ts 0.027 0.022 N/A NS NS
Eu v. Ts,Dyrk1a +/+/dox-cre 0.022 0.009 N/A 0.042 0.023
Ts v. Ts,Dyrk1a +/+/dox-cre NS NS N/A NS NS
Eu,Dyrk1a+/dox-cre v. Ts 0.019 0.008 N/A 0.002 0.001
Eu,Dyrk1a+/dox-cre v. Ts,Dyrk1a+/+/dox-cre 0.015 0.004 N/A 0.009 0.001
Tt.Ar Ma.Ar Ct.Ar Ct.Th Ps.Pm Ec.Pm Imax Imin TMD
Genotype 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002 0.002
Welch’s t-test 0.001 0.001 N/A N/A N/A 0.001 0.001 0.001 N/A
Post Hoc GH GH Tukey Tukey Tukey GH GH GH Tukey
Eu v. Eu,Dyrk1a +/dox-cre NS NS NS NS NS NS NS NS NS
Eu v. Ts 0.004 0.022 0.001 0.001 0.001 0.010 0.006 0.004 0.001
Eu v. Ts,Dyrk1a +/+/dox-cre 0.009 0.027 0.001 0.001 0.003 0.013 0.007 0.008 0.032
Ts v. Ts,Dyrk1a +/+/dox-cre NS NS NS NS NS NS NS NS NS
Eu,Dyrk1a+/dox-cre v. Ts 0.001 0.001 0.001 0.004 0.002 0.001 0.001 0.001 0.001
Eu,Dyrk1a+/dox-cre v. Ts,Dyrk1a+/+/dox-cre 0.013 0.001 0.005 0.007 0.017 0.003 0.009 0.008 0.002
ǂ

indicates the data was log-transformed for statistical analysis due to non-normal distribution. NS indicates p value was not significant. N/A indicates Welch’s t-test was not performed because Levene’s test was not significant or post hoc analysis was not performed because one-way ANOVA was not significant. GH stands for Games-Howell post hoc analysis. Euploid (n = 10), euploid,Dyrk1a+/dox-cre (n = 7), Ts65Dn (n = 11), Ts65Dn,Dyrk1a+/+/dox-cre (n = 4).