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The technique of X-ray diffraction has been successfully applied to enzymes associated with peptidoglycan biosynthesis. The technique has taught us a great deal about the structures and catalytic mechanisms of penicillin-binding proteins and β-lactamases. An insight into the structural basis for antibiotic resistance is given.
Keywords: Key words. X-ray diffraction; β-lactamases; peptidases; penicillin-binding proteins; active-site serine.
